D-Cysteine supplier | CasNO.921-01-7

Name
D-Cysteine
EINECS 213-062-0
CAS No. 921-01-7
Article Data198
CAS DataBase
Density 1.335 g/cm³
Solubility Soluble in water (partly).
Melting Point ~230 °C
Formula C₃H₇NO₂S
Boiling Point 293.9 °C at 760 mmHg
Molecular Weight 121.16
Flash Point 131.5 °C
Transport Information
Appearance white crystals or crystalline powder
Safety 26-36/37/39
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn; Xi
Synonyms Cysteine,D- (8CI);(S)-Cysteine;(S)-2-Amino-3-mercaptopropionic acid;
PSA 102.12000
LogP 0.02840

Synthetic route

: 444-27-9, 19291-02-2, 34592-47-7, 45521-09-3
L-thiaproline

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With hydroxylamine hydrochloride	83%
With hydroxylamine hydrochloride In methanol reflux, 120 min, ice bath, 60 min;	82%

: 17087-37-5, 17087-38-6, 17205-71-9, 57918-01-1, 85504-88-7, 85504-89-8, 88271-26-5, 88271-27-6, 88271-28-7, 88271-29-8, 88271-30-1, 110270-21-8, 110270-23-0, 110311-43-8, 124650-44-8, 124650-45-9, 124650-46-0, 124650-49-3, 124650-50-6, 124650-51-7, 132338-92-2, 149885-33-6
(4S-)-2-(D-gluco-1,2,3,4,5-Pentahydroxypentyl)-4-thiazolidincarbonsaeure

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol; water for 4h; Heating;	79%

: 17087-37-5, 17087-38-6, 17205-71-9, 57918-01-1, 85504-88-7, 85504-89-8, 88271-26-5, 88271-27-6, 88271-28-7, 88271-29-8, 88271-30-1, 110270-21-8, 110270-23-0, 110311-43-8, 124650-44-8, 124650-45-9, 124650-46-0, 124650-49-3, 124650-50-6, 124650-51-7, 132338-92-2, 149885-33-6
(4S)-2-(D-manno-1,2,3,4,5-Pentahydroxypentyl)-4-thiazolidincarbonsaeure

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With hydrazine hydrate In methanol for 0.75h; Heating;	75%

: 88271-26-5
(2S,4S)-2-(D-galacto-1,2,3,4,5-Pentahydroxypentyl)-4-thiazolidincarbonsaeure

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol for 2h; Heating;	73%

: 17087-36-4, 59246-17-2, 88271-31-2, 110270-13-8, 110270-14-9, 110270-15-0, 110270-16-1, 110270-17-2, 110270-18-3, 110270-19-4, 110270-20-7, 115184-30-0, 124650-47-1, 124650-48-2
(4S)-2-(L-arabino-1,2,3,4-Tetrahydroxybutyl)-4-thiazolidincarbonsaeure

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol; water for 3.5h; Heating;	60%

: 921-01-7, 3374-22-9, 4371-52-2, 40143-64-4, 40143-66-6, 40143-69-9, 52-90-4
rac-cysteine

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
beim selektiven Abbau durch Escherichia coli;

: 349-46-2
S,S-cystine

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With hydrogenchloride; tin

: 3054-01-1, 5680-65-9, 16597-46-9, 23032-53-3
(D)-2-Amino-3-(benzylthio)propanoic acid

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With ammonia; sodium

: 2998-83-6
(2R,2'R)-2-amino-4-(2'-amino-2'-carboxyethylsulfanyl)butanoic acid

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
Spaltung durch Leber-Extrakt;

: 52-90-4
L-Cysteine

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With water; acetone Product distribution; 1.) acetic acid, reflux, 2.5 h; 2.) methanol, room temp, 30 min;

: 3981-36-0
3-chloro-DL-alanine

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With sodium hydrogensulfide; potassium phosphate buffer; acetone at 30℃; for 2h; 3-chloro-D-alanine-lyase; Yield given;

