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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Buy Reliable Quality 125971-96-2 Cheap Price

Cas:125971-96-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide

Cas:125971-96-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide CAS No.

4-Fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,beta-diphenylbenzene butaneamide

Cas:125971-96-2

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 50Mt annually; Appearance:white to off-white crystalline powder Storage:room temprature Package:25kg/drum Application:Intermediate of Atrovastatin Calcium Port:Beijing/Shanghai/Shenzhen/Hangzhou

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

atovastatin calcium intermediates -M4

Cas:125971-96-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

4-FLUORO-ALPHA-(2-METHYL-1-OXOPROPYL-GAMA-OXO)-N,BETA-DIPHENYLBENZENE BUTANEAMIDE

Cas:125971-96-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Fluoro-α-(2-methyl-1-oxopropyl)-τ-oxo-N,β-diphenylbenzenebutanamide

Cas:125971-96-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide CAS NO:125971-96-2 Grade:Medical scientific research and export Molecular formula: C26H24FNO3 Molecular weight:417.47 Product Quality 12 years of chemical ra

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Fluoro-a-(2-methyl-1-oxopropyl)-γ-oxo-N,b-diphenyl-benzenebutanamide CAS 125971-96-2

Cas:125971-96-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide

Cas:125971-96-2

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 125971-96-2 with competitive price

Cas:125971-96-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

hemical name: 4-fluoro-alpha-(2-methyl-1-oxopropyl)-gama-oxo-n,beta-diphenylbenzene butaneamide English name: 4-fluoro- α -[2-methyl-1-oxopropyl]- γ -oxo-N, β - diphenylbenzene butaneamide CAS No.: 125971-96-2 MF: C26H24FNO3 Appea

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

(4-fluoro-a-[2-methyl-1-ooxopropyl]-y-oxo-N,b-diphenylbenzene butane amide(M4) CAS: 125971-96-2 with high purity

Cas:125971-96-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,bata-diphenylbenzene butaneamide 125971-96-2

Cas:125971-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide (M4)

Cas:125971-96-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide CAS: 125971-96-2 MF: C26H24FNO3 MW: 417.47 EINECS: 425-850-3 Mol File: 125971-96-2.mol 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl

2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide

Cas:125971-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

125971-96-2 cas SHIPPING DOOR TO DOOR 99% Atorvastatin intermediates M-4

Cas:125971-96-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Qingdao Beluga Import and Export Co., LTD

2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide CAS:125971-96-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemica

2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide CAS:125971-96-2

Cas:125971-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,bata-diphenylbenzene butaneamide

Cas:125971-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

4-fluoro-alpha-(2-methyl-1-oxopropyl)-gama-oxo-n,beta-diphenylbenzene butaneamide CAS: 125971-96-2 CAS: 125971-96-2 MF: C26H24FNO3 MW: 417.47 EINECS: 425-850-3 Product Categories: Chemical

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide Synonyms: Azithromycin Impurity 1;Atorvastatin Calcium Intermediates-M4;M-4;2[2-(4-FLUOROPHENYL)-2-OXO-1-PHENYLETHYL]-4-METHYL-3-OXO-PENTANOIC ACID PHENY

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-N,bata-diphenylbenzene butaneamide

Cas:125971-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-Fluoro-α-[2-Methyl-1-Oxopropyl]-γ-Oxo-N,β-Diphenyl Benzene Butane Amide

Cas:125971-96-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-[2-(4-Fluorophenyl)-2-Oxo-1-Phenylethyl]-4-Methyl-3-Oxo-N-Phenylpentanamide

Cas:125971-96-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

4-fluoro-alpha-(2-methyl-1-oxopropyl)-gama-oxo-n,beta-diphenylbenzene butaneamide

Cas:125971-96-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-phenylpropynoic acid phenylamide
7342-02-1

3-phenylpropynoic acid phenylamide

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

isobutyraldehyde
78-84-2

isobutyraldehyde

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With copper(II) hexafluoroantimonate; C32H44Cl2N4O6Pd In tetrahydrofuran at 50 - 60℃; for 24h; Solvent; Reagent/catalyst; Inert atmosphere;87.5%
2-chloro-1-(4-fluorophenyl)-2-phenylethan-1-one
62148-67-8

2-chloro-1-(4-fluorophenyl)-2-phenylethan-1-one

4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 25 - 60℃; Reflux;74%
2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one
88675-31-4

