Product Name

  • Name

    DIOXOPROMETHAZINE HCL

  • EINECS 1308068-626-2
  • CAS No. 13754-56-8
  • Article Data10
  • CAS DataBase
  • Density 1.224 g/cm3
  • Solubility
  • Melting Point 127-129 °C
  • Formula C17H20N2O2S
  • Boiling Point 478.451 °C at 760 mmHg
  • Molecular Weight 352.885
  • Flash Point 243.159 °C
  • Transport Information
  • Appearance white powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 13754-56-8 (DIOXOPROMETHAZINE HCL)
  • Hazard Symbols
  • Synonyms Phenothiazine,10-[2-(dimethylamino)propyl]-, 5,5-dioxide (8CI);9,9-Dioxopromethazine;9,9-Dioxypromethazin;Promethazine 5,5-dioxide;10H-Phenothiazine-10-ethanamine,N,N,a-trimethyl-, 5,5-dioxide;
  • PSA 49.00000
  • LogP 4.06680

Prothanon Chemical Properties


IUPAC Name: 1-(5,5-Dioxophenothiazin-10-yl)-N,N-dimethylpropan-2-amine
Canonical SMILES: CC(CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C31)N(C)C
InChI: InChI=1S/C17H20N2O2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)22(20,
21)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
InChIKey: FDXKCOBAFGSMDJ-UHFFFAOYSA-N
Molecular Weight: 316.4179 [g/mol]
Molecular Formula: C17H20N2O2S
XLogP3: 3.5
H-Bond Donor: 0
H-Bond Acceptor: 4 
Index of Refraction: 1.605
Molar Refractivity: 89.11 cm3
Molar Volume: 258.4 cm3
Surface Tension: 46.5 dyne/cm
Density: 1.224 g/cm3
Flash Point: 243.2 °C
Enthalpy of Vaporization: 74.26 kJ/mol
Boiling Point: 478.5 °C at 760 mmHg
Vapour Pressure of Dioxopromethazine hydrochloride (CAS NO.13754-56-8): 2.57E-09 mmHg at 25 °C

Prothanon Uses

  Dioxopromethazine hydrochloride (CAS NO.13754-56-8) is used in chemical reagents, organic intermediates, fine chemicals, pharmaceutical research and development.

Prothanon Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 8mg/kg (8mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
guinea pig LD50 oral 225mg/kg (225mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
guinea pig LD50 subcutaneous 33mg/kg (33mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
mouse LD50 intraperitoneal 49mg/kg (49mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
mouse LD50 intravenous 16mg/kg (16mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 155, 1983.
mouse LD50 oral 50mg/kg (50mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 155, 1983.
mouse LD50 subcutaneous 96mg/kg (96mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
rabbit LD50 oral 165mg/kg (165mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.

Prothanon Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx, SOx, and HCl.

Prothanon Specification

 Dioxopromethazine hydrochloride (CAS NO.13754-56-8), its Synonyms are 5,5-Dioxo-10-(2-(dimethylamino)propyl)phenothiazine hydrochloride ; 9,9-Dioxo-10-(2-dimethylaminopropyl)-phenothiazinhydrochlorid ; 9,9-Dioxopromethazine ; 9,9-Dioxypromethazin ; Dioxopromethazin ; Dioxoprothazin ; Promethazine 5,5-dioxide ; Promethazine SS oxide ; Prothanon ; 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, 5,5-dioxide (9CI) ; 10H-Phenothiazine-10-ethanamine,N,N,alpha-trimethyl-,5,5-dioxide ; Phenothiazine, 10-(2-(dimethylamino)propyl)-, 5,5-dioxide, monohydrochloride ; Phenothizine, 10-(2-(dimethylamino)propyl)-, 5,5-dioxide (8CI) ; Dioxopromethazine .

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