Dimethylamine hydrochloride supplier

Name
Dimethylamine hydrochloride
EINECS 208-046-5
CAS No. 506-59-2
Article Data135
CAS DataBase
Density 0.64 g/cm³
Solubility 3000 g/L (20 °C) in water
Melting Point 170-173 ºC (lit.)
Formula C₂H₇N^.HCl
Boiling Point 6.1 ºC at 760 mmHg
Molecular Weight 81.5452
Flash Point
Transport Information
Appearance white crystals
Safety 26-36/37-37/39-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Methanamine, N-methyl-, hydrochloride (9CI);Dimethylammonium chloride;
PSA 12.03000
LogP 1.02850

Synthetic route

: 103-83-3
N,N'-dimethylbenzylamine

: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With dichloromethane; hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; atmospheric pressure;	99%
With 1,1,2-trichloroethane; 10% palladium on activated carbon; hydrogen In methanol under 760.051 Torr; for 0.666667h; chemoselective reaction;	98%

: 94947-35-0
({(CH3)2NH}2B(Cl)C6H5)(1+)*Cl(1-)=({(CH3)2NH}2B(Cl)C6H5)Cl

A: 1196-44-7
chloro(dimethylamino)phenylborane

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In neat (no solvent) pyrolysis from 150 to 200°C;;	A 94.1% B n/a
In neat (no solvent) pyrolysis from 150 to 200°C;;	A 94.1% B n/a

: 57802-40-1
pentachloro-2H-pyrrole

: 2083-91-2
N,N-Dimethyltrimethylsilylamine

A: 506-59-2
N,N-dimethylammonium chloride

B: 2.5-Bis-(dimethylamino).3.4-dichlor-azacyclopentadienyliumchlorid

C: 2.3.5-Tris-(dimethylamino)-4-chlor-azacyclopentadienyliumchlorid

Conditions

Conditions	Yield
In tetrahydrofuran	A n/a B 91% C n/a

...Expand

: C6H19N4P*ClH

: 93766-28-0
N,N-dimethyl-N',N''-bisphosphorous triamide

A: 506-59-2
N,N-dimethylammonium chloride

B: tris<amino>phosphonium chloride

Conditions

Conditions	Yield
at 50℃; for 1h;	A 89% B 91%

...Expand

: 71-41-0
pentan-1-ol

: 3397-76-0, 100508-13-2
N,N-Dimethylformamide Hydrochloride

A: 543-59-9
1-Chloropentane

B: 638-49-3
n-pentyl formate

C: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
at 100℃; for 0.833333h; Product distribution; different alcohols;	A n/a B 90% C n/a

...Expand

: 93304-26-8
H(C5H5)Mo(CO)2(P(OC2H5)2N(CH3)2)

A: 93304-27-9
H(C5H5)Mo(CO)2(P(OC2H5)2Cl)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With HCl In toluene dry gaseous HCl bubbled through soln. of educt in toluene at -20°C; elem. anal.;	A 70% B 90%

: 7721-01-9
tantalum pentachloride

: 124-40-3
dimethyl amine

: 77071-69-3
mer,cis-[TaCl3(NMe2)2(NHMe2)]

: 77071-71-7
TaCl2(N(CH3)2)3(HN(CH3)2)

: 77071-70-6
(TaCl2(N(CH3)2)2(HN(CH3)2))2O

D: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In benzene dimethylamine added to frozen soln.TaCl5 in benzene at -178°C and slowly allowed to warm to room temp. and soln. stirred for 24 h under N2 atm.; Me2NH2Cl filtered, filtrate concd., pentane added slowly, crystals Ta(NMe2)2Cl3(HNMe2) filtered, filtrate allowed to stand for 10 days - Ta(NMe2)3Cl2(HNMe2) and (TaCl2(NMe2)2(HNMe2))2O; elem. anal.;	A 85% B 1.6% C 6.3% D n/a

