Fluoroacetamide supplier | CasNO.640-19-7

Name
FLUOROACETAMIDE
EINECS 211-363-1
CAS No. 640-19-7
Article Data18
CAS DataBase
Density 1.136 g/cm³
Solubility
Melting Point 106-108 °C(lit.)
Formula C₂H₄FNO
Boiling Point 259 °C at 760 mmHg
Molecular Weight 77.0583
Flash Point 110.4 °C
Transport Information
Appearance crystals
Safety 36/37-45
Risk Codes 24-28
Molecular Structure
Hazard Symbols T+, T, Xi
Synonyms 1081;2-Fluoroacetamide;AFL 1081;Compound 1081;Fluorakil 100;Fluoroacetamide;Fluoroacetic acid amide;Flutritex 1;Fussol;Megatox;Monofluoroacetamide;NSC31876;a-Fluoroacetamide;
PSA 43.09000
LogP 0.14150

Synthetic route

: 359-06-8
monofluoroacetyl chloride

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
With ammonia In dichloromethane at 25℃; for 10h; Solvent; Temperature;	99.3%
With diethyl ether; ammonia

: 79-07-2
Chloroacetamide

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
With potassium fluoride In water at 116℃; for 3h;	94%
With potassium fluoride In para-xylene at 100 - 120℃; for 20h; Inert atmosphere; Schlenk technique;	67%
With potassium fluoride; xylene

: 36015-63-1
α-fluoro-N-bromoacetamide

A: 640-19-7
fluoroacetamide

: 35077-30-6, 35077-31-7
N-((1S,2R)-2-Bromo-cyclohexyl)-2-fluoro-acetamide

: 35077-30-6, 35077-31-7
N-((1S,2S)-2-Bromo-cyclohexyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
With cyclohexene In dichloromethane at 15 - 20℃; for 1.5h; Irradiation; Yields of byproduct given;	A 30% B n/a C n/a

...Expand

: 36015-63-1
α-fluoro-N-bromoacetamide

: 110-83-8
cyclohexene

A: 640-19-7
fluoroacetamide

: 35077-30-6, 35077-31-7
N-((1S,2R)-2-Bromo-cyclohexyl)-2-fluoro-acetamide

: 35077-30-6, 35077-31-7
N-((1S,2S)-2-Bromo-cyclohexyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; for 1.5h; Irradiation; Yield given. Yields of byproduct given;	A 30% B n/a C n/a

...Expand

: 35077-08-8
N-Chloro-2-fluoroacetamid

A: 640-19-7
fluoroacetamide

: 35077-20-4, 35077-21-5
N-((1S,2R)-2-Chloro-cyclohexyl)-2-fluoro-acetamide

: 35077-20-4, 35077-21-5
N-((1S,2S)-2-Chloro-cyclohexyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
With cyclohexene In dichloromethane at 15 - 20℃; for 2.5h; Irradiation; Yields of byproduct given;	A 7% B n/a C n/a

...Expand

: 35077-08-8
N-Chloro-2-fluoroacetamid

: 110-83-8
cyclohexene

A: 640-19-7
fluoroacetamide

: 35077-20-4, 35077-21-5
N-((1S,2R)-2-Chloro-cyclohexyl)-2-fluoro-acetamide

: 35077-20-4, 35077-21-5
N-((1S,2S)-2-Chloro-cyclohexyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; for 2.5h; Irradiation; Yield given. Yields of byproduct given;	A 7% B n/a C n/a

...Expand

: 453-18-9
methyl fluoroacetate

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
With ammonia; water

: 459-72-3
ethyl 2-fluoroacetate

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
With ammonia; water

: 623-73-4
diazoacetic acid ethyl ester

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
(i) HF, Et2O, (ii) NH3, MeOH; Multistep reaction;

: 503-20-8
fluoroacetonitrile

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
(i) HCl, Et2O, (ii) H2O; Multistep reaction;

ammonium glycolamide sulfate: ammonium glycolamide sulfate

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
With potassium fluoride at 140 - 200℃; under 20 Torr;

potassium glycolamide sulfate: potassium glycolamide sulfate

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
With potassium fluoride at 250℃;

: sulfooxy-acetic acid amid; ammonium glycolamide sulfate

KF: KF

: 640-19-7
fluoroacetamide

Conditions

Conditions	Yield
at 140 - 200℃; under 20 Torr;

: 637-87-6
1-Chloro-4-iodobenzene

: 640-19-7
fluoroacetamide

: 404-41-1
4'-chloro-2-fluoroacetanilide

Conditions

Conditions	Yield
With copper(l) iodide; cesium fluoride; N,N`-dimethylethylenediamine In tetrahydrofuran at 25℃; for 18 - 24h; Inert atmosphere;	98%

