Methoxymethylamine supplier

Name
N-methoxymethylamine
EINECS 214-255-2
CAS No. 1117-97-1
Article Data28
CAS DataBase
Density 0.796 g/cm³
Solubility
Melting Point 97℃
Formula C₂H₇NO
Boiling Point 2.908 °C at 760 mmHg
Molecular Weight 61.0837
Flash Point -28.618 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Hydroxylamine, N,O-dimethyl-;Methoxyamine, N-methyl-;Methylmethoxyamine;N,O-Dimethylhydroxylamine;N-Methoxy-N-methylamine;N-Methoxymethanamine;N-Methoxymethylamine;N-Methylmethoxyamine;O,N-Dimethylhydroxylamine;Methylamine,N-methoxy- (6CI,7CI,8CI);(Methoxyamino)methane;
PSA 21.26000
LogP 0.15810

Synthetic route

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide distillation;	92%
With triethanolamine at 150℃;	81%
With triethanolamine In ethylene glycol at 150℃;	81%

: 6919-62-6
ethyl N-methoxy-N-methylcarbamate

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With hydrogenchloride

: 1576-17-6
N-methoxy-N-methyl-N'-phenylurea

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With aniline at 150℃;

: 34893-99-7
N,O-Dimethylhydroxymethan

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With potassium hydroxide

: 5725-96-2
N,N-dimethylhydroxylamine

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
at 298℃; Thermodynamic data; rearrangement of N-oxide to O-alkyl hydroxylamines , ΔH, ΔS, ΔG;

: 16339-12-1
N-nitroso-N,O-dimethylhydroxylamine

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With perchloric acid; ammonium sulfamate; sodium thiocyanide at 50℃; Rate constant;
With 2,2-dicloroethanol In cyclohexane at 25℃; Kinetics; Equilibrium constant; Decomposition;

: 162189-76-6
β-(N-methyl-N-methoxyamine)-α-nitrostilbene

A: 96746-56-4
(E)-β-Methoxy-α-nitrostilbene

B: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
In water; dimethyl sulfoxide at 20℃; Equilibrium constant;

O.N-dimethyl-oxy urethane: O.N-dimethyl-oxy urethane

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With potassium hydroxide durch Verseifung;

: 6919-62-6
ethyl N-methoxy-N-methylcarbamate

alcoholic KOH-solution: alcoholic KOH-solution

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
Verseifung;

: 78191-00-1
N-Methoxy-N-methylacetamide

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
In ethanol
With sulfuric acid at 76℃; for 5h;

: 153654-07-0
methyl methoxy methyl carbamate

: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water

: 77-78-1
dimethyl sulfate

A: 67-62-9
O-Methylhydroxylamin

B: 5725-96-2
N,N-dimethylhydroxylamine

C: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With hydroxylamine hemisulfate; sodium carbonate; sodium hydroxide In water at 2 - 5℃; for 2h;

...Expand

: 74-87-3
methylene chloride

A: 67-62-9
O-Methylhydroxylamin

B: 5725-96-2
N,N-dimethylhydroxylamine

C: 1117-97-1
N,0-dimethylhydroxylamine

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium carbonate; sodium hydroxide In water at 2 - 5℃; for 2h; Concentration; Temperature;

...Expand

: 195877-50-0
S-2-azido-3-(N-Boc-piperidyl)-propionic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 195877-51-1
4-[2-azido-2-(methoxy-methyl-carbamoyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In dichloromethane	100%

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 1117-97-1
N,0-dimethylhydroxylamine

: 87694-51-7
N-(tert-butoxycarbonyl)-L-isoleucine N'-methoxy-N'-methylamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -15℃; for 1h;	100%
Stage #1: N-(tert-butyloxycarbonyl)-L-isoleucine; N,0-dimethylhydroxylamine With triethylamine at 0℃; Stage #2: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine	95%
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane	94%

: 37784-17-1
N-(tert-butoxycarbonyl)-D-proline

: 1117-97-1
N,0-dimethylhydroxylamine

: 288086-98-6
[tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate]

Conditions

Conditions	Yield
Stage #1: N-(tert-butoxycarbonyl)-D-proline With HATU In dichloromethane at 0℃; for 1h; Stage #2: N,0-dimethylhydroxylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 20 - 27℃; for 16h;	100%
Stage #1: N-(tert-butoxycarbonyl)-D-proline With 1,1'-carbonyldiimidazole In dichloromethane for 0.5h; Stage #2: N,0-dimethylhydroxylamine In dichloromethane	52%
Stage #1: N-(tert-butoxycarbonyl)-D-proline With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 0.5h; Stage #2: N,0-dimethylhydroxylamine In dichloromethane at 20℃;	52%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

: 81136-08-5, 81136-06-3, 81136-09-6, 38385-67-0
2-methyl-3-phenylpropanoyl chloride

: 1117-97-1
N,0-dimethylhydroxylamine

: N-methoxy-N-methyl-α-methylhydrocinnamamide

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃;	100%

: 1117-97-1
N,0-dimethylhydroxylamine

: 170097-67-3
2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

: 371222-34-3
tert-butyl 6-(Methoxy(methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol at 20℃;	100%

