Product Name

  • Name

    N-(3-Chloropropyl)morpholine

  • EINECS 461-510-0
  • CAS No. 7357-67-7
  • Article Data57
  • CAS DataBase
  • Density 1.062 g/cm3
  • Solubility
  • Melting Point NA
  • Formula C7H14ClNO
  • Boiling Point 227.1 °C at 760 mmHg
  • Molecular Weight 163.647
  • Flash Point 91.2 °C
  • Transport Information
  • Appearance Light Yellow to Colourless Liquid
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 7357-67-7 (N-(3-Chloropropyl)morpholine)
  • Hazard Symbols
  • Synonyms 1-Chloro-3-morpholinopropane;3-(Morpholin-4-yl)propyl chloride;3-Chloro-1-(morpholin-4-yl)propane;3-Morpholinopropyl chloride;4-(3-Chloropropyl)morpholine;Morpholine,4-(3-chloropropyl)-;
  • PSA 12.47000
  • LogP 0.88540

Synthetic route

morpholine
110-91-8

morpholine

1,3-chlorobromopropane
109-70-6

1,3-chlorobromopropane

4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

Conditions
ConditionsYield
In toluene96%
In toluene for 2h; Reflux;96%
With zinc In tetrahydrofuran at 20℃; for 1h;95%
3-morpholin-4-ylpropan-1-ol
4441-30-9

3-morpholin-4-ylpropan-1-ol

4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

Conditions
ConditionsYield
With thionyl chloride In dichloromethane at 20℃; for 2h;96%
With thionyl chloride; chloroform
With thionyl chloride
4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde
861453-11-4

4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde

4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

Conditions
ConditionsYield
With nitric acid In water at 40 - 45℃; for 4.33333 - 4.5h;
5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one

5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one

A

4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

B

3-morpholinopropyl-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one

3-morpholinopropyl-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one

8-Hydroxy-(3-methylphenyl)-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one

8-Hydroxy-(3-methylphenyl)-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one

A

4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

B

2-(3-methylphenyl)-8-(3-morpholinopropoxy)-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one

2-(3-methylphenyl)-8-(3-morpholinopropoxy)-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one

morpholine
110-91-8

morpholine

pentaerythritol tetraacrylate
4986-89-4

pentaerythritol tetraacrylate

1,3-chlorobromopropane
109-70-6

1,3-chlorobromopropane

4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

Conditions
ConditionsYield
With sodium hydroxide In toluene
...Expand
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

ethyl vanillate
617-05-0

ethyl vanillate

ethyl 3-methoxy-4-(3-morpholinopropoxy)benzoate
108479-25-0

ethyl 3-methoxy-4-(3-morpholinopropoxy)benzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 2h;100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;100%
With potassium carbonate In N-methyl-acetamide; diethyl ether100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;100%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

1H-indole-5-sulfonamide
3074-27-9

1H-indole-5-sulfonamide

trifluoroacetic acid
76-05-1

trifluoroacetic acid

1-(3-morpholinopropyl)-1H-indole-5-sulfonamide trifluoroacetate

1-(3-morpholinopropyl)-1H-indole-5-sulfonamide trifluoroacetate

Conditions
ConditionsYield
Stage #1: 4-(3-chloropropyl)morpholine; 1H-indole-5-sulfonamide With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 2h; Inert atmosphere;
Stage #2: trifluoroacetic acid In methanol; water		100%
...Expand
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

methyl 4-(benzyloxy)-3-hydroxybenzoate
87687-75-0

methyl 4-(benzyloxy)-3-hydroxybenzoate

C22H27NO5

C22H27NO5

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 95℃; for 3h; Inert atmosphere;99.1%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

2-methoxy-5-cyanophenol
52805-46-6

2-methoxy-5-cyanophenol

4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile
675126-28-0

4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 10h;98%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 78℃; for 4h;96%
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 10h;95%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-bromo-phenol
106-41-2

