The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:125971-96-2
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct Description Product website: http://www.finerchem.com Product Name 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide CAS No.
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inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white crystalline powder Storage:room temprature Package:25kg/drum Application:Intermediate of Atrovastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou
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inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable
Cas:125971-96-2
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryName:2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide CAS NO:125971-96-2 Grade:Medical scientific research and export Molecular formula: C26H24FNO3 Molecular weight:417.47 Product Quality 12 years of chemical ra
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryhemical name: 4-fluoro-alpha-(2-methyl-1-oxopropyl)-gama-oxo-n,beta-diphenylbenzene butaneamide English name: 4-fluoro- α -[2-methyl-1-oxopropyl]- γ -oxo-N, β - diphenylbenzene butaneamide CAS No.: 125971-96-2 MF: C26H24FNO3 Appea
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:125971-96-2
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:125971-96-2
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:125971-96-2
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inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:125971-96-2
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inquiryProduct Name: 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide CAS: 125971-96-2 MF: C26H24FNO3 MW: 417.47 EINECS: 425-850-3 Mol File: 125971-96-2.mol 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl
Cas:125971-96-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:125971-96-2
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:125971-96-2
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inquiry2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide CAS:125971-96-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemica
Cas:125971-96-2
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:125971-96-2
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inquiry4-fluoro-alpha-(2-methyl-1-oxopropyl)-gama-oxo-n,beta-diphenylbenzene butaneamide CAS: 125971-96-2 CAS: 125971-96-2 MF: C26H24FNO3 MW: 417.47 EINECS: 425-850-3 Product Categories: Chemical
Cas:125971-96-2
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryProduct Name: 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide Synonyms: Azithromycin Impurity 1;Atorvastatin Calcium Intermediates-M4;M-4;2[2-(4-FLUOROPHENYL)-2-OXO-1-PHENYLETHYL]-4-METHYL-3-OXO-PENTANOIC ACID PHENY
Cas:125971-96-2
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:125971-96-2
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryAppearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se
Cas:125971-96-2
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inquiry3-phenylpropynoic acid phenylamide
4-fluorobenzaldehyde
isobutyraldehyde
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With copper(II) hexafluoroantimonate; C32H44Cl2N4O6Pd In tetrahydrofuran at 50 - 60℃; for 24h; Solvent; Reagent/catalyst; Inert atmosphere; | 87.5% |
2-chloro-1-(4-fluorophenyl)-2-phenylethan-1-one
4-methyl-3-oxo-N-phenylpentanamide
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 25 - 60℃; Reflux; | 74% |
2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one
4-methyl-3-oxo-N-phenylpentanamide
A
1-(4-fluorophenyl)-2-phenylethanone
B
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; for 5h; Reagent/catalyst; Time; Darkness; | A n/a B 80% |
4-methyl-3-oxo-N-phenylpentanamide
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With potassium carbonate In isopropyl alcohol at 10 - 45℃; Product distribution / selectivity; | 73% |
Multi-step reaction with 2 steps 1: β-alanine; glacial acetic acid / hexane / Heating 2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid; 4-amino-phenol / hexane / 24 h / Reflux 2.1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / neat (no solvent) / 16 h / 75 °C / Inert atmosphere 2.2: 4 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: glycine; acetic acid / n-heptane / 8 h / Inert atmosphere; Reflux 2: 10 h / 20 °C / Inert atmosphere View Scheme |
4-fluorobenzaldehyde
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide In tetrahydrofuran at 60 - 70℃; for 16 - 24h; Stetter reaction; |
4-fluorobenzaldehyde
4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Stage #1: 4-fluorobenzaldehyde; 4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine In neat (no solvent) at 75℃; for 16h; Inert atmosphere; Stage #2: With isopropyl alcohol at 25℃; for 4h; Inert atmosphere; | 85% |
With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine In ethanol Addition; Heating; | |
at 20℃; for 10h; Inert atmosphere; | 33 g |
With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine Stetter 1,4-Dicarbonyl Synthesis; Reflux; |
2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide
1-(4-fluorophenyl)-2-phenylethanone
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -25 - -10℃; for 0.5h; Stage #2: 1-(4-fluorophenyl)-2-phenylethanone In tetrahydrofuran; hexane at -78 - -60℃; for 1h; Stage #3: 2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide In tetrahydrofuran; hexane at -78 - 15℃; for 1.5h; | 85% |
Stage #1: 1-(4-fluorophenyl)-2-phenylethanone With sodium carbonate In N,N-dimethyl-formamide for 0.25h; Stage #2: 2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide In N,N-dimethyl-formamide at 90℃; for 23h; Product distribution / selectivity; | |
Stage #1: 1-(4-fluorophenyl)-2-phenylethanone With sodium carbonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.5h; Stage #2: 2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide In N,N-dimethyl-formamide at 20 - 95℃; for 29.17h; Product distribution / selectivity; |
2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one
4-methyl-3-oxo-N-phenylpentanamide
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 2h; Reflux; | 78% |
With potassium carbonate In acetone at 18.5 - 26℃; Product distribution / selectivity; | 77.7% |
With potassium carbonate In acetone at 18 - 26℃; | 74% |
