• Name

  N-(1-Ethylpropyl)-3,4-dimethylaniline

• EINECS
• CAS No. 56038-89-2
• Article Data5
• CAS DataBase
• Density 0.92 g/cm³
• Solubility
• Melting Point
• Formula C₁₃H₂₁N
• Boiling Point 290.2 °C at 760 mmHg
• Molecular Weight 191.316
• Flash Point 129 °C
• Transport Information
• Appearance Red-brown to brown liquid
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms N-(1-Ethylpropyl)-3,4-dimethylaniline;N-(1-Ethylpropyl)-3,4-xylidine;
• PSA 12.03000
• LogP 3.97690

Synthetic route

31599-61-8

3,4-dimethyliodobenzene

616-24-0

3-aminopentane

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; sodium carbonate; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 90℃; for 6h; Reagent/catalyst; Temperature; Buchwald-Hartwig Coupling;	99.5%

615-60-1

4-chloro-1,2-dimethylbenzene

616-24-0

3-aminopentane

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; sodium carbonate; sodium t-butanolate In toluene at 80℃; for 6h; Temperature; Reagent/catalyst; Buchwald-Hartwig Coupling;	98.9%

616-24-0

3-aminopentane

255837-23-1

3,4-dimethylphenyl trifluoromethanesulfonate

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; sodium carbonate; sodium t-butanolate In toluene at 90℃; for 6h; Reagent/catalyst; Buchwald-Hartwig Coupling;	98.4%

95-64-7

4-amino-o-xylene

96-22-0

pentan-3-one

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
platinum	95.4%
With naphthalene-2-sulfonate; platinum on carbon; hydrogen at 60 - 70℃; under 3750.38 - 7500.75 Torr; for 1h; Autoclave; Inert atmosphere;

583-71-1

4-bromo-o-xylene

616-24-0

3-aminopentane

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; caesium carbonate In toluene at 80℃; for 6h; Reagent/catalyst; Buchwald-Hartwig Coupling;	93.7%

99-10-5

3,5-Dihydroxybenzoic acid

95-64-7

4-amino-o-xylene

96-22-0

pentan-3-one

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
platinum	75.1%

...Expand

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

108-24-7

acetic anhydride

N-(1-ethylpropyl)-N-(3,4-dimethylphenyl)acetamide

Conditions

Conditions	Yield
at 110℃; for 5h;	99.1%

2969-81-5

4-bromoethylbutanoate

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

C19H31NO2

Conditions

Conditions	Yield
With potassium hydroxide In acetone for 3h; Reflux;	94.97%

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

108-90-7

chlorobenzene

40487-42-1

prowl

Conditions

Conditions	Yield
With sulfuric acid; nitric acid In water; 1,2-dichloro-ethane

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

A

56038-88-1

N-(1-Ethylpropyl)-6-nitro-3,4-xylidin

B

56038-87-0

N-(1-Ethylpropyl)-2-nitro-3,4-xylidin

Conditions

Conditions	Yield
With nitric acid at 30℃;

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

A

N-nitroso-N-(1-ethylpropyl)-2,6-dinitro-3,4-dimethyl-benzenamine

B

73215-09-5

N-(1-ethylpropyl)-N,2,6-trinitro-3,4-xylidine

C

40487-42-1

prowl

Conditions

Conditions	Yield
Stage #1: N-(1-ethylpropyl)-3,4-dimethyl-benzenamine With nitric acid at 30℃; Stage #2: at 30 - 60℃; Overall yield = 89 %;

...Expand

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

A

40487-42-1

prowl

B

1417827-06-5

C13H17N3O4

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitric acid / 1,2-dichloro-ethane; water / 1 h / 60 °C 2: 0.17 h / 180 °C View Scheme

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

40487-42-1

prowl

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: nitric acid / 30 °C 1.2: 30 - 60 °C 2.1: iron(III) chloride; hydrogenchloride / 3 h / 75 °C View Scheme
Multi-step reaction with 2 steps 1: nitric acid / 1,2-dichloro-ethane; water / 1 h / 60 °C 2: iron(III) chloride; hydrogenchloride / 3 h / 75 °C View Scheme
Multi-step reaction with 3 steps 1: 5 h / 110 °C 2: nitric acid / 1,2-dichloro-ethane / 7 h / 40 °C 3: sulfuric acid / 1,2-dichloro-ethane; water / 4 h / 85 °C View Scheme

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

A

N-nitroso-N-(1-ethylpropyl)-2,6-dinitro-3,4-dimethyl-benzenamine

B

40487-42-1

prowl

Conditions

Conditions	Yield
With nitric acid In water; 1,2-dichloro-ethane at 60℃; for 1h; Temperature; Concentration; Reagent/catalyst; Overall yield = 97 %; Overall yield = 0.54 kg;
Stage #1: N-(1-ethylpropyl)-3,4-dimethyl-benzenamine With nitric acid at 30℃; Stage #2: at 30 - 60℃; for 4h; Overall yield = 89 %;

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

N-(1-ethylpropyl)-2,6-dinitro-N-(3,4-dimethylphenyl)acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 5 h / 110 °C 2: nitric acid / 1,2-dichloro-ethane / 7 h / 40 °C View Scheme

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

C17H25N3O6

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium hydroxide / acetone / 3 h / Reflux 2: sulfuric acid; nitric acid / 4 h / 20 °C 3: potassium hydroxide; water / 3 h / 60 °C View Scheme

2969-81-5

4-bromoethylbutanoate

56038-89-2

N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

C19H29N3O6

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium hydroxide / acetone / 3 h / Reflux 2: sulfuric acid; nitric acid / 4 h / 20 °C View Scheme

N-(1-Ethylpropyl)-3,4-dimethylaniline Specification