4-bromo-phenol

1-bromo-4-(3-morpholin-4-yl-propoxy)benzene

1-bromo-4-(3-morpholin-4-yl-propoxy)benzene

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 2h; Reflux;98%
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide for 18h; Heating;61%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-((4-nitrophenyl)ethynyl)phenol
18938-22-2

4-((4-nitrophenyl)ethynyl)phenol

4-(3-(4-((4-nitrophenyl)ethynyl)phenoxy)propyl)morpholine

4-(3-(4-((4-nitrophenyl)ethynyl)phenoxy)propyl)morpholine

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 6h;98%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 6h;98%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

ethyl 3-hydroxy-4-methoxybenzoate
148527-38-2

ethyl 3-hydroxy-4-methoxybenzoate

ethyl 4-methoxy-3-(3-morpholin-4-ylpropoxy)benzoate
1040264-46-7

ethyl 4-methoxy-3-(3-morpholin-4-ylpropoxy)benzoate

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate In acetonitrile for 4h; Heating;97.7%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

3-methoxy-4-hydroxybenzoic acid
121-34-6

3-methoxy-4-hydroxybenzoic acid

3-methoxy-4-(3-morpholinopropoxy)benzoic acid
196603-84-6

3-methoxy-4-(3-morpholinopropoxy)benzoic acid

Conditions
ConditionsYield
With sodium hydroxide; potassium iodide; potassium carbonate In hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide97%
With sodium hydroxide; potassium iodide; potassium carbonate In hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide97%
With sodium hydroxide; potassium iodide; potassium carbonate In hydrogenchloride; methanol; ethanol; N,N-dimethyl-formamide97%
Stage #1: 4-(3-chloropropyl)morpholine; 3-methoxy-4-hydroxybenzoic acid With potassium carbonate; potassium iodide In DMF (N,N-dimethyl-formamide) at 100℃; for 3h;
Stage #2: With sodium hydroxide In ethanol; water at 90℃; for 2h;
Stage #3: With hydrogenchloride In ethanol; water		97%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

ethyl 6-amino-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylate
1393835-74-9

ethyl 6-amino-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylate

ethyl 6-amino-3-(3-morpholinopropyl)-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylate
1400881-52-8

ethyl 6-amino-3-(3-morpholinopropyl)-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylate

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 70℃; for 3h;97%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

2,3-dihydroxy-11-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-12-methoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

2,3-dihydroxy-11-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-12-methoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

11-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-12-methoxy-2,3-bis(3-morpholinopropoxy)-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

11-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-12-methoxy-2,3-bis(3-morpholinopropoxy)-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetone for 23h; Inert atmosphere; Reflux;97%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

6-bromoquinazolin-4(3H)-one
32084-59-6

6-bromoquinazolin-4(3H)-one

6-bromo-3-(3-morpholinylpropyl)-4(3H)-quinazolinone
878743-68-1

6-bromo-3-(3-morpholinylpropyl)-4(3H)-quinazolinone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 12h;96%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;92.4%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;92%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

N-(3-(tert-butyl)phenyl)-5-hydroxyquinolin-2-amine

N-(3-(tert-butyl)phenyl)-5-hydroxyquinolin-2-amine

N-(3-(tert-butyl)phenyl)-5-(3-morpholinopropoxy)quinolin-2-amine

N-(3-(tert-butyl)phenyl)-5-(3-morpholinopropoxy)quinolin-2-amine

Conditions
ConditionsYield
Stage #1: N-(3-(tert-butyl)phenyl)-5-hydroxyquinolin-2-amine With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 4-(3-chloropropyl)morpholine With sodium iodide In N,N-dimethyl-formamide at 95℃;		95.8%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

tertiary butyl(2-formyl-4-hydroxy-5-methoxyphenyl)aminobenzoic acid ester

tertiary butyl(2-formyl-4-hydroxy-5-methoxyphenyl)aminobenzoic acid ester

tert-butyl(2-formyl-5-methoxy-4-(3-morpholino-propoxy)phenyl)carbamate

tert-butyl(2-formyl-5-methoxy-4-(3-morpholino-propoxy)phenyl)carbamate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 10h;95.21%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