...Expand

: 124-40-3
dimethyl amine

: 5032-91-7
pentafluorophenyl dichlorophosphine

A: 506-59-2
N,N-dimethylammonium chloride

B: 5032-95-1
Bis-dimethylamino-pentafluorphenyl-phosphin

Conditions

Conditions	Yield
In diethyl ether byproducts: HCl; in presence of a trap for HCl;	A n/a B 81.5%
In diethyl ether byproducts: HCl; in presence of a trap for HCl;	A n/a B 81.5%

...Expand

: 124-40-3
dimethyl amine

: 698-16-8
benzohydroximoyl chloride

A: 65986-63-2
(E)-N,N-Dimethylbenzamid-oxim

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In diethyl ether for 48h; Ambient temperature;	A 80% B n/a

...Expand

: 1630-79-1
tetrakis(dimethylamido)diborane

A: 64541-76-0
dichlorobis(dimethylamino)diborane(4)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With HCl In diethyl ether	A 79.3% B n/a

: 126306-16-9
bis(dimethylamino)cyclohexylphosphine(pentacarbonyl)chromium(0)

A: 126306-27-2
chlorodimethylaminocyclohexylphosphine(pentacarbonyl)chromium(0)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In pentane Under stirring a strong stream of hydrogenhalogenide is bubbled for 10 min through the cooled (0°C) soln. of phosphine complex (inert atmosphere).; Solvent is evapd. at room temp. in vac., residue is digested with pentane, dialkylamminhydrohalogenide is filtered off, filtrate is dried to dryness in vac., recrystn. from pentane (-78°C), elem. anal.;	A 79% B n/a

: 72868-70-3
bis(dimethylamino)phenylphosphine(pentacarbonyl)chromium(0)

A: 126306-23-8
chlorodimethylaminophenylphosphine(pentacarbonyl)chromium(0)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In pentane Under stirring a strong stream of hydrogenhalogenide is bubbled for 10 min through the cooled (0°C) soln. of phosphins complex (inert atmosphere).; Solvent is evapd. at room temp. in vac., residue is digested with pentane, dialkylamminhydrohalogenide is filtered off, filtrate is dried to dryness in vac., chromy. (silica gel, pentane), elem. anal.;	A 74% B n/a

: 3356-73-8
2-piperidino-2,4,4,6,6-pentacholorocyclotriphosphazatriene

: 124-40-3
dimethyl amine

A: 506-59-2
N,N-dimethylammonium chloride

: Dimethyl-((2S,6R)-2,4,4,6-tetrachloro-6-piperidin-1-yl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinin-2-yl)-amine

: Dimethyl-((2R,6R)-2,4,4,6-tetrachloro-6-piperidin-1-yl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinin-2-yl)-amine

Conditions

Conditions	Yield
In tetrahydrofuran	A n/a B 30% C 70%

...Expand

: 3720-88-5
penatchloromonoisopropylaminocyclotriphosphazatriene

: 124-40-3
dimethyl amine

A: 506-59-2
N,N-dimethylammonium chloride

: (2R,4R)-2,4,6,6-Tetrachloro-N-isopropyl-N',N'-dimethyl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinine-2,4-diamine

: (2R,4S)-2,4,6,6-Tetrachloro-N-isopropyl-N',N'-dimethyl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinine-2,4-diamine

Conditions

Conditions	Yield
	A n/a B 70% C 30%
at 30℃;	A n/a B 70% C 30%

...Expand

: 3998-23-0
Pentachlor--triphosphonitril

: 124-40-3
dimethyl amine

A: 506-59-2
N,N-dimethylammonium chloride

: (2R,4R)-N-Butyl-2,4,6,6-tetrachloro-N',N'-dimethyl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinine-2,4-diamine

: (2S,4R)-N-Butyl-2,4,6,6-tetrachloro-N',N'-dimethyl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinine-2,4-diamine

Conditions

Conditions	Yield
Thermodynamic data; Kinetics; ΔH (excit.), ΔS (excit.);	A n/a B 70% C 30%
at 30℃;	A n/a B 70% C 30%

...Expand

: 77215-38-4
Dibutyl-(2,4,4,6,6-pentachloro-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinin-2-yl)-amine

