Product Name

  • Name

    Naproxen sodium

  • EINECS 247-486-2
  • CAS No. 26159-34-2
  • Article Data7
  • CAS DataBase
  • Density ==
  • Solubility Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
  • Melting Point 250-251 °C
  • Formula C14H13O3.Na
  • Boiling Point 403.9 °C at 760 mmHg
  • Molecular Weight 252.245
  • Flash Point 154.5 °C
  • Transport Information
  • Appearance white powder
  • Safety 53-45
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 26159-34-2 (Naproxen sodium)
  • Hazard Symbols HarmfulXn
  • Synonyms 2-Naphthaleneaceticacid, 6-methoxy-a-methyl-, sodiumsalt, (S)-;2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, L-(-)- (8CI);(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt;Aflaxen;Agilxen;Aleve;Anaprox;Anaprox DS;Apranax;Apraxin;Dafloxen;Duk-F;Flanax;Flanax Forte;Gynestrel;Lefaine;Licorax;Miranax;Naprelan;Naprogesic;
  • PSA 49.36000
  • LogP 1.70180

Synthetic route

racemic 2-(6-methoxy-2-naphthyl)propionic acid

racemic 2-(6-methoxy-2-naphthyl)propionic acid

naproxen
23981-80-8

naproxen

Naprelan
26159-34-2

Naprelan

Conditions
ConditionsYield
With sodium hydroxide In water; toluene
naproxen
23981-80-8

naproxen

Naprelan
26159-34-2

Naprelan

Conditions
ConditionsYield
With sodium hydroxide In toluene
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

Naprelan
26159-34-2

Naprelan

Conditions
ConditionsYield
In methanol
With sodium hydroxide In methanol
With sodium hydroxide In methanol at 55℃; Industry scale;
With sodium hydroxide In water Schlenk technique; Inert atmosphere;
C14H13O3(1-)*C56H98O35*Na(1+)

C14H13O3(1-)*C56H98O35*Na(1+)

A

heptakis(2,6-di-O-methyl)cyclomaltoheptaose
51166-71-3

heptakis(2,6-di-O-methyl)cyclomaltoheptaose

B

Naprelan
26159-34-2

Naprelan

Conditions
ConditionsYield
With pluronic copolymer F127 In water at 25℃; Equilibrium constant; Reagent/catalyst;
Naprelan
26159-34-2

Naprelan

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃;98%
With hydrogenchloride In water pH=< 2; Inert atmosphere;94.3%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Naprelan
26159-34-2

Naprelan

[Ru(η6-p-cymene)(naproxenate)Cl]

[Ru(η6-p-cymene)(naproxenate)Cl]

Conditions
ConditionsYield
In methanol at 20℃; for 1h; Schlenk technique; Inert atmosphere;87%
In methanol at 20℃; for 4h;78%
cis-dichlorobis(2,2′-bipyridine)ruthenium(II)
345911-20-8, 19542-80-4, 158060-65-2, 34795-02-3, 15746-57-3

cis-dichlorobis(2,2′-bipyridine)ruthenium(II)

ammonium hexafluorophosphate

ammonium hexafluorophosphate

Naprelan
26159-34-2

Naprelan

[Ru(2,2'-bipyridine)2(naproxen)][hexafluorophosphate]

[Ru(2,2'-bipyridine)2(naproxen)][hexafluorophosphate]

Conditions
ConditionsYield
Stage #1: Naprelan With triethylamine In ethanol at 24.84℃;
Stage #2: cis-dichlorobis(2,2′-bipyridine)ruthenium(II) In ethanol for 8h; Reflux;
Stage #3: ammonium hexafluorophosphate In ethanol		66%
...Expand
[Ru(1,10-phenanthroline)2Cl2]

[Ru(1,10-phenanthroline)2Cl2]

ammonium hexafluorophosphate

ammonium hexafluorophosphate

Naprelan
26159-34-2

Naprelan

[Ru(1,10-phenanthroline)2(naproxen)][hexafluorophosphate]

