Product Name

  • Name

    Proxan sodium

  • EINECS 205-443-5
  • CAS No. 140-93-2
  • Article Data9
  • CAS DataBase
  • Density 1.225
  • Solubility Complete solubility in water
  • Melting Point 216-218°C(lit.)
  • Formula C4H7NaOS2
  • Boiling Point 138 °C at 760 mmHg
  • Molecular Weight 158.221
  • Flash Point 37.2 °C
  • Transport Information
  • Appearance White to yellowish powder or lumps
  • Safety 13-61
  • Risk Codes 22-38-51/53
  • Molecular Structure Molecular Structure of 140-93-2 (Proxan sodium)
  • Hazard Symbols DangerousN,HarmfulXn
  • Synonyms Carbonicacid, dithio-, O-isopropyl ester, sodium salt (8CI);Aeroxanthate 343;Good-rite Nix;NIX;O-Isopropyl sodium dithiocarbonate;O-Isopropyl sodium xanthate;Sodium O-isopropyl dithiocarbonate;Sodiumisopropylxanthogenate;Z 11;
  • PSA 66.62000
  • LogP 1.89380

Synthetic route

carbon disulfide
75-15-0

carbon disulfide

isopropyl alcohol
67-63-0

isopropyl alcohol

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

Conditions
ConditionsYield
With sodium hydroxide In Petroleum ether
With sodium hydroxide In toluene at 25 - 30℃; for 2h;
Stage #1: isopropyl alcohol With sodium at 65℃; for 3h; Inert atmosphere;
Stage #2: carbon disulfide for 1h;		136.67 g
Stage #1: isopropyl alcohol With sodium at 65℃; for 6h; Inert atmosphere;
Stage #2: carbon disulfide at 35℃; for 1h;		136.67 g
isopropyl alcohol
67-63-0

isopropyl alcohol

CS2

CS2

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

Conditions
ConditionsYield
With sodium hydroxide
carbon disulfide
75-15-0

carbon disulfide

sodium isopropylate
683-60-3

sodium isopropylate

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

Conditions
ConditionsYield
at 0 - 20℃;
cis-dichlorodioxobis(triphenylphosphine oxide)molybdenum(VI)

cis-dichlorodioxobis(triphenylphosphine oxide)molybdenum(VI)

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

(dioxomolybdenum)Cl(isopropyl xanthate)(triphenylphosphine oxide)

(dioxomolybdenum)Cl(isopropyl xanthate)(triphenylphosphine oxide)

Conditions
ConditionsYield
In dichloromethane byproducts: OP(C6H5)3, NaCl; soln. of MoO2Cl2(OP(C6H5)3)2 in CH2Cl2 added with stirring at room temp.to susp. of Na(C3H7OCS2)2 in CH2Cl2, mixt. stirring 3 h; NaCl fitered off, washed with CH2Cl2, filtrate concd., solid dried in vacuo and repeated washing with dried benzene; elem. anal.;98%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

benzyl chloride
100-44-7

benzyl chloride

2-propylcarbonothioylthiomethylbenzene
51698-64-7

2-propylcarbonothioylthiomethylbenzene

Conditions
ConditionsYield
In water at 75℃; for 4h;97.1%
at 75℃; for 3h;
at 75℃; for 3h;
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

S-ethoxycarbonyl O-2-propyl dithiocarbonate
67969-80-6

S-ethoxycarbonyl O-2-propyl dithiocarbonate

Conditions
ConditionsYield
With cetyltrimethylammonim bromide In N,N-dimethyl-aniline at 10 - 25℃; for 6.5h;97.1%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

