Product Name

  • Name

    Diclofenac sodium

  • EINECS 239-346-4
  • CAS No. 15307-79-6
  • Article Data20
  • CAS DataBase
  • Density 0.781 g/cm3
  • Solubility Water solubility: 50 mg/mL
  • Melting Point 288-290 °C
  • Formula C14H10Cl2NNaO2
  • Boiling Point 412 °C at 760 mmHg
  • Molecular Weight 318.135
  • Flash Point 203 °C
  • Transport Information UN 2811 6.1/PG 3
  • Appearance white or off-white powder
  • Safety 22-36/37-45
  • Risk Codes 25
  • Molecular Structure Molecular Structure of 15307-79-6 (Diclofenac sodium)
  • Hazard Symbols ToxicT,IrritantXi
  • Synonyms Neriodin;Dichronic;Hyanalgese D;Diclofenac sodium [USAN:JAN];Solaraze;Sodium (2-((2,6-dichlorophenyl)amino)phenyl)acetate;Voltaren;Sodium (o-(2,6-dichloroanilino)phenyl)acetate;Naclof;
  • PSA 52.16000
  • LogP 3.10240

Synthetic route

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester
15307-78-5

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium hydroxide In water; N,N-dimethyl-formamide at 80℃; for 24h;96.1%
1-(2,6-dichlorophenyl)indolin-2-one
15362-40-0

1-(2,6-dichlorophenyl)indolin-2-one

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 4h; Heating;93%
With sodium dithionite; water; sodium hydroxide for 6h; Reflux;92.3%
With sodium hydroxide In ethanol for 3h; Heating;85%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In toluene for 10h; Reflux;83.6%
With sodium hydroxide for 2h; Temperature; Reflux;4.035 g
C22H17Cl2NO3

C22H17Cl2NO3

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With water; sodium hydroxide In methanol for 6h; Solvent; Reflux;86%
potassium 2-iodophenylacetate
100754-92-5

potassium 2-iodophenylacetate

2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; copper; potassium carbonate at 120℃; for 22h;56%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

butan-1-ol
71-36-3

butan-1-ol

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium hydroxide; potassium iodide; copper(I) iodide; potassium carbonate In N,N-dimethyl-formamide42.9%
...Expand
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Stage #1: 2'-chloro-benzeneacetic acid; 2,6-Dichloroaniline With copper(l) iodide; iodine; potassium carbonate; potassium iodide In N,N-dimethyl-formamide for 12h; Inert atmosphere; Schlenk technique; Reflux;
Stage #2: With sodium hydroxide In water for 4h; Reflux;		31%
2-(2-((2,6-dichlorophenyl)amino)phenyl)-2-oxoacetic acid
66156-75-0

2-(2-((2,6-dichlorophenyl)amino)phenyl)-2-oxoacetic acid

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium methylate; hydrazine hydrate In 2-methoxy-ethanol 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h; Yield given;
N-phenyl-2,6-dichloroaniline
15307-93-4

N-phenyl-2,6-dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: benzene / 6 h / Heating
2: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature
3: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating
4: 97 percent / Zn / acetic acid / 4 h / Heating
5: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: benzene / 6 h / Heating
2: N-chlorosuccinimide / CCl4 / 1 h / Ambient temperature
3: SnCl4 / CCl4 / 0.83 h / Ambient temperature
4: 97 percent / Zn / acetic acid / 4 h / Heating
5: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: benzene / 2 h / Ambient temperature
2: AlCl3 / various solvent(s) / 20 h / Ambient temperature
3: 1 N NaOH / ethanol; H2O / 0.17 h / Heating
4: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h
View Scheme
Multi-step reaction with 3 steps
1: 66 percent / 16 h / Heating
2: 75.4 percent / AlCl3 / 2 h / 160 °C
3: 93 percent / 2 N NaOH / ethanol; H2O / 4 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: toluene / 3 h / 120 °C
2: triethylamine hydrochloride-aluminum trichloride / 4.5 h / 20 - 60 °C
3: sodium hydroxide / 2 h / Reflux
View Scheme
N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide
83281-93-0

