Product Name

  • Name

    PROTRIPTYLINE HYDROCHLORIDE

  • EINECS
  • CAS No. 1225-55-4
  • Density
  • Solubility
  • Melting Point 169-171°
  • Formula C19H21 N . Cl H
  • Boiling Point 407.7°C at 760 mmHg
  • Molecular Weight 299.87
  • Flash Point 198.3°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx and HCl.
  • Risk Codes 20/21/22-36/37/38
  • Molecular Structure Molecular Structure of 1225-55-4 (PROTRIPTYLINE HYDROCHLORIDE)
  • Hazard Symbols
  • Synonyms 5H-Dibenzo[a,d]cycloheptene-5-propanamine,N-methyl-, hydrochloride (9CI); 5H-Dibenzo[a,d]cycloheptene-5-propylamine,N-methyl-, hydrochloride (7CI,8CI); Concordin; MK-240; Maximed; Maximet;N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine hydrochloride; NormethylEX4442; Protriptyline hydrochloride; Protryptyline hydrochloride; Triptil;Triptil Hydrochloride; Vivactil
  • PSA 12.03000
  • LogP 5.49480

Protriptyline hydrochloride Chemical Properties

Empirical Formula:C19H22ClN
Molecular Weight: 299.8377 g/mol
Flash Point: 198.3 °C
Enthalpy of Vaporization: 65.96 kJ/mol
Boiling Point: 407.7 °C at 760 mmHg
Vapour Pressure: 7.41E-07 mmHg at 25 °C
Product Category of Protriptyline hydrochloride (CAS NO.1225-55-4): Biogenic Amine Transport Inhibitors;Obesity Research;Neurotransmitters
Structure of Protriptyline hydrochloride (CAS NO.1225-55-4):
                          
Canonical SMILES: C[NH2+]CCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.[Cl-]
InChI: InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H
InChIKey: OGQDIIKRQRZXJH-UHFFFAOYSA-N

Protriptyline hydrochloride Toxicity Data With Reference

1.    

orl-rat LD50:299 mg/kg

     TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
2.    

ipr-rat LD50:44 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
3.    

orl-mus LD50:211 mg/kg

     TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
4.    

scu-mus LD50:192 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
5.    

ivn-mus LD50:49 mg/kg

     APTOA6    Acta Pharmacologica et Toxicologica. 24 (1966),121.
6.    

orl-dog LDLo:400 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
7.    

orl-rbt LD50:310 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
8.    

ivn-rbt LD50:8200 µg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
9.    

orl-gpg LD50:180 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
10.  

Protriptyline hydrochloride Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Hazard Codes of Protriptyline hydrochloride (CAS NO.1225-55-4): HarmfulXn
Risk Statements: 20/21/22-36/37/38 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

Protriptyline hydrochloride Specification

 Protriptyline hydrochloride , its cas register number is 1225-55-4. It also can be called Vivactil ; N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine hydrochloride ; and 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-, hydrochloride (8CI) .

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