Product Name

  • Name

    chlorоphentermine

  • EINECS 207-314-9
  • CAS No. 461-78-9
  • Article Data8
  • CAS DataBase
  • Density 1.074g/cm3
  • Solubility
  • Melting Point
  • Formula C10H14 Cl N
  • Boiling Point 255.8°Cat760mmHg
  • Molecular Weight 183.681
  • Flash Point 127°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: blood pressure elevation and sympathetic nervous system stimulation. An experimental teratogen. Mutation data reported. An anorectic drug which diminishes the appetite. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 461-78-9 (chlorоphentermine)
  • Hazard Symbols
  • Synonyms Phenethylamine,p-chloro-a,a-dimethyl- (6CI,8CI);1-(4-Chlorophenyl)-2-methylpropan-2-amine;1-(p-Chlorophenyl)-2-methyl-2-aminopropane;4-Chloro-a,a-dimethylphenethylamine;Chlorphentermine;Clorfentermina;Desopimon;Effox;Lucofen SA;Teramine;p-Chloro-a,a-dimethylphenethylamine;a,a-Dimethyl-4-chlorobenzeneethanamine;
  • PSA 26.02000
  • LogP 3.32010

Chlorphentermine Chemical Properties

IUPAC Name: 1-(4-Chlorophenyl)-2-methylpropan-2-amine
Synonyms of Chlorphentermine (CAS NO.461-78-9) : 1-(4-Chlorophenyl)-2-methylpropan-2-amine ; 4-Chloro-a,a-dimethylbenzeneethanamine ; a,a-Dimethyl-p-chlorophenethylamine ; Avicol ; Benzeneethanamine, 4-chloro-.alpha.,.alpha.-dimethyl-
CAS NO: 461-78-9
Molecular Formula:C10H14ClN
Molecular Weight :183.6779
Molecular Structure :
EINECS: 207-314-9
Index of Refraction: 1.537
Surface Tension: 37.6 dyne/cm
Density: 1.074 g/cm3
Flash Point: 127 °C
Enthalpy of Vaporization: 49.33 kJ/mol
Boiling Point: 255.8 °C at 760 mmHg
Vapour Pressure: 0.016 mmHg at 25°C
 

Chlorphentermine History

 Chlorphentermine (CAS NO.461-78-9) is developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine,which is still in current use.Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.

Chlorphentermine Uses

 Chlorphentermine (CAS NO.461-78-9) (trade names Apsedon, Desopimon, Lucofen) is an appetite suppressant.

Chlorphentermine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 5357ug/kg (5.357mg/kg) AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION		 Therapie. Vol. 34, Pg. 205, 1979.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Acta Pharmaceutica Suecica. Vol. 15, Pg. 87, 1978.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00697,
mouse LD50 oral 270mg/kg (270mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: EXCITEMENT		 Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969.
mouse LD50 subcutaneous 260mg/kg (260mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969.
rat LD50 oral 250mg/kg (250mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(6), Pg. 218S, 1969.

Chlorphentermine Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: blood pressure elevation and sympathetic nervous system stimulation. An experimental teratogen. Mutation data reported. An anorectic drug which diminishes the appetite. When heated to decomposition it emits very toxic fumes of Cl− and NOx.

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