Diethyldiselenide supplier

Name
Diethyldiselenide
EINECS 211-042-6
CAS No. 628-39-7
Article Data33
CAS DataBase
Density 1.23 g/cm³
Solubility
Melting Point
Formula C₄H₁₀Se₂
Boiling Point 199.164 °C at 760 mmHg
Molecular Weight 216.043
Flash Point 74.252 °C
Transport Information
Appearance Red liquid
Safety 20/21-28-45
Risk Codes 23/25-33-50/53
Molecular Structure
Hazard Symbols
Synonyms Ethyldiselenide (6CI,7CI,8CI);Diselenide, diethyl;
PSA 0.00000
LogP 1.18620

Synthetic route

: 74-96-4
ethyl bromide

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With potassium hydroxide; selenium; hydrazine hydrate In water at 40 - 45℃;	97%
With potassium hydroxide; selenium(IV) oxide; hydrazine hydrate In water at 40 - 45℃;	95%
With disodium diselenide In N,N-dimethyl-formamide at 50℃; for 0.5h;	88%

: 75-03-6
ethyl iodide

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With disodium diselenide; tetrabutylammomium bromide In water for 0.05h;	90%
With potassium hydroxide; selenium; hydrazine hydrate In water at 60 - 70℃;	89%
With sodium hydroxide; selenium; hydrazine hydrate 1.) MeOH, 6 h; Multistep reaction;
With selenium; copper(II) oxide; potassium hydroxide In dimethyl sulfoxide at 90℃; Inert atmosphere;

: 75-07-0
acetaldehyde

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With disodium diselenide; sodium hydrogen selenide; N,N-dimethyl-formamide In ethanol at 60 - 70℃; for 7h;	90%

: 95494-85-2
1,2-bis(ethylseleno)-1-phenylethene

A: 18782-55-3
2,5-bis-phenylselenophene

B: 628-39-7
diethyl diselenide

C: (1-ethylseleno)-1-phenylethene

D: (tris-ethylselanyl-vinyl)-benzene

Conditions

Conditions	Yield
at 180℃; for 25h;	A n/a B n/a C 81% D n/a

...Expand

: 693-03-8
n-butyl magnesium bromide

: 175538-67-7
(Z)-1,2-bis(ethylseleno)ethene

A: 628-39-7
diethyl diselenide

B: 111-65-9
octane

C: 7433-78-5
cis-5-decene

D: (Z)-ethyl-1-hexene-1-yl selenide

Conditions

Conditions	Yield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In diethyl ether at 20℃; Further byproducts given;	A 145 mg B 226 mg C 78% D 42 mg

...Expand

: 75-07-0
acetaldehyde

A: 15732-69-1
2,4,6-trimethyl-1,3,5-triselenane

B: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With bis(trimethylsilyl)selenide; boron trifluoride diethyl etherate In dichloromethane at 0℃; for 6h;	A 54% B n/a

: 5926-26-1
(chloromethyl)trimethoxysilane

: GENERIC INORGANIC CATION; ethaneselenolate

A: 628-39-7
diethyl diselenide

B: 126912-03-6
bis(trimethoxysilylmethyl) selenide

C: ethyl (trimethoxysilyl)methyl selenide

D: bis(trimethoxysilylmethyl)diselenide

Conditions

Conditions	Yield
In tetrahydrofuran for 1.5h; Heating;	A n/a B n/a C n/a D 35%

...Expand

: 17912-00-4
bis-(1-bromo-vinyl) sulfoxide

: 57796-75-5
divinyl selenide

A: 628-39-7
diethyl diselenide

B: 136308-15-1
di<2-(vinylseleno)vinyl> sulfoxide

Conditions

Conditions	Yield
With ammonia; sodium for 0.666667h;	A 20% B 12%

...Expand

: 64-67-5
diethyl sulfate

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With disodium diselenide
With potassium diselenide

: 60-29-7
diethyl ether

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With aluminum selenide at 250 - 300℃;

: 64-17-5
ethanol

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With aluminum selenide at 250 - 300℃;

: 593-69-1
ethaneselenol

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With air
With oxygen for 24h;