: 7623-09-8
2-chloropropionyl chloride

: 1117-97-1
N,0-dimethylhydroxylamine

: 2-chloro-N-methoxy-N-methylpropionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 884512-77-0
(R)-4-(tert-butyloxycarbonyl)morpholine-2-carboxylic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 952593-44-1
tert-butyl (2R)-2-[methoxy(methyl)carbamoyl]morpholine-4-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In dichloromethane	85%

: 117738-82-6
4-methoxy-3-cyanobenzoic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 1202376-84-8
3-cyano-N,4-dimethoxy-N-methylbenzamide

Conditions

Conditions	Yield
With triethylamine; HATU In dichloromethane at 20℃; for 2h; Inert atmosphere;	100%

: 39716-58-0
pent-4-enoyl chloride

: 1117-97-1
N,0-dimethylhydroxylamine

: 95091-90-0
N-methoxy-N-methyl-4-pentenamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0 - 20℃;	3.54 g

: 30766-03-1
4-bromo-2-picolinic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 1005342-94-8
4-bromo-pyridine-2-carboxylic acid N-methoxy-N-methyl-amide

Conditions

Conditions	Yield
With triethylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;	100%

: trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: C11H19NO4

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;	100%

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 148148-48-5
4-(N-methoxy-N-methyl-carbamoyl)-piperidine-1-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 15h;	100%

: 1009376-52-6
1-(tert-butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: tert-butyl 3-(methoxy(methyl)carbamoyl)-4-methylpiperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine; HATU In dichloromethane for 14h; Cooling with ice;	100%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane for 14h; Reagent/catalyst; Solvent;	100%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane for 14h;	100%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane for 14h; Solvent; Reagent/catalyst;	100%

: C12H21NO4

: 1117-97-1
N,0-dimethylhydroxylamine

: C14H26N2O4

Conditions

Conditions	Yield
With triethylamine; 1,1'-carbonyldiimidazole In tetrahydrofuran; acetonitrile at 20 - 80℃; for 168h; Inert atmosphere;	100%

: 61496-44-4
2-nitro-4-dichloromethylsulfonylchlorobenzene

: 1117-97-1
N,0-dimethylhydroxylamine

: 4-dichloromethylsulfonyl-2-nitro-N,N-dimethylaniline

Conditions

Conditions	Yield
With triethylamine In benzene Heating;	99.2%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1117-97-1
N,0-dimethylhydroxylamine

: 87694-53-9
Boc-Phe-OH N,O-dimethyl hydroxamate

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In dichloromethane	99%
With 1,1'-carbonyldiimidazole	98%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate	95%

: 1117-97-1
N,0-dimethylhydroxylamine

: 74-11-3
para-chlorobenzoic acid

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

Conditions

Conditions	Yield
Stage #1: N,0-dimethylhydroxylamine; para-chlorobenzoic acid In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	99%
With 1,1'-carbonyldiimidazole
With triethylamine; 1,1'-carbonyldiimidazole

: 103-80-0
phenylacetyl chloride

: 1117-97-1
N,0-dimethylhydroxylamine

: 95092-10-7
N-methoxy-N-methyl-2-phenylacetamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 1.16667h; Inert atmosphere;	99%
With pyridine In dichloromethane	98%
With diaminopyridine; triethylamine In dichloromethane at 20℃;	78.7%
	65%
With pyridine In chloroform

: 614-47-1
1,3-diphenyl-propen-3-one

: 1117-97-1
N,0-dimethylhydroxylamine

: 3-(Methoxy-methyl-amino)-1,3-diphenyl-propan-1-one

Conditions

Conditions	Yield
In ethanol for 4h; Heating;	99%

: 943861-08-3
tert-butyl N-(1S,5E)-1-methyl-6-[(1S,4R,5S)-3-oxo-2-oxabicyclo[2.2.1]hept-5-yl]-5-hexenylcarbamate

: 1117-97-1
N,0-dimethylhydroxylamine

: C20H36N2O5

Conditions

Conditions	Yield
With isopropylmagnesium chloride In tetrahydrofuran at -20℃;	99%

: 215595-66-7
N6-Boc-N2-Cbz-lysine

: 1117-97-1
N,0-dimethylhydroxylamine

: [5-(phenylmethyloxycarbonyl)amino-5-(N-methoxy-N-methyl-carbamoyl)-pentyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 19h;	99%

: 21120-65-0
4-(4-methylphenoxy)benzoic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: N-methoxy-N-methyl-4-(p-tolyloxy)benzamide

Conditions

Conditions	Yield
Stage #1: 4-(4-methylphenoxy)benzoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N,0-dimethylhydroxylamine With triethylamine In N,N-dimethyl-formamide at 20℃; for 24h;	99%
Stage #1: 4-(4-methylphenoxy)benzoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N,0-dimethylhydroxylamine In N,N-dimethyl-formamide at 20℃; for 24h;

