Terazosin

The IUPAC name of Terazosin is [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone. With the CAS registry number 63590-64-7, it is also named as Fosfomic. The product's categories are Terazosin; Intermediates & Fine Chemicals; Pharmaceuticals; API's; API. Besides, it is white to off-white crystalline powder. In addition, its molecular formula is C₁₉H₂₅N₅O₄ and molecular weight is 387.44.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.96; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.95; (4)ACD/LogD (pH 7.4): -1.01; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 6.42; (9)#H bond acceptors: 9; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4 ; (12)Index of Refraction: 1.636; (13)Molar Refractivity: 104.26 cm³; (14)Molar Volume: 290.6 cm³; (15)Surface Tension: 64.1 dyne/cm; (16)Density: 1.332 g/cm³; (17)Flash Point: 355.7 °C; (18)Melting Point: 281-283 °C; (19)Solubility: H2O: 25 mg/mL; (20)Enthalpy of Vaporization: 97.72 kJ/mol; (21)Boiling Point: 664.5 °C at 760 mmHg; (22)Vapour Pressure: 1.59E-17 mmHg at 25 °C.

Preparation of Terazosin: this chemical can be prepared by Furoic acid. The reaction equation is as follows:

Uses of Terazosin: this chemical is used for treatment of symptoms of an enlarged prostate (BPH) as selective alpha 1 antagonist. It is also used to lower the blood pressure. Additionally, it is used in the treatment of benign prostatic hyperplasia by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. It is also harmful if swallowed. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)C4OCCC4
(2)InChI: InChI=1/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
(3)InChIKey: VCKUSRYTPJJLNI-UHFFFAOYAV

The toxicity data is as follows: