L-Histidine supplier | CasNO.71-00-1

Name
Histidine
EINECS 200-745-3
CAS No. 71-00-1
Article Data194
CAS DataBase
Density 1.423 g/cm³
Solubility 41.6 g/L (25 ºC)
Melting Point 282 °C (dec.)(lit.)
Formula C₆H₉N₃O₂
Boiling Point 458.9 °C at 760 mmHg
Molecular Weight 155.156
Flash Point 231.3 °C
Transport Information
Appearance white crystalline powder
Safety 24/25-36/37-26-22
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms (S)-alpha-amino-1H-Imidazole-4-propanoic acid;Histidinum [INN-Latin];alpha-Amino-4(or 5)-imidazolepropionic acid;(L)-Histidine;1H-Imidazole-4-alanine, (S)-;4-(2-Amino-2-carboxyethyl)imidazole;(S)-4-(2-Amino-2-carboxyethyl)imidazole;(2S)-2-azaniumyl-3-(3H-imidazol-4-yl)propanoate;Histidine (VAN);L-Alanine, 3-(1H-imidazol-4-yl)-;Glyoxaline-5-alanine;S-Histidine;alpha-amino-4-imidazoleproprionic acid;Histidine (USP);Istidina;L-Histidine (JAN);(S)-2-Amino-3-(4-imidazolyl)propionsaeure;L-Histidine Base;L-2-Amino-3-(4-imidazolyl)propionic acid;L-His-OH;L-Histidine;HIS;(S)-alpha-Amino-1H-imidazole-4-propionic acid;
PSA 92.00000
LogP 0.06440

Synthetic route

: 83468-83-1
N(α)-t-butoxycarbonyl-N(ϖ)-benzyloxymethyl-L-histidine

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With Nafion H; dimethylsulfide; 3-methyl-phenol; trifluoroacetic acid for 3h;	100%
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;	90.2%

: 35899-43-5
Boc-His(Tos)-OH

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;	100%
With trifluoroacetic acid-thioanisole for 1h; Product distribution; various reagents;	16.7%

: 73475-63-5
H-His(MBS)-OH

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With sodium hydroxide at 23℃; for 1h; Product distribution; various reagents;	100%

: 111-26-2
hexan-1-amine

: 78641-69-7
(S)-2-(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-3-(1H-imidazol-4-yl)-propionic acid

A: 74197-48-1
1-hexyl-3,5-dinitro-4-pyridone

B: 71-00-1
L-histidine

Conditions

Conditions	Yield
In pyridine Product distribution;	A n/a B 92%

...Expand

: 17791-52-5
N-(tert-butoxycarbonyl)-L-histidine

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;	92%

: C6H9N3O2*H3N*ClH

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane	87%

: 2002-22-4
(2S)-2-amino-3-(2-mercapto-1H-imidazol-4-yl)propanoic acid

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With iron(III) sulfate In water at 95℃; for 1h;	85%

: C19H17N3O2

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With palladium In methanol; cyclohexane for 120h; Reflux;	84.5%

: 305-84-0
Carnosine

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With trans-[Co(3,2,3-tet)Cl2]Cl; water In water at 45℃; for 6h; pH=7.5;	75%

: 50-99-7
D-glucose

A: 56-41-7
L-alanin

B: 56-40-6
glycine

C: 71-00-1
L-histidine

Conditions

Conditions	Yield
With ammonium sulfate; ammonium hydroxide; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; (S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide; calcium (R)-pantothenate; Thiamine hydrochloride; magnesium sulfate; iron(II) sulfate; urea; calcium carbonate; sodium chloride; manganese(ll) chloride; biotin In water at 28℃; for 46h; Mechanism; fermentation with Corynebacterium glutamicum N-730; pH=7.4;	A n/a B n/a C 5%

