Product Name

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  • Name

    7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo-1,4-diazepin-2-one monohydrochloride

  • EINECS
  • CAS No. 36105-20-1
  • Density 1.21g/cm3
  • Solubility
  • Melting Point
  • Formula C21H23 Cl F N3 O . Cl H
  • Boiling Point 551.4°Cat760mmHg
  • Molecular Weight 424.345
  • Flash Point 287.2°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−, NOx and HCl. See also DIAZEPAM.
  • Risk Codes
  • Molecular Structure Molecular Structure of 36105-20-1 (7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo-1,4-diazepin-2-one monohydrochloride)
  • Hazard Symbols
  • Synonyms 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-,monohydrochloride (9CI);7-Chloro-1-[2-(diethylamino)ethyl]-1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-onehydrochloride; 7-Chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onemonohydrochloride; Flurazepam monohydrochloride
  • PSA 35.91000
  • LogP 4.30750

Flurazepam monohydrochloride Chemical Properties

Product Name: Flurazepam monohydrochloride (CAS NO.36105-20-1)


Molecular Formula: C21H24Cl2FN3O
Molecular Weight: 424.3391632g/mol
Mol File: 36105-20-1.mol
EINECS: 252-867-1
Boiling point: 551.4 °C at 760 mmHg
Flash Point: 287.2 °C
Enthalpy of Vaporization: 83.17 kJ/mol
Vapour Pressure: 3.34E-12 mmHg at 25°C
H-Bond Donor: 1
H-Bond Acceptor: 4
Structure Descriptors of Flurazepam monohydrochloride (CAS NO.36105-20-1):
  IUPAC Name: 7-chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one hydrochloride
  Canonical SMILES: CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl
  InChI: InChI=1S/C21H23ClFN3O.ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;/h5-10,13H,3-4,11-12,14H2,1-2H3;1H 
  InChIKey: PUGVROXLRUQCAF-UHFFFAOYSA-N

Flurazepam monohydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 205mg/kg (205mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 381, 1973.
mouse LD50 intravenous 58mg/kg (58mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 381, 1973.
mouse LD50 oral 684mg/kg (684mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
mouse LD50 subcutaneous 598mg/kg (598mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rabbit LD50 oral 460mg/kg (460mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 intraperitoneal 179mg/kg (179mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 intravenous 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 oral 978mg/kg (978mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 subcutaneous 859mg/kg (859mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.

Flurazepam monohydrochloride Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−, NOx and HCl. See also DIAZEPAM.
Safety Information of Flurazepam monohydrochloride (CAS NO.36105-20-1):
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Flurazepam monohydrochloride Specification

 Flurazepam monohydrochloride , its CAS NO. is 36105-20-1, the synonyms are EINECS 252-867-1 ; Flurazepam HCl ; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, monohydrochloride ; 7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo-1,4-diazepin-2-one monohydrochloride .

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