Factory direct sales, accept customization. (S)-(+)-Glycidyl Phthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid. Kind Pharma has its own laboratory, we can do analytical testing for API (A
Cas:161596-47-0
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inquiryThis product can be produced in large scale in our factory 1, Good appearance :white solid 2, High purity,99%; 3, Related compound: Impurity Piperazine <0.2%; 4, isomer<0.5% Appearance:white to off-white solid Storage:room temperatrue A
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:161596-47-0
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inquiryItems Standard Result Appearance White or slightly yellow powder slightly yellow powder Melting point, ℃
Cas:161596-47-0
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryHigh quality (S)-(+)-Glycidyl phthalimide CAS 161596-47-0 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Fo
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inquiryRivaroxaban Intermediate (S)-(+)-N-(2,3-Epoxypropyl)phthalimide[CAS:161596-47-0] Items Standards Results Appearance: off-white or white solid Complies Identification:
Cas:161596-47-0
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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inquiry(S)-(+)-Glycidyl Phthalimide Manufacturer Factory CAS 161596-47-0 (S)-(+)-N-(2,3-Epoxypropyl)phthalimide Manufacturer High quality Best price In stock factory CAS 161596-47-0 (S)-(+)-N-(2,3-Epoxypropyl)phthalimide COA TDS price MSDS Name
Cas:161596-47-0
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Type:Manufacturers
inquiryName:(S)-(+)-Glycidyl Phthalimide CAS:161596-47-0 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without v
Cas:161596-47-0
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/224.html Product Name (S)-(+)-N-(2,3-Epoxypropyl)phthalimide CAS No. 161596-47-0
Cas:161596-47-0
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inquiryTIANFUCHEM--161596-47-0-- (S)-(+)-GLYCIDYL PHTHALIMIDE in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable busines
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inquiryWe are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare
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Min.Order:1 Gram
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct name (S)-(+)-N-(2,3-Epoxypropyl)phthalimide CAS NO.: 161596-47-0 MolecularFormua C11H9NO3 MolecularWeight 203.19 Melting point 102℃
Cas:161596-47-0
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inquiryAppearance:White powder Storage:ln stock Package:25kg/Barrel Application:Rivaroxaban intermediate Transportation:Express/Sea/Air Port:Any port in china
Cas:161596-47-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:161596-47-0
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Min.Order:100 Kilogram
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Type:Trading Company
inquiryProduct Name: (S)-(+)-GLYCIDYL PHTHALIMIDE CAS: 161596-47-0 MF: C11H9NO3 MW: 203.19 EINECS: 1308068-626-2 Mol File: 161596-47-0.mol (S)-(+)-GLYCIDYL PHTHALIMIDE Structure (S)-(+)-GLYCIDYL PHTHALIMIDE Chemical Properties Melting p
Cas:161596-47-0
Min.Order:1 Gram
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Type:Lab/Research institutions
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inquiry2-((S)-3-chloro-2-hydroxypropyl)isoindoline-1,3-dione
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene for 4h; Reflux; Green chemistry; | 94% |
With sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene for 4h; Reflux; | 89% |
With potassium phosphate In 1,2-dichloro-ethane at 80℃; for 14h; Product distribution / selectivity; | n/a |
1H-isoindole-1,3(2H)-dione, 2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Stage #1: 1H-isoindole-1,3(2H)-dione, 2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl] With hydrogen bromide In 1,2-dichloro-ethane at 10 - 15℃; for 4h; Stage #2: With sodium methylate In methanol at 0 - 15℃; for 3h; | 93.6% |