: 2731-73-9, 3981-36-0, 13215-35-5, 39217-38-4
(S)-3-chloroalanine

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With dinitrogen sulphide; pyridoxal 5'-phosphate; sodium dodecyl-sulfate at 30℃; for 3.5h; Pseudomonas fluorescens CR 19-1, 0.1 M phosphate buffer, pH 8.5;
With sodium hydrogensulfide; potassium phosphate buffer; pyridoxal 5'-phosphate In acetone at 30℃; for 2h; Pseudomonas putida CR 1-1 cells; Yield given;

: 4-ethylbenzenesulfonic acid D-cysteine salt

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With triethylamine In methanol for 0.5h;

: 921-01-7, 3374-22-9, 4371-52-2, 40143-64-4, 40143-66-6, 40143-69-9, 52-90-4
rac-cysteine

A: 921-01-7
D-cysteine

B: 52-90-4
L-Cysteine

Conditions

Conditions	Yield
With teicoplanin In methanol; water Product distribution; Further Variations:; Reagents; pH-values; Solvents;
Resolution of racemate; enantioselective reaction;	A n/a B n/a
Resolution of racemate; enantioselective reaction;	A n/a B n/a
With R-(3,3'-dibromo-1,1'-binaphthyl)-20-crown-6 coated C18 silica gel column at 25℃; pH=2; Resolution of racemate;
With capillary electrochromatography open-tubular column coated with 1-allylimidazolium-β-cyclodextrin In aq. acetate buffer at 20℃; pH=8; pH-value; Resolution of racemate;

: hydrgensulfide(1-)

: 6020-39-9
L-cystine

A: 921-01-7
D-cysteine

B: disulfide

Conditions

Conditions	Yield
In further solvent(s) Kinetics; in pH 10.0 borate buffer; detected with UV-vis sectroscopy and ion-exchange chromatography;

...Expand

: 1359827-55-6
hapalocyclamide

A: 56-41-7
L-alanin

B: 338-69-2
D-Alanine

C: 921-01-7
D-cysteine

D: 150-30-1
Phenylalanine

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 19h;

...Expand

: 1359827-55-6
hapalocyclamide

A: 338-69-2
D-Alanine

B: 921-01-7
D-cysteine

C: 63-91-2
L-phenylalanine

D: 673-06-3
D-(R)-phenylalanine

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 1h;

...Expand

: Z-Ile-Glu(OMe)-Thr-Asp(OMe)-D-Cys

: 921-01-7
D-cysteine

Conditions

Conditions	Yield
With caspase 8 for 1h;

: 921-01-7
D-cysteine

: 172949-72-3
2,4-Di-tert-butoxy-pyrimidine-5-carbaldehyde

: 1025823-01-1
(2S,4S)-2-(2,4-Di-tert-butoxy-pyrimidin-5-yl)-thiazolidine-4-carboxylic acid

Conditions

Conditions	Yield
In ethanol; water	100%

: 921-01-7
D-cysteine

: 106-94-5
propyl bromide

: 85955-34-6
S-propyl-D-cysteine

Conditions

Conditions	Yield
With ammonia; sodium	98%

: 921-01-7
D-cysteine

: 107-18-6
allyl alcohol

: Fudosteine

Conditions

Conditions	Yield
With potassium sulfate In water at 30℃;	98%

: 921-01-7
D-cysteine

: 6182-78-1
tert-butyl 4-iodobutanoate

: 4-((2S)-amino-2-carboxy-ethylsulfanyl)-butyric acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: D-cysteine With sodium hydroxide; water In methanol at 0℃; Stage #2: tert-butyl 4-iodobutanoate In methanol for 0.0833333h; Stage #3: With hydrogenchloride; water In methanol pH=~ 8;	97%

