Orotic acid supplier | CasNO.65-86-1

Name
Orotic acid
EINECS 200-619-8
CAS No. 65-86-1
Article Data66
CAS DataBase
Density 1.642 g/cm³
Solubility slightly soluble in water, very slightly soluble in alcohol and organic solvents, insoluble in ether
Melting Point 345-346 °C
Formula C₅H₄N₂O₄
Boiling Point 656.9 °C at 760 mmHg
Molecular Weight 156.098
Flash Point 351.1 °C
Transport Information
Appearance white crystalline powder
Safety 26-36/37/39-22
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Orotic acid(8CI);1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid;2,4-Dihydroxypyrimidine-6-carboxylic acid;2,6-Dihydroxy-4-pyrimidinecarboxylicacid;2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid;6-Carboxyuracil;6-Uracilcarboxylic acid;Animal galactose factor;NSC 79560;NSC 9791;Orodin;Orotonin;Oroturic;Orotyl;Vitamin B13;Whey factor;
PSA 103.02000
LogP -1.23860

Synthetic route

: 626-48-2
6-Methyluracil

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); oxygen; cobalt(II) acetate; acetic acid at 80℃; for 15h;	92%
With potassium hydroxide; potassium hexacyanoferrate(III)

: 461-72-3
2,4-imidazolidinedione

: 298-12-4
Glyoxilic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 115 - 120℃; for 2h; Temperature; Large scale;	91.9%

: 153816-00-3
(2Z)-(2,5-dioxoimidazolidin-4-ylidene)acetic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With potassium hydroxide at 64℃; for 3h;	85%
With potassium hydroxide at 64℃; for 3h; Mechanism; Kinetics; var. conc. of KOH;	85%

: C5H6N2O4

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With oxygen; palladium dichloride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 36h; Reagent/catalyst; Solvent; Pressure; Temperature;	85%

: 496-46-8
glycoluril

: 131543-46-9
Glyoxal

: 65-86-1
orotic acid

Conditions

Conditions	Yield
Stage #1: glycoluril; Glyoxal With sodium hydroxide In water for 8h; Autoclave; Reflux; Large scale; Stage #2: With chlorine at 20℃; Time; Large scale;	33%

: 36327-91-0
orotoaldehyde

A: 22126-44-9
6-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

B: 65-86-1
orotic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 36327-91-0
orotoaldehyde

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With sodium dichromate; sulfuric acid

: 16953-46-1
6-oxo-2-thioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbaldehyde

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With sodium dichromate; sulfuric acid
Multi-step reaction with 2 steps 1: aqueous KOH 2: aqueous alkali .H2O2 View Scheme

: 6953-78-2
2-thioorotic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With alkali .H2O2

: 4628-39-1
6-carboxymethyluracil

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With potassium hydroxide; potassium hexacyanoferrate(III) 22 d;

: 6314-14-3
2-(methylthio)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 16953-48-3
6-diethoxymethyl-1H-pyrimidine-2,4-dione

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With sodium dichromate; sulfuric acid
Multi-step reaction with 2 steps 1: Hydrolysis 2: Na2Cr2O7/H2SO4 View Scheme

: 16953-49-4
6-diethoxymethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With sodium dichromate; sulfuric acid
Multi-step reaction with 3 steps 1: aqueous H2O2; aqueous NaOH 2: Hydrolysis 3: Na2Cr2O7/H2SO4 View Scheme
Multi-step reaction with 2 steps 1: aqueous H2O2; aqueous NaOH 2: Na2Cr2O7/H2SO4 View Scheme

: 58668-24-9
(2,5-dioxo-imidazolidin-4-yliden)-acetic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 119767-58-7
2,6-Dioxo-3,6-dihydro-2H-[1,3]oxazine-4-carboxylic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With ammonia In various solvent(s)

: 80140-18-7
methyl N1,N3-dibenzyloxymethyl-orotate

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With trimethylsilyl iodide; water 1.) chloroform, reflux, 6 h, 2.) reflux, 30 min; 160-180 deg C, 15 min; reflux; Yield given. Multistep reaction;

