Conditions | Yield |
---|---|
With chlorine at 20 - 740℃; Reagent/catalyst; Temperature; | 98.6% |
Conditions | Yield |
---|---|
With chlorine; iron In water at 50℃; for 6h; | 94.3% |
With chlorine at 30 - 40℃; for 3h; Temperature; Green chemistry; | 92.1% |
With chlorine; benzene | |
With chlorine In tetrachloromethane at 0℃; Inert atmosphere; | |
With chlorine; benzene |
Conditions | Yield |
---|---|
With trichlorophosphate at 0 - 5℃; for 1h; | 93% |
methanol
methyl phosphorodichloridothionate
dimethyl chlorothiophosphate
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at -5 - 5℃; for 1h; Inert atmosphere; | 88% |
Conditions | Yield |
---|---|
With sulfuryl dichloride In benzene for 0.5h; | 45% |
Conditions | Yield |
---|---|
With phosphorous (V) sulfide; benzene und anschliessendes Behandeln mit Chlor; | |
With trichlorothiophosphine; sodium hydroxide at -10℃; |
Conditions | Yield |
---|---|
With phosphorus pentachloride |
Conditions | Yield |
---|---|
With dichloromethane Irradiation; |
methanol
A
methyl phosphorodichloridothionate
B
O,O,O-trimethylthiophosphate
C
dimethyl chlorothiophosphate
Conditions | Yield |
---|---|
With trichlorophosphate at 20℃; Product distribution; multistep reaction; varying of molar ratio of components; time taken in the addition of alcohol; consumption time of reactants; alcoholysis of PSCl3 (estimation of rel. rates); |
Conditions | Yield |
---|---|
With trichlorothiophosphine In methanol; benzene for 3h; Ambient temperature; |
O,O-dimethyl-O-(2,5-dichloro-4-cyano-phenyl)-thionophosphate
B
dimethyl chlorothiophosphate
dimethyl chlorothiophosphate
O,O-dimethyl phosphoramidothioate
Conditions | Yield |
---|---|
With ammonium hydroxide In dichloromethane at 0 - 44℃; | 99% |
With ammonium hydroxide In dichloromethane at 0 - 44℃; pH=8.4 - 9.1; | 99% |
With ammonia In dichloromethane at 5 - 10℃; for 10h; Solvent; Temperature; | 99.8% |
dimethyl chlorothiophosphate
2-diethylamino-4-hydroxy-6-methyl-pyrimidine
Pirimiphos-methyl
Conditions | Yield |
---|---|
Stage #1: 2-diethylamino-4-hydroxy-6-methyl-pyrimidine With potassium carbonate In water; toluene at 78 - 93℃; for 0.5h; Green chemistry; Stage #2: dimethyl chlorothiophosphate at 20℃; Solvent; Temperature; Green chemistry; | 98.6% |
Stage #1: 2-diethylamino-4-hydroxy-6-methyl-pyrimidine With potassium carbonate In benzene for 3h; Reflux; Stage #2: dimethyl chlorothiophosphate In butanone; benzene at 60 - 95℃; for 2h; Reflux; |
methylamine hydrochloride
dimethyl chlorothiophosphate
N-methyl O,O-dimethyl phosphoramidothioate
Conditions | Yield |
---|---|
In dichloromethane at 0 - 35℃; for 1h; pH=8.4 - 9.1; | 96% |
methyl 3-hydroxybenzoate, sodium salt
dimethyl chlorothiophosphate
carbomethoxydenitrofenitrothion
Conditions | Yield |
---|---|
95% |
dimethyl chlorothiophosphate
sodium salt of meta-hydroxybenzaldehyde
formyldenitrofenitrothion
Conditions | Yield |
---|---|
95% |
Conditions | Yield |
---|---|
With tributyl-amine; triethylamine In dichloromethane at 0 - 5℃; for 3h; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With dmap; N-benzyl-N,N,N-triethylammonium chloride; sodium dodecyl sulfate; potassium carbonate In water at 50℃; for 2.5h; pH=9.5 - 10; | 94.1% |
dimethyl chlorothiophosphate
O,O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
Conditions | Yield |
---|---|
With dmap; N-benzyl-N,N,N-triethylammonium chloride; sodium dodecyl sulfate; potassium carbonate In water at 50℃; for 2.5h; pH=9.5 - 10; | 93.4% |
dimethyl chlorothiophosphate
O,O-dimethyl O-(3-formyl-4-nitro)phenyl phosphorothioate
Conditions | Yield |
---|---|
92% |
sodium 3-methylphenoxide
dimethyl chlorothiophosphate
denitrofenitrothion
Conditions | Yield |
---|---|
91% | |
With pyridine In toluene |
N,N-dimethylammonium chloride
dimethyl chlorothiophosphate
N,N-dimethyl O,O-dimethyl phosphoramidothioate
Conditions | Yield |
---|---|
In dichloromethane at 0 - 35℃; for 1h; pH=8.4 - 9.1; | 91% |
With triethylamine In tetrahydrofuran 0 deg C to RT; |
benzamide
dimethyl chlorothiophosphate
N-[dimethoxy(thio)phosphoryl]benzamide
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran | 90% |
dimethyl chlorothiophosphate
methylamine
N-methyl O,O-dimethyl phosphoramidothioate
Conditions | Yield |
---|---|
In diethyl ether for 0.5h; | 87% |
With triethylamine In diethyl ether | |
With triethylamine In benzene |
dimethyl chlorothiophosphate
1-amino-2-propene
O,O-dimethyl-N-allylaminothiophosphate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane Ambient temperature; | 87% |
Conditions | Yield |
---|---|
With aluminum oxide at 20℃; | 87% |
