Penicillin V supplier | CasNO.87-08-1

Name
PENICILLIN V
EINECS 201-722-0
CAS No. 87-08-1
Article Data34
CAS DataBase
Density 1.3121 (rough estimate)
Solubility Soluble x and NO_x.
Risk Codes 42/43
Molecular Structure
Hazard Symbols Not regulated UN NO.
Synonyms 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-,[2S-(2a,5a,6b)]-;6-(Phenoxyacetamido)penicillanic acid; Acipen-V; Calcipen; Crystapen V;Distaquaine V; Eskacillin V; Fenacilin; Meropenin; Oracillin; Oracilline;Oratren; Orocillin; Ospen; Pen-Oral; Pen-Vee; Pen-vee-oral; Penicillin V;Penicillin, phenoxymethyl-; Phenocillin; Phenopenicillin; Phenospen;Phenoxymethylpenicillin; Phenoxymethylpenicillinic acid; Stabicillin; V-Cil;V-Cillin; V-Cylina; V-Cyline; V-Tablopen; Vebecillin
PSA 121.24000
LogP 1.02590

Synthetic route

: 551-16-6
6-Aminopenicillanic Acid

: 2065-23-8
methyl 2-phenoxyacetate

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With recombinant Streptomyces lavendulae penicillinacylase In dimethyl sulfoxide at 30℃; for 10.8h; pH=7; Catalytic behavior; Kinetics; Concentration; pH-value; Solvent; Time; Enzymatic reaction;	94.5%

: 65538-78-5
Penicillin-V-2'-bromethylester

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With lithium cobalt(I)-phthalocyanine; phenol In acetone for 4h; Ambient temperature;	81%

: (R)-2-[(2R,3R)-2-[(2R,3R)-1-((R)-1-Carboxy-2-methyl-propyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-butyric acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; dihydrogen peroxide; iron(II) sulfate; ascorbic acid In water	1.3%

: 123314-55-6
(R)-((2R)-4t-carboxy-5,5-dimethyl-thiazolidin-2r-yl)-(2-phenoxy-acetylamino)-acetic acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With 1,4-dioxane; sodium hydroxide; dicyclohexyl-carbodiimide

: 1025-55-4
6-aminopenicillanic acid trimethylsilyl ester

: 701-99-5
Phenoxyacetyl chloride

: 87-08-1
penicilin V

Conditions

Conditions	Yield
(i) Et3N, CHCl3, dioxane, (ii) /BRN= 1082694/; Multistep reaction;

: 1203-85-6
6-β-aminopenicillanic acid sodium salt

: 701-99-5
Phenoxyacetyl chloride

: 87-08-1
penicilin V

: 53059-76-0
6β-benzylideneamino-penicillanic acid; 1,1,3,3-tetramethyl-butylamine salt

: 701-99-5
Phenoxyacetyl chloride

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With sodium 2-ethylhexanoic acid In chloroform-d1

: 701-99-5
Phenoxyacetyl chloride

: 40124-92-3
6R(β)-tritylaminopenicillanic acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetone

: 1098-87-9
penicillin V sodium salt

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Yield given;

: Phenoxyacetyl-L-cysteinyl-D-valine

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With ammonium bicarbonate; iron(II) sulfate; catalase; ascorbic acid; diothiothreitol isopenicillin N synthetase from Cephalosporium acremonium CO728;
With isopenicillin N synthetase from Cephalosporium acremonium CO728; oxygen; ammonium bicarbonate; iron(II) sulfate; catalase; ascorbic acid; diothiothreitol In water at 27℃; Michaelis constant, maximum velocity;

: (R)-2-[(2R,3R)-2-Mercapto-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-butyric acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; oxygen; iron(II) sulfate; ascorbic acid In water at 37℃; for 2h;

: 72-18-4
L-valine

: 122-59-8
2-phenoxyacetic acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With phosphate buffer; Penicillium chrysogenum mycelium at 24℃; for 20h; Mechanism; <1-14C>- or <18O2>-labelled;

: 40966-75-4
penicillin V methoxymethyl ester

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With water-d2 In d(4)-methanol at 25℃; Rate constant;

cultures of penicillium chrysogenum-stems: cultures of penicillium chrysogenum-stems