: 66-22-8
uracil

A: 65-86-1
orotic acid

B: 489-36-1
isoorotidine

Conditions

Conditions	Yield
at 37℃; for 72h; Product distribution; strain 556F from Bacillus subtilis, pH 7.2; effect of different amounts of uracil, other mutants of Bacillus subtilis;

: 5988-19-2
L-dihydroorotic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With dihydroorotate dehydrogenase; bis(1-chloro-2-propyl) ether; All-Trans Coenzyme Q6; Triton X-100 In water at 37℃; pH=7.8;
With dihydroorotate dehydrogenase In phosphate buffer at 22℃; pH=7; Enzyme kinetics; Further Variations:; also in the presence of detergent;
With human dihydroorotate dehydrogenase; 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone Enzyme kinetics;
With 2,3-Dimethoxy-5-methyl-1,4-benzoquinone; 2,6-Dichlorophenolindophenol; glycerol; sodium chloride; Triton X-100 In water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid Microbiological reaction; Enzymatic reaction;
With decylubiquinone; pfDHODH at 25℃; Enzyme kinetics; buffer C;

4.5-dichloro-2.6-dioxo-hexahydropyrimidine-carboxylic acid-(4): 4.5-dichloro-2.6-dioxo-hexahydropyrimidine-carboxylic acid-(4)

: 65-86-1
orotic acid

: 58668-24-9
(2,5-dioxo-imidazolidin-4-yliden)-acetic acid

aqueous KOH: aqueous KOH

: 65-86-1
orotic acid

uracil-carboxylic acid-(4)-amide: uracil-carboxylic acid-(4)-amide

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With potassium hydroxide

uracil-carboxylic acid-(4)-ethyl ester: uracil-carboxylic acid-(4)-ethyl ester

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With potassium hydroxide

dialuryldiazoacetic acid ethyl ester: dialuryldiazoacetic acid ethyl ester

A: 65-86-1
orotic acid

B 5-ethoxycarbonylmethylene-hydantoin: 5-ethoxycarbonylmethylene-hydantoin

Conditions

Conditions	Yield
With sodium hydroxide

: 923-37-5, 173298-46-9
ureidosuccinic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 77 percent / 20percent aq. HCl 2: 71 percent / Br2 / acetic acid / 4 h / 100 °C 3: 85 percent / aq. KOH / 3 h / 64 °C / var. conc. of KOH View Scheme

: 5427-26-9
5-hydantoinacetic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 71 percent / Br2 / acetic acid / 4 h / 100 °C 2: 85 percent / aq. KOH / 3 h / 64 °C / var. conc. of KOH View Scheme
Multi-step reaction with 2 steps 1: bromine; acetic acid / Beim Erhitzen des Reaktionsprodukts mit H2O 2: aqueous KOH View Scheme

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 7164-43-4
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
	1.1 g (73%)

: 5962-07-2
cyanomethylurea

: 298-12-4
Glyoxilic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water
With sodium hydroxide for 2h; Reflux; Large scale;

: 2149-82-8
orotidine 5'-monophosphate

A: 65-86-1
orotic acid

B: 97-55-2, 7540-64-9, 99945-37-6, 130384-52-0
5-phosphoribosyl-1-pyrophosphate

Conditions

Conditions	Yield
With Salmonella typhimurium OMP synthase wild type; magnesium chloride at 30℃; pH=8; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction;

: 155-54-4
4,5-dihydroorotic acid

: 65-86-1
orotic acid

Conditions

Conditions	Yield
With dihydroorotate dehydrogenase Enzymatic reaction;
With dihydroorotate dehydrogenase; coenzyme Q0 pH=8; Enzymatic reaction;

