Chlorothiazide

The Chlorothiazide with the cas number 58-94-6, is also called (1)2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide; (2)6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide ; (3)6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; (4) Alurene ; (5) Chlorosal ; (6) Chlorothiazid ; (7) Chlorothiazide ; (8) Chlorothiazidum ; (9) Chlorthiazid ; (10) Chlorthiazide ; (11) Chlorthiazidum ; (12) Chlortiazid ; (13) Chlorurit ; (14) Chlotride ; (15) Clorotiazida ; (16) Clorotiazide ; (17) Clotride ; (18) Diuresal ; (19) Diuril ; (20) Diuril Boluses, Veterinary ; (21) Diurilix ; (22) Diurite ; (23) Diutrid ; (24) Flumen ; (25) Minzil ; (26) Neo-dema ; (27) SK-Chlorothiazide ; (28) Salisan ; (29) Salunil ; (30) Saluretil ; (31) Saluric ; (32) Thiazide ; (33) Urinex ; (34) Warduzide ; (35) Yadalan . It belongs to the following product categories: (1)Heterocycles; (2)Intermediates & Fine Chemicals; (3)Pharmaceuticals; (4)Sulfur & Selenium Compounds and so on.

Propertes of Chlorothiazide: (1)ACD/LogP: -0.18 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): -0.3 ; (4)ACD/LogD (pH 7.4): -1.51 ; (5)ACD/BCF (pH 5.5): 1 ; (6)ACD/BCF (pH 7.4): 1 ; (7)ACD/KOC (pH 5.5): 14.43 ; (8)ACD/KOC (pH 7.4): 1 ; (9)#H bond acceptors: 7 ; (10)#H bond donors: 3 ; (11)#Freely Rotating Bonds: 1 ; (12)Polar Surface Area: 103.88 Å² ; (13)Index of Refraction: 1.801 ; (14)Molar Refractivity: 61.83 cm³ ; (15)Molar Volume: 144.4 cm³ ; (16)Polarizability: 24.51 ×10^-24cm³ ; (17)Surface Tension: 96.5 dyne/cm ; (18)Density: 2.04 g/cm³ ; (19)Flash Point: 322 °C Enthalpy of Vaporization: 90.44 kJ/mol ; (20)Boiling Point: 608.8 °C at 760 mmHg Vapour Pressure: 9.17E-15 mmHg at 25°C

The Chlorothiazide is off-white solid. Stable. It is stable and incompatible with strong oxidizing agents. It is mainly used for all sorts of edema and hypertension. Diuretic: oral administration or mainline 0.5-1g/times, 1-2 times per day; Depressurization: beginning oral administration 0.5-1g, 2 times per day, and maintain quantity can achieve 2gb/day; Children, younger than 6 months, 30mg/kg/day, 2 times oral; 6 months-2 years old, 0.125-0.375g/day, 2 times; 2-12 years old, 0.375-1g/day, 2 times. The adverse reactions includ as the following：dry mouth, muscle pain, drowsiness, gout, nausea, vomiting, diarrhea, rashes, acute pancreatitis, thrombocytopenia, hyponatremia, low concentration and chlorine alkali hypokalemia disease.

You can still convert the following datas into molecular structure :
1. SMILES: O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C\N2)N
2. InChI: InChI=1/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

The Chlorothiazide toxic data can be showed in the following sheet.|