N-Boc-L-lysine methyl ester hydrochloride supplier

Name
N-Boc-L-lysine methyl ester hydrochloride
EINECS
CAS No. 2389-48-2
Density g/cm³
Solubility
Melting Point 158-159 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
Formula C12H24 N2 O4 . Cl H
Boiling Point 364.6°Cat760mmHg
Molecular Weight 296.794
Flash Point 174.3°C
Transport Information
Appearance
Safety WGK Germany 3
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms L-Lysine,N6-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, monohydrochloride (9CI);Lysine, N6-carboxy-, N-tert-butyl methyl ester, monohydrochloride, L-(6CI,7CI,8CI); Methyl (2S)-2-amino-6-[(tert-butoxycarbonyl)amino]hexanoatehydrochloride; Ne-BOC-L-lysinemethyl ester hydrochloride; Ne-tert-Butoxycarbonyllysine methyl ester hydrochloride
PSA 90.65000
LogP 3.07490

Synthetic route

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 2937-50-0
Allyl chloroformate

: 140174-71-6
N-α-Alloc-N-ε-Boc-L-lysine methyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 16h;	100%

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 215161-79-8
N,N'-bis(N-(carboxymethyl))-N,N'-bis(N-(2-(4-fluorophenyl)ethyl)carboxamidomethyl)benzene-1,3-dicarboxamide

: C56H76F2N8O14

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 12h; Condensation;	99%

: 4285-42-1
N-phenyl-N-methylcarbamoyl chloride

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 1462366-90-0
methyl N6-(tert-butoxycarbonyl)-N2-(methyl(phenyl)carbamoyl)-L-lysinate

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 15h; Reflux;	99%
With dmap; triethylamine In 1,2-dimethoxyethane for 2h; Inert atmosphere; Reflux;	93%

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: Boc-Ser-Lys(Boc)-OMe

Conditions

Conditions	Yield
With C12H6B2Br4O3 In 1,2-dichloro-ethane at 90℃; for 24h; Molecular sieve; chemoselective reaction;	99%

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 57-10-3
1-hexadecylcarboxylic acid

: N6-(tert-butoxycarbonyl)-N2-hexadecanoyl-L-lysine methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 22h; Cooling with ice;	98%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 22h; Inert atmosphere;	57%

: 3006-58-4, 13030-01-8, 42890-10-8, 42973-23-9, 77059-32-6, 121785-09-9, 7474-40-0
2-carbobenzyloxyamino-2-deoxy-D-glucopyranose

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 315229-51-7
(S)-2-((2S,3R,4S,5R)-2-Benzyloxycarbonylamino-3,4,5,6-tetrahydroxy-hexylamino)-6-tert-butoxycarbonylamino-hexanoic acid methyl ester

Conditions

Conditions	Yield
With sodium cyanoborohydride In methanol for 8h; Condensation; reduction; Heating;	97%

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 171813-89-1
(2S)-2-acetamido-3-(4-allyloxyphenyl)propanoic acid

: methyl (2S,5S)-5-(4-allyloxybenzyl)-3,6-diaza-2-[4-(tert-butoxycarbonyl)aminobutyl]-4,7-dioxooctanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Sealed tube; Inert atmosphere;	94%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 14h; Inert atmosphere; Sealed tube;	94%

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 95494-51-2
4-(4-oxo-3,4-dihydro-quinazolin-2-yl)-butyric acid

: 1310488-10-8
methyl 6-(tert-butoxycarbonylamino)-2-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanamido)hexanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide	93%

: 79-33-4
L-Lactic acid

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: (S)-N-(L)-Lys(Boc)-OMe lactamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 48.5h;	93%

: 2483-46-7
Boc-Lys(Boc)-OH

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 1350811-87-8
(S)-methyl 2-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-6-((tert-butoxycarbonyl)amino)hexanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;	92%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Cooling with ice;	78.1%

: 1161-13-3
N-Cbz-L-Phe

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 42362-08-3
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-6-((tert-butoxycarbonyl)amino)hexanoate

