L-Histidine hydrochloride monohydrate supplier

Name
L-Histidine hydrochloride monohydrate
EINECS 211-438-9
CAS No. 5934-29-2
Article Data3
CAS DataBase
Density 1.485 g/cm3
Solubility H₂O: 100 mg/mL
Melting Point 254 °C (dec.)(lit.)
Formula C₆H₁₂ClN₃O₃
Boiling Point 458.9 °C at 760 mmHg
Molecular Weight 209.633
Flash Point 231.3 °C
Transport Information
Appearance white crystals or cryst, or granular powder
Safety 22-24/25-36/37-26
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Histidine,monohydrochloride, monohydrate, L- (8CI);L-Histidine, monohydrochloride,monohydrate (9CI);L-Histidinemonohydrate monohydrochloride;L-Histidine Hcl Mono;
PSA 101.23000
LogP 0.80210

Synthetic route

: 71-00-1
L-histidine

: 5934-29-2
L-histidine hydrochloride monohydrate

Conditions

Conditions	Yield
With hydrogenchloride; water at 26.84℃;

: 5934-29-2
L-histidine hydrochloride monohydrate

A: (S)-4,4-dimethyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridinyl-6-carboxylic acid dihydrochloride

B: 154056-78-7
(S)-4,4-dimethyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridinyl-6-carboxylic acid hydrochloride

Conditions

Conditions	Yield
With sodium hydroxide In water; hydrogen; acetone	A 100% B n/a

: 25474-85-5
4-methoxybenzyloxycarbonyl azide

: 5934-29-2
L-histidine hydrochloride monohydrate

: (S)-3-(1H-Imidazol-4-yl)-2-(4-methoxy-benzyloxycarbonylamino)-propionic acid; hydrate

Conditions

Conditions	Yield
	66%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 5934-29-2
L-histidine hydrochloride monohydrate

: (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-imidazol-4-yl)-propionic acid; hydrate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In 1,4-dioxane for 5h;	62%

: bis(L-histidine)ZnCl2

: 5934-29-2
L-histidine hydrochloride monohydrate

: (L-histidine)ZnCl2*HCl

Conditions

Conditions	Yield
In water soln. of ZnCl2 added slowly;; acetone added; crystd. at -27°C; elem. anal.;;	56%

: 5934-29-2
L-histidine hydrochloride monohydrate

: 2002-22-4, 13552-61-9, 51302-10-4
2-mercapto-L-histidine

Conditions

Conditions	Yield
Stage #1: L-histidine hydrochloride monohydrate With bromine In water at -2 - 0℃; for 0.0833333 - 0.116667h; Stage #2: With L-Cysteine In water at 0℃; for 1h; Stage #3: With 3-mercaptopropionic acid at 95℃; for 18h;	49%

: 67714-30-1
S-benzoyl-3-mercaptopropanoyl chloride

: 5934-29-2
L-histidine hydrochloride monohydrate

: 64991-73-7
N2-(S-benzoyl-3-mercaptopropanoyl)-L-histidine

Conditions

Conditions	Yield
With sodium hydroxide; potassium carbonate In water for 1h;	39%

: potassium pentachloronitrosylruthenate(III)

: 5934-29-2
L-histidine hydrochloride monohydrate

: Ru(NO)Cl2(L-histidine(1-))*0.5H2O

Conditions

Conditions	Yield
With KCl In water Ru-complex, ligand and KCl dissolved in H2O, pH 4 adjusted by HCl, refluxed for 2 h; evapd. to dryness on rotary evaporator, suspended in H2O, centrifuged, vac. dried; elem. anal.;	37.7%

: 5934-29-2
L-histidine hydrochloride monohydrate

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 17791-52-5
N-(tert-butoxycarbonyl)-L-histidine

Conditions

Conditions	Yield
With Dowex 50; triethylamine 1.) H2O, dioxane, 5 h, pH=8; 2.) MeOH, 0.1M pyridinium acetate buffer; Yield given. Multistep reaction;

: 5934-29-2
L-histidine hydrochloride monohydrate

: 501-53-1
benzyl chloroformate

: 14997-58-1
N-[(benzyloxy)carbonyl]-L-histidine

Conditions

Conditions	Yield
With sodium hydroxide; Dowex 50 1.) 3 h; 2.) MeOH, 0.1M pyridinium acetate buffer; Yield given. Multistep reaction;

: 98-91-9
thiobenzoic acid

: 5934-29-2
L-histidine hydrochloride monohydrate

haloacetyl chloride: haloacetyl chloride

: 64991-72-6
Nα-benzoylsulfanylacetyl-histidine

Conditions

Conditions	Yield
With 1.) aq. alkali; 2.) aq. alkali Yield given. Multistep reaction;

