Product Name

  • Name

    2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid

  • EINECS 230-906-3
  • CAS No. 7365-44-8
  • Article Data3
  • CAS DataBase
  • Density 1.554 g/cm3
  • Solubility H2O: 1 M at 20 °C, clear, colorless
  • Melting Point ~223-225 °C
  • Formula C6H15NO6S
  • Boiling Point
  • Molecular Weight 229.254
  • Flash Point
  • Transport Information
  • Appearance White crystalline powder
  • Safety 22-24/25-36-26
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 7365-44-8 (2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid)
  • Hazard Symbols IrritantXi
  • Synonyms Taurine,N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]- (7CI,8CI);2-[[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]ethanesulfonicacid;2-[[Tris(hydroxymethyl)methyl]amino]ethanesulfonic acid;N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid;N-[Tris(hydroxymethyl)methyl]aminoethanesulfonic acid;TES;TES (bufferingagent);
  • PSA 135.47000
  • LogP -1.34880

Synthetic route

1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

Conditions
ConditionsYield
Stage #1: 1-Bromo-2-chloroethane; 2-amino-2-hydroxymethyl-1,3-propanediol With sodium hydroxide In water for 4h; pH=< 7.0; Reflux;
Stage #2: With copper; sodium sulfite In water for 16h; Reflux;		87%
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride
27668-52-6

octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride

disodium 2-[[1-[[3-[dimethyl(octadecyl)ammonio]propyl-[3-hydroxy-2-(hydroxymethyl)-2-(2-sulfoethylamino)propoxy]-[3-hydroxy-2-(hydroxymethyl)-2-(2-sulfonatoethylamino)propoxy]silyl]oxymethyl]-2-hydroxy-1-(hydroxymethyl)ethyl]amino]ethanesulfonate chloride

disodium 2-[[1-[[3-[dimethyl(octadecyl)ammonio]propyl-[3-hydroxy-2-(hydroxymethyl)-2-(2-sulfoethylamino)propoxy]-[3-hydroxy-2-(hydroxymethyl)-2-(2-sulfonatoethylamino)propoxy]silyl]oxymethyl]-2-hydroxy-1-(hydroxymethyl)ethyl]amino]ethanesulfonate chloride

Conditions
ConditionsYield
Stage #1: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride In N,N-dimethyl-formamide at 145℃;
Stage #2: With sodium methylate In N,N-dimethyl-formamide		97%
(Z)-9-octadecenoyl chloride
112-77-6

(Z)-9-octadecenoyl chloride

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

trioleate 2-[tris(oleoyloxymethyl)methylamino]-1-ethanesulfonic acid

trioleate 2-[tris(oleoyloxymethyl)methylamino]-1-ethanesulfonic acid

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 65℃; for 3h; Large scale;77.8%
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

1-ethyl-3-methylimidazolium hydroxide

1-ethyl-3-methylimidazolium hydroxide

C6H11N2(1+)*C6H14NO6S(1-)

C6H11N2(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

C4H12N(1+)*C6H14NO6S(1-)
1421259-95-1

C4H12N(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

tetraethylammonium hydroxide
77-98-5

tetraethylammonium hydroxide

C8H20N(1+)*C6H14NO6S(1-)
1612259-34-3

C8H20N(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

C16H36N(1+)*C6H14NO6S(1-)
1612259-35-4

C16H36N(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

cholin hydroxide
123-41-1

cholin hydroxide

cholinium 2-[(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethane sulfonate

cholinium 2-[(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethane sulfonate

Conditions
ConditionsYield
In aq. buffer for 12h;
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

TPO chloride

TPO chloride

C29H35NO8PS(1-)*K(1+)

C29H35NO8PS(1-)*K(1+)

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

(3,5-bis(chloromethyl)-2,4,6-trimethylphenyl)(diphenylphosphoryl)methanone

(3,5-bis(chloromethyl)-2,4,6-trimethylphenyl)(diphenylphosphoryl)methanone

C36H49N2O14PS2(2-)*2K(1+)

C36H49N2O14PS2(2-)*2K(1+)

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

TES sodium

TES sodium

octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride
27668-52-6

octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride

sodium 7,7-bis(3-hydroxy-2-(hydroxymethyl)-2-((2-sulfoethyl)amino)propoxy)-4,4-bis(hydroxymethyl)-11,11-dimethyl-6-oxa-3,11-diaza-7-silanonacosan-11-ium-1-sulfonate chloride

sodium 7,7-bis(3-hydroxy-2-(hydroxymethyl)-2-((2-sulfoethyl)amino)propoxy)-4,4-bis(hydroxymethyl)-11,11-dimethyl-6-oxa-3,11-diaza-7-silanonacosan-11-ium-1-sulfonate chloride

Conditions
ConditionsYield
With sodium methylate In N,N-dimethyl-formamide at 145℃;
...Expand
didecylmethyl[3-(trimethoxysilyl)propyl]ammonium chloride

didecylmethyl[3-(trimethoxysilyl)propyl]ammonium chloride

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

TES sodium

TES sodium

N-decyl-N-(3-(7-(3-hydroxy-2-(hydroxymethyl)-2-((2-sulfoethyl)amino)propoxy)-4,4,10,10-tetrakis(hydroxymethyl)-1,14-disulfo-6,8-dioxa-3,11-diaza-7-silatetradecan-7-yl)propyl)-N-methyldecan-1-aminium chloride

N-decyl-N-(3-(7-(3-hydroxy-2-(hydroxymethyl)-2-((2-sulfoethyl)amino)propoxy)-4,4,10,10-tetrakis(hydroxymethyl)-1,14-disulfo-6,8-dioxa-3,11-diaza-7-silatetradecan-7-yl)propyl)-N-methyldecan-1-aminium chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 145℃;
...Expand

TES Specification

The TES, with the CAS registry number 7365-44-8, is also known as N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid. It belongs to the product categories of Biochemistry; Good's Buffers; Buffer. Its EINECS registry number is 230-906-3. This chemical's molecular formula is C6H15NO6S and molecular weight is 229.2514. Its IUPAC name is called 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]ethanesulfonic acid. The product should be sealed and stored in cool and dry place. TES is mainly used for the production of ph buffers for biological systems.

Physical properties of TES: (1)# of Rule of 5 Violations: 1; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 7; (7)#H bond donors: 5; (8)#Freely Rotating Bonds: 10; (9)Index of Refraction: 1.571; (10)Molar Refractivity: 48.442 cm3; (11)Molar Volume: 147.496 cm3; (12)Surface Tension: 82.13 dyne/cm; (13)Density: 1.554 g/cm3.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(CS(=O)(=O)O)NC(CO)(CO)CO
(2)InChI: InChI=1S/C6H15NO6S/c8-3-6(4-9,5-10)7-1-2-14(11,12)13/h7-10H,1-5H2,(H,11,12,13)
(3)InChIKey: JOCBASBOOFNAJA-UHFFFAOYSA-N

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