: 124-40-3
dimethyl amine

A: 506-59-2
N,N-dimethylammonium chloride

: (2R,4S)-N,N-Dibutyl-2,4,6,6-tetrachloro-N',N'-dimethyl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinine-2,4-diamine

: (2R,4R)-N,N-Dibutyl-2,4,6,6-tetrachloro-N',N'-dimethyl-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinine-2,4-diamine

Conditions

Conditions	Yield
at 18 - 30℃;	A n/a B 30% C 70%

...Expand

: 650-52-2
bis(trifluoromethyl)chlorophosphine

: 124-40-3
dimethyl amine

A: 432-01-9
dimethylamino-bis-trifluoromethyl-phosphine

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In gaseous matrix 0°C;	A 70% B n/a

...Expand

: 680-31-9
N,N,N,N,N,N-hexamethylphosphoric triamide

: 931-59-9
benzenesulfenyl chloride

A: 1212-08-4
S-Phenyl benzenethiosulfonate

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 4h; Inert atmosphere;	A 70% B n/a

...Expand

: 680-31-9
N,N,N,N,N,N-hexamethylphosphoric triamide

: 933-01-7
4-chloro-benzenesulfenyl chloride

A: 1146-44-7
4,4'-dichlorophenyl thiosulfonate

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 4h; Inert atmosphere;	A 70% B n/a

...Expand

: 26459-63-2
hexakis(dimethylamino)tetraborane(6)

A: pentakis(dimethylamino)chlorotetraborane(6)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether -20°C;	A 65% B n/a

: 32882-73-8
{(CH3)3Si}2NB{N(CH3)2}2

A: 32882-72-7
Bis(trimethylsilyl)aminochlorodimethylaminoboran

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With HCl In toluene sepn. of dimethylamine hydrochloride and toluene, distn.;	A 65% B n/a

: dichloro(nitrosyl)[tris(3,5-dimethylpyrazolyl)-borato]molybdenum

: 124-40-3
dimethyl amine

A: Mo(HB(Me2pyz)3)(NO)Cl(NMe2)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In dichloromethane under N2 to Mo(HB(Me2pyz)3)(NO)Cl2 dissolved in dichloromethane added dimethylamine and mixt. stirred for 30 min; volume soln. reduced in vacuo, treated with Et2O, (NH2Me2)Cl filtered off, filtrate slowly evapd.; elem. anal.;	A 61% B n/a

...Expand

: 124-40-3
dimethyl amine

: tris(dimethylamino)isothiocyanatophosphonium chloride

A: 506-59-2
N,N-dimethylammonium chloride

B: N'''-(dimethylthiocarbamoyl)hexamethylphosphorimidic triamide

Conditions

Conditions	Yield
for 6h;	A n/a B 60%

...Expand

: 73939-32-9
(η5-chlorodivinylborane)(η5-cyclopentadienyl)cobalt

: 124-40-3
dimethyl amine

A: 11486-73-0
(η5-(dimethylamino)divinylborane)(η5-cyclopentadienyl)cobalt

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In diethyl ether Under nitrogen, dimethylamine is bubbled through a stirred soln. of Co-complex in ether, ppt. of dimethylamine*HCl forms, addn. of amine is continued for 15 min.; Filtn., redn. of solvent under high vac., extn. with pentane, coolg. of the red soln. to -78°C, filtn., drying under high vac, elem. anal.;	A 54% B n/a

...Expand

: 1,1,3,3-tetrakis(dimethylamino)-2-diethylaminotriborane(5)

A: diethylamino-tris(dimethylamino)chlorotriborane(5)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether -20°C for 2 h; distn. at 78-82°C/1 Torr;	A 53% B n/a

: 26459-62-1
1,1,3,3-tetrakis(dimethylamino)-2-dimethylamino-triboran(5)

A: tetrakis(dimethylamino)chlorotriborane(5)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether -20°C; distn. at 70-72°C/1 Torr;	A 48% B n/a

: 832-53-1
pentafluorobenzenesulonyl chloride

: 124-40-3
dimethyl amine

A: 36650-05-2
2,3,4,5,6-pentafluoro-N,N-dimethylbenzenesulfonamide

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
In diethyl ether 20°C,20 h,in presence of Et3N;	A 42.5% B n/a
In diethyl ether 20°C,20 h,in presence of Et3N;	A 42.5% B n/a