Yield

With ammonium sulfate; ammonium hydroxide; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; (S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide; calcium (R)-pantothenate; Thiamine hydrochloride; magnesium sulfate; iron(II) sulfate; urea; calcium carbonate; sodium chloride; manganese(ll) chloride; biotin In water at 28℃; for 46h; Mechanism; fermentation with Corynebacterium glutamicum N-730; pH=7.4;

A n/a
B n/a
C 5%

...Expand

: 4998-57-6
His

A: 71-00-1
L-histidine

B: 351-50-8
D-histidin

Conditions

Conditions	Yield
durch fraktionierte Krystallisation des d-weinsaeuren Salzes; das Salz des d-Histidins krystallisiert zuerst aus;

: 10101-30-1
N-acetylhistidine

A: 71-00-1
L-histidine

B: 75983-68-5
Nα-acetyl-D-histidine

Conditions

Conditions	Yield
With enzymesubstance from pig's kidney

: 101301-56-8
His-Ala-Asp-Gly

A: 56-41-7
L-alanin

B: 56-84-8
L-Aspartic acid

C: 56-40-6
glycine

D: 71-00-1
L-histidine

Conditions

Conditions	Yield
With Tris-HCl buffer In water at 37℃; Product distribution;

...Expand

: 101301-51-3
His-Ser-Asn-Gly

A: 56-45-1
L-serin

B: 70-47-3
L-asparagine

C: 56-40-6
glycine

D: 71-00-1
L-histidine

Conditions

Conditions	Yield
With Tris-HCl buffer In water at 37℃; Product distribution;

...Expand

: 101301-54-6
His-Ser-Glu-Gly

A: 56-45-1
L-serin

B: 56-86-0
L-glutamic acid

C: 56-40-6
glycine

D: 71-00-1
L-histidine

Conditions

Conditions	Yield
With Tris-HCl buffer In water at 37℃; Product distribution;

...Expand

: 86741-98-2
H-His-Ser-Asp-Ala-OH

A: 56-41-7
L-alanin

B: 56-45-1
L-serin

C: 56-84-8
L-Aspartic acid

D: 71-00-1
L-histidine

Conditions

Conditions	Yield
With acetic acid In water at 37℃; for 720h; Product distribution; further reagent, pH;

...Expand

: 484-42-4
angiotensin I

A: 61-90-5
L-leucine

B: 73-32-5
L-isoleucine

C: 63-91-2
L-phenylalanine

D: 60-18-4
L-tyrosine

E: 147-85-3
L-proline

F: 71-00-1
L-histidine

Conditions

Conditions	Yield
With 155K Aspergillus oryzae ACID CPASE O at 30℃; for 1h; pH 3.7, release of C-terminal amino acid residues at longer incubation times;

...Expand

: 14029-59-5
Nα-(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethylene)-histidine

A: 65-22-5
pyridoxal hydrochloride

B: 71-00-1
L-histidine

Conditions

Conditions	Yield
With buffer solution In various solvent(s) at 25℃; Rate constant;

: 27510-94-7
His-Ser-Asp-Gly

A: 56-45-1
L-serin

B: 56-84-8
L-Aspartic acid

C: 56-40-6
glycine

D: 71-00-1
L-histidine

Conditions

Conditions	Yield
With Tris-HCl buffer In water at 37℃; Product distribution;

...Expand

: 3465-72-3
urocanic Acid

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With Tris buffer; ammonium acetate In water at 25℃; for 6h; Equilibrium constant; pH 8.41;

: 71-00-1
D,L-histidine

A: 71-00-1
L-histidine

B: 351-50-8
D-histidin

: cyclo(Gly-L-Leu-L-His-L-Phe-L-Ala-L-Phe-L-Pro)

A: 56-41-7
L-alanin

B: 61-90-5
L-leucine

C: 63-91-2
L-phenylalanine

D: 56-40-6
glycine

E: 147-85-3
L-proline

F: 71-00-1
L-histidine

Conditions

Conditions	Yield
With hydrogenchloride; mercaptoacetic acid at 110℃; for 24h; Product distribution;