[Ru(1,10-phenanthroline)2(naproxen)][hexafluorophosphate]

Conditions
ConditionsYield
Stage #1: Naprelan With triethylamine In ethanol at 24.84℃;
Stage #2: [Ru(1,10-phenanthroline)2Cl2] In ethanol for 8h; Reflux;
Stage #3: ammonium hexafluorophosphate In ethanol		61%
...Expand
didecyldimethylammonium chloride
7173-51-5

didecyldimethylammonium chloride

Naprelan
26159-34-2

Naprelan

didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate
934544-44-2

didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate

Conditions
ConditionsYield
In water at 20℃; for 1h;95%
Naprelan
26159-34-2

Naprelan

zinc(II) chloride
7646-85-7

zinc(II) chloride

[Zn2(nap)4]

[Zn2(nap)4]

Conditions
ConditionsYield
In water at 20℃;86%
Naprelan
26159-34-2

Naprelan

C28H30CaO8

C28H30CaO8

Conditions
ConditionsYield
With water; calcium chloride at 20℃;76%
Naprelan
26159-34-2

Naprelan

2-bromoethanol
540-51-2

2-bromoethanol

2-Hydroxyethyl 2-(6-methoxy-2-naphthyl)propionat
87426-50-4

2-Hydroxyethyl 2-(6-methoxy-2-naphthyl)propionat

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 60 - 80℃; for 3.5h;84%
1,4-butanediol dinitrate
3457-91-8

1,4-butanediol dinitrate

Naprelan
26159-34-2

Naprelan

naproxcinod
163133-43-5

naproxcinod

Conditions
ConditionsYield
In dimethyl sulfoxide for 120h;75%
1,3-dibromo-propane
109-64-8

1,3-dibromo-propane

Naprelan
26159-34-2

Naprelan

3-bromopropyl (2S)-2-(6-methoxy-2-naphthyl)propanoate
639857-84-4

3-bromopropyl (2S)-2-(6-methoxy-2-naphthyl)propanoate

Conditions
ConditionsYield
In DMF (N,N-dimethyl-formamide) at 20℃; for 24h;
3-Bromophthalide
6940-49-4

3-Bromophthalide

Naprelan
26159-34-2

Naprelan

phthalidyl d-2-(6-methoxy-2-naphthyl)propionate

phthalidyl d-2-(6-methoxy-2-naphthyl)propionate

Conditions
ConditionsYield
With sodium carbonate In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
curcumin
458-37-7

curcumin

Naprelan
26159-34-2

Naprelan

C21H20O6*C14H13O3(1-)*Na(1+)

C21H20O6*C14H13O3(1-)*Na(1+)

Conditions
ConditionsYield
In acetone at 20℃; for 24h;
Naprelan
26159-34-2

Naprelan

[2-(2,6-dichloroanilino)phenyl]acetic acid
15307-86-5

[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;82.2%
zirconium phosphate chloride dimethyl sulfoxide
191654-67-8

zirconium phosphate chloride dimethyl sulfoxide

water
7732-18-5

water

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

Naprelan
26159-34-2

Naprelan

Zr(4+)*O4P(3-)*C2H6OS*0.35HO(1-)*0.65C14H13O3(1-)

Zr(4+)*O4P(3-)*C2H6OS*0.35HO(1-)*0.65C14H13O3(1-)

Conditions
ConditionsYield
In dimethyl sulfoxide at 75℃; for 72h;0.34 g
...Expand
Naprelan
26159-34-2

Naprelan

(+)-6-O-Demethylnaproxen
52079-10-4

(+)-6-O-Demethylnaproxen

Conditions
ConditionsYield
With glucose dehydrogenase; D-glucose; cytochrome P450BM3 R47L/Y51F/A191T/N239H/I259V/A276T/P329V/A330P/L353I mutant; β-nicotinamide adenine dinucleotide phosphate sodium salt In methanol; aq. phosphate buffer at 25℃; for 2h; pH=7.5; Enzymatic reaction;57%
(+/-)-ketamine hydrochloride
1867-66-9

