• Name

  PROPERICYAZINE

• EINECS
• CAS No. 2622-26-6
• Article Data4
• CAS DataBase
• Density 1.32g/cm³
• Solubility 38.01mg/L(37 oC)
• Melting Point 116-117°
• Formula C21H23 N3 O S
• Boiling Point 593.4°Cat760mmHg
• Molecular Weight 365.499
• Flash Point 312.7°C
• Transport Information
• Appearance
• Safety Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN⁻, NO_x, and SO_x. See also NITRILES.
• Risk Codes 22-36/37/38-20/21/22
• Molecular Structure
• Hazard Symbols
• Synonyms Phenothiazine-2-carbonitrile,10-[3-(4-hydroxypiperidino)propyl]- (6CI,7CI,8CI); 10-[3-(4-Hydroxypiperidino)propyl]phenothiazine-2-carbonitrile;2-Cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine;2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine; Aolept; Bayer 1409; FI6145; Nelactil; Nemactil; Neulactil; Neuleptil; Periciazine; Periciazinum;Pericyazine; Properciazine; Propericiazine; Propericyazine; RP 8909; SKF 20716
• PSA 75.80000
• LogP 4.01068

Synthetic route

5382-16-1

4-HYDROXYPIPERIDINE

38642-74-9

10H-phenothiazine-2-carbonitrile

109-70-6

1,3-chlorobromopropane

2622-26-6

periciazine

Conditions

Conditions	Yield
Stage #1: 10H-phenothiazine-2-carbonitrile; 1.3-chlorobromopropane With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 7h; Stage #2: 4-HYDROXYPIPERIDINE With triethylamine In N,N-dimethyl-formamide at 0 - 60℃; for 42h;	40%

...Expand

2622-26-6

periciazine

96265-39-3

10-(3-(4-oxopiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile

Conditions

Conditions	Yield
With dmap; 2-azatricyclo[3.3.1.13,7]dec-2-yloxidanyl; copper(l) chloride In acetonitrile at 20℃; for 1h; chemoselective reaction;	97%

13494-98-9

yttrium(III) nitrate

2622-26-6

periciazine

Y(3+)*2C21H23N3OS*3NO3(1-) = [Y(C21H23N3OS)2(NO3)2](NO3)

Conditions

Conditions	Yield
In ethanol 15 min; pptn. washing (EtOH), drying (vac.); elem. anal.;	74%

uranyl(VI) acetate dihydrate

2622-26-6

periciazine

UO2(CH3CO2)2(C6H4SN((CH2)3NC5H9OH)C6H3CN)(H2O)2

Conditions

Conditions	Yield
In water soln. refluxed for 6 h; cooling under ice-cold water for 4 d; ppt. filtered and dried in vac.; elem. anal.;	50%

zirconium(IV) nitrate

2622-26-6

periciazine

Zr(NO3)4 (propericiazine)

Conditions

Conditions	Yield
In sulfuric acid; water aq. H2SO4; stirring (soln. of Zr(NO3)4 in water), addn. (soln. of ligand in water, sulphuric acid), pptn., set aside (2 h); sepn. (filtration), washing (water, EtOH), drying (vac., over fused CaCl2); elem. anal.;

rhodium(III) chloride trihydrate

2622-26-6

periciazine

rhodium (II,III) (propericiazine)2 Cl8

Conditions

Conditions	Yield
In ethanol addn. of ethanolic soln. of PPC to a constantly stirred ethanolic soln. of RhCl3*3H2O at room temp., pptn.; filtration, washing with ethanol and ether, drying in vac. over fused CaCl2, elem. anal.;

ruthenium(III) chloride trihydrate

2622-26-6

periciazine

Ru3(C6H4SN(C3H6N(C5H9OH))C6H3(CN))2Cl8

Conditions

Conditions	Yield
In ethanol addn. of ethanolic N-alkylphenothiazine soln. to ethanolic RuCl3*3H2O soln., stirring slowly; filtration; washing (ethanol, ether, several times); drying (anhydrous CaCl2, desiccator); elem. anal.;

10213-10-2

sodium tungstate (VI) dihydrate

2622-26-6

periciazine

W2O4(C6H4SN((CH2)3NC5H9OH)C6H3CN)2(H2O)2

Conditions

Conditions	Yield
With HCl In water a soln. of Na2WO4*2H2O in distd. H2O was added with stirring to a soln.of PPC in distd. H2O containing few drops of 2 M HCl; the suspn. was set aside for 3 h, filtered, washed (H2O, EtOH), dried in vac. over fused CaCl2; elem. anal.;

hexaammonium heptamolybdate tetrahydrate

2622-26-6

periciazine

Mo2O4(C6H4SN(CH2)3NC5H9OHC6H3CN)2(H2O)2

Conditions

Conditions	Yield
In hydrogenchloride (NH4)6Mo7O24*4H2O in 2 M HCl was added to soln. of ligand in water with vigorous stirring, suspn. set aside for 2 h; suspn. filtered, washed with water, ethanol and dried in vacuo over fused CaCl2; elem. anal.;	67-79

Propericiazine Chemical Properties

Propericiazine Toxicity Data With Reference

Propericiazine Consensus Reports

Propericiazine Safety Profile

Propericiazine Specification