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With 2-phenoxyacetic acid

penicillium notatum-stems: penicillium notatum-stems

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With N-(2-hydroxyethyl)-2-phenoxyacetamide
With bis-[2-(phenoxyacetyl-amino)-ethyl]-disulfide
With 2-phenoxyacetic acid
With 2-Phenoxyethanol

: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2-oxo-propyl ester

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.1 M aq. NaOH / acetonitrile View Scheme

: (R)-2-[(2R,3R)-2-Mercapto-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-butyric acid 4-methoxy-benzyl ester

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CF3COOH / benzene; various solvent(s) / 1 h / 20 °C 2: FeSO4, ascorbic acid, EDTA, O2 / H2O / 2 h / 37 °C View Scheme

: 52-67-5
3,3-dimethyl-D-cysteine

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: sodium acetate; aqueous ethanol 2: dioxane; N2H4+H2O / Behandeln des Reaktionsprodukts mit Essigsaeure und wss. HCl 3: triethylamine; CH2Cl2 4: HCl; CH2Cl2 5: dicyclohexylcarbodiimide; aqueous NaOH; dioxane View Scheme
Multi-step reaction with 6 steps 1: sodium acetate; aqueous ethanol 2: pyridine 3: dioxane; N2H4+H2O / Behandeln des Reaktionsprodukts mit Essigsaeure und wss. HCl 4: triethylamine; CH2Cl2 5: HCl; CH2Cl2 6: dicyclohexylcarbodiimide; aqueous NaOH; dioxane View Scheme

: 701-99-5
Phenoxyacetyl chloride

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine; CH2Cl2 2: HCl; CH2Cl2 3: dicyclohexylcarbodiimide; aqueous NaOH; dioxane View Scheme

: 1030-50-8
(4S)-2t-((R)-amino-tert-butoxycarbonyl-methyl)-5,5-dimethyl-thiazolidine-4r-carboxylic acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine; CH2Cl2 2: HCl; CH2Cl2 3: dicyclohexylcarbodiimide; aqueous NaOH; dioxane View Scheme

: 1057-37-0, 1105-48-2
(4S)-2t-[(R)-tert-butoxycarbonyl-(2-phenoxy-acetylamino)-methyl]-5,5-dimethyl-thiazolidine-4r-carboxylic acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl; CH2Cl2 2: dicyclohexylcarbodiimide; aqueous NaOH; dioxane View Scheme

: 1056-69-5, 1056-70-8, 6966-35-4, 52049-65-7, 59168-65-9
(4S)-2t-((R)-tert-butoxycarbonyl-phthalimido-methyl)-5,5-dimethyl-thiazolidine-4r-carboxylic acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: dioxane; N2H4+H2O / Behandeln des Reaktionsprodukts mit Essigsaeure und wss. HCl 2: triethylamine; CH2Cl2 3: HCl; CH2Cl2 4: dicyclohexylcarbodiimide; aqueous NaOH; dioxane View Scheme

: 59168-65-9
(4S)-2c-((S)-tert-butoxycarbonyl-phthalimido-methyl)-5,5-dimethyl-thiazolidine-4r-carboxylic acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine 2: dioxane; N2H4+H2O / Behandeln des Reaktionsprodukts mit Essigsaeure und wss. HCl 3: triethylamine; CH2Cl2 4: HCl; CH2Cl2 5: dicyclohexylcarbodiimide; aqueous NaOH; dioxane View Scheme

: 551-16-6
6-Aminopenicillanic Acid

: 87-08-1
penicilin V

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: KHCO3 / acetone View Scheme
Multi-step reaction with 2 steps 1: CHCl3 2: (i) Et3N, CHCl3, dioxane, (ii) /BRN= 1082694/ View Scheme

: 551-16-6
6-Aminopenicillanic Acid

: 701-99-5
Phenoxyacetyl chloride

: 87-08-1
penicilin V

Conditions

Conditions	Yield
With potassium hydrogencarbonate In water; acetone at 0 - 20℃; for 1.25h;
Stage #1: 6-Aminopenicillanic Acid; Phenoxyacetyl chloride With sodium hydrogencarbonate In water; acetone at 10 - 15℃; for 0.35h; Stage #2: With sulfuric acid pH=2;