: 563-17-7
potassium ethyl sulfate

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With potassium diselenide

: 64-17-5
ethanol

: 593-69-1
ethaneselenol

: 106-93-4
ethylene dibromide

: 628-39-7
diethyl diselenide

...Expand

: 75-03-6
ethyl iodide

: 80637-16-7
1-(2-Chloro-ethylsulfanyl)-propyne

A: 628-39-7
diethyl diselenide

B: 13597-15-4
1-ethylsulfanyl-propyne

Conditions

Conditions	Yield
With lithium selenide In ammonia

...Expand

: 106-93-4
ethylene dibromide

Na salt of ethylseleno mercaptan: Na salt of ethylseleno mercaptan

A: 628-39-7
diethyl diselenide

B: 74-85-1
ethene

...Expand

: 593-69-1
ethaneselenol

air: air

: 628-39-7
diethyl diselenide

: 60-29-7
diethyl ether

aluminium selenide: aluminium selenide

A: 628-39-7
diethyl diselenide

B: 627-53-2
diethylselenium

Conditions

Conditions	Yield
at 300 - 350℃;

...Expand

: 74-96-4
ethyl bromide

A: 628-39-7
diethyl diselenide

B: 107976-06-7
diethyl-triselenide

C: 3600-24-6
diethyltrisulfane

D: C4H10S2Se

Conditions

Conditions	Yield
With sodium hydroxide; selenium; sulfur; hydrazine hydrate In water at 52 - 56℃; Further byproducts given;

...Expand

: 74-96-4
ethyl bromide

A: 110-81-6
Diethyl disulfide

B: 628-39-7
diethyl diselenide

C: 352-93-2
diethyl sulphide

D: 627-53-2
diethylselenium

Conditions

Conditions	Yield
With sodium hydroxide; selenium; sulfur; hydrazine hydrate In water at 35℃; Product distribution; Further Variations:; Reagents;	A 29.7 % Chromat. B 36.2 % Chromat. C 2.2 % Chromat. D 5.5 % Chromat.

...Expand

: 74-96-4
ethyl bromide

A: 110-81-6
Diethyl disulfide

B: 628-39-7
diethyl diselenide

C: 627-53-2
diethylselenium

D: 88890-93-1
ethyl ethylselenosulfenate

Conditions

Conditions	Yield
With sodium hydroxide; selenium; sulfur; hydrazine hydrate In water at 35℃; Further byproducts given;	A 29.7 % Chromat. B 36.2 % Chromat. C 5.5 % Chromat. D 25.9 % Chromat.

...Expand

: 74-96-4
ethyl bromide

A: 628-39-7
diethyl diselenide

B: 627-54-3
diethyl telluride

C: 26105-63-5
diethyl ditelluride

D: C4H10SeTe

Conditions

Conditions	Yield
With sodium hydroxide; tellurium; sulfur; hydrazine hydrate In water at 35℃; Further byproducts given;	A 43.7 % Chromat. B 3.5 % Chromat. C 30.3 % Chromat. D 1.03 % Chromat.

...Expand

: 628-39-7
diethyl diselenide

: (2,3,4,6-tetra-O-benzyl-2-β-D-glucopyranosyl)tri-n-butylstannane

: ethyl-2,3,4,6-tetra-O-benzyl-1-seleno-β-D-glucopyranoside

Conditions

Conditions	Yield
With potassium fluoride; copper(l) chloride In 1,4-dioxane at 110℃; for 24h; Inert atmosphere; stereospecific reaction;	96%

: 628-39-7
diethyl diselenide

: bis[bis(trimethylsilyl)amido]stannylene

: C16H46N2Se2Si4Sn

Conditions

Conditions	Yield
In hexane at 20℃; for 1h; Inert atmosphere;	95%

: 628-39-7
diethyl diselenide

: 59863-12-6
bis[bis(trimethylsilyl)amino]germanium(II)

: C16H46GeN2Se2Si4

Conditions

Conditions	Yield
In hexane at 20℃; for 1h; Inert atmosphere;	93%

: 628-39-7
diethyl diselenide

: 84806-15-5
1,3-di-tert-butyl-2,2-dimethyl-1,3,2,4-diazasilagermaetidine

: [Me2Si(Nt-Bu2)Ge{SeEt}2]

Conditions

Conditions	Yield
In hexane at 70℃; for 1h;	92%

: 628-39-7
diethyl diselenide

: 33578-05-1
methyl 2-(phenylethynyl)benzoate

4-(ethylselanyl)-3-phenyl-1H-isochromen-1-one: 1314961-26-6
4-(ethylselanyl)-3-phenyl-1H-isochromen-1-one

Conditions

Conditions	Yield
With Oxone In ethanol for 0.666667h; Sonication; regioselective reaction;	90%
With tetrabutylammonium tetrafluoroborate In acetonitrile at 20℃; for 0.0833333h; Electrochemical reaction; Green chemistry;	89%
Stage #1: diethyl diselenide With iron(III) chloride In dichloromethane at 20℃; for 0.333333h; Stage #2: methyl 2-(phenylethynyl)benzoate In dichloromethane at 20℃; for 18h; regioselective reaction;	85%

