N-(Hydroxymethyl)acetamide supplier

Name
N-(HYDROXYMETHYL)ACETAMIDE
EINECS 210-897-2
CAS No. 625-51-4
Article Data26
CAS DataBase
Density 1.14
Solubility soluble
Melting Point 48-52 °C
Formula C3H7 N O2
Boiling Point 321.3 °C at 760 mmHg
Molecular Weight 89.0941
Flash Point 148.1 °C
Transport Information
Appearance white solid
Safety 22-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Acetamidomethanol;Formicin; Monomethylolacetamide; N-(Hydroxymethyl)acetamide;N-Methylolacetamide; N-Monomethylolacetamide
PSA 49.33000
LogP -0.53680

Synthetic route

: 60-35-5
acetamide

: 50-00-0
formaldehyd

: 625-51-4
N-(hydroxymethyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate
Versetzen mit 40prozentiger KOH;
With potassium carbonate

: 60-35-5
acetamide

: 50-00-0
formaldehyd

A: 3852-14-0
N,N-methylenediacetamide

B: 625-51-4
N-(hydroxymethyl)acetamide

Conditions

Conditions	Yield
In 1,4-dioxane; water at 40 - 60℃; Thermodynamic data; Kinetics; Mechanism; activation energy, pH 1.2-3.5;

...Expand

: 556-50-3
glycylglycine

A: 625-51-4
N-(hydroxymethyl)acetamide

B: {2-[(Acetylamino-methyl)-amino]-acetylamino}-acetic acid

Conditions

Conditions	Yield
In water Mechanism; Quantum yield; Irradiation; neutral solution;

: 556-50-3
glycylglycine

A: 60-35-5
acetamide

B: 3852-14-0
N,N-methylenediacetamide

C: 625-51-4
N-(hydroxymethyl)acetamide

D: 543-24-8
N-acetylglycine

Conditions

Conditions	Yield
In water Product distribution; Quantum yield; Mechanism; Irradiation; pH 6; var. dipeptides, other pH and times;

...Expand

: 32516-05-5
3,7-diacetyl-1,3,5,7-tetraaza-bicyclo[3.3.1]nonane

A: 50-00-0
formaldehyd

B: 625-51-4
N-(hydroxymethyl)acetamide

Conditions

Conditions	Yield
With hydrogenchloride In water at 25℃; for 0.333333h;	A 1.7 % Turnov. B n/a

: 60-35-5
acetamide

polyoxymethylene: polyoxymethylene

: 625-51-4
N-(hydroxymethyl)acetamide

Conditions

Conditions	Yield
at 120 - 150℃;

: 224633-83-4
6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-4-ium bromide

: 625-51-4
N-(hydroxymethyl)acetamide

: 103844-36-6
C18H19N3O

Conditions

Conditions	Yield
Stage #1: 6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-4-ium bromide; N-(hydroxymethyl)acetamide With sulfuric acid In acetic acid at 20℃; for 3.5h; Heating / reflux; Stage #2: With ammonia In water; acetic acid	97%

: 625-51-4
N-(hydroxymethyl)acetamide

: 177412-46-3
5,17-dibromo-25,27-bis(2-ethoxyethoxy)calix[4]arene

: 5,17-bis<(acetamido)methyl>-26,28-dihydroxy-25,27-bis(2-ethoxyethoxy)calix<4>arene

Conditions

Conditions	Yield
With trifluoroacetic acid In chloroform Ambient temperature;	95%

: 21407-29-4
2-mercapto-4,5-dimethoxybenzylamine hydrochloride

: 625-51-4
N-(hydroxymethyl)acetamide

: S-acetamidomethyl 4,5-dimethoxy-2-mercaptobenzylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride	94%

: 99-24-1
methyl galloate

: 625-51-4
N-(hydroxymethyl)acetamide

: C11H13NO6

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 35℃; for 96h; Friedel-Crafts Alkylation;	91.36%

: 625-51-4
N-(hydroxymethyl)acetamide

: 144449-11-6
6-benzylthio-2-phenethylimidazo<1,2-b>pyridazine

: 144449-35-4
3-acetamidomethyl-6-benzylthio-2-phenethylimidazo<1,2-b>pyridazine

Conditions

Conditions	Yield
With sulfuric acid In acetic acid Heating;	90%

: 625-51-4
N-(hydroxymethyl)acetamide

: 1844-53-7
2-phenyl-6-chloroimidazo<1,2-b>pyridazine

: 3-acetamidomethyl-6-chloro-2-phenylimidazo<1,2-b>pyridazine

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 14h; Heating;	90%

: 121-79-9
Propyl gallate

: 625-51-4
N-(hydroxymethyl)acetamide

: C13H17NO6

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 35℃; for 96h; Friedel-Crafts Alkylation;	89.68%

