Product Name

  • Name

    Rasagiline mesylate

  • EINECS 694-423-3
  • CAS No. 161735-79-1
  • Article Data22
  • CAS DataBase
  • Density 1.05 g/cm3
  • Solubility
  • Melting Point 155-158 °C
  • Formula C12H13N.CH4O3S
  • Boiling Point 305.5 °C at 760 mmHg
  • Molecular Weight 267.349
  • Flash Point 146.8 °C
  • Transport Information
  • Appearance white to off-white crystalline solid
  • Safety 24/25
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 161735-79-1 (Rasagiline mesylate)
  • Hazard Symbols Xn
  • Synonyms R-(+)-Rasagiline mesylate;methanesulfonic acid; (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine;Rasagiline methanesulfonate;1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, (R)-, methanesulfonate;(R)-N-2-Propynyl-1-indanamine methanesulfonate;(R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine methanesulfonate;
  • PSA 74.78000
  • LogP 2.87240

Synthetic route

methanesulfonic acid
75-75-2

methanesulfonic acid

rasagiline
136236-51-6

rasagiline

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In isopropyl alcohol for 1h; Reflux;98%
In toluene; acetonitrile at 40 - 80℃; Product distribution / selectivity;86.2%
In isopropyl alcohol at 5 - 10℃; for 0.5h;83%
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate

(1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate With potassium carbonate In water pH=Ca. 10; Large scale;
Stage #2: methanesulfonic acid In isopropyl alcohol at 20℃; for 1.5h; Large scale;		92.6%
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate With sodium hydrogencarbonate In water; ethyl acetate at 20 - 25℃; Inert atmosphere;
Stage #2: methanesulfonic acid In isopropyl alcohol Reflux;		89%
methanesulfonic acid
75-75-2

methanesulfonic acid

rasagiline tartrate

rasagiline tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In isopropyl alcohol at 5℃; for 1.5h; Reflux;83%
methanesulfonic acid
75-75-2

methanesulfonic acid

rasagiline tartrate

rasagiline tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In isopropyl alcohol at 5 - 10℃; for 0.75h;83%
methanesulfonic acid
75-75-2

methanesulfonic acid

N-(2,3 dibromopropyl)-1-aminoindan
1166392-46-6

N-(2,3 dibromopropyl)-1-aminoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: N-(2,3 dibromopropyl)-1-aminoindan With potassium hydroxide In denaturated industrial spirit; water at 80 - 90℃; for 5h;
Stage #2: methanesulfonic acid In isopropyl alcohol at 25 - 30℃;
methanesulfonic acid
75-75-2

methanesulfonic acid

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In acetone for 0.75h; Product distribution / selectivity; Reflux;n/a
2,3-dihydro-1H-inden-1-amine
34698-41-4

2,3-dihydro-1H-inden-1-amine

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 24 h / 55 °C
2.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux
3.1: ammonia / water / pH ~ 8.5 - 9
3.2: 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
2: 0.75 h / 25 - 65 °C
3: sodium hydroxide / water / 20 °C
4: acetone / 1 h / 25 - 35 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
2.1: 0.75 h / 25 - 65 °C
3.1: sodium hydroxide / water / 20 °C
4.1: hydrogen bromide / 0.5 h / 25 - 65 °C
5.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
5.2: 0.5 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
2: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
3: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
4: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 6 steps
1: ethanol; tert-butyl methyl ether / 20 °C
2: ethanol / 2.32 h / 79 °C
3: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
4: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
5: sodium hydroxide / toluene / 29 h / 30 °C
6: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate
1201685-18-8

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate With ammonia In water pH=~ 8.5 - 9;
Stage #2: methanesulfonic acid In acetone at 25 - 30℃; for 2h; Product distribution / selectivity;
inden-1-one
83-33-0

inden-1-one

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethanol / 8 h / 25 - 30 °C
2.1: ethanol; sodium tetrahydroborate / 8 h / 25 - 30 °C
3.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux
4.1: ammonia / water / pH ~ 8.5 - 9
4.2: 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / tert-butyl methyl ether / 8 h
1.2: 1 h / -70 - -30 °C
2.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C
2.2: 1 h / 20 °C
3.1: tert-butyl methyl ether / 21 h / 10 °C / Heating
4.1: sodium hydroxide
5.1: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
Multi-step reaction with 6 steps
1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 70 - 75 °C
2: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
3: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
4: 0.75 h / 25 - 65 °C
5: sodium hydroxide / water / 20 °C
6: acetone / 1 h / 25 - 35 °C
View Scheme
C21H33NO4Ti