...Expand

: 10294-34-5
boron trichloride

: 124-40-3
dimethyl amine

A: 1113-31-1
dichlorodimethylaminoborane

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
	A 35% B n/a

...Expand

: 1630-79-1
tetrakis(dimethylamido)diborane

A: 7360-75-0
tris(dimethylamino)monochlorodiborane(4)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether -20°C; distn.;	A 28% B n/a
With HCl In diethyl ether -20°C; distn.;	A 28% B n/a
With HCl In diethyl ether -20°C;

: 126306-18-1
bis(dimethylamino)-t-butylphosphine(pentacarbonyl)chromium(0)

A: 126289-56-3
chlorodimethylamino-t-butylphosphine(pentacarbonyl)chromium(0)

B: 506-59-2
N,N-dimethylammonium chloride

Conditions

Conditions	Yield
With hydrogenchloride In pentane Under stirring a strong stream of hydrogenhalogenide is bubbled for 10 min through the cooled (0°C) soln. of phosphine complex (inert atmosphere).; Solvent is evapd. at room temp. in vac., residue is digested with pentane, dialkylamminhydrohalogenide is filtered off, filtrate is dried to dryness in vac., recrystn. from pentane (-78°C), not isolated.;	A 10% B n/a

: 934-37-2
2-methylimidazo[1,2-a]pyridine

: 50-00-0
formaldehyd

: 506-59-2
N,N-dimethylammonium chloride

: 133395-11-6
3-<(dimethylamino)methyl>-2-methylimidazo<1,2-a>pyridine

Conditions

Conditions	Yield
In methanol for 1.5h; Heating;	100%

...Expand

: 506-59-2
N,N-dimethylammonium chloride

: 90905-31-0
2-(methylsulfanyl)pyrimidine-5-carbaldehyde

: 55551-49-0
2-(N,N-dimethylamino)pyrimidine-5-carbaldehyde

Conditions

Conditions	Yield
With sodium carbonate In ethanol Heating;	100%

: 506-59-2
N,N-dimethylammonium chloride

: 3-(β-D-ribofuranosyl)-7-(1,2,4-triazol-4-yl)pyrazolo<4,3-d>pyrimidine

: 13263-97-3
7-(dimethylamino)-3-(β-D-ribofuranosyl)pyrazolo<4,3-d>pyrimidine

Conditions

Conditions	Yield
With pyridine at 57℃; for 22h;	100%

: 75-15-0
carbon disulfide

: 506-59-2
N,N-dimethylammonium chloride

: 128-04-1
sodium dimethyldithiocarbamate

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 3h; Ambient temperature;	100%

: 506-59-2
N,N-dimethylammonium chloride

: 165180-39-2
6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methanesulfonyloxymethyl-5-pivaloylamino-4H-1-benzopyran-4-one

: 165180-41-6
7-dimethylaminomethyl-6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 0.75h; Ambient temperature;	100%
With sodium chloride; potassium carbonate In N-methyl-acetamide; water	100%
With sodium chloride; potassium carbonate In N-methyl-acetamide; water	100%

: 506-59-2
N,N-dimethylammonium chloride

: 2243-83-6
2-naphthaloyl chloride

: 13577-85-0
N,N-dimethyl-2-naphthylcarboxamide

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether; water; ethyl acetate at 0℃; for 1h;	100%
With pyridine In dichloromethane for 20h; Substitution;	572 mg

: 506-59-2
N,N-dimethylammonium chloride

: 297751-32-7
3-[1-(benzenesulfonyl)-1H-indol-4-yl]propionic acid ethyl ester

: 297751-33-8
N,N-dimethyl-4-[1-(benzenesulfonyl)-1H-indol-4-yl]propionamide

Conditions

Conditions	Yield
With trimethylaluminum In hexane; benzene for 18h; Heating;	100%
With hydrogenchloride; trimethylaluminum In benzene