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; water; mercury(II) oxide In tetrahydrofuran for 0.5h; | 49% |
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With water; copper(II) oxide; copper dichloride In acetone for 1h; Heating / reflux; | 54% |
4-fluorobenzaldehyde
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide
4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With triethylamine In ethanol; isopropyl alcohol | |
With triethylamine In ethanol; isopropyl alcohol |
4-fluorobenzaldehyde
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide
4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With triethylamine In ethanol; isopropyl alcohol |
4-methyl-3-oxo-N-phenyl-2-(phenylmethylene) pentanamide
4-fluorobenzaldehyde
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide
B
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With triethylamine In ethanol |
4-fluorobenzaldehyde
4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With triethylamine at 65 - 70℃; | 84% |
4-methyl-3-oxo-N-phenylpentanamide
A
3-[2-(4-fluorophenyl)-2-oxo-1-phenyl-ethoxy]-4-methyl-pent-2-enoic acid phenylamide
B
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 10 - 45℃; Product distribution / selectivity; | A 14.7 %Chromat. B n/a |
Methyl 4-methyl-3-oxopentanoate
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / 80 - 125 °C 2: potassium carbonate / acetone / 18.5 - 26 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide / neat (no solvent) / 12 h / 135 °C 2.1: acetic acid; 4-amino-phenol / hexane / 24 h / Reflux 3.1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / neat (no solvent) / 16 h / 75 °C / Inert atmosphere 3.2: 4 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: ethylenediamine / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 140 - 150 °C / Inert atmosphere 2: glycine; acetic acid / n-heptane / 8 h / Inert atmosphere; Reflux 3: 10 h / 20 °C / Inert atmosphere View Scheme |
aniline
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / 80 - 125 °C 2: potassium carbonate / acetone / 18.5 - 26 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / 80 - 125 °C 2: potassium carbonate / acetone / 25 - 60 °C / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide / neat (no solvent) / 12 h / 135 °C 2.1: acetic acid; 4-amino-phenol / hexane / 24 h / Reflux 3.1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / neat (no solvent) / 16 h / 75 °C / Inert atmosphere 3.2: 4 h / 25 °C / Inert atmosphere View Scheme |
phenylacetyl chloride
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere 2: sulfuryl dichloride / dichloromethane / 10 - 20 °C 3: potassium carbonate / acetone / 25 - 60 °C / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere 2: bromine; hydrogen bromide; acetic acid / dichloromethane / 26 °C 3: potassium carbonate / acetone / 18.5 - 26 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 1 h / 10 °C 2.1: hydrogen bromide / water / 0.08 h / 20 °C / Darkness 2.2: 5 h / 20 °C 2.3: 12 h / 20 °C 3.1: potassium carbonate / acetone / 5 h / 20 °C / Darkness View Scheme | |
Multi-step reaction with 3 steps 1: zeolite / dichloromethane / 2 h / 10 °C / Cooling with ice; Molecular sieve 2: hydrogen bromide; dihydrogen peroxide; acetic acid / 16 h / 40 °C 3: potassium carbonate / acetone / 2 h / Reflux View Scheme |
1-(4-fluorophenyl)-2-phenylethanone
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuryl dichloride / dichloromethane / 10 - 20 °C 2: potassium carbonate / acetone / 25 - 60 °C / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: bromine; hydrogen bromide; acetic acid / dichloromethane / 26 °C 2: potassium carbonate / acetone / 18.5 - 26 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen bromide; dihydrogen peroxide; acetic acid / 16 h / 40 °C 2: potassium carbonate / acetone / 2 h / Reflux View Scheme |
benzaldehyde
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: β-alanine; glacial acetic acid / hexane / Heating 2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating View Scheme |
aniline
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 96 percent / toluene / Heating 2: β-alanine; glacial acetic acid / hexane / Heating 3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating View Scheme |
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 96 percent / toluene / Heating 2: β-alanine; glacial acetic acid / hexane / Heating 3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating View Scheme |
fluorobenzene
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere 2: sulfuryl dichloride / dichloromethane / 10 - 20 °C 3: potassium carbonate / acetone / 25 - 60 °C / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere 2: bromine; hydrogen bromide; acetic acid / dichloromethane / 26 °C 3: potassium carbonate / acetone / 18.5 - 26 °C View Scheme |
4-fluorobenzaldehyde
4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
B
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
With triethylamine; ethyl thiazolium catalyst or with methyl thiazolium catalyst; 1) EtOH; Yield given. Multistep reaction; |
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 1 h / 10 °C 2.1: hydrogen bromide / water / 0.08 h / 20 °C / Darkness 2.2: 5 h / 20 °C 2.3: 12 h / 20 °C 3.1: potassium carbonate / acetone / 5 h / 20 °C / Darkness View Scheme |
phenylacetic acid
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / chloroform / Reflux 2: zeolite / dichloromethane / 2 h / 10 °C / Cooling with ice; Molecular sieve 3: hydrogen bromide; dihydrogen peroxide; acetic acid / 16 h / 40 °C 4: potassium carbonate / acetone / 2 h / Reflux View Scheme |
3-methyl-butan-2-one
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium tert-butylate / tetrahydrofuran / 8 h / 60 °C / Inert atmosphere 2: ethylenediamine / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 140 - 150 °C / Inert atmosphere 3: glycine; acetic acid / n-heptane / 8 h / Inert atmosphere; Reflux 4: 10 h / 20 °C / Inert atmosphere View Scheme |
aniline
phenylpropyolic acid
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 0 - 30 °C / Large scale 2: copper(II) hexafluoroantimonate; C32H44Cl2N4O6Pd / tetrahydrofuran / 24 h / 50 - 60 °C / Inert atmosphere View Scheme |
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