C21H33NO4Ti

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ethanol; sodium tetrahydroborate / 8 h / 25 - 30 °C
2.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux
3.1: ammonia / water / pH ~ 8.5 - 9
3.2: 2 h / 25 - 30 °C
View Scheme
rasagiline
136236-51-6

rasagiline

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen bromide / 0.5 h / 25 - 65 °C
2.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
2.2: 0.5 h / 40 °C
View Scheme
N-propargyl-1-aminoindan
1875-50-9

N-propargyl-1-aminoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tert-butyl methyl ether / 21 h / 10 °C / Heating
2: sodium hydroxide
3: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: 0.75 h / 25 - 65 °C
2: sodium hydroxide / water / 20 °C
3: acetone / 1 h / 25 - 35 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 0.75 h / 25 - 65 °C
2.1: sodium hydroxide / water / 20 °C
3.1: hydrogen bromide / 0.5 h / 25 - 65 °C
4.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
4.2: 0.5 h / 40 °C
View Scheme
N-(2,3-dihydroinden-1-ylidene)prop-2-yn-1-amine
1227784-59-9

N-(2,3-dihydroinden-1-ylidene)prop-2-yn-1-amine

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C
1.2: 1 h / 20 °C
2.1: tert-butyl methyl ether / 21 h / 10 °C / Heating
3.1: sodium hydroxide
4.1: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate
1309125-23-2

R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide
2: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 15 - 20 °C
1.2: 2.75 h / 15 - 20 °C
2.1: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 0.58 h / 20 °C / Ice bath
2.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C
2.2: 4 h / 30 - 35 °C
3.1: potassium hydroxide / water; methanol / 30 - 35 °C
4.1: isopropyl alcohol / 20 - 60 °C
4.2: 0.42 h / 20 - 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 15 - 20 °C
1.2: 2.75 h / 15 - 20 °C
2.1: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / toluene / 29 h / 30 °C
2: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
N-trifluoroacetyl-(R)-1-aminoindan
155666-94-7

N-trifluoroacetyl-(R)-1-aminoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C
1.2: 4 h / 30 - 35 °C
2.1: potassium hydroxide / water; methanol / 30 - 35 °C
3.1: isopropyl alcohol / 20 - 60 °C
3.2: 0.42 h / 20 - 60 °C
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate / acetonitrile; toluene / 30 - 35 °C
2: potassium hydroxide; water / methanol / 0.5 h / 30 - 35 °C
3: isopropyl alcohol / 50 - 60 °C
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide
694436-33-4

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide With sodium hydroxide In ethyl acetate at 65℃; for 4h;
Stage #2: methanesulfonic acid In ethyl acetate at 40℃; for 0.5h;
indan-1-one oxime
68253-35-0, 100485-57-2, 3349-60-8

indan-1-one oxime

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
2: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
3: 0.75 h / 25 - 65 °C
4: sodium hydroxide / water / 20 °C
5: acetone / 1 h / 25 - 35 °C
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
2.1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
3.1: 0.75 h / 25 - 65 °C
4.1: sodium hydroxide / water / 20 °C
5.1: hydrogen bromide / 0.5 h / 25 - 65 °C
6.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
6.2: 0.5 h / 40 °C
View Scheme
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C
2: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
3: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
4: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
5: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 7 steps
1: ammonia; hydrogen / methanol / 20 h / 42 °C / 2625.26 Torr
2: ethanol; tert-butyl methyl ether / 20 °C
3: ethanol / 2.32 h / 79 °C
4: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
5: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
6: sodium hydroxide / toluene / 29 h / 30 °C
7: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
di-(R-(+)-N-propargyl-1-aminoindan) L-tartrate

di-(R-(+)-N-propargyl-1-aminoindan) L-tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 20 °C
2.1: hydrogen bromide / 0.5 h / 25 - 65 °C
3.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
3.2: 0.5 h / 40 °C
View Scheme
N-[(1R)-2,3-dihydro-1H-inden-1-yl]-2-methoxyacetamide

N-[(1R)-2,3-dihydro-1H-inden-1-yl]-2-methoxyacetamide

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
2: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
3: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
(S)-1-Aminoindane
10277-74-4, 34698-41-4, 61341-86-4, 61949-83-5