: 1117-97-1
N,0-dimethylhydroxylamine

: 62-23-7
4-nitro-benzoic acid

: 52898-51-8
N-methoxy-N-methyl-4-nitrobenzamide

Conditions

Conditions	Yield
Stage #1: N,0-dimethylhydroxylamine; 4-nitro-benzoic acid In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	99%

: 86-55-5
1-naphthalenecarboxylic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: naphthalene-1-(N-methoxy-N-methyl)carboxamide

Conditions

Conditions	Yield
Stage #1: 1-naphthalenecarboxylic acid; N,0-dimethylhydroxylamine In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	99%

: 88-14-2
2-furanoic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 95091-92-2
N-methoxy-N-methyl-2-furancarboxamide

Conditions

Conditions	Yield
Stage #1: 2-furanoic acid; N,0-dimethylhydroxylamine In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	99%

: tert-butyl (R)-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-1-phenylethyl)carbamate

: 1117-97-1
N,0-dimethylhydroxylamine

: tert-butyl (R)-(5-(methoxy(methyl)amino)-3,5-dioxo-1-phenylpentyl)carbamate

Conditions

Conditions	Yield
In toluene at 90℃; Schlenk technique; Inert atmosphere;	99%

: 4630-82-4
methyl cyclohexylcarboxylate

: 1117-97-1
N,0-dimethylhydroxylamine

: 80783-98-8
N-methoxy-N-methylcyclohexanecarboxamide

Conditions

Conditions	Yield
With isopropylmagnesium chloride In tetrahydrofuran at -20 - 20℃; for 10h; Inert atmosphere;	99%

: 1-(tert-butyl) 2-ethyl (2R,4S)-4-(((tert-butyldiphenylsilyl)oxy)methyl)pyrrolidine-1,2-dicarboxylate

: 1117-97-1
N,0-dimethylhydroxylamine

: tert-butyl (2R,4S)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With isopropylmagnesium chloride In tetrahydrofuran at -20℃; for 1h;	99%
With isopropylmagnesium chloride In tetrahydrofuran at -20℃; for 1h; Grignard Reaction;	99%

: 53484-17-6
1-methyl-1H-benzo[d]imidazole-5-carboxylic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 1378023-17-6
N-methoxy-N,1-dimethyl-1H-benzo[d]imidazole-5-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0 - 20℃;	98.78%

: 140-29-4
phenylacetonitrile

: 1117-97-1
N,0-dimethylhydroxylamine

: 95092-10-7
N-methoxy-N-methyl-2-phenylacetamide

Conditions

Conditions	Yield
Stage #1: phenylacetonitrile With potassium phosphate at 30℃; for 12h; pH=6; Enzymatic reaction; Stage #2: N,0-dimethylhydroxylamine at 20℃; for 0.5h; Concentration; Temperature; pH-value;	98.5%

Methoxymethylamine Specification

The Methoxymethylamine, with the CAS registry number 1117-97-1, is also known as O,N-Dimethylhydroxylamine. Its EINECS number is 214-255-2. This chemical's molecular formula is C₂H₇NO and molecular weight is 61.08. What's more, its systematic name is N-Methoxymethanamine.

Physical properties of Methoxymethylamine are: (1)ACD/LogP: 0.13; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.06; (4)ACD/LogD (pH 7.4): 0.13; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 23.82; (8)ACD/KOC (pH 7.4): 27.99; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 21.26 Å²; (13)Index of Refraction: 1.353; (14)Molar Refractivity: 16.655 cm³; (15)Molar Volume: 76.728 cm³; (16)Polarizability: 6.602×10^-24cm³; (17)Surface Tension: 18.6 dyne/cm; (18)Density: 0.796 g/cm³; (19)Flash Point: -28.618 °C; (20)Enthalpy of Vaporization: 25.189 kJ/mol; (21)Boiling Point: 2.908 °C at 760 mmHg; (22)Vapour Pressure: 1706.8 mmHg at 25°C.

Preparation: this chemical can be prepared by N,O-dimethyl-hydroxylamine; hydrochloride by distillation. This reaction will need reagent NaOH and solvent dimethylformamide. The yield is about 92%.

Methoxymethylamine can be prepared by N,O-dimethyl-hydroxylamine; hydrochloride by distillation

Uses of Methoxymethylamine: it can be used to produce N-methoxy-N-methyl-a-monohydrohexafluoroisobutyramide at the temperature of 20 °C. It will need solvent diethyl ether with the reaction time of 48 hours. The yield is about 78.1%.

Methoxymethylamine can be used to produce N-methoxy-N-methyl-a-monohydrohexafluoroisobutyramide at the temperature of 20 °C

You can still convert the following datas into molecular structure:
(1)SMILES: O(NC)C
(2)Std. InChI: InChI=1S/C2H7NO/c1-3-4-2/h3H,1-2H3
(3)Std. InChIKey: KRKPYFLIYNGWTE-UHFFFAOYSA-N

Product Name

N-methoxymethylamine

Synthetic route

Methoxymethylamine Specification

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