Dimethylamine supplier | CasNO.124-40-3

Name
Dimethylamine
EINECS 204-697-4
CAS No. 124-40-3
Article Data604
CAS DataBase
Density 0.68 g/cm³
Solubility miscible with water
Melting Point -93 °C
Formula C₂H₇N
Boiling Point 6.1 °C at 760 mmHg
Molecular Weight 45.0843
Flash Point 60°F
Transport Information UN 2924 3/PG 2
Appearance colourless compressed liquefied gas
Safety 3-16-26-29-36/37/39-45
Risk Codes 12-20-37/38-41-34-20/22-11-39/23/24/25
Molecular Structure
Hazard Symbols F,Xn
Synonyms N,N-Dimethylamine;N-Methylmethanamine;NSC 8650;
PSA 12.03000
LogP 0.22650

Synthetic route

: 62-75-9
N-Nitrosodimethylamine

: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With iron; nickel In water pH=6.3 - 9.2; Kinetics; Further Variations:; Reagents; Hydrogenation;	100%
With isocyanate de chlorosulfonyle In diethyl ether for 10h; Ambient temperature;	65%
With titanium(III) chloride; water

: 85809-41-2
3-ethynyl-cyclohepta-1.3.5-triene

: 993-50-0
(dimethylamino)trimethyltin

A: 286387-63-1
3-(trimethylstannylethynyl)-1,3,5-cycloheptatriene

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
In neat (no solvent) Me3SnNMe2 added to 3-ethynyl-1,3,5-cycloheptatriene, react. mixture stirred without a solvent for 5 min at ambient temp., Me2NH evapd.; Me2NH evapd., product isolated in quant. yield;	A 100% B n/a

...Expand

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 100-46-9
benzylamine

A: 6343-54-0
N-benzylformamide

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With 2,3-dihydrophthalazine-1,4-dione at 80 - 95℃; for 40h;	A 99% B n/a
With cerium(IV) oxide at 100℃; for 12h; Reagent/catalyst;

...Expand

: C13H23N3O3S

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: C15H23N3O5S

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With 2,3-dihydrophthalazine-1,4-dione at 80 - 95℃; for 40h;	A 98% B n/a

...Expand

: 39139-79-2
1-dimethylamino-2,4-dinitronaphthalene

: 75-04-7
ethylamine

A: 27210-67-9
N-ethyl-2,4-dinitro-1-naphthylamine

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
In water at 30℃; for 2h;	A 98% B n/a

...Expand

: 107-10-8
propylamine

: 71240-22-7
2-(1H-benzoimidazol-2-yl)-3-dimethylamino-acrylic acid ethyl ester

A: 124-40-3
dimethyl amine

B: (E)-2-(1H-Benzoimidazol-2-yl)-3-propylamino-acrylic acid ethyl ester

Conditions

Conditions	Yield
at 40℃; for 0.5h; Irradiation;	A n/a B 98%

...Expand

: 33966-50-6
SEC-BUTYLAMINE

: 71240-22-7
2-(1H-benzoimidazol-2-yl)-3-dimethylamino-acrylic acid ethyl ester

A: 124-40-3
dimethyl amine

B: (E)-2-(1H-Benzoimidazol-2-yl)-3-sec-butylamino-acrylic acid ethyl ester

Conditions

Conditions	Yield
at 60℃; for 0.5h; Irradiation;	A n/a B 98%

...Expand

: 506-59-2
N,N-dimethylammonium chloride

: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With potassium hydroxide In water Inert atmosphere;	98%
With potassium hydroxide In dichloromethane at -15 - -5℃; for 1h;	90%
With potassium hydroxide Alkaline conditions;

: 29882-02-8
N',N''-dicyclohexyl-N,N-dimethylguanidine

: 108-91-8
cyclohexylamine

A: 4833-41-4
N,N',N''-tricyclohexylguanidine

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With [ς:η1:η5-(OCH2)(Me2CH2)C2B9H9]Ti(NMe2) at 110 - 115℃;	A 98% B n/a

