Product Name

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
  • Name

    FLURAZEPAM

  • EINECS
  • CAS No. 17617-23-1
  • Density 1.21g/cm3
  • Solubility
  • Melting Point 77-82°
  • Formula C21H23 Cl F N3 O
  • Boiling Point 551.4°Cat760mmHg
  • Molecular Weight 387.885
  • Flash Point 287.2°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Caution: May be habit-forming. This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14. When heated to decomposition it emits very toxic fumes of Cl−, F− and NOx. See also DIAZEPAM.
  • Risk Codes 22-33
  • Molecular Structure Molecular Structure of 17617-23-1 (FLURAZEPAM)
  • Hazard Symbols
  • Synonyms 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro- (8CI);7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Felmane; Flurazepam; Noctosom; Ro 56901/3; Stauroderm
  • PSA 35.91000
  • LogP 3.50550

FLURAZEPAM Chemical Properties

Empirical Formula: C21H23ClFN3O
Molecular Weight: 387.8782 g/mol
EINECS: 241-591-7
Index of Refraction: 1.589
Density: 1.21 g/cm3
Flash Point: 287.2 °C
Boiling Point: 551.4 °C at 760 mmHg
Vapour Pressure: 3.34E-12 mmHg at 25 °C 
Appearance: Light yellow solid
Structure of Flurazepam (CAS NO.17617-23-1):
                   
IUPAC Name: 7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
Solubility: Easily soluble in Chloroform , soluble in Acetone , Methanol , Ethanol , Glacial acetic acid and Ether , insoluble in Cyclohexane , almost insoluble in water

FLURAZEPAM Uses

  Flurazepam (CAS NO.17617-23-1) is a drug which is a benzodiazepine derivative. It is used for short-term treatment of patients with insomnia and is sometimes used in patients who have difficulty in maintaining sleep.

FLURAZEPAM Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 250mg/kg (250mg/kg)   Drugs of the Future. Vol. 9, Pg. 152, 1984.
human TDLo oral 380ug/kg (0.38mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 American Journal of Medicine. Vol. 73, Pg. 239, 1982.
mouse LD50 intraperitoneal 540mg/kg (540mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
mouse LD50 intravenous 59100ug/kg (59.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
mouse LD50 oral 500mg/kg (500mg/kg)   Therapie. Vol. 26, Pg. 439, 1971.
mouse LD50 subcutaneous 3844mg/kg (3844mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat LD50 intraperitoneal 600mg/kg (600mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat LD50 intravenous 38700ug/kg (38.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
rat LD50 oral 980mg/kg (980mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat LD50 subcutaneous > 3844mg/kg (3844mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.

FLURAZEPAM Safety Profile

Poison by intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Caution: May be habit-forming. This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14. When heated to decomposition it emits very toxic fumes of Cl−, F− and NOx. See also DIAZEPAM.
Hazard Codes: HarmfulXn
Risk Statements: 22-33 
R22:Harmful if swallowed. 
R33:Danger of cumulative effects.
Safety Statements: 1/2-22-36 
S1/2:Keep locked up and out of the reach of children. 
S22:Do not breathe dust. 
S36:Wear suitable protective clothing.

FLURAZEPAM Specification

 Flurazepam ,its cas register number is 17617-23-1. It also can be called Flurazepam hydrochloride ; Dobutamine hydrochloride ; Flurazepam dihydrochloride ; and Dalmane . It produces a metabolite with a very long half-life (40–250 hours), therefore unsuitable as a sleeping medication for some individuals due to next day sedation. Flurazepam (CAS NO.17617-23-1) has abuse potential and should never be used with alcohol or any other substance that can cause drowsiness. And a review paper found that its long term use is associated with drug dependence, drug tolerance, rebound insomnia and CNS related adverse effects. It is contraindicated in pregnancy and is recommended to withdraw flurazepam during breast feeding.

Related Products

Hot Products

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View