N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature
2: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating
3: 97 percent / Zn / acetic acid / 4 h / Heating
4: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: N-chlorosuccinimide / CCl4 / 1 h / Ambient temperature
2: SnCl4 / CCl4 / 0.83 h / Ambient temperature
3: 97 percent / Zn / acetic acid / 4 h / Heating
4: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
1-(2,6-dichlorophenyl)-3-(methylthio)oxindole
83281-94-1

1-(2,6-dichlorophenyl)-3-(methylthio)oxindole

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / Zn / acetic acid / 4 h / Heating
2: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
N-(2,6-dichlorophenyl)-α-(methylsulfinyl)acetanilide
83281-96-3

N-(2,6-dichlorophenyl)-α-(methylsulfinyl)acetanilide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating
2: 97 percent / Zn / acetic acid / 4 h / Heating
3: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
α-chloro-N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

α-chloro-N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SnCl4 / CCl4 / 0.83 h / Ambient temperature
2: 97 percent / Zn / acetic acid / 4 h / Heating
3: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
1-(2,6-Dichlorphenyl)-2,3-indoldion
24542-74-3

1-(2,6-Dichlorphenyl)-2,3-indoldion

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1 N NaOH / ethanol; H2O / 0.17 h / Heating
2: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h
View Scheme
[(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride
24542-55-0

[(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: AlCl3 / various solvent(s) / 20 h / Ambient temperature
2: 1 N NaOH / ethanol; H2O / 0.17 h / Heating
3: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h
View Scheme
2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide
15308-01-7

2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75.4 percent / AlCl3 / 2 h / 160 °C
2: 93 percent / 2 N NaOH / ethanol; H2O / 4 h / Heating
View Scheme
N-(2,6-dichlorophenyl)phenylacetamide

N-(2,6-dichlorophenyl)phenylacetamide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tert-butylhypochlorite / dichloromethane / 10 h / 25 °C / Cooling with ice
2: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice
3: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / toluene / 10 h / Reflux
View Scheme
2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: calcium chloride; pyridine / 4 h / Reflux; Cooling with ice
2: tert-butylhypochlorite / dichloromethane / 10 h / 25 °C / Cooling with ice
3: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice
4: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / toluene / 10 h / Reflux
View Scheme
phenylacetyl chloride
103-80-0

phenylacetyl chloride

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: calcium chloride; pyridine / 4 h / Reflux; Cooling with ice
2: tert-butylhypochlorite / dichloromethane / 10 h / 25 °C / Cooling with ice
3: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice
4: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / toluene / 10 h / Reflux
View Scheme
(2-benzoylamino-phenyl)-acetic acid methyl ester
3559-26-0

(2-benzoylamino-phenyl)-acetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / 3 h / Reflux
1.2: 3 h / Cooling with ice; Reflux
2.1: diphenylether / 3 h / Reflux
3.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
methyl (2-nitrophenyl)acetate
30095-98-8

methyl (2-nitrophenyl)acetate

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: palladium on activated charcoal; hydrogen / toluene / 5 °C / 760.05 Torr
2.1: triethylamine / toluene / 2 h / 0 °C
3.1: thionyl chloride / 3 h / Reflux
3.2: 3 h / Cooling with ice; Reflux
4.1: diphenylether / 3 h / Reflux
5.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid / dichloromethane / 24 h / 0 - 20 °C
2.1: palladium on activated charcoal; hydrogen / toluene / 5 °C / 760.05 Torr
3.1: triethylamine / toluene / 2 h / 0 °C
4.1: thionyl chloride / 3 h / Reflux
4.2: 3 h / Cooling with ice; Reflux
5.1: diphenylether / 3 h / Reflux
6.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
2-aminophenylacetic acid methyl ester
35613-44-6