...Expand

: 71240-24-9
2-benzooxazol-2-yl-3-dimethylamino-acrylic acid ethyl ester

: 75-64-9
tert-butylamine

A: 124-40-3
dimethyl amine

B: (E)-2-Benzooxazol-2-yl-3-tert-butylamino-acrylic acid ethyl ester

Conditions

Conditions	Yield
at 40℃; for 0.5h; Irradiation;	A n/a B 97%

...Expand

: 75-64-9
tert-butylamine

: 71240-22-7
2-(1H-benzoimidazol-2-yl)-3-dimethylamino-acrylic acid ethyl ester

A: 124-40-3
dimethyl amine

B: (E)-2-(1H-Benzoimidazol-2-yl)-3-tert-butylamino-acrylic acid ethyl ester

Conditions

Conditions	Yield
at 40℃; for 0.5h; Irradiation;	A n/a B 97%

...Expand

: 1198-55-6
o-chloranil

: 1608-26-0
Hexamethylphosphorous triamide

A: 124-40-3
dimethyl amine

B: 320747-63-5
tetrachlorobenzo<1,3,2>dioxaphosphol-2-yl-dimethylamine

Conditions

Conditions	Yield
With ammonium chloride In toluene for 1.5h; Heating;	A n/a B 97%

...Expand

: 123-75-1
pyrrolidine

: 29882-02-8
N',N''-dicyclohexyl-N,N-dimethylguanidine

A: 60006-28-2
N,N'-dicyclohexylpyrrolidine-1-carboximidamide

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With [ς:η1:η5-(OCH2)(Me2CH2)C2B9H9]Ti(NMe2) at 110 - 115℃;	A 97% B n/a

...Expand

: 29882-02-8
N',N''-dicyclohexyl-N,N-dimethylguanidine

: 75-31-0
isopropylamine

A: N,N'-Dicyclohexyl-N''-isopropyl-guanidin

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With [ς:η1:η5-(OCH2)(Me2CH2)C2B9H9]Ti(NMe2) at 110 - 115℃;	A 97% B n/a

...Expand

: 5815-08-7
tert-Butoxybis(dimethylamino)methane

: 74119-34-9
3-Dimethylamino-2-(formylaminomethyl)acrylsaeure-ethylester

A: 924-99-2, 1117-37-9, 114894-59-6
ethyl 3-(dimethylamino)acrylate

B: 124-40-3
dimethyl amine

C: 75-65-0
tert-butyl alcohol

Conditions

Conditions	Yield
at 160℃; for 3h;	A 96% B n/a C n/a

...Expand

: 110-89-4
piperidine

: 29882-02-8
N',N''-dicyclohexyl-N,N-dimethylguanidine

A: 60006-25-9
N,N'-dicyclohexylpiperidine-1-carboximidamide

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With [ς:η1:η5-(OCH2)(Me2CH2)C2B9H9]Ti(NMe2) at 110 - 115℃;	A 96% B n/a

...Expand

: 75712-80-0
N,N-dimethylhexa-1,5-dien-3-amine

A: 764-59-0
hex-5-en-1-al

B: 82574-98-9
(E)-N,N-Dimethyl-1,5-hexadien-1-amin

C: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
at 223.5℃; for 12h;	A n/a B 95.8% C n/a
at 160.2 - 200.1℃; Yield given. Yields of byproduct given;
With N,N-dimethyl-cyclohexanamine at 160.2 - 200.1℃; under 3 Torr; Kinetics; Thermodynamic data; Cope rearrengament, ΔH, ΔG, ΔS*, Ea;

...Expand

: 116018-88-3
((CH3)2N)2PH(Fe(CO)4)

: 103616-27-9
(PPh4)(hydridoiron(carbonyl)4)