...Expand

: (S)-2-[(6-Bromo-1H-indole-3-carbonyl)-amino]-3-(1H-imidazol-4-yl)-propionic acid

A: 101774-27-0
6-bromo-1H-indole-3-carboxylic acid

B: 71-00-1
L-histidine

Conditions

Conditions	Yield
With hydrogenchloride at 120℃; for 12h; Product distribution;

blood substances: blood substances

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With hydrogenchloride Hydrolysis;

blood: blood

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With hydrogenchloride Hydrolysis;

bovine blood: bovine blood

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With hydrogenchloride
With hydrogenchloride

carnosine: carnosine

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With sulfuric acid Hydrolysis;

casein: casein

: 71-00-1
L-histidine

DL-histidine-hydrochloride: DL-histidine-hydrochloride

: 71-00-1
L-histidine

Conditions

Conditions	Yield
With water bei Kristallisation;Produkt:Monohydrochlorid;

: 17720-18-2
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

: 71-00-1
L-histidine

: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate (S)-2-ammonio-3-(1H-imidazol-4-yl)propanoate

Conditions

Conditions	Yield
In water Cooling with ice;	100%

: 59-67-6
nicotinic acid

: 71-00-1
L-histidine

: (S)-1-carboxy-2-(1H-imidazol-4-yl)ethanaminium nicotinate

Conditions

Conditions	Yield
In water for 0.166667h; pH=Ca. 5.5 - 5.8; Cooling with ice;	100%

: 67-56-1
methanol

: 71-00-1
L-histidine

: 1499-46-3
L-Histidine methyl ester

Conditions

Conditions	Yield
With thionyl chloride at 40℃; for 36h;	99%
With hydrogenchloride	95%
With hydrogenchloride for 16h; Heating;

: 50-00-0
formaldehyd

: 71-00-1
L-histidine

: (S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloric acid salt

Conditions

Conditions	Yield
Stage #1: formaldehyd; L-histidine With hydrogenchloride In water for 1.75h; Heating / reflux; Stage #2: With hydrogenchloride In 1,4-dioxane; isopropyl alcohol for 0.5h;	99%
With hydrogenchloride In water at 0 - 75℃; for 6.5h;

: 67-56-1
methanol

: [Co(2,2',2''-triaminotriethylamine)(L-alaninate)][toluene-p-sulphonate]

: 71-00-1
L-histidine

: [Co(2,2',2''-triaminotriethylamine)(Ala-L-HisOCH3)]Cl3

Conditions

Conditions	Yield
With N-ethylmorpholine;; toluene-4-sulfonic acid In methanol complex, amino-acid, sulphonic acid, dimethyl sulphite in methanol was esterified at 70 degree.C for 3 h, then N-ethylmorpholine was added; dild. with water, chromd. on Amberlite IRC 50 column (Na-form), evapn. to dryness, taken up in MeOH, filtration, evapn.;	99%

...Expand

: 7647-01-0
hydrogenchloride

: 50-00-0
formaldehyd

: 71-00-1
L-histidine

: (S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloric acid salt

Conditions

Conditions	Yield
Stage #1: formaldehyd; L-histidine With hydrogenchloride In water at 0℃; for 0.5h; Stage #2: In water for 1.25h; Heating / reflux; Stage #3: hydrogenchloride In 1,4-dioxane; isopropyl alcohol for 0.5h;	99%

...Expand

: 108-24-7
acetic anhydride

: 71-00-1
L-histidine

: 2497-02-1
N-acetyl-L-histidine

Conditions

Conditions	Yield
With acetic acid for 15h; Reflux;	98%
In water for 0.0666667h; Irradiation;	96%
With acetic acid for 2h; Heating;	68.9%

: 123-41-1
cholin hydroxide

: 71-00-1
L-histidine

: 1361335-95-6
(2-hydroxyethyl)trimethylammonium L-histidinate

Conditions

Conditions	Yield
In water at 3℃; Darkness;	98%
In water at 3℃; for 48h; Darkness;	95%
In water at 3℃; for 48h; Darkness;	95%

