Product Name

  • Name

    Isepamicin sulfate

  • EINECS 1592732-453-0
  • CAS No. 67814-76-0
  • Density 1.53g/cm3
  • Solubility
  • Melting Point >210°C (dec.)
  • Formula C22H43N5O12.H2SO4
  • Boiling Point 926.8°Cat760mmHg
  • Molecular Weight 667.78
  • Flash Point 514.3°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by intraperitoneal and intramuscular route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. See also SULFATES.
  • Risk Codes
  • Molecular Structure Molecular Structure of 67814-76-0 (Isepamicin sulfate)
  • Hazard Symbols
  • Synonyms (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-2-[(2R,3R,4R,5S)-3,5-dihydroxy-5-methyl-4-methylamino-oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide sulfate
  • PSA 386.36000
  • LogP -4.89890

Isepamicin sulfate Chemical Properties

Molecular Formula: C22H45N5O16S
Molar mass: 667.68 g/mol
Product categories of Isepamicin sulfate (67814-76-0): Antibacterial
Structure of Isepamicin sulfate (67814-76-0):
        
H-Bond Donor: 14
H-Bond Acceptor: 20
IUPAC Name: (2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,
6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(2R,3R,4R,5R)-3,
5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-
2-hydroxypropanamide; sulfuric acid
Canonical SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(C(C(C(O3)CN)O)O)O)N)NC(=O)C(CN)O)O.OS(=O)(=O)O
Isomeric SMILES: C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N)NC(=O)[C@H](CN)O)O.OS(=O)(=O)O
InChI: InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1 
InChIKey: DDXRHRXGIWOVDQ-MGAUJLSLSA-N

Isepamicin sulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular > 1800mg/kg (1800mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: NAUSEA OR VOMITING		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
dog LD50 intravenous 720mg/kg (720mg/kg)   Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse LD50 intramuscular 2508mg/kg (2508mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
 
mouse LD50 intraperitoneal 2244mg/kg (2244mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
 
mouse LD50 intravenous 234mg/kg (234mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
 
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 109, 1990.
mouse LD50 subcutaneous 3320mg/kg (3320mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
 
rat LD50 intramuscular 2088mg/kg (2088mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
 
rat LD50 intraperitoneal 1591mg/kg (1591mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
 
rat LD50 intravenous 476mg/kg (476mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
 
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 109, 1990.
rat LD50 subcutaneous 3392mg/kg (3392mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.

Isepamicin sulfate Safety Profile

Moderately toxic by intraperitoneal and intramuscular route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. See also SULFATES.

Isepamicin sulfate Specification

 Isepamicin sulfate (67814-76-0) also can be called Isepacin ; 1-N-(S-3-Amino-2-hydroxypropionyl)-gentamicin B sulfate and HAPA-B sulfate .

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View