A: ((CH3)2N)PH(Fe(CO)4)2(1-)*(C6H5)4P(1+)={(C6H5)4P}{(CH3)2NPH(Fe(CO)4)2}

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
	A 95% B n/a

...Expand

: 87-52-5
3-(Dimethylaminomethyl)indole

: 75-04-7
ethylamine

A: 57506-90-8
3-(N-ethylamino)methylindole

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
Heating;	A 94% B n/a

...Expand

: 75-31-0
isopropylamine

: 71240-22-7
2-(1H-benzoimidazol-2-yl)-3-dimethylamino-acrylic acid ethyl ester

A: 124-40-3
dimethyl amine

B: (E)-2-(1H-Benzoimidazol-2-yl)-3-isopropylamino-acrylic acid ethyl ester

Conditions

Conditions	Yield
at 30℃; for 0.5h; Irradiation;	A n/a B 94%

...Expand

: 75-31-0
isopropylamine

: 68897-42-7
N′,N″-diisopropyl-N,N-dimethyl guanidine

A: 121948-77-4
N,N', N''-tri(isopropyl)guanidine

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With [ς:η1:η5-(OCH2)(Me2CH2)C2B9H9]Ti(NMe2) at 110 - 115℃;	A 94% B n/a

...Expand

: 38353-77-4
N-(N3-p-toluenesulfonyl)-3-aminopropylphthalimide

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 1445-69-8
2,3-dihydrophthalazine-1,4-dione

B: 107976-50-1
N1-formyl-N3-tosyl-1,3-propanediamine

C: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With hydrazine hydrate at 80℃; for 3h;	A n/a B 93% C n/a

...Expand

: 71240-23-8
ethyl (2E/Z)-2-(1,3-benzothiazol-2-yl)-3-(dimethylamino)acrylate

: 107-10-8
propylamine

A: 124-40-3
dimethyl amine

B: (Z)-2-Benzothiazol-2-yl-3-propylamino-acrylic acid ethyl ester

Conditions

Conditions	Yield
at 40℃; for 0.5h; Irradiation;	A n/a B 93%

...Expand

: 1630-79-1
tetrakis(dimethylamido)diborane

: 109-73-9
N-butylamine

A: 7360-73-8
tetrakis(n-butylamino)diborane(4)

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
In hexane heating from 76 to 174°C during 21.6 h;	A 93% B n/a
4 equiv. n-C4H9NH2, slow react. at room temp.;
4 equiv. n-C4H9NH2, slow react. at room temp.;

...Expand

: 58369-78-1
(2-bromoethyl)dimethyl-(3,3-dimethylallyl)ammonium bromide

: 107-11-9
1-amino-2-propene

A: 88019-80-1
Allyl-[3,3-dimethyl-pent-4-en-(E)-ylidene]-amine

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With potassium hydroxide In water at 90 - 95℃; for 1h;	A 92.7% B 79.5%
With potassium hydroxide In water at 90 - 95℃; for 1h; Product distribution; ratio of reactants;	A 92.7% B 79.5%

...Expand

: 108-91-8
cyclohexylamine

: 68897-42-7
N′,N″-diisopropyl-N,N-dimethyl guanidine

A: 124-40-3
dimethyl amine

B: 2-Cyclohexyl-1,3-diisopropylguanidine

Conditions

Conditions	Yield
With [ς:η1:η5-(OCH2)(Me2CH2)C2B9H9]Ti(NMe2) at 110 - 115℃;	A n/a B 92%

...Expand

: 87-52-5
3-(Dimethylaminomethyl)indole

: 108-91-8
cyclohexylamine

A: 53924-03-1
N-indol-3-ylmethylcyclohexylamine

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
Heating;	A 91% B n/a

...Expand

: 552-79-4, 1201-56-5, 14222-20-9, 17605-71-9, 39263-91-7, 42151-56-4, 51018-28-1, 62560-55-8, 87040-40-2
(+/-)-erythro-methylephedrine

A: 50-00-0
formaldehyd

: 90-81-3, 90-82-4, 299-42-3, 321-97-1, 321-98-2, 4125-58-0, 34783-90-9, 38732-95-5, 53214-57-6
ephedrine