: 74-96-4
ethyl bromide

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With potassium hydroxide; selenium; hydrazine hydrate In water at 40 - 45℃;	97%
With potassium hydroxide; selenium(IV) oxide; hydrazine hydrate In water at 40 - 45℃;	95%
With disodium diselenide In N,N-dimethyl-formamide at 50℃; for 0.5h;	88%

: 75-03-6
ethyl iodide

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With disodium diselenide; tetrabutylammomium bromide In water for 0.05h;	90%
With potassium hydroxide; selenium; hydrazine hydrate In water at 60 - 70℃;	89%
With sodium hydroxide; selenium; hydrazine hydrate 1.) MeOH, 6 h; Multistep reaction;
With selenium; copper(II) oxide; potassium hydroxide In dimethyl sulfoxide at 90℃; Inert atmosphere;

: 75-07-0
acetaldehyde

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With disodium diselenide; sodium hydrogen selenide; N,N-dimethyl-formamide In ethanol at 60 - 70℃; for 7h;	90%

: 95494-85-2
1,2-bis(ethylseleno)-1-phenylethene

A: 18782-55-3
2,5-bis-phenylselenophene

B: 628-39-7
diethyl diselenide

C: (1-ethylseleno)-1-phenylethene

D: (tris-ethylselanyl-vinyl)-benzene

Conditions

Conditions	Yield
at 180℃; for 25h;	A n/a B n/a C 81% D n/a

...Expand

: 693-03-8
n-butyl magnesium bromide

: 175538-67-7
(Z)-1,2-bis(ethylseleno)ethene

A: 628-39-7
diethyl diselenide

B: 111-65-9
octane

C: 7433-78-5
cis-5-decene

D: (Z)-ethyl-1-hexene-1-yl selenide

Conditions

Conditions	Yield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In diethyl ether at 20℃; Further byproducts given;	A 145 mg B 226 mg C 78% D 42 mg

...Expand

: 75-07-0
acetaldehyde

A: 15732-69-1
2,4,6-trimethyl-1,3,5-triselenane

B: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With bis(trimethylsilyl)selenide; boron trifluoride diethyl etherate In dichloromethane at 0℃; for 6h;	A 54% B n/a

: 5926-26-1
(chloromethyl)trimethoxysilane

: GENERIC INORGANIC CATION; ethaneselenolate

A: 628-39-7
diethyl diselenide

B: 126912-03-6
bis(trimethoxysilylmethyl) selenide

C: ethyl (trimethoxysilyl)methyl selenide

D: bis(trimethoxysilylmethyl)diselenide

Conditions

Conditions	Yield
In tetrahydrofuran for 1.5h; Heating;	A n/a B n/a C n/a D 35%

...Expand

: 17912-00-4
bis-(1-bromo-vinyl) sulfoxide

: 57796-75-5
divinyl selenide

A: 628-39-7
diethyl diselenide

B: 136308-15-1
di<2-(vinylseleno)vinyl> sulfoxide

Conditions

Conditions	Yield
With ammonia; sodium for 0.666667h;	A 20% B 12%

...Expand

: 64-67-5
diethyl sulfate

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With disodium diselenide
With potassium diselenide

: 60-29-7
diethyl ether

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With aluminum selenide at 250 - 300℃;

: 64-17-5
ethanol

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With aluminum selenide at 250 - 300℃;

: 593-69-1
ethaneselenol

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With air
With oxygen for 24h;

: 563-17-7
potassium ethyl sulfate

: 628-39-7
diethyl diselenide

Conditions

Conditions	Yield
With potassium diselenide

: 64-17-5
ethanol

: 593-69-1
ethaneselenol

: 106-93-4
ethylene dibromide

: 628-39-7
diethyl diselenide

...Expand

: 75-03-6
ethyl iodide

: 80637-16-7
1-(2-Chloro-ethylsulfanyl)-propyne

A: 628-39-7
diethyl diselenide

B: 13597-15-4
1-ethylsulfanyl-propyne

Conditions

Conditions	Yield
With lithium selenide In ammonia

...Expand

: 106-93-4
ethylene dibromide

Na salt of ethylseleno mercaptan: Na salt of ethylseleno mercaptan

A: 628-39-7
diethyl diselenide

B: 74-85-1
ethene

...Expand

: 593-69-1
ethaneselenol

air: air

: 628-39-7
diethyl diselenide

: 60-29-7
diethyl ether

aluminium selenide: aluminium selenide

A: 628-39-7
diethyl diselenide

B: 627-53-2
diethylselenium

Conditions

Conditions	Yield
at 300 - 350℃;

