Product Name

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  • Name

    DIPHENOXYLATE HYDROCHLORIDE

  • EINECS
  • CAS No. 3810-80-8
  • Density g/cm3
  • Solubility
  • Melting Point 220.5-222°
  • Formula C30H32 N2 O2 . Cl H
  • Boiling Point 602.3°Cat760mmHg
  • Molecular Weight 489.10
  • Flash Point 318°C
  • Transport Information
  • Appearance
  • Safety A poison by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 3810-80-8 (DIPHENOXYLATE HYDROCHLORIDE)
  • Hazard Symbols
  • Synonyms 4-Piperidinecarboxylicacid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride(9CI); Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethylester, hydrochloride (6CI,7CI); Isonipecotic acid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride (8CI);1-(3-Cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid ethyl esterhydrochloride; 2,2-Diphenyl-4-(4-carbethoxy-4-phenyl-1-piperidino)butyronitrilehydrochloride; 2,2-Diphenyl-4-(4-carboxy-4-phenyl-1-piperidino)butyronitrileethyl ester hydrochloride; Diphenoxylate hydrochloride; R 1132; R 1132(antiperistaltic)
  • PSA 53.33000
  • LogP 6.22318

Lomotil Chemical Properties

Molecular Structure of Lomotil (CAS NO.3810-80-8):

IUPAC Name: ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidin-1-ium-4-carboxylate chloride
Empirical Formula: C30H33ClN2O2 
Molecular Weight: 489.0482 
Flash Point: 318 °C  Enthalpy of Vaporization: 89.61 kJ/mol 
Boiling Point: 602.3 °C at 760 mmHg  Vapour Pressure: 1.84E-14 mmHg at 25°C 
Classification Code : Antiperistaltic ; Drug / Therapeutic Agent
Synonyms of Lomotil (CAS NO.3810-80-8): 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester Monohydrochloride ; 1-(3-cyano-3,3-diphénylpropyl)-4-phénylpipéridine-4-carboxylate d'éthyle chlorhydrate ; 4-piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, hydrochloride (1:1) ; Diphenoxylate hydrochloride (USP) ; ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride ; ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride (1:1) ; Ethyl-1-(3-cyan-3,3-diphenylpropyl)-4-phenylpiperidin-4-carboxylathydrochlorid ; 4-Ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile, hydrochloride

Lomotil Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 320mg/kg (320mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1636, 1974.
mouse LD50 subcutaneous > 160mg/kg (160mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1636, 1974.
rat LD50 oral 221mg/kg (221mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1633, 1974.

Lomotil Safety Profile

A poison by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Lomotil Specification

 Lomotil (CAS NO.3810-80-8) is a toxic material,burning will produce toxic nitrogen oxide gases.Besides should be stored and transported in low-temperature,drying environment. separately with oxidizing agents.Fire extinguishing agents water, carbon dioxide, dry powder, foam would be used if emergency.

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