...Expand

: 5934-29-2
L-histidine hydrochloride monohydrate

fuming hydrochloric acid: fuming hydrochloric acid

concentrated sodium nitrite: concentrated sodium nitrite

α-chloro-β--propionic acid: α-chloro-β--propionic acid

...Expand

: 5934-29-2
L-histidine hydrochloride monohydrate

: 98-88-4
benzoyl chloride

alkali: alkali

: 5354-94-9
N-benzoyl-L-histidine

...Expand

: 5934-29-2
L-histidine hydrochloride monohydrate

sodium hypochlorite: sodium hypochlorite

-acetaldehyde: -acetaldehyde

: 5934-29-2
L-histidine hydrochloride monohydrate

methanolic hydrochloric acid: methanolic hydrochloric acid

-methyl ester: -methyl ester

Conditions

Conditions	Yield
Reaktion des wasserfreies Salzes;

: 5934-29-2
L-histidine hydrochloride monohydrate

A: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

B ammonium chloride: ammonium chloride

Conditions

Conditions	Yield
at 255℃;

: 5934-29-2
L-histidine hydrochloride monohydrate

silver nitrite: silver nitrite

water: water

levorotatory β--lactic acid: levorotatory β--lactic acid

...Expand

: 5934-29-2
L-histidine hydrochloride monohydrate

water: water

NH3: NH3

Conditions

Conditions	Yield
mit Roentgen-Strahlen.Irradiation;
Kathoden-Strahlen;

: 5934-29-2
L-histidine hydrochloride monohydrate

water: water

sensitizer: sensitizer

NH3: NH3

Conditions

Conditions	Yield
UV-Licht;

...Expand

: 5934-29-2
L-histidine hydrochloride monohydrate

: 62404-82-4
N-mercaptoacetyl-L-histidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) aq. alkali; 2.) aq. alkali 2: 80 percent / aq. NH4OH View Scheme

: 5934-29-2
L-histidine hydrochloride monohydrate

: 62404-83-5
Nα-(3-mercaptopropanoyl)-L-histidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 39 percent / NaOH, K2CO3 / H2O / 1 h 2: 60 percent / aq. ammonia / 1 h / Ambient temperature View Scheme

: copper (II) acetate monohydrate

: 5934-29-2
L-histidine hydrochloride monohydrate

: 90-02-8
salicylaldehyde

: Cu(sal-his)*1.5H2O

Conditions

Conditions	Yield
With NaOH In ethanol; water EtOH soln. of salicylaldehyde was added to aq. soln. of histidine hydrochloride with stirring; aq. soln. of Cu salt was added to prepd. soln. with stirring, soln. of NaOH was added and the soln. was heated at 70°C for 30 min; filtration, washing with water, EtOH, Et2O, drying in vac.; elem. anal.;

...Expand

: 67-56-1
methanol

: Mo3S4(4+)*9H2O = {Mo3S4(H2O)9}(4+)

: 5934-29-2
L-histidine hydrochloride monohydrate

A: [Mo3(L-histidinato)3(μ-S)3(μ3-S)]Cl*KCl*6H2O

B: [Mo3(L-histidinato)3(μ-S)3(μ3-S)]Cl*0.5KCl*MeOH*6H2O

Conditions

Conditions	Yield
With KOH In hydrogenchloride byproducts: KCl; to a soln. of Mo-contg. compd. in aq. HCl, L-HhisHClH2O was added; Ph = ca. 7; the ppt. was removed by filtration; MeOH was added to deposit KCl; KCl was removed by filtration; the filtrate was evapd.; MeOH was added; recrystn. from a hot satd. KCl aq. soln.; elem. anal.;

...Expand

: 621-59-0
isovanillin

: uranyl nirate hexahydrate

: 5144-89-8
1,10-phenanthroline hydrate

: 5934-29-2
L-histidine hydrochloride monohydrate

: UO2(N-o-vanillylidene-L-histidinate)(1,10-phenanthroline) * H2O

Conditions

Conditions	Yield
With KOH In methanol; water treatment of aminoacid with aldehyde in presence of KOH, evapn., addn. of 1 equiv. UO2-salt and 1,10-phenanthroline; elem. anal.;

...Expand

: 621-59-0
isovanillin

: uranyl nirate hexahydrate

: 5934-29-2
L-histidine hydrochloride monohydrate

: UO2(N-o-vanillylidene-L-histidinate)(2,2'-bipyridyl) * 3 H2O

Conditions

Conditions	Yield
With KOH; 2,2'-bipyridyl In methanol; water treatment of aminoacid with aldehyde in presence of KOH, evapn., addn. of 1 equiv. UO2-salt and 2,2'-bipyridine; elem. anal.;