4-anisidinium hydrogen sulfate

4-anisidinium hydrogen sulfate

C11H15NO2S

C11H15NO2S

Conditions
ConditionsYield
Stage #1: sodium isopropylxanthate; 4-anisidinium hydrogen sulfate With dihydrogen peroxide In water at 40℃; for 1.1h; Green chemistry;
Stage #2: With sulfuric acid In water at 80℃; for 2.2h; pH=7; Green chemistry;		97%
diisopropylammonium hydrogen sulphate
65087-26-5

diisopropylammonium hydrogen sulphate

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

C10H21NOS

C10H21NOS

Conditions
ConditionsYield
Stage #1: diisopropylammonium hydrogen sulphate; sodium isopropylxanthate With dihydrogen peroxide In water at 45℃; for 1.4h; Green chemistry;
Stage #2: With sulfuric acid In water at 80℃; for 2.3h; pH=7; Green chemistry;		96%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

aniline sulfate
2424-53-5

aniline sulfate

phenyl-thiocarbamic acid S-iso-propyl ester
10129-28-9

phenyl-thiocarbamic acid S-iso-propyl ester

Conditions
ConditionsYield
Stage #1: sodium isopropylxanthate; aniline sulfate With dihydrogen peroxide In water at 40℃; for 1h; Green chemistry;
Stage #2: With sulfuric acid In water at 100℃; for 2h; pH=7; Green chemistry;		96%
di-n-propylammonium hydrogen sulphate
908126-51-2

di-n-propylammonium hydrogen sulphate

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

C10H21NOS

C10H21NOS

Conditions
ConditionsYield
Stage #1: di-n-propylammonium hydrogen sulphate; sodium isopropylxanthate With dihydrogen peroxide In water at 40℃; for 1h; Green chemistry;
Stage #2: With sulfuric acid In water at 70℃; for 2h; pH=7; Green chemistry;		95%
isopropylamine sulfate
859043-64-4

isopropylamine sulfate

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

Isopropyl-thiocarbamic acid S-isopropyl ester

Isopropyl-thiocarbamic acid S-isopropyl ester

Conditions
ConditionsYield
Stage #1: isopropylamine sulfate; sodium isopropylxanthate With dihydrogen peroxide In water at 45℃; for 1.3h; Green chemistry;
Stage #2: With sulfuric acid In water at 80℃; for 2.2h; pH=7; Green chemistry;		94%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

4-chloroanilinium hydrogen sulfate

4-chloroanilinium hydrogen sulfate

N-(4-chlorophenyl)-S-(isopropyl)thiocarbamate
10129-38-1

N-(4-chlorophenyl)-S-(isopropyl)thiocarbamate

Conditions
ConditionsYield
Stage #1: sodium isopropylxanthate; 4-chloroanilinium hydrogen sulfate With dihydrogen peroxide In water at 40℃; for 1.1h; Green chemistry;
Stage #2: With sulfuric acid In water at 90℃; for 2.2h; pH=7; Green chemistry;		94%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

ethylamine
75-04-7

ethylamine

O-isopropyl-N-ethylthionocarbamate
141-98-0

O-isopropyl-N-ethylthionocarbamate

Conditions
ConditionsYield
Stage #1: sodium isopropylxanthate With sodium carbonate; chloroacetic acid In water at 60℃; for 2h; pH=Ca. 8;
Stage #2: ethylamine In water at 20 - 70℃; for 1h;		94%
With palladium supported titanium-hexagonal mesoporous silica-10 In water at 75℃; for 10h; Reagent/catalyst; Solvent;93%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

bis(dichlorostibino)methane
32278-97-0

bis(dichlorostibino)methane

{Sb(S2COC3H7)2}2CH2

{Sb(S2COC3H7)2}2CH2

Conditions
ConditionsYield
In methanol byproducts: NaCl; addition of a solution of 6.00 mmol of NaS2COiPr in 20 ml CH3OH drop by drop to a solution of 1.50 mmol of (Cl2Sb)2CH2 (1 hour) and stirring at 25°C, 3 - 5 hours;; filtration, washing with CH3OH and drying; elem. anal.;;92%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

methylamine
74-89-5

methylamine

O-isopropyl methylcarbamothioate
20753-31-5

O-isopropyl methylcarbamothioate

Conditions
ConditionsYield
With palladium supported titanium-hexagonal mesoporous silica-10 In water at 75℃; for 10h;90%
bis(benzoylacetonato-O,O)dichlorotin(IV)

bis(benzoylacetonato-O,O)dichlorotin(IV)

