2,2'-dithiodibenzoic acid dichloride
methylamine
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 20℃; for 16h; | 96% |
In tetrahydrofuran at 0 - 20℃; for 11h; pH=9 - 10; | 75% |
In tetrahydrofuran at 0 - 20℃; for 16.6667h; | 65% |
2,2'-dithiodibenzoic acid dichloride
methylamine hydrochloride
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 75% |
2-bromo-N-methylbenzamide
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
With sodium sulfide hydrate; copper(l) chloride In 1-methyl-pyrrolidin-2-one; ethylene glycol at 70 - 100℃; for 6h; | 69.8% |
Conditions | Yield |
---|---|
With ethanol |
Conditions | Yield |
---|---|
(i) SOCl2, dioxane, (ii) /BRN= 741851/; Multistep reaction; |
2-methyl-1,2-benzisothiazole-3(2H)-one
ethanol
hydrogen sulfide
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
at 50℃; |
Conditions | Yield |
---|---|
at 20℃; |
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
With ethanol; hydrogen sulfide at 50℃; | |
With ethanol; sulfur dioxide |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: SOCl2 / 1 h / Heating 2: 147 g / benzene; tetrahydrofuran / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / Reflux 2: dichloromethane / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux 2: tetrahydrofuran / 11 h / 0 - 20 °C / pH 9 - 10 View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 42 h / 20 - 50 °C 2: tetrahydrofuran / 16 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; thionyl chloride / toluene / 20 h / 82 °C 2: tetrahydrofuran / 16.67 h / 0 - 20 °C View Scheme |
Conditions | Yield |
---|---|
In methanol; ethanol at 0 - 21℃; for 17h; | 4.56 g |
Conditions | Yield |
---|---|
With chlorine; potassium iodide In 1,4-dioxane at 55 - 70℃; for 0.333333h; | 92% |
With tetrachloromethane durch Bromierung und Kochen des Reaktionsprodukts mit Eisessig; |
2,2'-dithiobis(N-methylbenzamide)
2-mercapto-N-methylbenzamide
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran; ethanol at 20℃; for 4h; | 90% |
With sodium tetrahydroborate; water In tetrahydrofuran at 20℃; Inert atmosphere; | 89% |
Stage #1: 2,2'-dithiobis(N-methylbenzamide) With sodium tetrahydroborate In ethanol at 0℃; for 9h; Stage #2: With hydrogenchloride In ethanol; water for 0.25h; pH=1.73; | 72% |
2,2'-dithiobis(N-methylbenzamide)
benzoic acid anhydride
S-2-(methylcarbamoyl)phenyl benzothioate
Conditions | Yield |
---|---|
Stage #1: 2,2'-dithiobis(N-methylbenzamide) With sodium tetrahydroborate In ethanol at 0 - 20℃; for 0.5h; Stage #2: benzoic acid anhydride With potassium carbonate In ethanol at 0 - 20℃; pH=9 - 10; Further stages.; | 77% |
2,2'-dithiobis(N-methylbenzamide)
N-methylsaccharin
Conditions | Yield |
---|---|
With dihydrogen peroxide; acetic acid at 100℃; |
2,2'-dithiobis(N-methylbenzamide)
(2-methylcarbamoyl-phenylsulfanyl)-acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; ethanol; zinc Erwaermen des erhaltenen 2-Mercapto-N-methyl-benzamids mit Natrium-chloracetat und wss. Natronlauge; |
2,2'-dithiobis(N-methylbenzamide)
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
2-(tetra-O-acetyl-β-D-glucopyranosylmercapto)-benzoic acid methylamide
Conditions | Yield |
---|---|
With potassium hydroxide; acetone |
2,2'-dithiobis(N-methylbenzamide)
potassium acetate
acetic anhydride
A
2-acetyl-3-hydroxybenzo[b]thiophene
B
benzo[b]thiophen-3-yl acetate
Conditions | Yield |
---|---|
at 130℃; |
Conditions | Yield |
---|---|
at 100℃; |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 4-methoxyphenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 74 percent / Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 2-methoxyphenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 70 percent / Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
spiro(3H-2,1-benzoxathiol-3'-one-1,1'-3H-2,1-benzazathiol)-2-methyl-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: Cu2O / pyridine / 2 h / Heating 3: t-BuOCl / CH2Cl2 / 20 °C View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-<2-(N-methylcarbamoyl)phenylthio>benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 70 percent / Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: Cu2O / pyridine / 2 h / Heating 3: t-BuOCl / CH2Cl2 / 20 °C 4: 78 percent / H2O / CH2Cl2 / 6 h / 20 °C View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: Cu2O / pyridine / 2 h / Heating 3: t-BuOCl / CH2Cl2 / 20 °C View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 4-methylphenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 74 percent / Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 2-chlorophenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 66 percent / Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 4-chlorophenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 74 percent / Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
2-(N-methylcarbamoyl)phenyl 2-methylphenyl sulfide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 67 percent / Cu2O / pyridine / 2 h / Heating View Scheme |
2,2'-dithiobis(N-methylbenzamide)
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 40 percent / Zn; AcOH / 6 h / Heating 2: 74 percent / Cu2O / pyridine / 2 h / Heating 3: 59 percent / t-BuOCl / CH2Cl2 / 20 °C View Scheme |
This chemical is called Benzamide, 2,2'-dithiobis(N-methyl-, and its systematic name is 2,2'-disulfanediylbis(N-methylbenzamide). With the molecular formula of C16H16N2O2S2, its molecular weight is 199.29. The CAS registry number of this chemical is 2527-58-4.
Other characteristics of the Benzamide, 2,2'-dithiobis(N-methyl- can be summarised as followings: (1)ACD/LogP: 2.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.09; (4)ACD/LogD (pH 7.4): 2.09; (5)ACD/BCF (pH 5.5): 22.96; (6)ACD/BCF (pH 7.4): 22.96; (7)ACD/KOC (pH 5.5): 327.96; (8)ACD/KOC (pH 7.4): 327.96; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 91.22 Å2; (13)Index of Refraction: 1.663; (14)Molar Refractivity: 93.53 cm3; (15)Molar Volume: 252.1 cm3; (16)Polarizability: 37.08×10-24cm3; (17)Surface Tension: 61.3 dyne/cm; (18)Density: 1.31 g/cm3; (19)Flash Point: 283.9 °C; (20)Enthalpy of Vaporization: 82.48 kJ/mol; (21)Boiling Point: 545.9 °C at 760 mmHg; (22)Vapour Pressure: 5.69E-12 mmHg at 25°C.
Uses of this chemical: The 2-mercapto-N-methyl-benzamide could be obtained by the reactant of Benzamide, 2,2'-dithiobis(N-methyl-. This reaction needs the reagent of Zn, aq. HCl.
You can still convert the following datas into molecular structure:
1.SMILES: O=C(NC)c2c(SSc1ccccc1C(=O)NC)cccc2
2.InChI: InChI=1/C16H16N2O2S2/c1-17-15(19)11-7-3-5-9-13(11)21-22-14-10-6-4-8-12(14)16(20)18-2/h3-10H,1-2H3,(H,17,19)(H,18,20)
3.InChIKey: JEVCLNJEBFWVPD-UHFFFAOYAL
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