: 506-59-2
N,N-dimethylammonium chloride

: 221087-71-4
2-(2,5-dimethylpyrrolyl)-6-(4-(2-carboxymethyloxy)-1-naphthyl)pyridine

: 221087-73-6
2-(2,5-dimethylpyrrolyl)-6-((4-(N,N-dimethylcarboxamido)methyloxy)-1-naphthyl)pyridine

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In acetonitrile at 20℃; for 80h;	100%

: 506-59-2
N,N-dimethylammonium chloride

: 221087-93-0
2-(2,5-dimethylpyrrolyl)-6-[4-carboxymethoxy-5,6,7,8-tetrahydronaphthalen-1-yl]pyridine

: 221087-95-2
2-(2,5-dimethylpyrrolyl)-6-[4-(N,N-dimethylcarboxamido)methoxy-5,6,7,8-tetrahydronaphthalen-1-yl]pyridine

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In acetonitrile at 20℃;	100%

: 506-59-2
N,N-dimethylammonium chloride

: 76-05-1
trifluoroacetic acid

: 711020-56-3
2-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl]-3-methyl-1-oxo-1,3,4,6-tetrahydro-2H-naphtho[1,2-f][1,4]oxazocine-7-carbonitrile

: (3R)-2-[(2S)-2-(3,4-dichlorophenyl)-4-(dimethylamino)butyl]-3-methyl-1-oxo-1,3,4,6-tetrahydro-2H-naphtho[1,2-f][1,4]oxazocine-7-carbonitrile trifluoroacetate

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid; triethylamine In methanol	100%

...Expand

: 506-59-2
N,N-dimethylammonium chloride

: 147471-66-7
(S)-4-tert-Butoxycarbonylamino-5-ethoxycarbonyloxy-5-oxo-pentanoic acid benzyl ester

: 841233-80-5
benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-N,N-dimethylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 20h;	100%

: 506-59-2
N,N-dimethylammonium chloride

: methyl (R)-2'-(((trifluoromethyl)sulfonyl)oxy)-[1,1'-binaphthalene]-2-carboxylate

: (R)-2-N,N-dimethylcarbamoyl-2'-trifluoromethanesulfonyloxy-1,1'-binaphthyl

Conditions

Conditions	Yield
Stage #1: N,N-dimethylammonium chloride With trimethylaluminum In toluene at 20℃; for 1h; Stage #2: 2'-trifluoromethanesulfonyloxy-[1,1']binaphthalenyl-2-carboxylic acid methyl ester In toluene for 3h; Heating; Further stages.;	100%

: 227449-41-4
2-methylsulfanyl-4-(3-trifluoromethylanilino)pyrimidine-5-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 863029-03-2
N,N-dimethyl-2-methylsulfanyl-4-(3-trifluoromethylanilino)pyrimidine-5-carboxamide

Conditions

Conditions	Yield
Stage #1: 2-methylsulfanyl-4-(3-trifluoromethylanilino)pyrimidine-5-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 4h; Stage #2: N,N-dimethylammonium chloride In N,N-dimethyl-formamide at 20℃; for 14h;	100%

: 506-59-2
N,N-dimethylammonium chloride

: 126093-01-4
methyl 4-<<<4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylic acid

: 292073-28-0
{5-[5-(5-dimethylcarbamoyl-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-yl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 14h;	100%

: 774213-95-5
[3-cyclohexyl-6-(methoxycarbonyl)-2-phenyl-1H-pyrrolo[2,3-b]pyridin-1-yl]acetic acid

: 506-59-2
N,N-dimethylammonium chloride

: 774213-96-6
methyl 3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-pyrrolo[2,3-b]pyridine-6-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	100%
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 20℃; for 1.5h;	100%

: 1015174-82-9
1-(2-methoxyethyl)-2-methyl-8-phenyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1-(2-methoxyethyl)-N,N.2-trimethyl-8-phenyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	100%

: 918650-03-0
(5S)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-2-methyl-4,5-dihydro-1H-pyrrole-3-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1-tert-butyl 2-methyl (2S)-4-(dimethylcarbamoyl)-5-methyl-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 4h;	100%

