Product Name

  • Name

    ISOXSUPRINE HYDROCHLORIDE

  • EINECS 209-443-6
  • CAS No. 579-56-6
  • Density 1.146g/cm3
  • Solubility
  • Melting Point 203-204°
  • Formula C18H23NO3.HCl
  • Boiling Point 484.2 °C at 760 mmHg
  • Molecular Weight 337.846
  • Flash Point 246.6 °C
  • Transport Information
  • Appearance
  • Safety 36
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 579-56-6 (ISOXSUPRINE HYDROCHLORIDE)
  • Hazard Symbols HarmfulXn
  • Synonyms Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-,hydrochloride (9CI);Benzyl alcohol, p-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-,hydrochloride (8CI);Norephedrine, p-hydroxy-N-(1-methyl-2-phenoxyethyl)-,hydrochloride (6CI);1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1hydrochloride;Dilavase;Divadilan;Duvadilan;Duviculine;Isolait;Isoxsuprinhydrochloride;Isoxsuprine hydrochloride;Navilox;Suprilent;Suprox SR;Vadosilan;Vasodilan;Vasoplex;Vasotran;
  • PSA 61.72000
  • LogP 4.06410

Isoxsuprine hydrochloride Chemical Properties

Chemistry informtion about Vasodilan (CAS NO.579-56-6) is:
IUPAC Name: 4-[1-Hydroxy-2-(1-Phenoxypropan-2-Ylamino)Propyl]Phenol Hydrochloride
Synonyms: Isoxsuprine Hcl ; Isoxsuprine Hydrochloride ; 1-(P-Hydroxyphenyl)-2-(1'-Methyl-2'-Phenoxy)Ethylaminopropanol-1hydrochlorid ; 2-(3-Phenoxy-2-Propylamino)-1-(P-Hydroxyphenyl)-1-Propanolhydrochloride ; Isolait ; Isoxsuprinhydrochloride ; P-Hydroxy-Alpha-(1-((1-Methyl-2-Phenoxyethyl)Amino)Ethyl)-Benzylalcohohyd ; Suprilent
MF: C18H24ClNO3
MW: 337.84
EINECS: 209-443-6 
Flash Point: 246.6 °C
Boiling Point: 484.2 °C at 760 mmHg
Vapour Pressure: 3.45E-10 mmHg at 25°C 
Enthalpy of Vaporization: 78.94 kJ/mol
Following is the molecular structure of Vasodilan (CAS NO.579-56-6) is:

Isoxsuprine hydrochloride Uses

Vasodilan (CAS NO.579-56-6) relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. These actions may help treat the symptoms of conditions such as cerebral vascular insufficiency (poor blood flow to the brain), arteriosclerosis (hardening of the arteries), Raynaud's phenomenon, and other conditions involving poor blood flow in the veins and arteries. It may also be used for purposes other than those listed in this medication guide.

Isoxsuprine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 57mg/kg (57mg/kg) behavioral: ataxia cardiac: change in rate skin and appendages (skin): "dermatitis, other: after systemic exposure" Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
dog LD50 oral > 1200mg/kg (1200mg/kg) gastrointestinal: nausea or vomiting Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
dog LD50 subcutaneous 143mg/kg (143mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse LD50 intraperitoneal 185mg/kg (185mg/kg) behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse LD50 intravenous 61mg/kg (61mg/kg) behavioral: excitement gastrointestinal: changes in structure or function of salivary glands lungs, thorax, or respiration: respiratory depression Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse LD50 oral 1100mg/kg (1100mg/kg) behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
mouse LD50 subcutaneous 1500mg/kg (1500mg/kg) behavioral: excitement lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands Toxicology and Applied Pharmacology. Vol. 1, Pg. 579, 1959.
rat LD50 intraperitoneal 164mg/kg (164mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intravenous 77mg/kg (77mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat LD50 oral 1750mg/kg (1750mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Isoxsuprine hydrochloride Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Used as a vasodilator. When heated to decomposition it emits toxic fumes of NOx and HCl. 
Hazard Codes:
HarmfulXn
Risk Statements:
R22:Harmful if swallowed.
Safety Statements:
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DO8225000

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