2-aminophenylacetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / toluene / 2 h / 0 °C
2.1: thionyl chloride / 3 h / Reflux
2.2: 3 h / Cooling with ice; Reflux
3.1: diphenylether / 3 h / Reflux
4.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
didecyldimethylammonium chloride
7173-51-5

didecyldimethylammonium chloride

diclofenac sodium
15307-79-6

diclofenac sodium

diclofenac didecyldimethylammonium salt
934544-42-0

diclofenac didecyldimethylammonium salt

Conditions
ConditionsYield
In water at 20℃; for 0.5h; Product distribution / selectivity;100%
diclofenac sodium
15307-79-6

diclofenac sodium

cadmium(II) chloride
10108-64-2

cadmium(II) chloride

{Cd(C6H3Cl2NHC6H4CH2COO)2(H2O)}
149753-43-5

{Cd(C6H3Cl2NHC6H4CH2COO)2(H2O)}

Conditions
ConditionsYield
With H2O; KOH In water byproducts: NaCl; mixing aq. soln. of the components, adjusting to pH 5.5-7.5 with KOH and stirring at room temp. for 4-6 h; filtn., washing with water, drying over silica gel (vac.) and over P4O10 at 90°C (vac.);100%
diclofenac sodium
15307-79-6

diclofenac sodium

zinc(II) chloride
7646-85-7

zinc(II) chloride

{Zn(C6H3Cl2NHC6H4CH2COO)2(H2O)}
149753-42-4

{Zn(C6H3Cl2NHC6H4CH2COO)2(H2O)}

Conditions
ConditionsYield
With H2O; KOH In water byproducts: NaCl; mixing aq. soln. of the components, adjusting to pH 5.5-7.5 with KOH and stirring at room temp. for 4-6 h; filtn., washing with water, drying over silica gel (vac.) and over P4O10 at 90°C (vac.);100%
diclofenac sodium
15307-79-6

diclofenac sodium

[2-(2,6-dichloroanilino)phenyl]acetic acid
15307-86-5

[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 20 - 45℃; for 3h; pH=1.4 - 1.6; Solvent;99%
With hydrogenchloride In water Cooling with ice;90%
With hydrogenchloride In water at 0 - 20℃;70%
diclofenac sodium
15307-79-6

diclofenac sodium

1-(2,6-dichlorophenyl)-1,3-dihydro-indol-2-one-[3,3,5,7-D4]
1401311-49-6

1-(2,6-dichlorophenyl)-1,3-dihydro-indol-2-one-[3,3,5,7-D4]

Conditions
ConditionsYield
With water-d2; hydrogen chloride at 160℃; for 0.333333h; Microwave irradiation;96%
choline chloride
67-48-1

choline chloride

diclofenac sodium
15307-79-6

diclofenac sodium

(2-hydroxyethyl)tri-methylammonium [o-(2,6-dichloroanilino)phenyl]acetate
148439-51-4

(2-hydroxyethyl)tri-methylammonium [o-(2,6-dichloroanilino)phenyl]acetate

Conditions
ConditionsYield
In ethanol at 20℃; for 1h;96%
diclofenac sodium
15307-79-6

diclofenac sodium

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

1-O-<2-<(2,6-dichlorophenyl)amino>phenylacetyl>-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose
87906-12-5

1-O-<2-<(2,6-dichlorophenyl)amino>phenylacetyl>-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose

Conditions
ConditionsYield
citrimide In water; 1,2-dichloro-ethane Ambient temperature;95%
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester
139272-68-7

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester

Conditions
ConditionsYield
With potassium iodide In ethanol at 61 - 65℃; for 3h; Temperature; Large scale;94.45%
With potassium iodide In acetonitrile at 30℃; for 0.25h; Microwave irradiation;91.6%
With tetra(n-butyl)ammonium hydrogensulfate; potassium iodide In water; acetone at 60 - 65℃; for 2h;17.3 g
In N,N-dimethyl-formamide at 20 - 45℃;
4-methyloxetan-2-one
3068-88-0, 32082-74-9, 36536-46-6, 65058-82-4