: 728015-44-9
4-(3-cyano-phenyl)-7-ethyl-3-(methylsulfonyl)-pyrrolo[1,2-b]pyridazine-2-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 4-(3-cyano-phenyl)-7-ethyl-N,N-dimethyl-3-(methylsulfonyl)-pyrrolo[1,2-b]pyridazine-2-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) at 20℃; for 3h;	100%

: C23H23ClN2O4

: 506-59-2
N,N-dimethylammonium chloride

: 5,6-bis(4-methoxyphenyl)-4-dimethyl-carbamoyl-2-isobutyl-2H-pyridazin-3-one

Conditions

Conditions	Yield
In benzene Heating / reflux;	100%

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 506-59-2
N,N-dimethylammonium chloride

: 17417-10-6
2-cyano-4-nitro-N,N-dimethylaniline

Conditions

Conditions	Yield
With potassium hydrogencarbonate In water; N,N-dimethyl-formamide	100%

: 506-59-2
N,N-dimethylammonium chloride

: 79463-77-7
N-cyanodiphenylcarbonimidate

: 167494-04-4
O-phenyl-N-cyano-N',N'-dimethylurea

Conditions

Conditions	Yield
In tetrahydrofuran	100%

: 170364-87-1
1-N-[1-N-(3-chloropropyl)-piperidin-4-yl]-indole

: 506-59-2
N,N-dimethylammonium chloride

: [3-(4-Indol-1-yl-piperidin-1-yl)-propyl]-dimethylamine

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water	100%

: 2-chloro-N-{4-[(2S)-4-((1R)-1-phenylethyl)morpholin-2-yl]phenyl}acetamide

: 506-59-2
N,N-dimethylammonium chloride

: N2,N2-dimethyl-N1-(4-((2S)-4-((1R)-1-phenylethyl)morpholin-2-yl)phenyl)glycinamide

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; acetonitrile at 95℃; for 10h;	100%
With potassium carbonate In tetrahydrofuran; acetonitrile at 95℃; for 10h;	100%

: 2604-39-9
4-amino-2-chloro-5-nitropyridine

: 506-59-2
N,N-dimethylammonium chloride

: 886435-69-4
N,N-dimethyl-5-nitropyridine-2,4-diamine

Conditions

Conditions	Yield
Stage #1: 4-amino-2-chloro-5-nitropyridine; N,N-dimethylammonium chloride With triethylamine In ethanol at 85℃; for 0.166667h; Microwave irradiation; Stage #2: With sodium hydroxide In water	100%
With triethylamine In isopropyl alcohol at 100℃; for 12h;

: 928774-42-9
2-methyl-8-[(5-methyl-3,4-dihydro-2H-chromen-4-yl)amino]imidazo[1,2-a]pyridine-6-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 950595-98-9
N,N,2-trimethyl-8-[(5-methyl-3,4-dihydro-2H-chromen-4-yl)amino]imidazo[1,2-a]pyridine-6-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 24h;	100%

: 37366-09-9
dichloro(benzene)ruthenium(II) dimer

: 76189-55-4, 76189-56-5, 98327-87-8
(R)-(+)-2,2’-bis(diphenylphosphino)-1,1’-binaphthalene

: 506-59-2
N,N-dimethylammonium chloride

: [(RuCl((C6H5)2PC10H6C10H6P(C6H5)2))2Cl3](1-)*[(CH3)2NH2](1+)=[(RuCl((C6H5)2PC10H6C10H6P(C6H5)2))2Cl3][(CH3)2NH2]

Conditions

Conditions	Yield
In 1,4-dioxane (Ar); heating a soln. of ruthenium complex with ammonium salt and phosphine in dioxane at 50°C for 2 h with stirring, refluxing with stirring for 12 h; cooling, evapn.;	100%

...Expand

: 130004-33-0, 145926-28-9, 376354-47-1
(2,2'-bis(diphenylphosphino)-1,1'-binaphathalene)chloro(p-cymene)ruthenium chloride

