Sulfamonomethoxine supplier

Name
Sulfamonomethoxine
EINECS 624-483-8
CAS No. 1220-83-3
Article Data7
CAS DataBase
Density 1.465 g/cm³
Solubility Soluble in water at 10mg/ml with warming. Also soluble in ethanol or methanol
Melting Point 203-206 °C
Formula C₁₁H₁₂N₄O₃S
Boiling Point 513.2 °C at 760 mmHg
Molecular Weight 280.307
Flash Point 264.2 °C
Transport Information
Appearance white to off-white crystalline powder
Safety 26-36
Risk Codes 36/37/38-43
Molecular Structure
Hazard Symbols Xi
Synonyms Sulfanilamide,N1-(6-methoxy-4-pyrimidinyl)- (6CI,8CI);4-Methoxy-6-sulfanilamidopyrimidine;4-Sulfanilamido-6-methoxypyrimidine;6-Methoxy-4-sulfanilamidopyrimidine;6-Sulfanilamido-4-methoxypyrimidine;DJ 1550;DS 36;Daimeton;ICI 32525;N1-(6-Methoxy-4-pyrimidinyl)sulfanilamide;Ro 4-3476;
PSA 115.58000
LogP 2.60320

Synthetic route

: 1748-50-1
4-Nitrobenzenesulfonamido-6-methoxypyrimidine

: 1220-83-3
sulfamonomethoxine

Conditions

Conditions	Yield
With iron; ammonium chloride In water for 10h; Heating; Yield given;

: 100-05-0
4-nitrobenzenediazonium chloride

benzo<b>thiophen-3-yl-glyoxal phenylhydrazone: benzo<b>thiophen-3-yl-glyoxal phenylhydrazone

: 1220-83-3
sulfamonomethoxine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: SO2 / CuSO4 / acetic acid / 6 - 20 °C 2: 92 percent / pyridine / 2 h / 56 - 58 °C 3: Fe, NH4Cl / H2O / 10 h / Heating View Scheme

: 98-74-8
4-Nitrobenzenesulfonyl chloride

(+-)-2-amino-5-butyl-thiazol-4-one: (+-)-2-amino-5-butyl-thiazol-4-one

: 1220-83-3
sulfamonomethoxine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / pyridine / 2 h / 56 - 58 °C 2: Fe, NH4Cl / H2O / 10 h / Heating View Scheme

: 940-93-2
2,4,6-trimethylpyrylium chlorate(VII)

: 1220-83-3
sulfamonomethoxine

: 1-[4-(6-Methoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-2,4,6-trimethyl-pyridinium; perchlorate

Conditions

Conditions	Yield
In acetic acid for 2h; Heating;	97%

: 1220-83-3
sulfamonomethoxine

: glycyrrhyzic acid

: C75H92N12O22S3

Conditions

Conditions	Yield
pyridine; dicyclohexyl-carbodiimide In 1,4-dioxane at 20 - 22℃; for 24h; Condensation;	90.4%

: 34446-64-5, 42996-84-9
(E)-3-(4-methoxyphenyl)propenoyl chloride

: 1220-83-3
sulfamonomethoxine

: p-methoxycinnamoyl sulfamonomethoxine

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran for 25.5h; Cooling with ice;	85%

: 1220-83-3
sulfamonomethoxine

: 1,3-bis(N1-4-amino-6-methoxypyrimidinebenzenesulfonamide)-2,2,2,4,4,4-hexa-chlorocyclodiphosph(V)azane

Conditions

Conditions	Yield
With phosphorus pentachloride In benzene at 15℃; for 0.5h;	81%

: 63673-58-5
2,6-dimethyl-4-oxo-5-phenyl-1,3-oxazinium perchlorate

: 1220-83-3
sulfamonomethoxine

: 4-(2,6-dimethyl-4-oxo-5-phenyl-4H-pyrimidin-1-yl)-N-(6-methoxy-pyrimidin-4-yl)-benzenesulfonamide; compound with perchloric acid

Conditions

Conditions	Yield
In acetic acid for 48h; Ambient temperature;	65%

: 1220-83-3
sulfamonomethoxine

: 165068-34-8
(3R,5aS,6R,9R,10S,12R,12aR)-10-(3-bromopropoxy)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene

: 4-amino-N-(6-methoxypyrimidin-4-yl)-N-(3-((3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzenesulfonamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h;	56%

: 3-(o-methoxyphenyl)-2,6-dimethyl-4-oxo-1,3-oxazinium perchlorate

: 1220-83-3
sulfamonomethoxine

: 4-[5-(2-methoxy-phenyl)-2,6-dimethyl-4-oxo-4H-pyrimidin-1-yl]-N-(6-methoxy-pyrimidin-4-yl)-benzenesulfonamide; compound with perchloric acid