C: 100-52-7
benzaldehyde

D: 75-07-0
acetaldehyde

E: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;	A 6.4% B 0.5% C 91% D 90% E 91%

...Expand

: 57-14-7
1,1-dimethylhydrazine

: 135-19-3
β-naphthol

A: 2834-92-6
1-amino-2-naphthol

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
at 80℃; for 4h;	A 91% B n/a

...Expand

: 58369-78-1
(2-bromoethyl)dimethyl-(3,3-dimethylallyl)ammonium bromide

: 62-53-3
aniline

A: 88019-86-7
[3,3-Dimethyl-pent-4-en-(E)-ylidene]-phenyl-amine

B: 124-40-3
dimethyl amine

Conditions

Conditions	Yield
With potassium hydroxide In water at 90 - 95℃; for 1h;	A 90.9% B 84.9%

...Expand

: 558-30-5
2-methyl-1,2-epoxypropane

: 124-40-3
dimethyl amine

: 14123-48-9
1-dimethylamino-2-methyl-propan-2-ol

Conditions

Conditions	Yield
In water at -5 - 20℃; Schlenk technique; Inert atmosphere; Sealed tube;	100%
With water In water at 20 - 50℃; for 120h; Sealed tube;	91%
In water at 20℃; for 12h; Cooling with ice; Inert atmosphere;	89%

: 6684-39-5
2-chloropyridine-5-sulfonyl chloride

: 124-40-3
dimethyl amine

: 52480-31-6
6-chloro-N,N-dimethylpyridine-3-sulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 2h;	100%
With triethylamine In tetrahydrofuran at 20℃; for 0.5h;	95%
With triethylamine In tetrahydrofuran at 20℃; for 0.5h;	95%

: 4101-68-2
1,10-dibromodecane

: 124-40-3
dimethyl amine

: 1938-62-1
N,N,N',N'-tetramethyl-1,10-diaminodecane

Conditions

Conditions	Yield
In chloroform at 20℃; for 24h;	100%
With sodium carbonate In ethanol; water for 24h; Heating;	92%
With ethanol
In benzene at 4 - 5℃;
at 4 - 5℃;

: 543-20-4
succinoyl dichloride

: 124-40-3
dimethyl amine

: 7334-51-2
N,N,N',N'-tetramethylsuccinamide

Conditions

Conditions	Yield
In water at 0℃; for 0.5h;	100%
In diethyl ether at -78 - 20℃;	91%
In dichloromethane; water at 0 - 20℃; for 20h; Inert atmosphere;	81%
With diethyl ether
In water at 0℃; for 0.5h;

: 629-03-8
1 ,6-dibromohexane

: 124-40-3
dimethyl amine

: 111-18-2
N,N,N',N'-tetramethylhexamethylenediamine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 24h;	100%
In chloroform at 20℃; for 24h;	100%
With sodium carbonate In ethanol; water for 24h; Heating;	98%

: 81-25-4
cholic acid

: 124-40-3
dimethyl amine

: 86678-85-5
(R)-N,N-dimethyl-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-17-yl)valeramide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	100%
With tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane 10 deg C, 30 min then rt., 2 h;	78%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 10h;	74.2%
With water at 250℃;
With tributyl-amine; chloroformic acid ethyl ester Multistep reaction;

: 124-40-3
dimethyl amine

: 106-93-4
ethylene dibromide

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 24h;	100%
In chloroform at 20℃; for 24h;	100%

: 124-40-3
dimethyl amine

: 922-67-8
propynoic acid methyl ester

: 999-59-7
methyl 3-(N,N-dimethylamino)-2-propenoate

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 1h;	100%
With benzene

: 124-40-3
dimethyl amine

: 98-59-9
p-toluenesulfonyl chloride

: 599-69-9
N,N,4-trimethylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 25℃; for 1h;	100%
	99%
With cesium fluoride supported on Celite at 50℃; for 0.75h; chemoselective reaction;	91%

: 124-40-3
dimethyl amine

: 62-75-9
N-Nitrosodimethylamine

Conditions

Conditions	Yield
With sulfuric acid; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.5h; Nitrosation;	100%
With Nafion-H(R); silica gel; sodium nitrite In dichloromethane at 20℃; for 0.166667h;	100%
With trichloromelamine; silica gel; sodium nitrite In dichloromethane; water at 20℃; for 0.0333333h;	100%

: 615-18-9
2-chloro-1,3-benzoxazole

: 124-40-3
dimethyl amine

: 13858-89-4
2-dimethylaminobenzoxazole

Conditions

Conditions	Yield
In tetrahydrofuran; water for 0.166667h; Inert atmosphere; Reflux;	100%
In water at 20℃; for 1h;	90%
In water at 20℃; for 5h; Green chemistry;	71%

: 100-47-0
benzonitrile

: 124-40-3
dimethyl amine

: 20548-18-9, 39116-58-0
N,N-Dimethyl-benzamidine

Conditions

Conditions	Yield
Stage #1: dimethyl amine With n-butyllithium In diethyl ether; hexane at -20℃; for 0.166667h; Stage #2: benzonitrile at -20℃; for 1h;	100%

: 873-51-8
phenylborondichloride

: 124-40-3
dimethyl amine

: 1201-45-2
Bis-(dimethylamino)-phenylboran

Conditions

Conditions	Yield
In pentane at -78 - 20℃; Inert atmosphere;	100%
In hexane	87%
In hexane	87%

: 4044-65-9
1 ,4-phenylenediisothiocyanate

: 124-40-3
dimethyl amine

: 16349-56-7
3-[4-(3,3-dimethyl-thioureido)-phenyl]-1,1-dimethyl-thiourea

Conditions

Conditions	Yield
at 20℃; under 750.06 Torr; Addition; solid-gas reaction;	100%

: 124-40-3
dimethyl amine

: 102-92-1
Cinnamoyl chloride

: 17431-39-9
(E)-N,N-dimethylcinnamamide

Conditions

Conditions	Yield
In water at 0℃; for 0.75h;	100%
In methanol for 15h; Ambient temperature;	81%
In diethyl ether for 0.5h;	46.9%

: 124-40-3
dimethyl amine

: 10199-89-0
NBD chloride

: 1455-87-4
N,N-dimethyl-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine

Conditions

Conditions	Yield
In methanol	100%
In dichloromethane at 20℃; for 2h;	98%
With triethylamine In dichloromethane; water at 20℃; for 1.5h;	52.7%
In ethanol
In water; ethyl acetate 1.) 0 deg C, 30 min, 2.) r.t., 2 h;

: 124-40-3
dimethyl amine

: 645-45-4
hydrocinnamic acid chloride

: 5830-31-9
N,N-dimethyl-3-phenylpropanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 14h; Inert atmosphere;	100%
With triethylamine In diethyl ether	93%
With triethylamine In diethyl ether Inert atmosphere;	93%

: 2930-05-4
Benzyloxymethyl-oxiran

: 124-40-3
dimethyl amine

: 97807-83-5
(+/-)-dimethyl<2-hydroxy-3-(benzyloxy)propyl>amine

Conditions

Conditions	Yield
In tetrahydrofuran; water for 2h; Heating;	100%

: 5247-85-8
1,8-naphtholactone

: 124-40-3
dimethyl amine

: 69674-57-3
N,N-Dimethyl-8-hydroxy-naphthalin-1-carboxamid

Conditions

Conditions	Yield
In toluene Heating;	100%

: 1973-09-7
6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

: 124-40-3
dimethyl amine

: 7710-42-1
N,N’-diphenyl-6-(isopropylamino)-[1,3,5]triazine-2,4-diamine

Conditions

Conditions	Yield
With water; sodium carbonate for 1.5h; Heating;	100%

: 52813-87-3
ethylthio-8 methyl-5 5H-dibenzazepine-10-acetate de nitro-4 phenyle

: 124-40-3
dimethyl amine

: 52813-88-4
ethylthio-8 trimethyl-N,N,5 5H-dibenzazepine-10-acetamide

Conditions

Conditions	Yield
In chloroform for 1h; Ambient temperature;	100%

: 933-88-0
ortho-toluoyl chloride

: 124-40-3
dimethyl amine

: 6639-19-6
N,N,2-trimethylbenzamide

Conditions

Conditions	Yield
	100%
In water; toluene
In diethyl ether at 20℃; for 16h;