: 71-00-1
L-histidine

: 5-((3H-diazirin-3-yl)methyl)-1H-imidazole

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; ammonia In methanol at 0 - 20℃; for 2h; Reagent/catalyst; Inert atmosphere;	98%

: 3025-95-4
N-acetyl-β-alanine

: 71-00-1
L-histidine

: 56353-15-2
N-acetyl-β-alanyl-L-histidine

Conditions

Conditions	Yield
With 2-chloro-1,3-dimethylimidazolinium chloride In ethanol at 40℃; for 3h; Concentration; Reagent/catalyst; Solvent; Temperature;	97.9%

: 79-11-8
chloroacetic acid

: 71-00-1
L-histidine

: N,N,N',N''-tetra(carboxymethyl)histidine tetrasodium salt

Conditions

Conditions	Yield
Stage #1: L-histidine With potassium iodide; sodium hydroxide In water at 58℃; for 1.08333h; pH=9.5 - 10.5; Stage #2: chloroacetic acid In water at 45 - 90℃;	97.8%

: 71-00-1
L-histidine

: 29745-04-8
norcantharidin

: L-histidine norcantharimide

Conditions

Conditions	Yield
In ethanol; water for 48h; Reflux;	97%

: 501-53-1
benzyl chloroformate

: 71-00-1
L-histidine

: 14997-58-1
N-[(benzyloxy)carbonyl]-L-histidine

Conditions

Conditions	Yield
β‐cyclodextrin In various solvent(s) at 20℃; for 0.116667h; pH=8;	96%
In ethyl acetate Heating;	31%
With trimethylsilyl cyanide In tetrahydrofuran at -15℃; Yield given;

: 67-56-1
methanol

: C11H11N3O4

: 78-84-2
isobutyraldehyde

: 71-00-1
L-histidine

: 1375004-50-4
C23H32N6O7

Conditions

Conditions	Yield
at 20℃; for 48h; Ugi reaction; chemoselective reaction;	96%

...Expand

: 71-00-1
L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
cyclohexenone In various solvent(s) at 154℃; for 26h;	95%

: 67-56-1
methanol

: 71-00-1
L-histidine

: 4467-54-3, 5619-10-3, 7389-87-9, 18684-16-7, 22888-60-4, 32381-17-2, 92742-29-5, 100009-20-9
l-histidine methyl ester dihydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0℃; for 16h; Inert atmosphere; Reflux;	95%
With thionyl chloride at 0 - 20℃; for 6h; Inert atmosphere; Reflux;	92%
With hydrogenchloride; sulfuric acid for 3h; Esterification; Heating;	91%

: 874-42-0
2,4-dichlorobenzaldeyhde

: 71-00-1
L-histidine

: 4-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In water; isopropyl alcohol for 4h; Heating;	95%