tert-butyl 3-(6-acetoxy-7-methoxyquinazolin-4-yl)-5-chloro-6-fluoroindole-1-carboxylate
905953-16-4

tert-butyl 3-(6-acetoxy-7-methoxyquinazolin-4-yl)-5-chloro-6-fluoroindole-1-carboxylate

tert-butyl 5-chloro-6-fluoro-3-[7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]indole-1-carboxylate
905953-17-5

tert-butyl 5-chloro-6-fluoro-3-[7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]indole-1-carboxylate

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate In acetonitrile at 60℃; for 4h;95.1%
With 18-crown-6 ether; potassium carbonate In acetonitrile at 60℃; for 4h;
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

3-hydroxy-4-methoxybenzoate
6702-50-7

3-hydroxy-4-methoxybenzoate

4-methoxy-5-[3-(4-morpholinyl)propoxy]benzoic acid methyl ester
214472-17-0

4-methoxy-5-[3-(4-morpholinyl)propoxy]benzoic acid methyl ester

Conditions
ConditionsYield
With tri-n-butylammonium iodide; potassium carbonate In butanone Heating;95%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 6h;86%
With sodium carbonate In N,N-dimethyl-formamide at 85℃; for 10h;86%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In butanone for 20h; Heating / reflux;
With potassium carbonate; tetra-(n-butyl)ammonium iodide In butanone for 20h; Heating / reflux;
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

2-methoxy-4-nitrophenol
3251-56-7

2-methoxy-4-nitrophenol

3-methoxy-4-(3'-N-morpholino)propoxynitro-benzene
700804-28-0

3-methoxy-4-(3'-N-morpholino)propoxynitro-benzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 8h;95%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-piperidone hydrochloride
41979-39-9

4-piperidone hydrochloride

1-(3-morpholin-4-yl-propyl)-piperidin-4-one

1-(3-morpholin-4-yl-propyl)-piperidin-4-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 80℃; for 6h; Inert atmosphere;95%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-Iodophenol
540-38-5

4-Iodophenol

4-(3-(4-iodophenoxy)propyl)morpholine
331978-37-1

4-(3-(4-iodophenoxy)propyl)morpholine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 5h; Reflux;95%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-(2,4-dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one
956010-91-6

4-(2,4-dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

4-(2,4-Dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(3-morpholin-4-ylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
956011-10-2

4-(2,4-Dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(3-morpholin-4-ylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
Stage #1: 4-(2,4-dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;
Stage #2: 4-(3-chloropropyl)morpholine With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 20℃; for 20h;		94%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

2-nitro-4-methoxy-5-hydroxybenzonitrile

2-nitro-4-methoxy-5-hydroxybenzonitrile

2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile
675126-26-8

2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 85℃; for 4h;94%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

C9H6N2O3(2-)*2K(1+)

C9H6N2O3(2-)*2K(1+)

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 55 - 60℃; for 5h;93.7%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-(6-bromo-1H-benzo[d]imidazol-1-yl)phenol

4-(6-bromo-1H-benzo[d]imidazol-1-yl)phenol

4-(3-(4-(6-bromo-1H-benzo[d]imidazol-1-yl)phenoxy)propyl)morpholine

4-(3-(4-(6-bromo-1H-benzo[d]imidazol-1-yl)phenoxy)propyl)morpholine

Conditions
ConditionsYield
Stage #1: 4-(6-bromo-1H-benzo[d]imidazol-1-yl)phenol With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.166667h;
Stage #2: 4-(3-chloropropyl)morpholine In N,N-dimethyl-formamide at 60℃; for 12h;		92.1%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 3h; Reagent/catalyst; Temperature;92%
With tetrabutylammomium bromide; sodium carbonate; potassium iodide In iso-butanol Reflux;90%
In N,N-dimethyl-formamide at 80 - 90℃; Concentration;88%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