4-methyloxetan-2-one

diclofenac sodium
15307-79-6

diclofenac sodium

Reaxys ID: 15741354

Reaxys ID: 15741354

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃;94%
diclofenac sodium
15307-79-6

diclofenac sodium

C14H3(2)H6Cl2NO

C14H3(2)H6Cl2NO

Conditions
ConditionsYield
With trifluoroacetic acid-d1 at 110℃; for 16h; Sealed tube;94%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

diclofenac sodium
15307-79-6

diclofenac sodium

silver nitrate

silver nitrate

Ag(2-(2,6-dicholoroanilino)phenylacetic acid)(4,4'-bipyridine)

Ag(2-(2,6-dicholoroanilino)phenylacetic acid)(4,4'-bipyridine)

Conditions
ConditionsYield
In water; acetonitrile at 50℃;94%
...Expand
diclofenac sodium
15307-79-6

diclofenac sodium

3-(bromomethyl)-4-methyl-1,2,5-oxadiazole-2-oxide
169614-77-1

3-(bromomethyl)-4-methyl-1,2,5-oxadiazole-2-oxide

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 4-methyl-2-oxy-furazan-3-ylmethyl ester

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 4-methyl-2-oxy-furazan-3-ylmethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20 - 25℃; for 2h;93%
2-(2-Hydroxyethyl)pyridine
103-74-2

2-(2-Hydroxyethyl)pyridine

diclofenac sodium
15307-79-6

diclofenac sodium

copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

C42H36Cl4Cu2N4O6

C42H36Cl4Cu2N4O6

Conditions
ConditionsYield
In methanol at 50℃;91%
...Expand
diclofenac sodium
15307-79-6

diclofenac sodium

N,N-didecyl-N,N-dimethylammonium bromide
2390-68-3

N,N-didecyl-N,N-dimethylammonium bromide

diclofenac didecyldimethylammonium salt
934544-42-0

diclofenac didecyldimethylammonium salt

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium hydroxide In methanol; water at 20℃; for 0.5h;91%
diclofenac sodium
15307-79-6

diclofenac sodium

methyl iodide
74-88-4

methyl iodide

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester
15307-78-5

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide90%
In acetone Heating;
copper(ll) sulfate pentahydrate

copper(ll) sulfate pentahydrate

diclofenac sodium
15307-79-6

diclofenac sodium

2C14H10Cl2NO2(1-)*Cu(2+)*2H2O

2C14H10Cl2NO2(1-)*Cu(2+)*2H2O

Conditions
ConditionsYield
In water at 20℃;90%
tert-Butyl chloroacetate
107-59-5

tert-Butyl chloroacetate

diclofenac sodium
15307-79-6

diclofenac sodium

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester
139272-68-7

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester

Conditions
ConditionsYield
With sodium iodide In acetonitrile at 77 - 78℃; for 2h;89.6%
In acetonitrile for 4h; Reflux;
With potassium iodide In N,N-dimethyl-formamide for 2h; Reflux; Large scale;25.5 g
diclofenac sodium
15307-79-6

diclofenac sodium

6-bromomethyl-benzo[1,2,5]oxadiazole-1-oxide

6-bromomethyl-benzo[1,2,5]oxadiazole-1-oxide

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 1-oxy-benzo[1,2,5]oxadiazol-6-ylmethyl ester

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 1-oxy-benzo[1,2,5]oxadiazol-6-ylmethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20 - 25℃; for 2h;89%
diclofenac sodium
15307-79-6

diclofenac sodium

5-(bromomethyl)benzofuroxan
175609-21-9

5-(bromomethyl)benzofuroxan

given name is incorrect
883738-54-3

given name is incorrect

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In N,N-dimethyl-formamide at 25℃; for 2h;89%
2-(2-Hydroxyethyl)pyridine
103-74-2

2-(2-Hydroxyethyl)pyridine

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

diclofenac sodium
15307-79-6

diclofenac sodium

[Ni(diclofenac)2(2-pyridineethanol)2]

[Ni(diclofenac)2(2-pyridineethanol)2]

Conditions
ConditionsYield
In methanol at 50℃;89%
...Expand
methanol
67-56-1

methanol

diclofenac sodium
15307-79-6

diclofenac sodium

copper(II) nitrate

copper(II) nitrate

tetrakis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O:O'}bis(methanol-κO)copper(II)

tetrakis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O:O'}bis(methanol-κO)copper(II)