Conditions

Conditions	Yield
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	91%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Inert atmosphere;	90%
Stage #1: N-Cbz-L-Phe With 4-methyl-morpholine In chloroform at -20℃; for 0.25h; Stage #2: With isobutyl chloroformate In chloroform at -20℃; for 0.166667h; Stage #3: N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride In chloroform for 0.166667h;	76%
With N-ethylmorpholine;; benzotriazol-1-ol; dicyclohexyl-carbodiimide 1a) DMF, 0 deg C, 1 h, 1b) r.t., 1 h, 2) DMF, r.t., pH 7, 3 d; Yield given. Multistep reaction;

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 79-11-8
chloroacetic acid

: 914468-19-2
6-tert-butoxycarbonylamino-2-(2-chloro-acetylamino)-hexanoic acid methyl ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 18h;	91%

: 2-((R)-2'-(3-methylbutoxy)-1,1'-binaphth-2-yloxy)acetic acid

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: methyl (S)-6-(1,1-dimethylethoxycarbonylamino)-2-((R)-2'-(3-methylbutoxy)-1,1'-binaphthyl-2-oxyacetamido)hexanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 3h;	91%

: 2018-66-8
Z-Leu-OH

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 37169-25-8
methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Inert atmosphere;	91%

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 112920-78-2
benzyl 2S-(6-tert-butoxycarbonylamino)-1-(methoxy-1-oxohexan-2S-ylcarbamoyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Inert atmosphere;	90%

: 2-((S)-2'-(3-methylbutoxy)-1,1'-binaphth-2-yloxy)acetic acid

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: methyl (S)-6-(1,1-dimethylethoxycarbonylamino)-2-((S)-2'-(3-methylbutoxy)-1,1'-binaphthyl-2-oxyacetamido)hexanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 3h;	89%

: 770-12-7
O-phenyl phosphorodichloridate

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: phenyl-(methoxy-N-Boc-L-lysinyl) phosphorochloridate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -78 - 20℃; for 1.5h;	89%

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 5368-37-6
3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid

: 1310488-09-5
methyl 6-(tert-butoxycarbonylamino)-2-(3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamido)hexanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide	87%

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 553-12-8
protoporphyrin IX

: dimethyl (2S,2'S)-2,2'-{[2,7,12,18-tetramethyl-3,8-divinylporphyrin-13,17-diyl]bis[(1-oxopropane-3,1-diyl)imino]}bis{6[(tert-butoxycarbonyl)amino]hexanoate}

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere; Darkness;	87%

: 611-95-0
4-carboxybenzophenone

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 1188371-91-6
(S)-6-tert-butoxycarbonyl-2-(4-benzoylbenzoylamino)hexanoic acid methyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	87%
With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	0.28 g

: (S)-2-acetamido-5-(tert-butoxy)-5-oxopentanoic acid

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: methyl (2S,5S)-3,6-diaza-2-[4-(tert-butoxycarbonyl)aminobutyl]-5-[2-(tert-butoxycarbonyl)ethyl]-4,7-dioxooctanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; Sealed tube;	87%

N-Boc-L-lysine methyl ester hydrochloride Chemical Properties

Molecular Formula: C₁₂H₂₅ClN₂O₄

Formula Weight: 296.79
Synonyms: H-LYS(BOC)-OME HCL;H-LYS(BOC)-OME HYDROCHLORIDE; N-EPSILON-BOC-L-LYSINE METHYL ESTER HYDROCHLORIDE; N-epsilon-t-Butyloxycarbonyl-L-lysine methyl ester hydrochloride; N-EPSILON-T-BOC-L-LYSINE METHYL ESTER HYDROCHLORIDE
Melting Point of H-Lys(Boc)-OMe·HCl (2389-48-2): 155-165^°C
Flash Point of H-Lys(Boc)-OMe·HCl (2389-48-2): 174.3^°C
Boiling Point: 364.6^°C at 760 mmHg
Vapour Pressure: 1.67E-05 mmHg at 25^°C
storage temp. : 2-8^°C
Appearance: H-Lys(Boc)-OMe·HCl (2389-48-2) is a white powder

Product Name

N-Boc-L-lysine methyl ester hydrochloride

Synthetic route

N-Boc-L-lysine methyl ester hydrochloride Chemical Properties

N-Boc-L-lysine methyl ester hydrochloride Safety Profile

N-Boc-L-lysine methyl ester hydrochloride Standards and Recommendations

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