: 921-01-7
D-cysteine

: 939-69-5
2-cyano-6-hydroxybenzothiazole

: 2591-17-5
D-luciferin

Conditions

Conditions	Yield
In water at 20℃;	95%
With ammonia; sodium In methanol; water	94%
Stage #1: D-cysteine; 2-cyano-6-hydroxybenzothiazole In aq. buffer for 1h; Stage #2: With ATP; magnesium chloride; zinc(II) chloride; luciferase In aq. buffer	27%

: 67-56-1
methanol

: 921-01-7
D-cysteine

: 5714-80-7, 18598-63-5, 70361-61-4
D-cysteine methyl ester hydrochloride

Conditions

Conditions	Yield
With acetyl chloride at 0℃; for 2h; Reflux;	94%
With hydrogenchloride for 12h;
With hydrogenchloride at 100℃; for 0.5h;

: 151-56-4
ethyleneimine

: 921-01-7
D-cysteine

: 53526-71-9
2-amino-3-<(2-aminoethyl)thio>-propanoic acid

Conditions

Conditions	Yield
With phosphate buffer at 0℃; pH 8.0;	92%

: 921-01-7
D-cysteine

: 14470-28-1
mono-4-methoxytrityl chloride

: 926935-33-3
C23H23NO3S

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;	92%

: 934270-86-7
6-(methylamino)benzo[d]-thiazole-2-carbonitrile

: 921-01-7
D-cysteine

: D-(-)-2-(6'-methylamino-2'-benzothiazolyl)-Δ2-thiazoline-4-carboxylic acid

Conditions

Conditions	Yield
In methanol for 1h; pH=8; aq. sodium phosphate buffer; Inert atmosphere;	91%

: 921-01-7
D-cysteine

: 6812-16-4
2-Hydroxy-3-methoxybenzonitrile

: (S)-2-(2-Hydroxy-3-methoxy-phenyl)-4,5-dihydro-thiazole-4-carboxylic acid

Conditions

Conditions	Yield
With phosphate buffer In methanol at 70℃; for 17h;	90%

: 67-56-1
methanol

: 921-01-7
D-cysteine

: (S)-(+)-Cysteinmethylester

Conditions

Conditions	Yield
Stage #1: methanol With acetyl chloride at 0℃; for 0.0833333h; Stage #2: D-cysteine for 6h; Reflux;	90%

: 921-01-7
D-cysteine

: 24424-99-5
di-tert-butyl dicarbonate

: 126686-73-5
N,N’-di-Boc-L-cystine

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water for 24h; pH=10;	89%

: 921-01-7
D-cysteine

: 6-((4-(dimethylamino)phenyl)amino)benzo[d]thiazole-2-carbonitrile

: (S)-2-(6-((4-(dimethylamino)phenyl)amino)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer for 1h; pH=8; Inert atmosphere;	88%

: 64-17-5
ethanol

: 921-01-7
D-cysteine

: 75521-14-1
D-cysteine ethyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: ethanol With thionyl chloride at -5 - 20℃; for 1.5h; Stage #2: D-cysteine at 50℃; for 4h;	87.5%

: 921-01-7
D-cysteine

: 613-45-6
2,4-Dimethoxybenzaldehyde

: C12H15NO4S

Conditions

Conditions	Yield
In ethanol at 20℃; for 48h;	87%

: 921-01-7
D-cysteine

: N-(2-cyanobenzo[d]thiazol-6-yl)ethanesulfonamide

: (S)-2-(6-(ethylsulfonamido)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer for 1h; pH=8;	86%

: 921-01-7
D-cysteine

: N-(2-cyanobenzo[d]thiazol-6-yl)methanesulfonamide

: (S)-2-(6-(methylsulfonamido)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In aq. phosphate buffer; acetonitrile for 1h; pH=8;	86%

: 921-01-7
D-cysteine

: 501-53-1
benzyl chloroformate

: 74-88-4
methyl iodide

: 95406-98-7
N-(benzyloxycarbonyl)-S-methyl-D-cysteine

Conditions

Conditions	Yield
Stage #1: D-cysteine; methyl iodide With sodium In methanol Stage #2: benzyl chloroformate With sodium hydroxide	85%