C30H24ClFN3O4Pol

C30H24ClFN3O4Pol

C37H37ClFN4O5Pol

C37H37ClFN4O5Pol

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide for 72h; not specified;92%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

2-hydroxy-3-methoxy-5-nitronaphthalene
24309-45-3

2-hydroxy-3-methoxy-5-nitronaphthalene

4-(3-((3-methoxy-5-nitronaphthalene-2-yl)oxy)propyl)morpholine

4-(3-((3-methoxy-5-nitronaphthalene-2-yl)oxy)propyl)morpholine

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 3h;92%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;92%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 3h;92%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

2-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one
1355994-25-0

2-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one

2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one
1448438-03-6

2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one

Conditions
ConditionsYield
Stage #1: 2-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one With 15-crown-5; sodium t-butanolate In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: 4-(3-chloropropyl)morpholine In tetrahydrofuran Reflux;		90%
Stage #1: 2-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one With 15-crown-5; sodium t-butanolate In tetrahydrofuran for 0.0833333h; Inert atmosphere;
Stage #2: 4-(3-chloropropyl)morpholine In tetrahydrofuran Inert atmosphere; Reflux;		15 g
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

7-hydroxy-6-methoxy-4-pentafluorophenoxyquinazoline
263400-70-0

7-hydroxy-6-methoxy-4-pentafluorophenoxyquinazoline

4-pentafluorophenoxy-6-methoxy-7-(3-morpholinopropoxy)quinazoline
263400-67-5

4-pentafluorophenoxy-6-methoxy-7-(3-morpholinopropoxy)quinazoline

Conditions
ConditionsYield
With potassium carbonate In N-methyl-acetamide89%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

10H-pyrido<3,4-b><1,4>benzothiazine
261-90-5

10H-pyrido<3,4-b><1,4>benzothiazine

10-(3-Morpholin-4-yl-propyl)-10H-9-thia-2,10-diaza-anthracene
115072-07-6

10-(3-Morpholin-4-yl-propyl)-10H-9-thia-2,10-diaza-anthracene

Conditions
ConditionsYield
With sodium hydride In 1,4-dioxane; toluene for 10h; Heating;88%

N-(3-Chloropropyl)morpholine Chemical Properties


IUPAC Name: 4-(3-Chloropropyl)morpholine
Molecular Formula: C7H14ClNO
Molecular Weight: 163.64 g/mol
SMILES: N1(CCCCl)CCOCC1
InChI: InChI=1/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
Product Categories: Aromatic Morpholines; Benzomorpholines & Benzothiomorpholines; Methyl Halides;Morpholines & Thiomorpholines; API intermediates; Heterocycles; Intermediates; Intermediates & Fine Chemicals; Pharmaceuticals; Benzomorpholines & Benzothiomorpholines; Methyl Halides; Morpholines & Thiomorpholines
Index of Refraction: 1.463 
Molar Refractivity: 42.42 cm3 
Molar Volume: 154 cm3 
Polarizability: 16.81×10-24 cm3 
Surface Tension: 32 dyne/cm 
Density: 1.062 g/cm3 
Flash Point: 91.2 °C 
Enthalpy of Vaporization: 46.37 kJ/mol 
Boiling Point: 227.1 °C at 760 mmHg 
Vapour Pressure of N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7): 0.0789 mmHg at 25 °C

N-(3-Chloropropyl)morpholine Uses

 N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7) is commonly used as gefitinib intermediate.

N-(3-Chloropropyl)morpholine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 104mg/kg (104mg/kg)   Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 33, Pg. 169, 1976.

N-(3-Chloropropyl)morpholine Safety Profile

Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements of N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7): 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

N-(3-Chloropropyl)morpholine Specification

 N-(3-Chloropropyl)morpholine (CAS NO.7357-67-7), its Synonyms are 1-Chloro-3-morpholinopropane ; 3-Morpholinopropyl chloride ; 4-(3-Chloropropyl)morpholine ; Morpholine, 4-(3-chloropropyl)- .

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