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / 60 - 67 °C / Industrial scale 2: pyridinium p-toluenesulfonate / toluene / 0.25 h / 30 - 50 °C / Industrial scale 3: chloro-trimethyl-silane / toluene / 2.5 h / 30 °C 4: sodium methylate / methanol / 20 h / 30 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 2 h / 60 - 67 °C / Industrial scale 2: pyridinium p-toluenesulfonate / toluene / 3 h / Dean-Stark; Reflux; Industrial scale 3: N-Bromosuccinimide / 1,2-dichloro-ethane / 1.33 h / 12 - 22 °C / Industrial scale 4: sodium methylate / toluene; methanol / 5.17 h / 9 - 22 °C / Industrial scale View Scheme |
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; | 91% |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; | 91% |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20 - 25℃; for 18h; | 80% |
Conditions | Yield |
---|---|
With benzyltrimethylammonium chloride In isopropyl alcohol at 40℃; for 22h; | 90% |
With potassium tert-butylate; benzyltrimethylammonium chloride; sodium carbonate In tetrahydrofuran at 50℃; for 39h; | 81% |
With benzyltrimethylammonium chloride; sodium hydrogencarbonate In isopropyl alcohol at 20℃; for 25h; | 80% |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Stage #1: C15H17NO4 With hydrogenchloride In dichloromethane; water at 10 - 15℃; for 4h; Stage #2: With sodium methylate In methanol at 0 - 15℃; for 3h; Reagent/catalyst; | 89.7% |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Stage #1: C17H21NO4 With hydrogen iodide In chloroform at 10 - 15℃; for 4h; Stage #2: With sodium ethanolate In ethanol at 0 - 15℃; for 3h; | 85.9% |
(R)-(-)-epichlorohydrin
potassium phtalimide
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With benzyltrimethylammonium chloride In isopropyl alcohol at 10℃; for 46h; | 83% |
With benzyltrimethylammonium chloride In tetrahydrofuran at 50℃; for 44h; | 74% |
With benzyltrimethylammonium chloride In methanol at 20℃; for 15h; | 68% |
phthalimide
(R)-(-)-epichlorohydrin
A
(S)-N-glycidylphthalimide
B
2-((S)-3-chloro-2-hydroxypropyl)isoindoline-1,3-dione
Conditions | Yield |
---|---|
With potassium fluoride on basic alumina In 2-methyltetrahydrofuran for 3h; Inert atmosphere; Reflux; stereospecific reaction; | A 10% B 83% |
Conditions | Yield |
---|---|
at 70℃; for 1h; Temperature; | 83% |
With N-benzyl-N,N,N-triethylammonium chloride; potassium iodide In isopropyl alcohol at 28℃; for 72h; Reagent/catalyst; Temperature; Solvent; | 88.1 g |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With sodium methylate In methanol; toluene at 9 - 22℃; for 5.16667h; Industrial scale; | 80.8% |
Conditions | Yield |
---|---|
Stage #1: phthalimide; (S)-epichlorohydrin With methylamine In isopropyl alcohol at 60℃; for 5h; Stage #2: With sodium methylate In methanol; isopropyl alcohol at 10 - 30℃; Solvent; Reagent/catalyst; | 77.5% |
Stage #1: phthalimide; (S)-epichlorohydrin With N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate In isopropyl alcohol at 20 - 40℃; Stage #2: With potassium tert-butylate In isopropyl alcohol at 5 - 10℃; | |
With sodium acetate In isopropyl alcohol at 65 - 70℃; | 5 g |
With 1-hexylamine hydrochloride; potassium tert-butylate; potassium iodide In isopropyl alcohol at 28℃; for 72h; | 84.5 g |
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 4h; | 53% |
(R)-(-)-epichlorohydrin
potassium phtalimide
A
(-)-2-[(2R)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione
B
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With benzyltrimethylammonium chloride In DMF (N,N-dimethyl-formamide) at 20℃; for 16h; |
2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With potassium carbonate In toluene Reflux; | n/a |
In tetrahydrofuran; water |
(S)-2-(2-acetoxy-3-bromo-propyl)-isoindole-1,3-dione
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 0℃; for 1h; |
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In acetone at 35 - 60℃; for 12h; | |
With tetrabutylammomium bromide; potassium carbonate In acetone at 25 - 60℃; for 12h; |
phthalimide
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aluminum oxide / 1-methyl-pyrrolidin-2-one / 64 - 68 °C 1.2: 0.5 h 2.1: potassium carbonate / toluene / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum oxide / 1-methyl-pyrrolidin-2-one / 64 - 68 °C 1.2: 0.5 h 2.1: potassium carbonate / toluene / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum oxide / 1-methyl-pyrrolidin-2-one / 64 - 68 °C 1.2: 0.5 h 2.1: potassium carbonate / toluene / Reflux View Scheme |