...Expand

: 64-67-5
diethyl sulfate

: 921-01-7
D-cysteine

: (S)-2-amino-3-(ethylthio)propanoic acid

Conditions

Conditions	Yield
With barium(II) hydroxide at 20℃; for 3h;	85%

: 921-01-7
D-cysteine

: 623-05-2
(4-hydroxyphenyl)methanol

: D-[S-(4'-hydroxybenzyl)]cysteine

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; for 0.333333h; pH=2;	84.7%

: 921-01-7
D-cysteine

: 6-((4-hydroxyphenyl)amino)benzo[d]thiazole-2-carbonitrile

: (S)-2-(6-((4-hydroxyphenyl)amino)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer for 1h; pH=8; Inert atmosphere;	84%

: 921-01-7
D-cysteine

: 6-(2-oxooxazolidin-3-yl)benzo[d]thiazole-2-carbonitrile

: (S)-2-(6-(2-oxooxazolidin-3-yl)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer for 1h; pH=8; Inert atmosphere;	84%

: 921-01-7
D-cysteine

: 1417816-65-9
5-methoxythiazolo[5,4-b]pyridine-2-carbonitrile

: (S)-2-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In water; N,N-dimethyl-formamide; acetonitrile for 0.166667h;	83%

: 921-01-7
D-cysteine

: 169776-04-9
6-fluorobenzo[d]thiazole-2-carbonitrile

: (S)-2-(6-fluorobenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer for 1h; pH=8; Inert atmosphere;	81%

: 921-01-7
D-cysteine

: N-(2-cyanobenzo[d]thiazol-6-yl)cyclopentanesulfonamide

: (S)-2-(6-(cyclopentanesulfonamido)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer for 1h; pH=8;	80%

: 921-01-7
D-cysteine

: 2-cyanobenzo[d]thiazol-6-yl 4-oxopentanoate

: (S)-2-(6-((4-oxopentanoyl)oxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; dichloromethane; water at 0 - 25℃; for 0.5h; Inert atmosphere;	79.7%

: 921-01-7
D-cysteine

: N-(2-cyanobenzo[d]thiazol-6-yl)propane-2-sulfonamide

: (S)-2-(6-(1-methylethylsulfonamido)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
In methanol; aq. phosphate buffer for 1h; pH=8;	79%

: 1-(3',4'-dihydroxyphenyl)decan-3-one

: 921-01-7
D-cysteine

: 3’-S-cysteinyl-1-(3,4-dihydroxyphenyl)decan-3-one

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In methanol; aq. phosphate buffer at -78 - 20℃; for 1.5h;	78%

D-Cysteine Specification

The CAS registry number of D-Cysteine is 921-01-7. Its EINECS registry number is 213-062-0. In addition, the molecular formula is C₃H₇NO₂S and the molecular weight is 121.16. The IUPAC name is (2S)-2-amino-3-sulfanylpropanoic acid. What's more, it is a kind of white crystalline powder and should be stored in a cool and dry place.

Physical properties about D-Cysteine are: (1)ACD/LogP: 0.09; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 3; (7)#H bond donors: 3; (8)#Freely Rotating Bonds: 4; (9)Polar Surface Area: 102.12 Å²; (10)Index of Refraction: 1.55; (11)Molar Refractivity: 28.902 cm³; (12)Molar Volume: 90.783 cm³; (13)Polarizability: 11.458 ×10^-24cm³; (14)Surface Tension: 58.975 dyne/cm; (15)Density: 1.335 g/cm³; (16)Flash Point: 131.536 °C; (17)Enthalpy of Vaporization: 58.69 kJ/mol; (18)Boiling Point: 293.883 °C at 760 mmHg.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: C([C@H](C(=O)O)N)S
(2)Std.InChI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m1/s1
(3)Std.InChIKey: XUJNEKJLAYXESH-UWTATZPHSA-N

Product Name

D-Cysteine

Synthetic route

D-Cysteine Specification

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