...Expand

: 74-96-4
ethyl bromide

A: 628-39-7
diethyl diselenide

B: 107976-06-7
diethyl-triselenide

C: 3600-24-6
diethyltrisulfane

D: C4H10S2Se

Conditions

Conditions	Yield
With sodium hydroxide; selenium; sulfur; hydrazine hydrate In water at 52 - 56℃; Further byproducts given;

...Expand

: 74-96-4
ethyl bromide

A: 110-81-6
Diethyl disulfide

B: 628-39-7
diethyl diselenide

C: 352-93-2
diethyl sulphide

D: 627-53-2
diethylselenium

Conditions

Conditions	Yield
With sodium hydroxide; selenium; sulfur; hydrazine hydrate In water at 35℃; Product distribution; Further Variations:; Reagents;	A 29.7 % Chromat. B 36.2 % Chromat. C 2.2 % Chromat. D 5.5 % Chromat.

...Expand

: 74-96-4
ethyl bromide

A: 110-81-6
Diethyl disulfide

B: 628-39-7
diethyl diselenide

C: 627-53-2
diethylselenium

D: 88890-93-1
ethyl ethylselenosulfenate

Conditions

Conditions	Yield
With sodium hydroxide; selenium; sulfur; hydrazine hydrate In water at 35℃; Further byproducts given;	A 29.7 % Chromat. B 36.2 % Chromat. C 5.5 % Chromat. D 25.9 % Chromat.

...Expand

: 74-96-4
ethyl bromide

A: 628-39-7
diethyl diselenide

B: 627-54-3
diethyl telluride

C: 26105-63-5
diethyl ditelluride

D: C4H10SeTe

Conditions

Conditions	Yield
With sodium hydroxide; tellurium; sulfur; hydrazine hydrate In water at 35℃; Further byproducts given;	A 43.7 % Chromat. B 3.5 % Chromat. C 30.3 % Chromat. D 1.03 % Chromat.

...Expand

: 628-39-7
diethyl diselenide

: (2,3,4,6-tetra-O-benzyl-2-β-D-glucopyranosyl)tri-n-butylstannane

: ethyl-2,3,4,6-tetra-O-benzyl-1-seleno-β-D-glucopyranoside

Conditions

Conditions	Yield
With potassium fluoride; copper(l) chloride In 1,4-dioxane at 110℃; for 24h; Inert atmosphere; stereospecific reaction;	96%

: 628-39-7
diethyl diselenide

: bis[bis(trimethylsilyl)amido]stannylene

: C16H46N2Se2Si4Sn

Conditions

Conditions	Yield
In hexane at 20℃; for 1h; Inert atmosphere;	95%

: 628-39-7
diethyl diselenide

: 59863-12-6
bis[bis(trimethylsilyl)amino]germanium(II)

: C16H46GeN2Se2Si4

Conditions

Conditions	Yield
In hexane at 20℃; for 1h; Inert atmosphere;	93%

: 628-39-7
diethyl diselenide

: 84806-15-5
1,3-di-tert-butyl-2,2-dimethyl-1,3,2,4-diazasilagermaetidine

: [Me2Si(Nt-Bu2)Ge{SeEt}2]

Conditions

Conditions	Yield
In hexane at 70℃; for 1h;	92%

: 628-39-7
diethyl diselenide

: 33578-05-1
methyl 2-(phenylethynyl)benzoate

: 1314961-26-6
4-(ethylselanyl)-3-phenyl-1H-isochromen-1-one

Conditions

Conditions	Yield
With Oxone In ethanol for 0.666667h; Sonication; regioselective reaction;	90%
With tetrabutylammonium tetrafluoroborate In acetonitrile at 20℃; for 0.0833333h; Electrochemical reaction; Green chemistry;	89%
Stage #1: diethyl diselenide With iron(III) chloride In dichloromethane at 20℃; for 0.333333h; Stage #2: methyl 2-(phenylethynyl)benzoate In dichloromethane at 20℃; for 18h; regioselective reaction;	85%

: 628-39-7
diethyl diselenide

: 593-69-1
ethaneselenol

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride In various solvent(s) under 0.0750075 Torr; Reduction;	89%
With ethanol; sodium

: 628-39-7
diethyl diselenide

: 94217-36-4
1,2-diisocyanobenzene

: 2,3-bis(ethylselanyl)quinoxaline

Conditions

Conditions	Yield
In chloroform-d1 at 20℃; for 9h; Inert atmosphere; Irradiation;	88%