phthalimide
(S)-epichlorohydrin
A
2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione
B
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With aluminum oxide In 1-methyl-pyrrolidin-2-one at 64 - 68℃; |
potassium phtalimide
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 6 h / 100 - 120 °C / Industrial scale 2: pyridinium p-toluenesulfonate / toluene / 3 h / Dean-Stark; Reflux; Industrial scale 3: N-Bromosuccinimide / 1,2-dichloro-ethane / 1.33 h / 12 - 22 °C / Industrial scale 4: sodium methylate / toluene; methanol / 5.17 h / 9 - 22 °C / Industrial scale View Scheme | |
Multi-step reaction with 4 steps 1: N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 6 h / 100 - 120 °C / Industrial scale 2: pyridinium p-toluenesulfonate / toluene / 0.25 h / 30 - 50 °C / Industrial scale 3: chloro-trimethyl-silane / toluene / 2.5 h / 30 °C 4: sodium methylate / methanol / 20 h / 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium iodide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 2.1: hydrogen bromide / 1,2-dichloro-ethane / 4 h / 10 - 15 °C 2.2: 3 h / 0 - 15 °C View Scheme |
(S)-2-(2-methoxy-2-methyl-[1,3]dioxolane-4-ylmethyl)-isoindole-1,3-dione
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: chloro-trimethyl-silane / toluene / 2.5 h / 30 °C 2: sodium methylate / methanol / 20 h / 30 °C View Scheme |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With sodium methylate In methanol at 30℃; for 20h; | 65.6 kg |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-Bromosuccinimide / 1,2-dichloro-ethane / 1.33 h / 12 - 22 °C / Industrial scale 2: sodium methylate / toluene; methanol / 5.17 h / 9 - 22 °C / Industrial scale View Scheme |
1H-isoindole-1,3(2H)-dione, 2-[(2S)-2,3-dihydroxypropyl]
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridinium p-toluenesulfonate / toluene / 3 h / Dean-Stark; Reflux; Industrial scale 2: N-Bromosuccinimide / 1,2-dichloro-ethane / 1.33 h / 12 - 22 °C / Industrial scale 3: sodium methylate / toluene; methanol / 5.17 h / 9 - 22 °C / Industrial scale View Scheme | |
Multi-step reaction with 3 steps 1: pyridinium p-toluenesulfonate / toluene / 0.25 h / 30 - 50 °C / Industrial scale 2: chloro-trimethyl-silane / toluene / 2.5 h / 30 °C 3: sodium methylate / methanol / 20 h / 30 °C View Scheme |
2-oxiranylmethylisoindole-1,3-dione
A
(-)-2-[(2R)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione
B
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With Cu metal organic framework based on (R)-3,3′-bis(6-carboxy-2-naphthyl)-2,2′-dihydroxy-1,1′-binaphthyl*silica packed stainless steel column (10 cm long × 4.0 mm i.d.) In ethanol; hexane at 25℃; Resolution of racemate; |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With sodium methylate In methanol; toluene at 5℃; for 0.75h; | 34.1 g |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With sodium methylate In methanol; toluene at -5 - 20℃; for 1.25h; | 35.8 g |
N-(tert-butoxycarbonyl)-1,4-phenylenediamine
(S)-N-glycidylphthalimide
C22H25N3O5
Conditions | Yield |
---|---|
In isopropyl alcohol for 16h; Reflux; | 100% |
In isopropyl alcohol for 16h; Reflux; | 100% |
In isopropyl alcohol for 16h; Heating / reflux; | 100% |
N-benzyl-2,2-dimethoxyethylamine
(S)-N-glycidylphthalimide
(R)-2-{3-[benzyl-(2,2-dimethoxyethyl)amino]-2-hydroxypropyl}-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
In ethanol for 20h; Inert atmosphere; Reflux; | 100% |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 80℃; for 1h; | 100% |
With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 80℃; | 100% |
3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate
(S)-N-glycidylphthalimide
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
Conditions | Yield |
---|---|
With lithium bromide at 120℃; for 4h; Temperature; Solvent; | 96.51% |
With lithium bromide In N,N-dimethyl-formamide at 60℃; for 4h; Reagent/catalyst; Solvent; | 90.11% |
4-(4-isocyanatophenyl)morpholin-3-one
(S)-N-glycidylphthalimide
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
With 3-methyl-1-butyl acetate; magnesium chloride at 120℃; for 4h; Solvent; Reagent/catalyst; Temperature; | 95.5% |
With lithium iodide In chlorobenzene at 115℃; for 4h; Reagent/catalyst; Solvent; Temperature; | 94.09% |