: 75-77-4
chloro-trimethyl-silane

: 65-86-1
orotic acid

: 32865-94-4
2,6-Bis-trimethylsilanyloxy-pyrimidine-4-carboxylic acid

Conditions

Conditions	Yield
With 1,1,1,3,3,3-hexamethyl-disilazane Ambient temperature;	99%

: 65-86-1
orotic acid

: 486460-32-6
sitagliptin

: 1246343-77-0
sitagliptin orotate

Conditions

Conditions	Yield
In acetonitrile at 25 - 75℃; Product distribution / selectivity;	99%
In water at 35 - 37℃; for 0.166667h;

: 65-86-1
orotic acid

: acetyl 2,3-O-isopropylidene-α,β-ribofuranose

: 1'-O-acetyl-2',3'-O-isopropylidene-5'-O-orotyl-D-ribofuranoside

Conditions

Conditions	Yield
Stage #1: orotic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 16h; Stage #2: acetyl 2,3-O-isopropylidene-α,β-ribofuranose With pyridine hydrochloride In acetonitrile at 20℃;	98%

: 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine

: 65-86-1
orotic acid

: 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine orotate

Conditions

Conditions	Yield
In acetone for 0.5h; Solvent; Reflux;	98%

: 1293923-09-7
4-[ethyl(dimethyl)ammonio]butanoate

: 65-86-1
orotic acid

: 1404369-24-9
3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate

Conditions

Conditions	Yield
In isopropyl alcohol	97.4%

: 65-86-1
orotic acid

: tenofovir disoproxil

: 9-[2-[(R)[[bis[[isopropoxycarbonyl]oxy]methoxy]phosphinyl]methoxy]propyl]adenine orotate

Conditions

Conditions	Yield
With triethylamine In water; dimethyl sulfoxide at 20 - 30℃; Temperature; Solvent; Reagent/catalyst;	97%
In methanol; water at 20 - 70℃; Solvent;	85%

: 65-86-1
orotic acid

: 541-15-1
L-carnitine

: L-carnitine oroate

Conditions

Conditions	Yield
In water; acetone for 5h; Solvent; Reflux;	96%

: edoxaban

: 65-86-1
orotic acid

: N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide orotinate

Conditions

Conditions	Yield
In acetonitrile at 60℃; for 5h;	96%
In ethanol at 65℃;	5.5 g

: 186581-53-3, 908094-01-9
diazomethane

: 65-86-1
orotic acid

: 4116-39-6
1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-6-carbonsaeuremethylester

Conditions

Conditions	Yield
In methanol; diethyl ether at 0℃;	95%
In methanol Ambient temperature;	93%

: 558447-26-0
AMD070

: 65-86-1
orotic acid

: 880549-28-0
(S)-(N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl))-1,4-butanediamine orotate

Conditions

Conditions	Yield
In methanol; water at 20℃; for 1h;	95%

: 65-86-1
orotic acid

: 17687-24-0
5-nitroorotic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 15 - 48℃; for 6h; Temperature; Cooling with ice;	95%
With sulfuric acid; nitric acid In water at 50 - 55℃; for 3h;	90%
Stage #1: orotic acid With sodium hydroxide In water for 3h; Stage #2: With sulfuric acid; nitric acid In water at 25 - 45℃; Inert atmosphere;	88.6%
With sulfuric acid; nitric acid In water at 50 - 55℃;

: 65-86-1
orotic acid

: 37832-55-6
5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid

Conditions

Conditions	Yield
With hydrazine hydrate In water at 90℃; for 5h; Temperature;	95%

: 1-O-benzoyl-2,3-O-isopropylidene-D-ribofuranoside

: 65-86-1
orotic acid

: 1'-O-benzoyl-2',3'-O-isopropylidene-5'-O-orotyl-D-ribofuranoside

Conditions

Conditions	Yield
Stage #1: orotic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 16h; Stage #2: 1-O-benzoyl-2,3-O-isopropylidene-D-ribofuranoside With pyridine hydrochloride In acetonitrile at 20℃; for 4h;	94%