: 628-39-7
diethyl diselenide

: 189296-97-7
25,27-bis(2-chloroethoxy)-26,28-dihydroxy-5,11,17,23-tetra(tert-butyl)calix[4]arene

: C52H72O4Se2

Conditions

Conditions	Yield
With sodium hydroxide; potassium borohydride; ethanol In tetrahydrofuran for 8h; Substitution; Heating;	87%

: 628-39-7
diethyl diselenide

: 30541-56-1
adamantylidene-adamantane

: C22H33Se(1+)*Cl6Sb(1-)

Conditions

Conditions	Yield
Stage #1: diethyl diselenide With sulfuryl dichloride In dichloromethane at -196 - -20℃; for 0.5h; Stage #2: With antimonypentachloride In dichloromethane at -78℃; for 0.166667h; Stage #3: adamantylidene-adamantane In dichloromethane at -40 - 0℃; for 2h;	87%

: 628-39-7
diethyl diselenide

: 10-chloro-5,5-difluoro-3,7-dimethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f ][1,3,2]diazaborinine

: 10-(ethylselanyl)-5,5-difluoro-3,7-dimethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f ][1,3,2]diazaborinine

Conditions

Conditions	Yield
Stage #1: diethyl diselenide With sodium tetrahydroborate In tetrahydrofuran at 0 - 20℃; for 1.25h; Inert atmosphere; Stage #2: 10-chloro-5,5-difluoro-3,7-dimethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f ][1,3,2]diazaborinine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	87%

: 628-39-7
diethyl diselenide

: 91-64-5
coumarin

: 3-(ethylselanyl)-2H-chromen-2-one

Conditions

Conditions	Yield
With bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; for 5h; regioselective reaction;	83%

Diethyldiselenide Specification

Diethyldiselenide is an organic compound with the formula C₄H₁₀Se₂, and its systematic name is the same with the product name. With the CAS registry number 628-39-7, it is also named as Diselenide, diethyl. It belongs to the product category of Organoselenides. Its EINECS number is 211-042-6. In addition, the molecular weight is 216.04. Its classification code is Skin / Eye Irritant. This chemical should be sealed and stored below the temperature of 5 °C. Moreover, it should be protected from oxides.

Physical properties of Diethyldiselenide are: (1)ACD/LogP: 3.22; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.22; (4)ACD/LogD (pH 7.4): 3.22; (5)ACD/BCF (pH 5.5): 164.89; (6)ACD/BCF (pH 7.4): 164.89; (7)ACD/KOC (pH 5.5): 1344.87; (8)ACD/KOC (pH 7.4): 1344.87; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Flash Point: 74.252 °C; (13)Enthalpy of Vaporization: 41.757 kJ/mol; (14)Boiling Point: 199.164 °C at 760 mmHg; (15)Vapour Pressure: 0.49 mmHg at 25°C.

Preparation of Diethyldiselenide: this chemical can be prepared by bromoethane at the temperature of 50 °C. This reaction will need reagent Na₂Se₂ and solvent dimethylformamide with the reaction time of 30 min. The yield is about 88%.

Uses of Diethyldiselenide: it can be used to produce 3-ethylselanyl-propene at the temperature of 50 °C. It will need reagents ytterbium powder, TMSCl and solvent tetrahydrofuran with the reaction time of 2 hours. The yield is about 60%.

When you are using this chemical, please be cautious about it as the following:
This chemical is toxic by inhalation and if swallowed. It is very toxic to aquatic organisms as it may cause long-term adverse effects in the aquatic environment. This substance has a danger of cumulative effects. When using it, you must not eat, drink or smoke. After contact with skin, you need to wash immediately with plenty of ... (to be specified by the manufacturer). In case of accident or if you feel unwell, you should seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: [Se]([Se]CC)CC
(2)Std. InChI: InChI=1S/C4H10Se2/c1-3-5-6-4-2/h3-4H2,1-2H3
(3)Std. InChIKey: OMAWWKIPXLIPDE-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LCLo	skin	8600ug/kg (8.6mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	National Technical Information Service. Vol. OTS0555235,
rat	LCLo	inhalation	2200mg/m³/45M (2200mg/m³)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: EXCITEMENT	National Technical Information Service. Vol. OTS0555235,
rat	LD50	oral	90mg/kg (90mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Technical Information Service. Vol. OTS0555235,

Product Name

Diethyldiselenide

Synthetic route

Diethyldiselenide Specification

Related Products

Hot Products