: 506-59-2
N,N-dimethylammonium chloride

: [(RuCl((C6H5)2PC10H6C10H6P(C6H5)2))2Cl3](1-)*[(CH3)2NH2](1+)=[(RuCl((C6H5)2PC10H6C10H6P(C6H5)2))2Cl3][(CH3)2NH2]

Conditions

Conditions	Yield
In tetrahydrofuran (Ar); heating a soln. of ruthenium complex with ammonium salt in THF for 6 h; evapn., washing;	100%

: 713530-55-3
4-hydroxy-N,N,1,2-tetramethyl-1H-benzimidazole-6-carboxamide

: 50-00-0
formaldehyd

: 506-59-2
N,N-dimethylammonium chloride

: 1034771-47-5
5-[(dimethylamino)methyl]-4-hydroxy-N,N,1,2-tetramethyl-1H-benzimidazole-6-carboxamide hydrochloride

Conditions

Conditions	Yield
With triethylamine In water; isopropyl alcohol at 35 - 45℃; for 2 - 6h;	100%

...Expand

: 619-58-9
4-iodobenzoic acid

: 506-59-2
N,N-dimethylammonium chloride

: 24167-53-1
4-iodo-N,N-dimethylbenzamide

Conditions

Conditions	Yield
Stage #1: N,N-dimethylammonium chloride With triethylamine In dichloromethane for 0.5h; Stage #2: 4-iodobenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h;	100%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 506-59-2
N,N-dimethylammonium chloride

: 340161-34-4
(S)-tert-butyl 1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With HBTU In dichloromethane for 0.0333333h; Inert atmosphere; Stage #2: N,N-dimethylammonium chloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 1.5h; Inert atmosphere;	100%
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 12h; Cooling with ice;	91%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h;

Dimethylamine hydrochloride Specification

The Dimethylamine HCl, with the CAS registry number 506-59-2, is also known as Dimethylammonium chloride. It belongs to the product categories of Amine Salts; Nitrogen Compounds; Organic Building Blocks. Its EINECS registry number is 208-046-5. This chemical's molecular formula is C₂H₈ClN and molecular weight is 81.54. What's more, both its IUPAC name and systematic name are the same which is called N-Methylmethanamine hydrochloride. This chemical can be prepared by Dimethylamine with Hydrochloric acid.

Physical properties about Dimethylamine HCl are: (1)ACD/LogP: -0.43; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.53; (4)ACD/LogD (pH 7.4): -3.33; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 3.24 Å²; (13)Enthalpy of Vaporization: 26.4 kJ/mol; (14)Boiling Point: 6.1 °C at 760 mmHg; (15)Vapour Pressure: 1520 mmHg at 25 °C.

Uses of Dimethylamine HCl: (1) it is used as catalysator of acetylation analysis, raw materials of pharmaceutical and organic synthesis; (2) it is used to produce other chemicals. For example, it can react with 1-Methyl-pyrrole, Formaldehyde to get Dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine. The reaction occurs with solvent H₂O. The reaction time is 6 hours. The yield is 70 %.

Dimethylamine HCl can react with 1-Methyl-pyrrole, Formaldehyde to get Dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine.

When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes, respiratory system and skin. If swallowed, it's harmful to health. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: Cl.N(C)C
(2) InChI: InChI=1S/C2H7N.ClH/c1-3-2;/h3H,1-2H3;1H
(3) InChIKey: IQDGSYLLQPDQDV-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	1600mg/kg (1600mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(6), Pg. 12, 1967.
mouse	LD50	intraperitoneal	1570mg/kg (1570mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967. Link to PubMed
mouse	LD50	intravenous	1210mg/kg (1210mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 112, Pg. 36, 1957. Link to PubMed
mouse	LD50	oral	8100mg/kg (8100mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(6), Pg. 12, 1967.
mouse	LD50	subcutaneous	2gm/kg (2000mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 112, Pg. 36, 1957. Link to PubMed
rabbit	LD50	oral	1600mg/kg (1600mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(6), Pg. 12, 1967.
rat	LD50	oral	1070mg/kg (1070mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(6), Pg. 12, 1967.

Product Name

Dimethylamine hydrochloride

Synthetic route

Dimethylamine hydrochloride Specification

Related Products

Hot Products