: 67-56-1
methanol

: 65-86-1
orotic acid

: 6153-44-2
methyl orotate

Conditions

Conditions	Yield
With thionyl chloride at 0 - 5℃; for 6h; Reflux;	92.9%
With hydrogenchloride for 24h; Fischer esterification; Heating;	91%
With hydrogenchloride	90%

: 65-86-1
orotic acid

: 36313-98-1
α-chloroorotic acid

Conditions

Conditions	Yield
Stage #1: orotic acid With iron(III) chloride; acetic anhydride; acetic acid at 90 - 95℃; Stage #2: With sulfuryl dichloride Reagent/catalyst; Temperature; Reflux;	92%
With hydrogenchloride; dihydrogen peroxide

: 252870-53-4
(2S,4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine

: 65-86-1
orotic acid

: orotic acid salt of (2S)-(4E)-N-methyl-5-[5-isopropoxypyridin-3-yl]-4-penten-2-amine

Conditions

Conditions	Yield
In ethanol Heating / reflux;	91.4%

: 1-O-pivaloyl-2,3-O-isopropylidene-D-ribofuranoside

: 65-86-1
orotic acid

: 1'-O-pivaloyl-2',3'-O-isopropylidene-5'-O-orotyl-D-ribofuranoside

Conditions

Conditions	Yield
Stage #1: orotic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 16h; Stage #2: 1-O-pivaloyl-2,3-O-isopropylidene-D-ribofuranoside With pyridine hydrochloride In acetonitrile at 20℃;	90%

: 342373-13-1
N-hydroxy-2-(4-(4-phenylbutyl)phenyl)acetamide

: 65-86-1
orotic acid

: N-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	90%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide	90%

: 65-86-1
orotic acid

: 56-35-9
bis(tri-n-butyltin)oxide

: C34H62N4O9Sn2

Conditions

Conditions	Yield
In toluene for 6h; Reflux; Inert atmosphere; Dean-Stark;	90%

: ammonium hexafluorophosphate

: bis(2,2'-bipyridine)dichlororuthenium(II) dihydrate

: 65-86-1
orotic acid

: bis(2,2’-bipyridine) orotate ruthenium(II)

Conditions

Conditions	Yield
Stage #1: bis(2,2'-bipyridine)dichlororuthenium(II) dihydrate; orotic acid In ethanol at 125℃; for 2h; Sealed tube; Microwave irradiation; Stage #2: ammonium hexafluorophosphate In ethanol; water at 20℃;	89%

...Expand

: 65-86-1
orotic acid

: 75-03-6
ethyl iodide

: 1747-53-1
ethyl orotate

Conditions

Conditions	Yield
Stage #1: orotic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; N,N-dimethyl-formamide for 0.0833333h; Stage #2: ethyl iodide In water; N,N-dimethyl-formamide at 60℃; for 5h;	88%
Stage #1: orotic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 0.0833333h; Stage #2: ethyl iodide In N,N-dimethyl-formamide at 60℃; for 5h;	88%

: 10-ethoxy-6-(methoxymethyl)-8-(morpholinomethyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-5(6H)-one

: 65-86-1
orotic acid

: 10-ethoxy-8-(morpholinomethyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-5(6H)-one 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid

Conditions

Conditions	Yield
In ethanol at 90℃; for 3h;	88%

: 65-86-1
orotic acid

: 27532-96-3
glycine tert-butyl ester hydrochloride

: Ort-Gly-O-t-Bu

Conditions

Conditions	Yield
With 4-methyl-morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In N,N-dimethyl-formamide at 50 - 55℃;	87%

: 67814-68-0, 70266-87-4, 76249-50-8, 76249-51-9, 93451-15-1, 4099-88-1
2,3-O-isopropylidene-D-ribofuranose

: 65-86-1
orotic acid

: 1',5'-O-diorotyl-2',3'-O-isopropylidene-D-ribofuranoside

Conditions

Conditions	Yield
With pyridine hydrochloride; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃;	87%