2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one

4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

A

1-(4-fluorophenyl)-2-phenylethanone
347-84-2

1-(4-fluorophenyl)-2-phenylethanone

B

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 5h; Reagent/catalyst; Time; Darkness;A n/a
B 80%
4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With potassium carbonate In isopropyl alcohol at 10 - 45℃; Product distribution / selectivity;73%
Multi-step reaction with 2 steps
1: β-alanine; glacial acetic acid / hexane / Heating
2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: acetic acid; 4-amino-phenol / hexane / 24 h / Reflux
2.1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / neat (no solvent) / 16 h / 75 °C / Inert atmosphere
2.2: 4 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: glycine; acetic acid / n-heptane / 8 h / Inert atmosphere; Reflux
2: 10 h / 20 °C / Inert atmosphere
View Scheme
2-benzylidine isobutyryl acetanilide

2-benzylidine isobutyryl acetanilide

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide In tetrahydrofuran at 60 - 70℃; for 16 - 24h; Stetter reaction;
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
125971-57-5

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Stage #1: 4-fluorobenzaldehyde; 4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine In neat (no solvent) at 75℃; for 16h; Inert atmosphere;
Stage #2: With isopropyl alcohol at 25℃; for 4h; Inert atmosphere;
85%
With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine In ethanol Addition; Heating;
at 20℃; for 10h; Inert atmosphere;33 g
With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine Stetter 1,4-Dicarbonyl Synthesis; Reflux;
2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide
807361-46-2

2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide

1-(4-fluorophenyl)-2-phenylethanone
347-84-2

1-(4-fluorophenyl)-2-phenylethanone

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -25 - -10℃; for 0.5h;
Stage #2: 1-(4-fluorophenyl)-2-phenylethanone In tetrahydrofuran; hexane at -78 - -60℃; for 1h;
Stage #3: 2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide In tetrahydrofuran; hexane at -78 - 15℃; for 1.5h;
85%
Stage #1: 1-(4-fluorophenyl)-2-phenylethanone With sodium carbonate In N,N-dimethyl-formamide for 0.25h;
Stage #2: 2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide In N,N-dimethyl-formamide at 90℃; for 23h; Product distribution / selectivity;
Stage #1: 1-(4-fluorophenyl)-2-phenylethanone With sodium carbonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.5h;
Stage #2: 2-bromo-4-methyl-3-oxo-pentanoic acid phenylamide In N,N-dimethyl-formamide at 20 - 95℃; for 29.17h; Product distribution / selectivity;
2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one
88675-31-4

2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one

4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With potassium carbonate In acetone for 2h; Reflux;78%
With potassium carbonate In acetone at 18.5 - 26℃; Product distribution / selectivity;77.7%
With potassium carbonate In acetone at 18 - 26℃;74%
2-[2,2-bis-ethylsulphanyl-2-(4-fluoro-phenyl)-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide

2-[2,2-bis-ethylsulphanyl-2-(4-fluoro-phenyl)-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; water; mercury(II) oxide In tetrahydrofuran for 0.5h;49%
2-{[2-(4-fluoro-phenyl)-[1,3]dithian-2-yl]-phenyl-methyl}-4-methyl-3-oxo-pentanoic acid phenylamide

2-{[2-(4-fluoro-phenyl)-[1,3]dithian-2-yl]-phenyl-methyl}-4-methyl-3-oxo-pentanoic acid phenylamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With water; copper(II) oxide; copper dichloride In acetone for 1h; Heating / reflux;54%
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide
54016-70-5

3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide

4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide
222320-29-8

4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With triethylamine In ethanol; isopropyl alcohol
With triethylamine In ethanol; isopropyl alcohol
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide
54016-70-5

3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
125971-57-5

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With triethylamine In ethanol; isopropyl alcohol
4-methyl-3-oxo-N-phenyl-2-(phenylmethylene) pentanamide
222320-17-4

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene) pentanamide

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide
54016-70-5

3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide

A

(+-)4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenybenzenebutaneamide

(+-)4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenybenzenebutaneamide

B

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With triethylamine In ethanol
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide
222320-29-8

4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With triethylamine at 65 - 70℃;84%
4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

A

3-[2-(4-fluorophenyl)-2-oxo-1-phenyl-ethoxy]-4-methyl-pent-2-enoic acid phenylamide
1198087-00-1

3-[2-(4-fluorophenyl)-2-oxo-1-phenyl-ethoxy]-4-methyl-pent-2-enoic acid phenylamide

B

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 10 - 45℃; Product distribution / selectivity;A 14.7 %Chromat.
B n/a
Methyl 4-methyl-3-oxopentanoate
42558-54-3