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

isopropylxanthato(chloro)bis(benzoylacetonato)tin(IV)

isopropylxanthato(chloro)bis(benzoylacetonato)tin(IV)

Conditions
ConditionsYield
In acetone byproducts: NaCl; to a suspension of Cl2Sn(CH3COCHCOC6H5)2 in acetone a soln. of equimolar amount of sodium isopropyl xanthate was added, mixture was refluxed for 6 h, formed NaCl was filtered off, removal of the solvent under reduced pressure;; formed solid was recrystd. from a mixture of acetone and petroleum ether; elem. anal.;;89%
In acetone byproducts: NaCl; refluxed (6 h), exclusion of moisture; evapn. (low pressure); recrystn. (acetone/petroleum ether); elem. anal.;89%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

O-isopropyl-S-hydroxyethylxanthate

O-isopropyl-S-hydroxyethylxanthate

Conditions
ConditionsYield
In water at 60℃; for 5h;88.3%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

para-methylbenzylamine
104-84-7

para-methylbenzylamine

O-isopropyl 4-methylbenzylcarbamothioate

O-isopropyl 4-methylbenzylcarbamothioate

Conditions
ConditionsYield
With palladium supported titanium-hexagonal mesoporous silica-10 In water at 75℃; for 12h;88%
dichloro-bis(pentane-2,4-dionato)tin(IV)

dichloro-bis(pentane-2,4-dionato)tin(IV)

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

isopropylxanthato(chloro)bis(acetylacetonato)tin(IV)

isopropylxanthato(chloro)bis(acetylacetonato)tin(IV)

Conditions
ConditionsYield
In acetone byproducts: NaCl; to a suspension of Cl2Sn(CH3COCHCOCH3)2 in acetone a soln. of equimolar amount of sodium isopropyl xanthate was added, mixture was refluxed for 6 h, formed NaCl was filtered off, removal of the solvent under reduced pressure;; formed solid was recrystd. from a mixture of acetone and petroleum ether; elem. anal.;;87%
In acetone byproducts: NaCl; refluxed (6 h), exclusion of moisture; evapn. (low pressure); recrystn. (acetone/petroleum ether); elem. anal.;87%
chlorotriphenylgermane
1626-24-0

chlorotriphenylgermane

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

(O-isopropyl dithiocarbonato)triphenylgermane
133401-59-9

(O-isopropyl dithiocarbonato)triphenylgermane

Conditions
ConditionsYield
In carbon disulfide byproducts: NaCl; under vac.; CS2 was distilled to dithiocarbonate and halophenylgermane at -196°C; warmed up slowly toward ambient temp. with stirring; reaction started below 0°C; cooled; ice bath after 15 min; stirred for 3-4 h; filtration; solvent was pumped off; redissolved (CS2); evapn. at 4°C; crystn.; elem. anal.;86%
{C5H5Ni(P(C4H9-n)3)2}Cl

{C5H5Ni(P(C4H9-n)3)2}Cl

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

C5H5Ni(P(C4H9-n)3)SC(S)OCH(CH3)2
52247-34-4

C5H5Ni(P(C4H9-n)3)SC(S)OCH(CH3)2

Conditions
ConditionsYield
In water room temp.; with excess of NaSC(S)OCH(CH3)2; extn. of the brown ppt. with ether or benzene; drying, evapn. in vac.; recrystn. from benzene or benzene/hexane;85%
In water
bis(dibenzoylmethanato-O,O)dichlorotin(IV)

bis(dibenzoylmethanato-O,O)dichlorotin(IV)

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

isopropylxanthato(chloro)bis(dibenzoylmethanato)tin(IV)

isopropylxanthato(chloro)bis(dibenzoylmethanato)tin(IV)