(S)-N-glycidylphthalimide
4-(4-aminophenyl)morpholin-3-one
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
In ethanol; water at 20℃; for 15h; Solvent; Temperature; | 95% |
In ethanol; water for 27h; Heating; | 92% |
In methanol; water at 65 - 70℃; for 32h; | 92% |
(S)-N-glycidylphthalimide
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
In water; toluene at 30 - 85℃; Solvent; Temperature; | 94.6% |
3-fluoro-4-(morpholinyl)aniline
(S)-N-glycidylphthalimide
N-[3-phthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(4-morpholinyl)aniline
Conditions | Yield |
---|---|
In ethanol; water at 80℃; for 14h; | 94.4% |
In N,N-dimethyl-formamide for 5h; Product distribution / selectivity; Heating / reflux; | |
In N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
In isopropyl alcohol for 16h; Reflux; | 93.8% |
(S)-N-glycidylphthalimide
2-((S)-3-chloro-2-hydroxypropyl)isoindoline-1,3-dione
Conditions | Yield |
---|---|
Stage #1: (S)-N-glycidylphthalimide With Chloroiodomethane In 2-methyltetrahydrofuran at -78℃; for 0.0333333h; Stage #2: With methyllithium In 2-methyltetrahydrofuran; diethyl ether at -78℃; for 1h; Solvent; Reagent/catalyst; Temperature; enantioselective reaction; | 93% |
With C25H21OP; trichloroacetonitrile In water; N,N-dimethyl-formamide at 25℃; for 6h; Inert atmosphere; Irradiation; | 78% |
Conditions | Yield |
---|---|
In ethanol at 50℃; Solvent; Temperature; | 91% |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Stage #1: (S)-N-glycidylphthalimide With diiodomethane In 2-methyltetrahydrofuran at -78℃; for 0.0333333h; Stage #2: With methyllithium In 2-methyltetrahydrofuran; diethyl ether at -78℃; for 1h; enantioselective reaction; | 91% |
Conditions | Yield |
---|---|
In ethanol at 60℃; for 16h; Temperature; Inert atmosphere; | 90.09% |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
Stage #1: (S)-N-glycidylphthalimide With iodobromomethane In 2-methyltetrahydrofuran at -78℃; for 0.0333333h; Stage #2: With methyllithium In 2-methyltetrahydrofuran; diethyl ether at -78℃; for 1h; enantioselective reaction; | 89% |
Conditions | Yield |
---|---|
In ethanol; water at 0℃; for 32h; Reflux; | 88% |
2-hydroxy-2-methylpropanenitrile
(S)-N-glycidylphthalimide
(S)-4-(1,3-dioxoisoindol-2-yl)-3-hydroxybutyronitrile
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 75℃; | 87% |
phenyl isocyanate
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
With (2-hydroxy-5-methylphenyl)triphenylphosphonium iodide In chlorobenzene at 100℃; for 6h; Inert atmosphere; | 87% |
methyl (3-fluoro-4-morpholinophenyl)carbamate
(S)-N-glycidylphthalimide
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
Conditions | Yield |
---|---|
With lithium tert-butoxide In N,N-dimethyl-formamide at 25 - 85℃; Temperature; Solvent; Reagent/catalyst; | 85% |
With lithium tert-butoxide In ethyl acetate at 25 - 75℃; Solvent; Temperature; Reagent/catalyst; | 70% |
(S)-N-glycidylphthalimide
p-aminoiodobenzene
Conditions | Yield |
---|---|
In ethanol; water at 100℃; for 12h; | 84.9% |
Conditions | Yield |
---|---|
In methanol; ethanol at 75℃; for 48h; Temperature; Solvent; | 84.7% |
(S)-N-glycidylphthalimide
4-Aminobenzonitrile
4-(3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropylamino)benzonitrile
Conditions | Yield |
---|---|
at 105℃; for 13h; | 84% |
With magnesium(II) perchlorate In 1,4-dioxane for 10h; Reflux; | 78% |
(S)-N-glycidylphthalimide
dibenzylamine
2-[(2R)-3-(dibenzylamino)-2-hydroxy-propyl]isoindoline-1,3-dione
Conditions | Yield |
---|---|
In isopropyl alcohol at 0℃; for 9h; Reflux; Inert atmosphere; regioselective reaction; | 84% |
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
(S)-N-glycidylphthalimide
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
Conditions | Yield |
---|---|
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; N,N-dimethyl-formamide at 5℃; for 0.5h; Inert atmosphere; Stage #2: (S)-N-glycidylphthalimide In tetrahydrofuran; N,N-dimethyl-formamide at 5 - 20℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere; | 84% |
(S)-N-glycidylphthalimide
Conditions | Yield |
---|---|
In acetonitrile at 70℃; for 6h; | 84% |
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