: 28735-24-2
5-methyl-3-(methylsulfanyl)-1,2,4-triazine

: 124-40-3
dimethyl amine

: 115125-15-0
N,N,5-trimethyl-1,2,4-triazin-3-amine

Conditions

Conditions	Yield
In water a.) RT, 12 h b.) 70 deg C, 30 min;	100%

: 50-00-0
formaldehyd

: 67720-26-7
6,7,8,9-tetrahydrobenzoindole

: 124-40-3
dimethyl amine

: 110595-87-4
3-dimethylaminomethyl-6,7,8,9-tetrahydrobenzoindole

Conditions

Conditions	Yield
In acetic acid at 80℃; for 0.166667h;	100%

...Expand

: 50-00-0
formaldehyd

: 124-40-3
dimethyl amine

: 155330-95-3
1,3-Bis(3-thienyloxy)propane

: {3-[3-(2-Dimethylaminomethyl-thiophen-3-yloxy)-propoxy]-thiophen-2-ylmethyl}-dimethyl-amine

Conditions

Conditions	Yield
With acetic acid Mannich reaction; Heating;	100%
With acetic acid

...Expand

: 50-00-0
formaldehyd

: 124-40-3
dimethyl amine

: 155330-77-1
C14H18O4S2

: [3-(2-{2-[2-(2-Dimethylaminomethyl-thiophen-3-yloxy)-ethoxy]-ethoxy}-ethoxy)-thiophen-2-ylmethyl]-dimethyl-amine

Conditions

Conditions	Yield
With acetic acid at 20℃; for 48h; Mannich reaction;	100%
With acetic acid

...Expand

: 50-00-0
formaldehyd

: 124-40-3
dimethyl amine

: 172226-45-8
(+/-)-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4,4-dimethyl-3,4-dihydro-2H,10H-<1,4>dioxepino<2,3-g>indole

: 172226-24-3
(+/-)-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4,4-dimethyl-8-<(N,N-dimethylamino)methyl>-3,4-dihydro-2H,10H-<1,4>dioxepino<2,3-g>indole

Conditions

Conditions	Yield
In water; acetic acid for 24h;	100%
With acetic acid	99%
With acetic acid	99%

...Expand

: 112-77-6
(Z)-9-octadecenoyl chloride

: 124-40-3
dimethyl amine

: 2664-42-8
N,N-dimethyl oleamide

Conditions

Conditions	Yield
In benzene for 1h; Ambient temperature;	100%
In water for 1h; cooling;

: 764-85-2
Nonanoyl chloride

: 124-40-3
dimethyl amine

: 6225-08-7
octanecarboxylic acid dimethylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;	100%
In benzene 1.) 0 deg C, 1 h, 2.) r.t., 1h;	90%

Dimethylamine Chemical Properties

IUPAC Name: N-Methylmethanamine
Synonyms of Dimethylamine (CAS NO.124-40-3): Dimethylamine (anhydrous) ; Methanamine, N-methyl- ; N,N-Dimethylamine ; N-Methylmethanamine ; Dimethylamine, in aqueous solution
CAS NO: 124-40-3
Molecular Formula: C₂H₇N
Molecular Weight: 45.08
Molecular Structure:
EINECS: 204-697-4
H bond acceptors: 1
H bond donors: 1
Freely Rotating Bonds: 0
Polar Surface Area: 3.24 Å²
Vapor density: 1.55 (vs air)
Vapor pressure: 16.97 psi ( 55 °C)
Refractive index: n20/D 1.37
Density: 0.654
Melting Point: -93°C
Boiling Point: 7°C
Flash Point: 60 °F
Solubility: Miscible
Appearance: colourless compressed liquefied gas
Storage temp: Flammables area
Sensitive: Hygroscopic
Stability: Stable. Generally used as a solution in water at concentrations up to around 40%. Extremely flammable in the pure form. Incompatible with strong oxidizing agents.
Product Categories of Dimethylamine (CAS NO.124-40-3): Pharmaceutical Intermediates;Compressed and Liquefied GasesChemical Synthesis;Chemical Synthesis;Compressed and Liquefied Gases;C2 to C6Chemical Synthesis;Amines;Nitrogen Compounds;Organic Bases;Synthetic Reagents