Conditions
ConditionsYield
In acetone byproducts: NaCl; to a suspension of Cl2Sn(C6H5COCHCOC6H5)2 in acetone a soln. of equimolar amount of sodium isopropyl xanthate was added, mixture was refluxed for 6 h, formed NaCl was filtered off, removal of the solvent under reduced pressure;; formed solid was recrystd. from a mixture of acetone and petroleum ether; elem. anal.;;85%
bis(dibenzoylmethanato-O,O)dichlorotin(IV)

bis(dibenzoylmethanato-O,O)dichlorotin(IV)

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

isopropyl xanthato(chloro)bis(dibenzoylmethanato)tin(IV)

isopropyl xanthato(chloro)bis(dibenzoylmethanato)tin(IV)

Conditions
ConditionsYield
In acetone byproducts: NaCl; refluxed (6 h), exclusion of moisture; evapn. (low pressure); recrystn. (acetone/petroleum ether); elem. anal.;85%
dioxomolybdenum(VI) dibromide bis(dimethylsulfoxide)

dioxomolybdenum(VI) dibromide bis(dimethylsulfoxide)

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

MoO2Br(O-Pr(i) dithiocarbonate)(dimethylsulfoxide)

MoO2Br(O-Pr(i) dithiocarbonate)(dimethylsulfoxide)

Conditions
ConditionsYield
In dichloromethane byproducts: NaBr, Me2SO; suspn. of Na-compound in CH2Cl2 added to soln. of Mo-compound in CH2Cl2 in 1:1 molar ratio with constant stirring; stirred for 3 h; filtered; washed with CH2Cl2; excess solvent removed; dried in vacuo; washed repeatedly with dried benzene; elem. anal.;85%
(2-methylallyl)palladium-chloride dimer

(2-methylallyl)palladium-chloride dimer

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

[(η3-CH2C(CH3)CH2)Pd(S2CO(i-Pr))]

[(η3-CH2C(CH3)CH2)Pd(S2CO(i-Pr))]

Conditions
ConditionsYield
In acetonitrile under dry Ar using Schlenk techniques; to soln. of Pd complex in MeCN added soln. of anhyd. xanthate ligand in MeCN (molar ratio 1:2); mixt. stirred at room temp. for 0.5 h; filtered through small Celite pad; volatiles removed (vac); residue recrystd. (CH2Cl2-hexane); elem. anal.;85%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

propylamine; sulfate (1:1)
908126-52-3

propylamine; sulfate (1:1)

Propyl-thiocarbamic acid S-isopropyl ester

Propyl-thiocarbamic acid S-isopropyl ester

Conditions
ConditionsYield
Stage #1: sodium isopropylxanthate; propylamine; sulfate (1:1) With dihydrogen peroxide In water at 40℃; for 1.2h; Green chemistry;
Stage #2: With sulfuric acid In water at 80℃; for 2.3h; pH=7; Green chemistry;		85%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

benzylamine
100-46-9

benzylamine

O-isopropyl benzylcarbamothioate
188257-29-6

O-isopropyl benzylcarbamothioate

Conditions
ConditionsYield
With palladium supported titanium-hexagonal mesoporous silica-10 In water at 75℃; for 12h;85%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

Trimethylenediamine
109-76-2

Trimethylenediamine

O,O-diisopropyl propane-1,3-diyldicarbamothioate

O,O-diisopropyl propane-1,3-diyldicarbamothioate

Conditions
ConditionsYield
With palladium supported titanium-hexagonal mesoporous silica-10 In water at 75℃; for 12h;85%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

1,4-diaminobutane
110-60-1

1,4-diaminobutane

O,O-diisopropyl butane-1,4-diyldicarbamothioate

O,O-diisopropyl butane-1,4-diyldicarbamothioate

Conditions
ConditionsYield
With palladium supported titanium-hexagonal mesoporous silica-10 In water at 75℃; for 13h;85%
dichloro bis(acetonitrile) palladium(II)
21264-30-2, 90243-59-7, 14592-56-4

dichloro bis(acetonitrile) palladium(II)