Conditions
ConditionsYield
In water at 20℃;89%
...Expand
1H-imidazole
288-32-4

1H-imidazole

diclofenac sodium
15307-79-6

diclofenac sodium

copper(II) nitrate

copper(II) nitrate

bis{2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O,O'}bis(1H-imidazole-κN3)copper(II)

bis{2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O,O'}bis(1H-imidazole-κN3)copper(II)

Conditions
ConditionsYield
In methanol; water at 20℃;89%
...Expand
didecyldimethylammonium acesulfamate
934544-25-9

didecyldimethylammonium acesulfamate

diclofenac sodium
15307-79-6

diclofenac sodium

diclofenac didecyldimethylammonium salt
934544-42-0

diclofenac didecyldimethylammonium salt

Conditions
ConditionsYield
In acetone at 60℃; for 2h; Product distribution / selectivity;88%
diclofenac sodium
15307-79-6

diclofenac sodium

silver nitrate

silver nitrate

silver(I) diclofenac

silver(I) diclofenac

Conditions
ConditionsYield
In water87%
In methanol at 20℃; for 1h; Darkness;85%
With ammonia In ethanol; water at 20℃; for 0.25h; pH=8;
isopropyloxycarbonyloxymethyl iodide
258841-42-8

isopropyloxycarbonyloxymethyl iodide

diclofenac sodium
15307-79-6

diclofenac sodium

1-[(1-methylethoxy)carbonyloxy]methyl 2-[(2,6-dichlorophenyl)amino]phenylacetate
1264635-62-2

1-[(1-methylethoxy)carbonyloxy]methyl 2-[(2,6-dichlorophenyl)amino]phenylacetate

Conditions
ConditionsYield
Stage #1: diclofenac sodium With sodium carbonate In N,N-dimethyl acetamide at 30℃; for 0.166667h; Inert atmosphere;
Stage #2: isopropyloxycarbonyloxymethyl iodide In N,N-dimethyl acetamide at -10℃; for 0.75h; Inert atmosphere;		86.4%
trimethyltin(IV)chloride
1066-45-1

trimethyltin(IV)chloride

diclofenac sodium
15307-79-6

diclofenac sodium

(CH3)3SnOC(O)CH2C6H4NHC6H3Cl2

(CH3)3SnOC(O)CH2C6H4NHC6H3Cl2

Conditions
ConditionsYield
In chloroform byproducts: sodium chloride; under inert atmosphere; 1 equiv. of sodium salt of ligand refluxed withSn compd. in dry CHCl3 for 6-7 h; cooled to room temp.; filtered; solvent removed from filtrate by rotary evaporator; crystd. from CH2Cl2-hexane; elem. anal.;86%
1-(2-aminoethyl)pyrrolidine
7154-73-6

1-(2-aminoethyl)pyrrolidine

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

diclofenac sodium
15307-79-6

diclofenac sodium

[Ni(diclofenac)2(1-(2-aminoethyl)pyrrolidine)2]
1596252-87-7

[Ni(diclofenac)2(1-(2-aminoethyl)pyrrolidine)2]

Conditions
ConditionsYield
Stage #1: nickel(II) chloride hexahydrate; diclofenac sodium In ethanol at 50℃;
Stage #2: 1-(2-aminoethyl)pyrrolidine In ethanol at 20℃;		86%
...Expand
diclofenac sodium
15307-79-6

diclofenac sodium

water
7732-18-5

water

zinc(II) chloride
7646-85-7

zinc(II) chloride

C28H24Cl4N2O6Zn

C28H24Cl4N2O6Zn

Conditions
ConditionsYield
In water at 20℃; for 3h;86%
...Expand

Diclofenac sodium Chemical Properties

Molecular Formula: C14H10Cl2NNaO2
Molecular Weight: 318.13 g/mol
EINECS: 239-346-4
Melting point: 256-257 °C
Storage tempreture: 288-290 °C
Water solubility: 50 mg/mL
Flash Point: 203 °C
Enthalpy of Vaporization: 70.07 kJ/mol
Boiling Point: 412 °C at 760 mmHg
Vapour Pressure: 1.59E-07 mmHg at 25 °C
Appearance: Off-white crystalline solid
Structure of Diclofenac sodium (CAS NO.15307-79-6):
                