: 551-16-6
6-Aminopenicillanic Acid

: 107462-97-5
phenoxyacetyl-d5 chloride

: 87-08-1
penicilin V

: 91-01-0
1,1-Diphenylmethanol

: 87-08-1
penicilin V

: 52141-84-1
(2S,5R,6R)-benzhydryl 6-(2-phenoxyacetamido)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Conditions

Conditions	Yield
With pyridine; isocyanuric acid In dichloromethane at -7 - -5℃; for 0.666667h;	91.8%

: 87-08-1
penicilin V

: 33069-21-5
6β-phenoxyacetamidopenicillanic acid 1β-sulfoxide

Conditions

Conditions	Yield
With dihydrogen peroxide In dichloromethane at 25 - 30℃; for 6h;	90%

: 87-08-1
penicilin V

: Caesium; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Conditions

Conditions	Yield
With cesium hydroxide In tetrahydrofuran pH 5;	88.3%

: 87-08-1
penicilin V

: 1098-87-9
penicillin V sodium salt

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran pH 5;	86%

: 106-93-4
ethylene dibromide

: 87-08-1
penicilin V

: 65538-78-5
Penicillin-V-2'-bromethylester

Conditions

Conditions	Yield
With sodium carbonate In dimethyl sulfoxide for 20h;	80%

: potassium 2-ethylhexanoate

: 87-08-1
penicilin V

: 132-98-9
penicillin V potassium

Conditions

Conditions	Yield
In butan-1-ol	80%

: 87-08-1
penicilin V

: Lithium; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran; water pH 5;	78.3%

: 95-54-5
1,2-diamino-benzene

: 87-08-1
penicilin V

: C22H24N4O4S

Conditions

Conditions	Yield
In ethanol for 7h; Inert atmosphere; Reflux;	77%

: 87-08-1
penicilin V

: GENERIC INORGANIC CATION; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Conditions

Conditions	Yield
With rubidium hydroxide In tetrahydrofuran pH 5;	76.8%

: 63478-48-8
alanine trichloroethylester

: 87-08-1
penicilin V

: 113322-06-8
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-propionic acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With diisopropyl-carbodiimide In dichloromethane	69%

: 69472-81-7
H-S-Leu-OTce

: 87-08-1
penicilin V

: 113322-04-6
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-4-methyl-pentanoic acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With diisopropyl-carbodiimide In dichloromethane	67%

: 69472-79-3
L-Val-OCH2CCl3

: 87-08-1
penicilin V

: 113322-05-7
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-3-methyl-butyric acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With diisopropyl-carbodiimide In dichloromethane	64%

: 100865-93-8
O-diphenylmethyl 2,2,2-trichloroacetimidate

: 87-08-1
penicilin V

: 52141-84-1
(2S,5R,6R)-benzhydryl 6-(2-phenoxyacetamido)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 18h; Inert atmosphere;	63%

: 40126-72-5
2,2,2-trichloroethyl glycinate*HBr

: 87-08-1
penicilin V

: 113322-07-9
{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-acetic acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With triethylamine; diisopropyl-carbodiimide In dichloromethane	50%

: 72218-78-1
H2N-IleOTce

: 87-08-1
penicilin V

: 113322-08-0
(2S,3S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-3-methyl-pentanoic acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With diisopropyl-carbodiimide In dichloromethane	37%

: 113351-77-2
H2N-OTroc-TyrOTce

: 87-08-1
penicilin V

: 113322-11-5
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-3-[4-(2,2,2-trichloro-ethoxycarbonyloxy)-phenyl]-propionic acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With diisopropyl-carbodiimide In dichloromethane	36%

: 113322-03-5
(S)-2-Amino-pentanedioic acid bis-(2,2,2-trichloro-ethyl) ester; hydrobromide

: 87-08-1
penicilin V

: 113322-10-4
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-pentanedioic acid bis-(2,2,2-trichloro-ethyl) ester

Conditions

Conditions	Yield
With triethylamine; diisopropyl-carbodiimide In dichloromethane	26%

: 113322-02-4
H2N-TrpOTce

: 87-08-1
penicilin V

: 113322-09-1
(S)-2-{[(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-amino}-3-(1H-indol-3-yl)-propionic acid 2,2,2-trichloro-ethyl ester

Conditions

Conditions	Yield
With diisopropyl-carbodiimide In dichloromethane	14%

: 87-08-1
penicilin V

: 123314-55-6
(R)-((2R)-4t-carboxy-5,5-dimethyl-thiazolidin-2r-yl)-(2-phenoxy-acetylamino)-acetic acid

Conditions

Conditions	Yield
With water In 1,4-dioxane at 30℃; Rate constant; Bacillus cereus 569/H β-lactamase I, pH 7; also hydroxy ion instead of enzyme;
With sodium hydroxide

: 186581-53-3, 908094-01-9
diazomethane

: 87-08-1
penicilin V

: 15583-33-2
(3S,5R,6R)-3-diazoacetyl-2,2-dimethyl-6-phenoxyacetamidopenam

Conditions

Conditions	Yield
(i) Et3N, CH2Cl2, (ii) ClCO2Me, (iii) /BRN= 102415/; Multistep reaction;

: 186581-53-3, 908094-01-9
diazomethane

: 87-08-1
penicilin V

: 2315-05-1
methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Conditions

Conditions	Yield
In diethyl ether

: 67-56-1
methanol

: 87-08-1
penicilin V

: 2315-05-1
methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Conditions

Conditions	Yield
With pyridine; dicyclohexyl-carbodiimide In dichloromethane

Penicillin V Chemical Properties

Molecular Structure:

Molecular Formula: C₁₆H₁₈N₂O₅S
Molecular Weight: 350.3895
IUPAC Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Synonyms of Penicillin V (CAS NO.87-08-1): 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S,5R,6R)- ; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S-(2alpha,5alpha,6beta))- ; Penicillanic acid, 6-phenoxyacetamido- ; Phenoxymethylpenicillin
CAS NO: 87-08-1
Classification Code: Anti-Bacterial Agents ; Anti-Infective Agents ; Antibacterial ; Drug / Therapeutic Agent ; Human Data ; Mutation data
Melting point: 120-128°C
Index of Refraction: 1.65
Density: 1.45 g/cm³
Flash Point: 365.9 °C
Enthalpy of Vaporization: 105 kJ/mol
Boiling Point: 681.4 °C at 760 mmHg
Vapour Pressure: 1.69E-19 mmHg at 25 °C
Melting point: 120-128 °C
Storage tempreture: -20 °C
Solubility: Insoluble in water
Appearance: Crystalline solid

Penicillin V Uses

Penicillin V (CAS NO.87-08-1) has been used for antibacterial.

Penicillin V Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intramuscular	1096mg/kg (1096mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
guinea pig	LD50	intraperitoneal	822mg/kg (822mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse	LD50	intramuscular	> 1775mg/kg (1775mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse	LD50	intraperitoneal	1351mg/kg (1351mg/kg)		Antibiotics Annual. Vol. 3, Pg. 540, 1955/1956.
mouse	LD50	oral	6578mg/kg (6578mg/kg)		Antibiotiki. Vol. 3(4), Pg. 37, 1958.
mouse	LD50	subcutaneous	> 4gm/kg (4000mg/kg)		Antibiotics Annual. Vol. 3, Pg. 540, 1955/1956.
rat	LD50	intramuscular	> 1600mg/kg (1600mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat	LD50	intravenous	> 1775mg/kg (1775mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat	LD50	oral	> 2220mg/kg (2220mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
women	TDLo	oral	10mg/kg/2D (10mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Lancet. Vol. 2, Pg. 1297, 1976.

Penicillin V Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: impaired liver function, dermatitis, fever. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.
Hazard Codes of Penicillin V (CAS NO.87-08-1): Harmful Xn
Risk Statements: 42/43
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-36
S22: Do not breathe dust.
S36: Wear suitable protective clothing.

Penicillin V Specification

It is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, zinc and mercury; sympathomimetic amines, thiomersal, cetostearyl alcohol, hard paraffins, cocoa butter and many ionic an nonionic surface-active agents.

Product Name

PENICILLIN V

Synthetic route

Penicillin V Chemical Properties

Penicillin V Uses

Penicillin V Toxicity Data With Reference

Penicillin V Safety Profile

Penicillin V Specification

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