...Expand

: uranyl nirate hexahydrate

: 5144-89-8
1,10-phenanthroline hydrate

: 5934-29-2
L-histidine hydrochloride monohydrate

: 90-02-8
salicylaldehyde

: UO2(salicylidene-L-histidinate)(1,10-phenanthroline) * 4 H2O

Conditions

Conditions	Yield
With KOH In methanol; water treatment of aminoacid with aldehyde in presence of KOH, evapn., addn. of 1 equiv. UO2-salt and 1,10-phenanthroline; elem. anal.;

...Expand

: uranyl nirate hexahydrate

: 5934-29-2
L-histidine hydrochloride monohydrate

: 90-02-8
salicylaldehyde

: UO2(salicylidene-L-histidinate)(2,2'-bipyridyl) * 2 H2O

Conditions

Conditions	Yield
With KOH; 2,2'-bipyridyl In methanol; water treatment of aminoacid with aldehyde in presence of KOH, evapn., addn. of 1 equiv. UO2-salt and 2,2'-bipyridine; elem. anal.;

...Expand

: 5934-29-2
L-histidine hydrochloride monohydrate

: copper dichloride

: copper(L-histidine)2

Conditions

Conditions	Yield
With NaOH; H2SO4 In water soln. stirred for an hour at room temp.; pH adjusted to 7.3 using NaOH or H2SO4;

: 10025-73-7
chromium(III) chloride

: 5934-29-2
L-histidine hydrochloride monohydrate

Cr(3+) doped (L)-histidine hydrochloride monohydrate: Cr(3+) doped (L)-histidine hydrochloride monohydrate

Conditions

Conditions	Yield
In water aq. soln. contg. CrCl3 (0.01 mol%) slowly evapd. at room temp. for 15-20d;

L-Histidine hydrochloride monohydrate Specification

1. Introduction of L-Histidine hydrochloride monohydrate

L-Histidine hydrochloride monohydrate, with the IUPAC name of (2S)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid hydrate hydrochloride, has the systematic name is called L-Histidine hydrochloride hydrate. It is white crystals or cryst, or granular powder. This chemical belongs to the product categories of Amino Acid Derivatives; Alpha-Amino Acids; Amino Acids; Biochemistry and L-Amino Acids.

2. Properties of L-Histidine hydrochloride monohydrate

Physical properties about L-Histidine hydrochloride monohydrate are: (1) ACD/LogP: -1.27; (2) # of Rule of 5 Violations: 0; (3) #H bond acceptors: 5; (4) #H bond donors: 4; (5) #Freely Rotating Bonds: 4; (6) Polar Surface Area: 47.36 Å²; (7) Flash Point: 231.3 °C; (8) Enthalpy of Vaporization: 75.79 kJ/mol; (9) Boiling Point: 458.9 °C at 760 mmHg; (10) Vapour Pressure: 3.25E-09 mmHg at 25°C; (11) Melting Point: 254 °C.

3. Structure Descriptors of L-Histidine hydrochloride monohydrate

You can still convert the following datas into molecular structure:
(1) SMILES: Cl.O=C(O)[C@@H](N)Cc1cncn1.O
(2) InChI: InChI=1/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1
(3) InChIKey: CMXXUDSWGMGYLZ-XRIGFGBMBT

4. Toxicity of L-Histidine hydrochloride monohydrate

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 1677mg/kg (1677mg/kg)		Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.

5. Safety Information of L-Histidine hydrochloride monohydrate

Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 22-24/25-36/37-26
WGK Germany 3
RTECS MS3119000
F 10
HS Code 29332990
When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes, respiratory system, skin and harmful if swallowed. Besides, it may cause damage to health and can not breathe dust. Therefore, you should wear suitable protective clothing and gloves. And in case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

6. Use and Preparation of L-Histidine hydrochloride monohydrate

Uses of L-Histidine hydrochloride monohydrate: (1) it is used as accessorysubstance and can be used to strengthen infant foods; (2) it is used to aid in the treatment of peptic ulcer, also can cure anemia and angina, aortic inflammation, and cardiac function not congruent cardiovascular system diseases.

Preparation of L-Histidine hydrochloride monohydrate: Hemoglobin by Hydrochloric acid hydrolysis can product L-Histidine,hydrochloride.

Product Name

L-Histidine hydrochloride monohydrate

Synthetic route

L-Histidine hydrochloride monohydrate Specification

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