: 640-19-7
fluoroacetamide

: 503-20-8
fluoroacetonitrile

Conditions

Conditions	Yield
With phosphorus pentoxide at 110 - 150℃; Reagent/catalyst;	82%
With phosphorus pentachloride; xylene
With phosphorus pentoxide at 160℃;

: 640-19-7
fluoroacetamide

: 124-13-0
Octanal

: 618-41-7
Benzenesulfinic acid

: N-(1-benzenesulfonyl-octyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃;	82%

...Expand

: 640-19-7
fluoroacetamide

: 84350-43-6
2-fluorothioacetamide

Conditions

Conditions	Yield
With Lawessons reagent In N,N,N,N,N,N-hexamethylphosphoric triamide at 80℃; for 4h;	78%

: 104-53-0
3-phenyl-propionaldehyde

: 640-19-7
fluoroacetamide

: 618-41-7
Benzenesulfinic acid

: 609811-04-3
N-(1-benzenesulfonyl-3-phenyl-propyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃;	73%

...Expand

: 640-19-7
fluoroacetamide

: 75-87-6
chloral

: 687-01-4
N-(1-hydroxy-2,2,2-trichloroethyl)fluoroacetamide

Conditions

Conditions	Yield
	72%
With sulfuric acid at 95℃;

: 640-19-7
fluoroacetamide

: 618-41-7
Benzenesulfinic acid

: 2043-61-0
cyclohexanecarbaldehyde

: N-(benzenesulfonyl-cyclohexyl-methyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃;	70%

...Expand

: 640-19-7
fluoroacetamide

: 123-15-9
2-methylvaleraldehyde

: 618-41-7
Benzenesulfinic acid

: N-(1-benzenesulfonyl-2-methyl-pentyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃;	69%

...Expand

: 640-19-7
fluoroacetamide

: 76-02-8
Trichloroacetyl chloride

: N-fluoroacetyltrichloroacetamide

Conditions

Conditions	Yield
at 80 - 89℃;	65%

: 688-61-9, 53588-88-8, 90721-85-0, 151452-33-4, 151452-35-6
Triallylborane

: 640-19-7
fluoroacetamide

: 1228552-19-9
4-(fluoromethyl)-1,6-heptadien-4-amine

Conditions

Conditions	Yield
Stage #1: Triallylborane; fluoroacetamide In tetrahydrofuran for 1.5h; Reflux; Stage #2: With water; sodium hydroxide In methanol	54%
Stage #1: Triallylborane; fluoroacetamide In tetrahydrofuran at 65℃; Inert atmosphere; Stage #2: With methanol Stage #3: With sodium hydroxide	54%

: 640-19-7
fluoroacetamide

: 728-87-0
4,4'-Dimethoxybenzhydrol

A: 1062-99-3
diether

B: N-(4,4'-dimethoxybenzhydryl)fluoroacetamide

Conditions

Conditions	Yield
With sulfuric acid In acetic acid at 20℃; for 18h;	A n/a B 38%

...Expand

Fluoroacetamide Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Fluoroacetamide Specification

The IUPAC name of Fluoroacetamide is 2-fluoroacetamide. With the CAS registry number 640-19-7, it is also named as 2-Fluoroacetamide ; Amid kyseliny fluoroctove ; Amid kyseliny fluoroctove [Czech] ; Fluorakil 100 ; Fluorkill ; Fluoroacetamide ; Fluoroacetic acid amide ; Megatox ; Monofluoroacetamide ; Acetamide, 2-fluoro- .

Fluoroacetamide is an organic compound based on acetamide with one fluorine atom replacing hydrogen on the methyl group. It is a colorless crystalline powder. It is soluble in water, acetone and insoluble in chloroform. Heating can be sublimation, and when the temperature ia higher than 170 °C, it is easy to decompose.

Fluoroacetamide is a metabolic poison which disruptes the citric acid cycle and is used as a rodenticide. It is also used to control aphids of cotton, soybeans, sorghum, wheat and apples, particularly effective on cotton aphid resistance. Fluoroacetamide has a certain irritation to digestive tract mucosa.

Fluoroacetamide is a fluorinated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P₂O₅or SOCl₂ generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). It is super toxic; probable oral lethal dose in humans is less than 5 mg/kg, or a taste (less than 7 drops) for a 150-lb. person. Chemically inhibits oxygen metabolism by cells with critical damage occurring to the heart, brain, and lungs resulting in heart failure, respiratory arrest, convulsions, and death. Emits very toxic fumes of fluorine containing compounds and nitrogen oxides when heated to decomposition. Avoid decomposing heat.

Fluoroacetamide is obtained by the chlorine acetamide through fluorination. Fluorination may react in xylene, PCE and other solvents; it also can adopt dry method (without solvent), which heat dry chlorine acetamide and fluoride agent KF. Dry method is more easy, no explosion-proof requirements, and the yield is also higher than the solvent method.

Product Name

FLUOROACETAMIDE

Synthetic route

Fluoroacetamide Consensus Reports

Fluoroacetamide Specification

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