Methyl 4-methyl-3-oxopentanoate

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / 80 - 125 °C
2: potassium carbonate / acetone / 18.5 - 26 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / neat (no solvent) / 12 h / 135 °C
2.1: acetic acid; 4-amino-phenol / hexane / 24 h / Reflux
3.1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / neat (no solvent) / 16 h / 75 °C / Inert atmosphere
3.2: 4 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: ethylenediamine / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 140 - 150 °C / Inert atmosphere
2: glycine; acetic acid / n-heptane / 8 h / Inert atmosphere; Reflux
3: 10 h / 20 °C / Inert atmosphere
View Scheme
aniline
62-53-3

aniline

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / 80 - 125 °C
2: potassium carbonate / acetone / 18.5 - 26 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / 80 - 125 °C
2: potassium carbonate / acetone / 25 - 60 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / neat (no solvent) / 12 h / 135 °C
2.1: acetic acid; 4-amino-phenol / hexane / 24 h / Reflux
3.1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / neat (no solvent) / 16 h / 75 °C / Inert atmosphere
3.2: 4 h / 25 °C / Inert atmosphere
View Scheme
phenylacetyl chloride
103-80-0

phenylacetyl chloride

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere
2: sulfuryl dichloride / dichloromethane / 10 - 20 °C
3: potassium carbonate / acetone / 25 - 60 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere
2: bromine; hydrogen bromide; acetic acid / dichloromethane / 26 °C
3: potassium carbonate / acetone / 18.5 - 26 °C
View Scheme
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 1 h / 10 °C
2.1: hydrogen bromide / water / 0.08 h / 20 °C / Darkness
2.2: 5 h / 20 °C
2.3: 12 h / 20 °C
3.1: potassium carbonate / acetone / 5 h / 20 °C / Darkness
View Scheme
Multi-step reaction with 3 steps
1: zeolite / dichloromethane / 2 h / 10 °C / Cooling with ice; Molecular sieve
2: hydrogen bromide; dihydrogen peroxide; acetic acid / 16 h / 40 °C
3: potassium carbonate / acetone / 2 h / Reflux
View Scheme
1-(4-fluorophenyl)-2-phenylethanone
347-84-2

1-(4-fluorophenyl)-2-phenylethanone

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuryl dichloride / dichloromethane / 10 - 20 °C
2: potassium carbonate / acetone / 25 - 60 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1: bromine; hydrogen bromide; acetic acid / dichloromethane / 26 °C
2: potassium carbonate / acetone / 18.5 - 26 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen bromide; dihydrogen peroxide; acetic acid / 16 h / 40 °C
2: potassium carbonate / acetone / 2 h / Reflux
View Scheme
benzaldehyde
100-52-7

benzaldehyde

HI, I2

HI, I2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: β-alanine; glacial acetic acid / hexane / Heating
2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
View Scheme
aniline
62-53-3

aniline

Wang resin-bound styrene 4

Wang resin-bound styrene 4

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 96 percent / toluene / Heating
2: β-alanine; glacial acetic acid / hexane / Heating
3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
View Scheme
isobutyryl Meldrum's acid

isobutyryl Meldrum's acid

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 96 percent / toluene / Heating
2: β-alanine; glacial acetic acid / hexane / Heating
3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
View Scheme
fluorobenzene
462-06-6

fluorobenzene

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere
2: sulfuryl dichloride / dichloromethane / 10 - 20 °C
3: potassium carbonate / acetone / 25 - 60 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1: aluminum (III) chloride / -10 - 0 °C / Inert atmosphere
2: bromine; hydrogen bromide; acetic acid / dichloromethane / 26 °C
3: potassium carbonate / acetone / 18.5 - 26 °C
View Scheme
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
125971-57-5

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide

A

B

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
With triethylamine; ethyl thiazolium catalyst or with methyl thiazolium catalyst; 1) EtOH; Yield given. Multistep reaction;
fluorobenzene

fluorobenzene

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 1 h / 10 °C
2.1: hydrogen bromide / water / 0.08 h / 20 °C / Darkness
2.2: 5 h / 20 °C
2.3: 12 h / 20 °C
3.1: potassium carbonate / acetone / 5 h / 20 °C / Darkness
View Scheme
phenylacetic acid
103-82-2

phenylacetic acid

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / chloroform / Reflux
2: zeolite / dichloromethane / 2 h / 10 °C / Cooling with ice; Molecular sieve
3: hydrogen bromide; dihydrogen peroxide; acetic acid / 16 h / 40 °C
4: potassium carbonate / acetone / 2 h / Reflux
View Scheme
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate / tetrahydrofuran / 8 h / 60 °C / Inert atmosphere
2: ethylenediamine / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 140 - 150 °C / Inert atmosphere
3: glycine; acetic acid / n-heptane / 8 h / Inert atmosphere; Reflux
4: 10 h / 20 °C / Inert atmosphere
View Scheme
aniline
62-53-3

aniline

phenylpropyolic acid
637-44-5

phenylpropyolic acid

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 0 - 30 °C / Large scale
2: copper(II) hexafluoroantimonate; C32H44Cl2N4O6Pd / tetrahydrofuran / 24 h / 50 - 60 °C / Inert atmosphere
View Scheme
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