(+/-)-ketamine hydrochloride

Naprelan
26159-34-2

Naprelan

rac-ketamine naproxenate

rac-ketamine naproxenate

Conditions
ConditionsYield
In water for 1h;
morphine sulfate
64-31-3

morphine sulfate

Naprelan
26159-34-2

Naprelan

5R,6S,9R,13S,14R-morphine naproxenate

5R,6S,9R,13S,14R-morphine naproxenate

Conditions
ConditionsYield
In water for 1h;
codeine sulphate
29485-83-4

codeine sulphate

Naprelan
26159-34-2

Naprelan

5R,6S,9R,13S,14R-codeine naproxenate

5R,6S,9R,13S,14R-codeine naproxenate

Conditions
ConditionsYield
In water for 1h;
propoxyphene hydrochloride
1639-60-7

propoxyphene hydrochloride

Naprelan
26159-34-2

Naprelan

d-propoxyphene (S)-naproxenate

d-propoxyphene (S)-naproxenate

Conditions
ConditionsYield
In water for 1h;
(-)-Ketamine hydrochloride
33643-47-9

(-)-Ketamine hydrochloride

Naprelan
26159-34-2

Naprelan

(S)-ketamine naproxenate

(S)-ketamine naproxenate

Conditions
ConditionsYield
In water for 1h;
Naprelan
26159-34-2

Naprelan

levorphanol tartrate
125-72-4

levorphanol tartrate

levorphanol naproxenate

levorphanol naproxenate

Conditions
ConditionsYield
In water for 1h;
5R,9R,13S,14R-hydrocodone bitartrate

5R,9R,13S,14R-hydrocodone bitartrate

Naprelan
26159-34-2

Naprelan

5R,9R,13S,14R-hydrocodone naproxenate

5R,9R,13S,14R-hydrocodone naproxenate

Conditions
ConditionsYield
In water for 1h;
methadone hydrochloride
1095-90-5

methadone hydrochloride

Naprelan
26159-34-2

Naprelan

rac-methadone naproxenate

rac-methadone naproxenate

Conditions
ConditionsYield
In water for 1h;
oxycodone hydrochloride
124-90-3

oxycodone hydrochloride

Naprelan
26159-34-2

Naprelan

5R,9R,13R,14S-oxycodone naproxenate

5R,9R,13R,14S-oxycodone naproxenate

Conditions
ConditionsYield
In water for 1h;

Naproxen sodium Specification

The Naproxen sodium, with the CAS registry number 26159-34-2, is also known as 2-Naphthaleneacetic acid,6-methoxy-alpha-methyl-,sodium salt,(S)-. It belongs to the product categories of Essential Chemicals;Reagent Grade;Routine Reagents.Its EINECS number is 247-486-2. This chemical's molecular formula is C14H13NaO3 and molecular weight is 252.24.What's more,Its systematic name is Sodium (-)-2-(6-methoxy-2-naphthyl)propionate.It is an anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Physical properties about Midazolam are:
(1)ACD/LogP:  2.998; (2)# of Rule of 5 Violations:  0; (3)#H bond acceptors:  3; (4)#H bond donors:  1; (5)#Freely Rotating Bonds:  3; (6)Flash Point:  154.5 °C; (7)Enthalpy of Vaporization:  69.1 kJ/mol; (8)Boiling Point:  403.9 °C at 760 mmHg; (9)Vapour Pressure:  3.01E-07 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].[O-]C(=O)[C@H](c1ccc2c(c1)ccc(OC)c2)C;
(2)Std. InChI:InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1;
(3)Std. InChIKey:CDBRNDSHEYLDJV-FVGYRXGTSA-M.

The toxicity data of Midazolam as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 600mg/kg/30D- (600mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS		 American Journal of Diseases of Children. Vol. 142, Pg. 524, 1988.

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