dimethyl chlorothiophosphate
3-(hydroxymethyl)phenol, sodium salt
Conditions | Yield |
---|---|
85% |
dimethyl chlorothiophosphate
methylhydrazine
N1-dimethoxythiophosphoro-N1-methylhydrazide
Conditions | Yield |
---|---|
In chloroform for 6h; Ambient temperature; | 85% |
cyclohexylamine
dimethyl chlorothiophosphate
O,o'-dimethyl-N-cyclohexyl phosphoramido thionate
Conditions | Yield |
---|---|
With aluminum oxide at 20℃; | 85% |
dimethyl chlorothiophosphate
benzylamine
dimethyl N-benzylphosphoramidothionate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 20h; Ambient temperature; | 84% |
With triethylamine In tetrahydrofuran 0 deg C to RT; |
Conditions | Yield |
---|---|
With aluminum oxide at 20℃; | 83% |
In acetonitrile for 4h; |
Conditions | Yield |
---|---|
With triethylamine In chloroform for 2h; Ambient temperature; | 82% |
Conditions | Yield |
---|---|
With aluminum oxide at 20℃; | 82% |
1-bromo-3,5-di-tert-butylbenzene
dimethyl chlorothiophosphate
3, 5-di-tert-butyltoluene
Conditions | Yield |
---|---|
Stage #1: 1-bromo-3,5-di-tert-butylbenzene With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 1h; Stage #2: dimethyl chlorothiophosphate In tetrahydrofuran; pentane at -78 - 20℃; for 4h; Further stages.; | 80% |
diethyl amine hydrochloride
dimethyl chlorothiophosphate
N,N-diethyl O,O-dimethyl phosphoramidothioate
Conditions | Yield |
---|---|
In dichloromethane at 0 - 35℃; for 1h; pH=8.4 - 9.1; | 80% |
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-fluoro-pyrimidin-2-ol With sodium In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: dimethyl chlorothiophosphate In N,N-dimethyl-formamide at 20℃; for 48h; | 80% |
dimethyl chlorothiophosphate
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane at 10℃; for 4h; Reflux; | 80% |
MF: C2H6ClO2PS
MW: 160.56g/mol
Density: 1.364 g/cm3
Flash Point: 221 °F
Index of Refraction: 1.486
Density: 1.322 g/mL at 25 °C(lit.)
Vapor pressure: 0.67 psi ( 20 °C)
Enthalpy of Vaporization: 39.52 kJ/mol
Refractive index: n20/D 1.482(lit.)
Water Solubility: slowly hydrolyzes
Boiling Point: 175.8 °C at 760 mmHg
Vapour Pressure: 1.52 mmHg at 25°C
Appearance: Colorless to light amber liquid
IUPAC Name: Chloro-dimethoxy-sulfanylidene-$l^{5}-phosphane
Synonyms: AURORA KA-1651 ; Dimethylthiophosphoril chloride ; Dimethylthiophosphoryl chloride ; Dimethyl chlorothiophosphate ; Dimethyl phosphorochloridothionate ; Dimethylphosphorochlorothioate ; Dmpct
Following is the molecular structure of O,O-Dimethylphosphorochlorothioate (2524-03-0):
O,O-Dimethylphosphorochlorothioate (2524-03-0) is used as a chemical intermediate for insecticides, pesticides, and fungicides; oil and gasoline additives; plasticizers; corrosion inhibitors; flame retardants; and flotation agents.
Reactivity Profile of O,O-Dimethylphosphorochlorothioate (2524-03-0): Organothiophosphates, such as Dimethyl chlorothiophosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
1. | orl-rat LDLo:1000 mg/kg | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,393. | ||
2. | ihl-rat LC50:340 mg/m3/4H | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,56. | ||
3. | orl-mus LD50:1800 mg/kg | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,56. | ||
4. | ihl-mus LC50:320 mg/m3/2 | 85GMAT Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,56. | ||
5. | skn-rbt LDLo:750 mg/kg | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,393. |
Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.
Poison by inhalation. Moderately toxic by ingestion and skin contact. Corrosive. When heated to decomposition it emits very toxic fumes of Cl−, POx, and SOx.
Safety Information of O,O-Dimethylphosphorochlorothioate (2524-03-0):
Hazard Codes: T
T: Toxic
Risk Statements: 23/24/25-34-23-21/22
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
34: Causes burns
23: Toxic by inhalation
21/22: Harmful in contact with skin and if swallowed
Safety Statements: 23-26-36/37/39-45-24/25
23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25: Avoid contact with skin and eyes
RIDADR: UN 2267 6.1/PG 2
WGK Germany: 3
RTECS: TD1830000
HazardClass: 6.1(a)
PackingGroup: II
Health Hazard: Dimethyl chlorothiophosphate is a strong irritant to the eyes, skin, and mucous membranes.
Fire Hazard: Dimethyl chlorothiophosphate may burn but does not ignite readily. Dimethyl chlorothiophosphate may ignite combustibles (wood, paper, oil, etc.). When heated Dimethyl chlorothiophosphate emits very toxic fumes of chlorine containing compounds, phosphorus oxides, and sulfur oxides.
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View