Dimethylamine Uses

Dimethylamine (CAS NO.124-40-3) is a precursor to several industrially significant compounds. It is also raw material for dimefox and diphenhydramine.

Dimethylamine Production

Dimethylamine (CAS NO.124-40-3) is manufactured by the reaction of methanol with ammonla．
2CH₃OH + NH₃→ (CH₃)₂NH + 2H₂O

Dimethylamine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	240mg/kg (240mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.
mammal (species unspecified)	LC50	inhalation	3700mg/m³ (3700mg/m³)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.
mouse	LC50	inhalation	4725ppm/2H (4725ppm)		American Industrial Hygiene Association Journal. Vol. 43, Pg. 411, 1982.
mouse	LD50	intraperitoneal	736mg/kg (736mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
mouse	LD50	oral	316mg/kg (316mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.
rabbit	LD50	oral	240mg/kg (240mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.
rabbit	LDLo	intravenous	4gm/kg (4000mg/kg)		"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 509, 1989.
rat	LC50	inhalation	4540ppm/6H (4540ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	American Industrial Hygiene Association Journal. Vol. 43, Pg. 411, 1982.
rat	LD50	oral	698mg/kg (698mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Hygiene and Sanitation Vol. 32(6), Pg. 329, 1967.

Dimethylamine Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Dimethylamine Safety Profile

Safety Information of Dimethylamine (CAS NO.124-40-3):
Hazard Codes: F+,FXnCT
Risk Statements: 12-20-37/38-41-34-20/22-11-39/23/24/25
12: Extremely Flammable
20: Harmful by inhalation
37/38: Irritating to respiratory system and skin
41: Risk of serious damage to eyes
34: Causes burns
20/22: Harmful by inhalation and if swallowed
11: Highly Flammable
39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Statements: 3-16-26-29-36/37/39-45
3: Keep in a cool place
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
29: Do not empty into drains
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: UN 2924 3/PG 2
WGK Germany: 2
F: 3
HazardClass: 3
PackingGroup: II
Poison by ingestion. Moderately toxic by inhalation and intravenous routes. Mutation data reported. An eye irritant. Corrosive to the eyes, skin, and mucous membranes. A flammable gas. When heated to decomposition it emits toxic fumes of NO_x. Incompatible with acrylaldehyde, fluorine, and maleic anhydride

Dimethylamine Standards and Recommendations

OSHA PEL: TWA 10 ppm
ACGIH TLV: TWA 5 ppm; STEL 15 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: 2 ppm (3.7 mg/m³)
DOT Classification: 2.1; Label: Flammable Gas (UN 1032); DOT Class: 3; Label: Flammable Liquid (UN 1160)

Dimethylamine Specification

Dimethylamine is a base, neutralizing acids in exothermic reactions, and a reducing agent. Dimethylamine is temperature sensitive. It reacts vigorously with mercury and chlorine. Besides, it also reacts violently with strong oxidizing agents and attacks copper and copper compounds. It still reacts with hypochlorites to give N-chloroamines, some of which are explosives when isolated.

Product Name

Dimethylamine

Synthetic route

Dimethylamine Chemical Properties

Dimethylamine Uses

Dimethylamine Production

Dimethylamine Toxicity Data With Reference

Dimethylamine Consensus Reports

Dimethylamine Safety Profile

Dimethylamine Standards and Recommendations

Dimethylamine Specification

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