(S)-1-Aminoindane

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Pd/AlO(OH) / toluene / 6 h / 70 °C / Inert atmosphere; Schlenk technique
2: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
3: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
4: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
5: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
3-Phenylpropionic acid
501-52-0

3-Phenylpropionic acid

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: polyphosphoric acid / 0.5 h / 90 °C
2: hydroxylamine hydrochloride / ethanol; water / 0.75 h / Reflux
3: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C
4: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
5: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
6: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
7: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
2,3-dihydro-1H-inden-1-yl-acetate
26452-98-2

2,3-dihydro-1H-inden-1-yl-acetate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Candida rugosa lipase / tetrahydrofuran; aq. phosphate buffer / 24 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
4: potassium carbonate / acetonitrile / 16 h / 60 °C
5: isopropyl alcohol / 1 h / Reflux
View Scheme
1-Indanol
6351-10-6

1-Indanol

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Thermomyces lanuginosus lipase / hexane / 0.25 h / 35 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
4: potassium carbonate / acetonitrile / 16 h / 60 °C
5: isopropyl alcohol / 1 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: pseudomonas fluorescens lipase / toluene / 6 h / 30 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
4: potassium carbonate / acetonitrile / 16 h / 60 °C
5: isopropyl alcohol / 1 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1: dmap / dichloromethane / 4 h / 20 °C
2: Candida rugosa lipase / tetrahydrofuran; aq. phosphate buffer / 24 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction
3: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
4: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
5: potassium carbonate / acetonitrile / 16 h / 60 °C
6: isopropyl alcohol / 1 h / Reflux
View Scheme
(S)-indanol
25501-32-0

(S)-indanol

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
2: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
3: potassium carbonate / acetonitrile / 16 h / 60 °C
4: isopropyl alcohol / 1 h / Reflux
View Scheme
(R)-(+)-1-azidoindan

(R)-(+)-1-azidoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
2: potassium carbonate / acetonitrile / 16 h / 60 °C
3: isopropyl alcohol / 1 h / Reflux
View Scheme
(R)-1-Aminoindane
10277-74-4

(R)-1-Aminoindane

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 16 h / 60 °C
2: isopropyl alcohol / 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
2: sodium hydroxide / toluene / 29 h / 30 °C
3: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 16 h / 60 °C
2: isopropyl alcohol / 1 h / 70 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 15 - 20 °C / Inert atmosphere
2: triphenylsilyl radical; 2-Chlorobenzeneboronic acid / toluene / 24 h / 10 - 15 °C / Inert atmosphere
3: isopropyl alcohol / 1 h / 70 - 75 °C
View Scheme
(R)-1-aminoindan (S)-N-acetyl-L-glutaminate (2:1)

(R)-1-aminoindan (S)-N-acetyl-L-glutaminate (2:1)

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
2: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
3: sodium hydroxide / toluene / 29 h / 30 °C
4: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
rasagiline mesylate
161735-79-1

rasagiline mesylate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water at 3 - 5℃; for 1h; pH=7.5 - 11; Product distribution / selectivity;91.6%
With sodium hydroxide In water at 3 - 5℃; pH=11;91.6%
With sodium hydroxide In water; toluene pH=~ 14;
With sodium hydroxide In water; toluene pH=14;
(R-(+)-N-propargyl-1-aminoindan)L-tartarate

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

rasagiline mesylate
161735-79-1

rasagiline mesylate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 40 - 50℃; pH=14; Product distribution / selectivity;

Rasagiline Mesylate Chemical Properties

Product Name: Rasagiline Mesylate (CAS NO.161735-79-1)

IUPAC Name: methanesulfonic acid; (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
Molecular Formula: C13H17NO3S
Molecular Weight: 267.343980 g/mol
Appearance: White to Off-White Crystalline Solid
Density: 1.05 g/cm3
Boiling Point: 305.5 °C at 760 mmHg
Flash Point: 146.8 °C
Categories: APIs; Chiral; Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Rasagiline

Rasagiline Mesylate Uses

 Rasagiline Mesylate (CAS NO.161735-79-1) is a selective irreversible MAO-B inhibitor.

Rasagiline Mesylate Specification

  Rasagiline Mesylate , its CAS NO. is 161735-79-1, the synonyms are (r)-n-2-Propynyl-1-indanamine methanesulfonate ; (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine Mesylate ; (R)-N-2-Propynyl-1-indanamine Mesylate ; Agilect ; Azilect ; TVP-101 ; Rasagiline nesylate .

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