: chromium chloride hexahydrate

: 71-00-1
L-histidine

: Cr(His)Cl3*H2O

Conditions

Conditions	Yield
In water dried over P2O5; elem. anal.;	95%

: chromium chloride hexahydrate

: 71-00-1
L-histidine

: Cr(His)3Cl3*H2O

Conditions

Conditions	Yield
In water dried over P2O5; elem. anal.;	95%

: chromium chloride hexahydrate

: 71-00-1
L-histidine

: Cr(His)2Cl3*H2O

Conditions

Conditions	Yield
In water dried over P2O5; elem. anal.;	95%

: chromium(III) nitrate hexahydrate

: 71-00-1
L-histidine

: [Cr(L-α-histidine)2(NO3)3]*3H2O

Conditions

Conditions	Yield
In water dried over P2O5; elem. anal.;	95%

: chromium(III) nitrate hexahydrate

: 71-00-1
L-histidine

: [Cr(L-α-histidine)3(NO3)3]*3H2O

Conditions

Conditions	Yield
In water dried over P2O5; elem. anal.;	95%

: chromium(III) nitrate hexahydrate

: 71-00-1
L-histidine

: [Cr(L-α-histidine)(NO3)3]*3H2O

Conditions

Conditions	Yield
In water dried over P2O5; elem. anal.;	95%

: N-((1,3-dioxolan-4-yl)methyl)-N,N,N-triethylammonium hydroxide

: 71-00-1
L-histidine

: N-((1,3-dioxolan-4-yl)methyl)-N,N,N-triethylammonium L-histidinate

Conditions

Conditions	Yield
In water at 20℃; for 48h; Darkness; Cooling;	95%

: 10228-90-7
9-methoxyacridine

: 71-00-1
L-histidine

: (S)-2-(Acridin-9-ylamino)-3-(1H-imidazol-4-yl)-propionic acid

Conditions

Conditions	Yield
In methanol for 10h; Heating;	94%

: 3179-10-0, 5576-97-6
(E)-1-methoxy-4-(2-nitrovinyl)benzene

: 71-00-1
L-histidine

: 169037-23-4
5-trifluoromethoxy-1H-indole-2,3-dione

: 5'-((1H-imidazol-4-yl)methyl)-3'-(4-methoxyphenyl)-4'-nitro-5-(trifluoro methoxy) spiro[indoline-3,2'-pyrrolidin]-2-one

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 100℃; Ionic liquid; diastereoselective reaction;	94%

...Expand

: C6H10N2O2

: 1352831-40-3
2-(4-dimethylamino-1,8-naphthalimido)ethyl isocyanide

: 71-00-1
L-histidine

: 1352831-43-6
(3S,5R,6S)-3-((1H-imidazol-5-yl)methyl)-N-(2-(6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-2-oxo-1,4-diazabicyclo[4.1.0]heptane-5-carboxamide

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 20℃; for 1.5h;	93%

...Expand

L-Histidine Consensus Reports

Reported in EPA TSCA Inventory.

L-Histidine Specification

1. Introduction of L-Histidine

L-Histidine, with the IUPAC Name: (2S)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid, is one kind of white crystal powder. Histidine is used for food additives and raw materials of pharmaceutical .

2. Properties of L-Histidine

L-Histidine has the following datas: (1)Classification Code: Amino acid; Mutation data; (2)Melting point: 282 °C; (3)Index of Refraction: 1.614; (4)Molar Refractivity: 38.01 cm³; (5)Molar Volume: 108.9 cm³; (6)Surface Tension: 79.6 dyne/cm; (7)Density: 1.423 g/cm³; (8)Flash Point: 231.3 °C; (9)Enthalpy of Vaporization: 75.79 kJ/mol; (10)Boiling Point: 458.9 °C at 760 mmHg; (11)Vapour Pressure: 3.25E-09 mmHg at 25°C.

3. Structure Descriptors of L-Histidine

You could convert the following datas into the molecular structure:
InChI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChIKey: InChIKey=HNDVDQJCIGZPNO-YFKPBYRVSA-N
Smiles: c1(C[C@@H](C(O)=O)N)c[nH]cn1

4. Toxicity of L-Histidine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse	LD50	intravenous	> 2gm/kg (2000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse	LD50	oral	> 15gm/kg (15000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	intraperitoneal	> 8gm/kg (8000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	intravenous	> 2gm/kg (2000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	oral	> 15gm/kg (15000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.

5. Safety Information of L-Histidine

Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Other safty informations about Histidine (CAS NO.71-00-1):
Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36/37-26-22
S24/25: Avoid contact with skin and eyes.
S36/37: Wear suitable protective clothing and gloves.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S22: Do not breathe dust.
WGK Germany: 2
RTECS: MS3070000
F: 10-23
HS Code: 29332990

Product Name

Histidine

Synthetic route

L-Histidine Consensus Reports

L-Histidine Specification

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