: 65-86-1
orotic acid

: 93413-62-8
O-desmethylvenlafaxine

: 1174652-08-4
O-desmethyl-venlafaxine orotate

Conditions

Conditions	Yield
In diethyl ether; ethanol at 0 - 20℃; Reflux;	85.4%

: 65-86-1
orotic acid

: 6491-83-4, 63889-48-5, 66190-38-3
((S)-2-amino-4-methylpentanoyl)-L-leucine methyl ester hydrochloride

: 74019-79-7
orotyl-L-leucyl-L-leucine methyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In N,N-dimethyl-formamide at 50 - 55℃;	85%

: 617-89-0
furan-2-ylmethanamine

: 65-86-1
orotic acid

: 302603-04-9
N-(furan-2-ylmethyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxamide

Conditions

Conditions	Yield
for 0.166667h; microwave irradiation;	85%

Orotic acid Consensus Reports

Reported in EPA TSCA Inventory.

Orotic acid Specification

The Orotic acid, with the CAS registry number 65-86-1, is also known as 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidecarboxylic acid. It belongs to the product category of Vitamin Ingredients. Its EINECS number is 200-619-8. This chemical's molecular formula is C₅H₄N₂O₄ and molecular weight is 156.10. What's more, its systematic name is 2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid. Its classification codes are: (1)Drug / Therapeutic Agent; (2)Mutation data. This chemical should be sealed and stored in a cool and dry place. Moreover, it should be protected from moisture and mildew. It is a heterocyclic compound and an acid. Historically it was believed to be part of the Vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin. The compound is manufactured in the body by intestinal flora. It is sometimes used as a mineral carrier in some dietary supplements (to increase their bioavailability), most commonly for lithium orotate. This chemical is used in biochemical research, especially the biosynthesis of nucleic acids.

Physical properties of Orotic acid are: (1)ACD/LogP: -0.84; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.64; (4)ACD/LogD (pH 7.4): -4.56; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 6; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 95.5 Å²; (13)Index of Refraction: 1.568; (14)Molar Refractivity: 31.111 cm³; (15)Molar Volume: 95.051 cm³; (16)Polarizability: 12.333×10^-24cm³; (17)Surface Tension: 68.58 dyne/cm; (18)Density: 1.642 g/cm³; (19)Flash Point: 351.1 °C; (20)Enthalpy of Vaporization: 101.63 kJ/mol; (21)Boiling Point: 656.9 °C at 760 mmHg; (22)Vapour Pressure: 3.76E-18 mmHg at 25°C.

Preparation: this chemical can be prepared by (2,5-dioxo-imidazolidin-4-ylidene)-acetic acid at the temperature of 64 °C. This reaction will need reagent 1 M aq. KOH with the reaction time of 3 hours. The yield is about 85%.

Orotic acid can be prepared by (2,5-dioxo-imidazolidin-4-ylidene)-acetic acid at the temperature of 64 °C

Uses of Orotic acid: it can be used to produce orotic acid N-hydroxysuccinimide ester at the ambient temperature. It will need reagent dicyclohexylcarbodiimide and solvent dimethylsulfoxide. The yield is about 76%.

Orotic acid can be used to produce orotic acid N-hydroxysuccinimide ester at the ambient temperature

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. It is harmful if swallowed. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You should not breathe dust. When using it, you need to wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)\C1=C\C(=O)NC(=O)N1
(2)Std. InChI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
(3)Std. InChIKey: PXQPEWDEAKTCGB-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	841mg/kg (841mg/kg)	Drugs in Japan Vol. 6, Pg. 165, 1982.
mouse	LD50	intravenous	770mg/kg (770mg/kg)	Drugs in Japan Vol. 6, Pg. 165, 1982.
mouse	LD50	oral	2gm/kg (2000mg/kg)	Drugs in Japan Vol. 6, Pg. 165, 1982.

Product Name

Orotic acid

Synthetic route

Orotic acid Consensus Reports

Orotic acid Specification

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