IUPAC Name: Sodium 2-[2-(2,6-dichloroanilino)phenyl]acetate
Product Category of Diclofenac sodium (CAS NO.15307-79-6): Active Pharmaceutical Ingredients;Organics;Intermediates & Fine Chemicals;Steroids;API's;Lipid signaling

Diclofenac sodium Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 42mg/kg (42mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
dog LD50 oral 59mg/kg (59mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
mouse LD50 intraperitoneal 74mg/kg (74mg/kg)   Pharmaceutical Chemistry Journal Vol. 27, Pg. 343, 1993.
mouse LD50 intravenous 116mg/kg (116mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse LD50 oral 95mg/kg (95mg/kg)   Pharmaceutical Chemistry Journal Vol. 23, Pg. 579, 1989.
mouse LD50 subcutaneous 390mg/kg (390mg/kg)   Drugs in Japan Vol. 6, Pg. 311, 1982.
mouse LD50 unreported 380mg/kg (380mg/kg)   Pharmaceutical Chemistry Journal Vol. 21, Pg. 275, 1987.
rabbit LD50 intravenous > 100mg/kg (100mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rabbit LD50 oral 157mg/kg (157mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rat LD50 intraperitoneal 25mg/kg (25mg/kg)   Drugs in Japan Vol. 6, Pg. 311, 1982.
rat LD50 intravenous 117mg/kg (117mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 oral 53mg/kg (53mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981.
rat LD50 rectal 85400ug/kg (85.4mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 2259, 1986.
rat LD50 subcutaneous 83mg/kg (83mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
women TDLo intramuscular 9mg/kg/1W-I (9mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: NORMOCYTIC ANEMIA		 American Journal of Hematology. Vol. 58, Pg. 142, 1998.
women TDLo intramuscular 15mg/kg/5D-I (15mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
GASTROINTESTINAL: OTHER CHANGES		 Lancet. Vol. 340, Pg. 126, 1992.
women TDLo oral 30mg/kg/10D-I (30mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Postgraduate Medical Journal. Vol. 69, Pg. 486, 1993.
women TDLo oral 112mg/kg/8W-I (112mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
GASTROINTESTINAL: OTHER CHANGES		 Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women TDLo oral 180mg/kg/13W- (180mg/kg) BEHAVIORAL: ANOREXIA (HUMAN
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
KIDNEY, URETER, AND BLADDER: PROTEINURIS		 British Medical Journal. Vol. 295, Pg. 182, 1987.
women TDLo oral 183mg/kg/26W- (183mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"		 British Journal of Clinical Practice. Vol. 43, Pg. 125, 1989.
women TDLo oral 270mg/kg/90D- (270mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
GASTROINTESTINAL: OTHER CHANGES
BLOOD: CHANGES IN ERYTHROCYTE (RBC) COUNT		 Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women TDLo oral 300mg/kg/17W- (300mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Clinical Rheumatology. Vol. 11, Pg. 120, 1992.
women TDLo oral 2190mg/kg/2Y- (2190mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" American Journal of Gastroenterology. Vol. 90, Pg. 1871, 1995.
women TDLo unreported 364mg/kg/26W- (364mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
KIDNEY, URETER, AND BLADDER: PROTEINURIS		 Wiener Klinische Wochenschrift. Vol. 111, Pg. 523, 1999.
 

Diclofenac sodium Safety Profile

The Hazard Codes of Diclofenac sodium (CAS NO.15307-79-6): T,   Xi
Risk Statements:
25:  Toxic if swallowed 
36/37/38:  Irritating to eyes, respiratory system and skin 
Safety Statements:
22:  Do not breathe dust 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37:  Wear suitable protective clothing and gloves

Diclofenac sodium Specification

 Diclofenac sodium , its cas register number is 15307-79-6. It also can be called 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt ; Voltaren ; and Diclofenac .

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