Conditions

Conditions	Yield
In acetic acid for 48h; Ambient temperature;	35%

: 80756-85-0
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

: 1220-83-3
sulfamonomethoxine

: (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)-N-(4-(N-(6-methoxypyrimidin-4-yl)sulfamoyl)phenyl)acetamide

Conditions

Conditions	Yield
With pyridine; triethylamine In ethanol; dichloromethane at 20℃; Inert atmosphere;	32.7%

: 1220-83-3
sulfamonomethoxine

: 14762-26-6
4-amino-N-(6-hydroxy-4-pyrimidinyl)benzenesulfonamide

Conditions

Conditions	Yield
With sodium hydroxide for 14h; Heating;	16%
With sodium hydroxide at 80 - 90℃; for 50h; Yield given;

: 19602-82-5
2,2'-dithiodibenzoic acid dichloride

: 1220-83-3
sulfamonomethoxine

: C36H30N8O8S4

Conditions

Conditions	Yield
With pyridine In 1,4-dioxane Ambient temperature;

tropaeolin O: tropaeolin O

: 1220-83-3
sulfamonomethoxine

: 1312665-65-8
C23H18N7O8S2(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: sulfamonomethoxine With hydrogenchloride; sodium nitrite In water at 0℃; for 0.166667h; Stage #2: tropaeolin O With sodium hydroxide In water pH=10.5;

: 55882-65-0, 108608-07-7, 50906-12-2
4-acetoxyferuloyl chloride

: 1220-83-3
sulfamonomethoxine

: C23H22N4O7S

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 0 - 20℃; for 6h;

: 55882-65-0, 108608-07-7, 50906-12-2
4-acetoxyferuloyl chloride

: 1220-83-3
sulfamonomethoxine

: N1-feruloylsulfamonomethoxine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / tetrahydrofuran / 6 h / 0 - 20 °C 2: hydrogenchloride / tetrahydrofuran / 1 h / 60 °C View Scheme

: 53901-95-4, 108608-06-6, 58523-18-5
p-acetoxycinnamoyl chloride

: 1220-83-3
sulfamonomethoxine

: 4-acetoxycinnamoyl sulfamonomethoxine

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran for 25.5h; Cooling with ice;

Sulfamonomethoxine Chemical Properties

Molecular Structure of Sulfamonomethoxine (CAS NO.1220-83-3):

IUPAC Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
Molecular Formula: C₁₁H₁₂N₄O₃S
Molecular Weight: 280.302980 g/mol
XLogP3: 0.8
H-Bond Donor: 2
H-Bond Acceptor: 7
Canonical SMILES: COC1=NC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
InChIKey: WMPXPUYPYQKQCX-UHFFFAOYSA-N
Index of Refraction: 1.646
Molar Refractivity: 69.51 cm³
Molar Volume: 191.2 cm³
Surface Tension: 75 dyne/cm
Density: 1.465 g/cm³
Flash Point: 264.2 °C
Enthalpy of Vaporization: 78.46 kJ/mol
Boiling Point: 513.2 °C at 760 mmHg
Vapour Pressure: 1.2E-10 mmHg at 25 °C
Water Solubility: 4029 mg/L at 25 °C
BRN: 0621128

Sulfamonomethoxine Toxicity Data With Reference

1.		orl-mus LD50:4680 mg/kg		NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),391.
2.		ivn-mus LD50:1010 mg/kg		NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),391.

Sulfamonomethoxine Safety Profile

Safety Information of Sulfamonomethoxine (CAS NO.1220-83-3):
Hazard Symbols: Xi Irritant
Risk Codes: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Description: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
Moderately toxic by intravenous route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SO_x and NO_x.

Sulfamonomethoxine Specification

Sulfamonomethoxine with CAS registry number of 1220-83-3 is also known as 5-25-12-00493 (Beilstein Handbook Reference) ; DJ-1550 ; DS-36 ; Daimeton ; ICI 32525 ; N(sup 1)-(6-Methoxy-4-pyrimidinyl)sulfanilamide ; N1-(6-Methoxy-4-pyrimidinyl)sulfanilamide ; Ro 4-3476 ; Sulfamonomethoxin ; Sulfamonomethoxinum ; Sulfamonomethoxinum [INN-Latin] ; Sulfamonometoxina ; Sulfamonometoxina [INN-Spanish] ; Sulfamonomethoxine [USAN:INN:BAN:JAN] ; Sulfanilamide, N(sup 1)-(6-methoxy-4-pyrimidinyl)- ; UNII-U700P169W2 ; Benzenesulfonamide, 4-amino-N-(6-methoxy-4-pyrimidinyl)- . It is a sulfonamide for the treatment of infections caused by hemolytic streptococcus, pneumococcal, meningococcal.

Product Name

Sulfamonomethoxine

Synthetic route

Sulfamonomethoxine Chemical Properties

Sulfamonomethoxine Toxicity Data With Reference

Sulfamonomethoxine Safety Profile

Sulfamonomethoxine Specification

Related Products

Hot Products