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

Pd(S2COCH(CH3)2)2
40103-62-6

Pd(S2COCH(CH3)2)2

Conditions
ConditionsYield
In acetonitrile under dry Ar using Schlenk techniques; to soln. of Pd complex in MeCN added soln. of anhyd. xanthate ligand in MeCN (molar ratio 1:2); mixt. stirred at room temp. for 0.5 h; filtered through small Celite pad; volatiles removed (vac); residue recrystd. (CH2Cl2-hexane); elem. anal.;84%
1,1,2,3,4,5-hexahydro-1,1-diiodotellurophene
62292-22-2

1,1,2,3,4,5-hexahydro-1,1-diiodotellurophene

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

Telluracyclopentan-1,1-bis(isopropylxanthogenat)

Telluracyclopentan-1,1-bis(isopropylxanthogenat)

Conditions
ConditionsYield
In chloroform; isopropyl alcohol for 1h; Ambient temperature;83%
2-chloro-1,2-bis(4-nitrophenyl)ethanone
57507-83-2

2-chloro-1,2-bis(4-nitrophenyl)ethanone

sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

C18H16N2O6S2
1246173-44-3

C18H16N2O6S2

Conditions
ConditionsYield
In acetone83%
sodium isopropylxanthate
140-93-2

sodium isopropylxanthate

diethyl ammonium hydrogen sulfate
26292-53-5, 72962-45-9, 72962-47-1

diethyl ammonium hydrogen sulfate

C8H17NOS

C8H17NOS

Conditions
ConditionsYield
Stage #1: sodium isopropylxanthate; diethylammonium hydrogen sulphate With dihydrogen peroxide In water at 45℃; for 1.2h; Green chemistry;
Stage #2: With sulfuric acid In water at 80℃; for 2.2h; pH=7; Green chemistry;		83%

Proxan sodium Specification

The IUPAC name of Proxan-sodium is sodium propan-2-yloxymethanedithioate. With the CAS registry number 140-93-2, it is also named as Sodium isopropyl xanthate. The product's category is Inorganic & Organic Chemicals. Besides, it is mainly used for the flotation and collection of non-ferrous metal sulphide, which should be stored in ventilated and dry warehouse at low temperature. In addition, its molecular formula is C4H7NaOS2 and molecular weight is 158.21.

The other characteristics of Proxan-sodium can be summarized as: (1)EINECS: 205-443-5; (2)ACD/LogP: 2.29; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -0.58; (5)ACD/LogD (pH 7.4): -1.42; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 1; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 2; (13)Polar Surface Area: 80.12 Å2; (14)Flash Point: 37.2 °C; (15)Enthalpy of Vaporization: 35.98 kJ/mol; (16)Boiling Point: 138 °C at 760 mmHg; (17)Vapour Pressure: 8.55 mmHg at 25 °C.

When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed and irritating to skin. It is also toxic to aquatic organisms that may cause long-term adverse effects in the aquatic environment. Please keep away from food, drink and animal foodstuffs. Moreover, please avoid release to the environment. Refer to special instructions / safety data sheets.

People can use the following data to convert to the molecule structure.
(1)SMILES: [Na+].[S-]C(=S)OC(C)C
(2)InChI: InChI=1/C4H8OS2.Na/c1-3(2)5-4(6)7;/h3H,1-2H3,(H,6,7);/q;+1/p-1
(3)InChIKey: IRZFQKXEKAODTJ-REWHXWOFAU
(4)Std. InChI: InChI=1S/C4H8OS2.Na/c1-3(2)5-4(6)7;/h3H,1-2H3,(H,6,7);/q;+1/p-1
(5)Std. InChIKey: IRZFQKXEKAODTJ-UHFFFAOYSA-M

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo parenteral 600mg/kg (600mg/kg)   "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 696, 1955.

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