: 625-51-4
N-(hydroxymethyl)acetamide

: 143406-35-3
25,27-dihydroxy-26,28-dipropoxycalix[4]arene

: 5,17-bis<(acetamido)methyl>-26,28-dihydroxy-25,27-di(1-propoxy)calix<4>arene

Conditions

Conditions	Yield
With trifluoroacetic acid In chloroform Ambient temperature;	85%

: 625-51-4
N-(hydroxymethyl)acetamide

: 180900-96-3
6-(2-Methoxy-phenylsulfanyl)-2-phenyl-imidazo[1,2-b]pyridazine

: N-[6-(2-Methoxy-phenylsulfanyl)-2-phenyl-imidazo[1,2-b]pyridazin-3-ylmethyl]-acetamide

Conditions

Conditions	Yield
With sulfuric acid In acetic acid at 100℃; for 14h;	83%

: 625-51-4
N-(hydroxymethyl)acetamide

: 172472-58-1, 176299-00-6, 863555-70-8
5,17-dibromo-25,26,27,28-tetra-n-propylcalix[4]arene

: 11,23-bis<(acetamido)methyl>-5,17-dibromo-25,26,27,28-tetra(1-propoxy)calix<4>arene

Conditions

Conditions	Yield
With trifluoroacetic acid In chloroform for 36h; Ambient temperature;	83%

: 625-51-4
N-(hydroxymethyl)acetamide

: 141409-08-7
2-Benzo[1,3]dioxol-5-yl-6-chloro-imidazo[1,2-b]pyridazine

: 3-acetamidomethyl-6-chloro-2-(3',4'-methylenedioxyphenyl)imidazo<1,2-b>pyridazine

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 14h; Heating;	80%

: 625-51-4
N-(hydroxymethyl)acetamide

: 141409-27-0
2-(4'-methylphenyl)-6-phenylthioimidazo<1,2-b>pyridazine

: 3-acetamidomethyl-6-phenylthio-2-(4'-tolyl)imidazo<1,2-b>pyridazine

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 14h; Heating;	80%

: (4R)-1-{[6-(4-fluorophenoxy)pyridin-3-yl]methyl}-4-mercaptopyrrolidin-2-one dihydrochloride

: 625-51-4
N-(hydroxymethyl)acetamide

: N-((((3R)-1-((6-(4-fluorophenoxy)-3-pyridinyl)methyl)-5-oxo-3-pyrrolidinyl)thio)methyl)acetamide

Conditions

Conditions	Yield
With trifluoroacetic acid at 20℃; for 0.166667h;	79%

: 831-61-8
Ethyl gallate

: 625-51-4
N-(hydroxymethyl)acetamide

: C12H15NO6

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 35℃; for 96h; Friedel-Crafts Alkylation;	78.55%

: 79-42-5
2-mercaptopropanoic acid

: 625-51-4
N-(hydroxymethyl)acetamide

: 88568-98-3
(RS)-2-acetamidomethylthiopropionic acid

Conditions

Conditions	Yield
With trifluoroacetic acid for 0.75h; Ambient temperature;	78%

: 625-51-4
N-(hydroxymethyl)acetamide

: 180901-27-3
2-(4'-t-butylphenyl)-6-chloroimidazo<1,2-b>pyridazine

: N-[2-(4-tert-Butyl-phenyl)-6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl]-acetamide

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 14h; Heating;	74%

: 71310-21-9
11-mercaptounadecanoic acid

: 625-51-4
N-(hydroxymethyl)acetamide

: 11-(Acetylamino-methylsulfanyl)-undecanoic acid

Conditions

Conditions	Yield
In trifluoroacetic acid for 0.5h; Ambient temperature;	72%

: 52-67-5
3,3-dimethyl-D-cysteine

: 625-51-4
N-(hydroxymethyl)acetamide

: 111491-50-0
bis(S)(-5,5-dimethylthiazolidine-4-carboxylic acid)protium chloride hydrate

Conditions

Conditions	Yield
With hydrogenchloride In water for 0.5h; Ambient temperature;	70%

: 43180-45-6
2-amino-2-(1-mercaptocyclopentyl)acetic acid hydrochloride

: 625-51-4
N-(hydroxymethyl)acetamide

: 76-05-1
trifluoroacetic acid

: 1246849-65-9
C2HF3O2*C10H18N2O3S

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In water at 0 - 20℃;	70%

...Expand

: 625-51-4
N-(hydroxymethyl)acetamide

: 96228-29-4, 96228-30-7
tert-butyl 3,5-dihydroxy-6-mercapto-3-methylhexanoate

: 96228-35-2, 96228-36-3
6-<<(acetamidomethyl)thio>methyl>-4-hydroxy-4-methyl-3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions

Conditions	Yield
With formic acid for 2h; Ambient temperature;	69.2%

: 625-51-4
N-(hydroxymethyl)acetamide

: 122479-61-2
6-benzylthio-2-phenylimidazo<1,2-b>pyridazine

: 3-acetamidomethyl-6-benzylthio-2-phenylimidazo<1,2-b>pyridazine

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 14h; Heating;	66%

: 50-00-0
formaldehyd

: 99-99-0
1-methyl-4-nitrobenzene

: 625-51-4
N-(hydroxymethyl)acetamide

A: 86409-50-9
bis-(2-methyl-5-nitro-phenyl)-methane

B: 86392-53-2
N-(2-methyl-5-nitrobenzyl)acetamide

Conditions

Conditions	Yield
In sulfuric acid at 55℃; for 8h;	A n/a B 65%

...Expand

: 625-51-4
N-(hydroxymethyl)acetamide

: 141409-04-3
6-fluoro-2-phenylimidazo<1,2-b>pyridazine

: 3-acetamidomethyl-6-fluoro-2-phenylimidazo<1,2-b>pyridazine

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 14h; Heating;	65%

: 625-51-4
N-(hydroxymethyl)acetamide

: 507-09-5
thioacetic acid

: 256471-73-5
S-(acetylamino)methyl thioacetate

Conditions

Conditions	Yield
	64%

: 625-51-4
N-(hydroxymethyl)acetamide

: 10387-40-3
potassium thioacetate

: 256471-73-5
S-(acetylamino)methyl thioacetate

Conditions

Conditions	Yield
With potassium carbonate at 40℃; for 70h; Inert atmosphere;	64%

: 19685-09-7
(S)-10-hydroxycamptothecin

: 625-51-4
N-(hydroxymethyl)acetamide

: 1352172-57-6
C23H21N3O6

Conditions

Conditions	Yield
With sulfuric acid at 0 - 20℃; for 12h;	64%

: 625-51-4
N-(hydroxymethyl)acetamide

: 107-96-0
3-mercaptopropionic acid

: 52574-08-0
3-{[(acetylamino)methyl]sulfanyl}-propionic acid

Conditions

Conditions	Yield
In trifluoroacetic acid for 0.5h; Ambient temperature;	62%

: 625-51-4
N-(hydroxymethyl)acetamide

: 1844-56-0
6-chloro-2-(4'-chlorophenyl)imidazo<1,2-b>pyridazine

: N-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-acetamide

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 14h; Heating;	62%

: 625-51-4
N-(hydroxymethyl)acetamide

: 180900-93-0
2-(4-tert-Butyl-phenyl)-6-phenylsulfanyl-imidazo[1,2-b]pyridazine

: N-[2-(4-tert-Butyl-phenyl)-6-phenylsulfanyl-imidazo[1,2-b]pyridazin-3-ylmethyl]-acetamide

Conditions

Conditions	Yield
With sulfuric acid at 100℃; for 14h;	56%
With sulfuric acid In acetic acid for 14h; Heating;	56%

: C23H24ClNS

: 625-51-4
N-(hydroxymethyl)acetamide

: C7H15ClN2OS

Conditions

Conditions	Yield
Stage #1: C23H24ClNS With chlorotriisopropylsilane; trifluorormethanesulfonic acid; trifluoroacetic acid at 0℃; for 0.5h; Stage #2: N-(hydroxymethyl)acetamide at 0 - 20℃; for 2.5h;	55%

N-(Hydroxymethyl)acetamide Chemical Properties

The molecular formula of N-(Hydroxymethyl)acetamide(625-51-4) is C₃H₇NO₂ and its formula weight is 89.09.
The density of N-(Hydroxymethyl)acetamide(625-51-4) is 1.093 g/cm³ and it has a melting point of 48-52 °C. The boiling point is 321.3 °C at 760 mmHg. The refractive index is about 1.431. Its flash point is 148.1 °C.
The chemical synonyms of N-(Hydroxymethyl)acetamide(625-51-4) are ACETAMIDOMETHANOL;HYDROXYMETHYLACETAMIDE(N-);N-(HYDROXYMETHYL)ACETAMIDE;N-ACETYLMETHANOLAMINE;n-(hydroxymethyl)-acetamid;N-(Hydroxymethyl)acetamide,98+%;Hydroxymethylacetamide
The molecular structure of N-(Hydroxymethyl)acetamide(625-51-4):

N-(Hydroxymethyl)acetamide Safety Profile

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3

RTECS AC3610000

F 10

Product Name

N-(HYDROXYMETHYL)ACETAMIDE

Synthetic route

N-(Hydroxymethyl)acetamide Chemical Properties

N-(Hydroxymethyl)acetamide Safety Profile

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