Testosterone Propionate supplier

Name
Testosterone propionate
EINECS 200-351-1
CAS No. 57-85-2
Article Data28
CAS DataBase
Density 1.1 g/cm³
Solubility <0.1 g/100 mL at 24.5 °C in water
Melting Point 118-123 °C
Formula C₂₂H₃₂O₃
Boiling Point 454.6 °C at 760 mmHg
Molecular Weight 344.494
Flash Point 196.3 °C
Transport Information UN 2811
Appearance white or yellowish-white crystals or a white or creamy-white crystalline powder
Safety 53-36/37-45
Risk Codes 45-22-63
Molecular Structure
Hazard Symbols T
Synonyms Testosterone,propionate (8CI);17b-(Propionyloxy)androst-4-en-3-one;Agovirin;Androlon;Bio-testiculina;Enarmon;Enarmon-oil;Homandren;Hormoteston;Masenate;Nasdol;Orchisterone;Orchistin;Oreton;Pantestin;Primotestone;Propiokan;Sterandryl;Synerone;TP;Telipex;Testaform;Testex;Testonique;Testosid;Testosterone-17-propionate;Testrex;Testosterone Propionate;17-(1-oxopropoxy)-(17b)-androst-4-en-3-one;
PSA 43.37000
LogP 4.84010

Synthetic route

: 79-03-8
propionyl chloride

: 975-57-5
3,3-(ethylenedioxy)-5-androsten-17β-ol

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Stage #1: propionyl chloride; 3,3-(ethylenedioxy)-5-androsten-17β-ol With pyridine; dmap In 1,2-dichloro-ethane at 30℃; Inert atmosphere; Stage #2: With hydrogenchloride In water	97.4%

: 802294-64-0
propionic acid

: 17β-hydroxy-3-methoxyandrosta-3,5-diene

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Stage #1: propionic acid; 17β-hydroxy-3-methoxyandrosta-3,5-diene With diisopropyl-carbodiimide In dichloromethane at 5℃; Inert atmosphere; Stage #2: With hydrogenchloride In water	97.36%

: (8S,9S,10R,13S,14S,17S)-4,5-dibromo-10,13-dimethyl-3-oxohexadecahydro-1Hcyclopenta[a]phenanthren-17-yl propionate

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
With 1,1'-bis(trimethylsilyl)-1,1',4,4'-tetrahydro-4,4'-bipyridylidene In acetonitrile at 20℃; for 2h; Inert atmosphere;	89%

: 58-22-0
testosterone

: 79-03-8
propionyl chloride

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
With pyridine In N,N-dimethyl acetamide at 0 - 20℃; for 5h; Inert atmosphere;	73%
With immobilized p-toluenesulfonic acid polymer bound macroporous In neat (no solvent) at 100℃; for 0.0416667h; Microwave irradiation; Sealed tube; Green chemistry;	65%
With pyridine; diethyl ether
With pyridine; dmap In dichloromethane at 5℃; Inert atmosphere;	10.2 g

: 4076-66-8
androsten-(4)-yl-(17β)-propionate

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid
With chromium(VI) oxide; acetic acid

: 63088-08-4
3-acetoxy-17β-(1-oxopropoxy)-androsta-3,5-diene

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
With ethanol; potassium carbonate

: 38859-47-1
17β-propionyloxy-androst-5-en-3β-ol

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
With bromine; acetic acid nachfolgendes Behandeln mit CrO3 in wss.Essigsaeure und Erwaermen der Reaktionsloesung mit Zink-Pulver und Essigsaeure;
With copper at 225℃; unter vermindertem Druck;

: 58-22-0
testosterone

: 123-62-6
propionic acid anhydride

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
With pyridine at 125℃;
With pyridine at 25℃;
Stage #1: testosterone With pyridine at 80℃; for 0.5h; Stage #2: propionic acid anhydride With dmap at 25℃; for 3.75h;	166.5 g

17β-propionyloxy-5α-androstanone-(3): 17β-propionyloxy-5α-androstanone-(3)

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
With bromine kurzes Erhitzen des erhaltenen 2α-Brom-17β-propionyloxy-5α-androstanons-(3) mit Pyridin auf Siedetemperatur und Erhitzen des Reaktionsprodukts unter 12 Torr bis auf 400grad;

: 521-17-5, 1963-03-7, 4593-57-1, 4593-58-2, 14504-94-0, 16895-59-3, 47122-33-8, 64162-67-0, 75767-22-5, 139973-51-6, 151284-19-4
5-androstenediol

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetone; aluminium isobutylate; benzene 2: pyridine / 25 °C View Scheme

: 58-22-0
testosterone

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: orthoformic acid triethyl ester; toluene-4-sulfonic acid / 40 °C / Inert atmosphere 2: dmap; pyridine / 1,2-dichloro-ethane / 30 °C / Inert atmosphere View Scheme

: 972-46-3
3-ethoxyandrosta-3,5-dien-17-one

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium borohydride; pyridine / ethanol / 60 °C 2: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C 3: orthoformic acid triethyl ester; toluene-4-sulfonic acid / 40 °C / Inert atmosphere 4: dmap; pyridine / 1,2-dichloro-ethane / 30 °C / Inert atmosphere View Scheme

: 26614-48-2
17β-hydroxy-3-ethoxyandrosta-3,5-diene

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C 2: orthoformic acid triethyl ester; toluene-4-sulfonic acid / 40 °C / Inert atmosphere 3: dmap; pyridine / 1,2-dichloro-ethane / 30 °C / Inert atmosphere View Scheme

: 63-05-8
Androstenedione

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridinium p-toluenesulfonate / methanol / 20 °C / Inert atmosphere 2: pyridine; sodium tetrahydroborate / methanol / 40 °C 3: diisopropyl-carbodiimide / dichloromethane / 5 °C / Inert atmosphere View Scheme
Multi-step reaction with 5 steps 1: pyridinium p-toluenesulfonate / ethanol / 40 °C / Inert atmosphere 2: potassium borohydride; pyridine / ethanol / 60 °C 3: hydrogenchloride / water; tetrahydrofuran / 20 - 30 °C 4: orthoformic acid triethyl ester; toluene-4-sulfonic acid / 40 °C / Inert atmosphere 5: dmap; pyridine / 1,2-dichloro-ethane / 30 °C / Inert atmosphere View Scheme

: 57144-06-6
3-methoxyandrosta-3,5-dien-17-one

: 57-85-2
testosterone propionate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine; sodium tetrahydroborate / methanol / 40 °C 2: diisopropyl-carbodiimide / dichloromethane / 5 °C / Inert atmosphere View Scheme

: 57-85-2
testosterone propionate

: 107-21-1
ethylene glycol

: 81275-73-2
5-androstene-17β-propionyloxy-3-spiro-2'-(1',3'-dioxolane)

Conditions

Conditions	Yield
With montmorillonite K-10 In benzene for 2h; Heating;	99%
With toluene-4-sulfonic acid; benzene

: 57-85-2
testosterone propionate

: 3510-18-7
5-oxo-17β-propionyloxy-4-nor-3,5-secoandrostan-3-oic acid

Conditions

Conditions	Yield
With potassium permanganate; sodium periodate; potassium carbonate In water; tert-butyl alcohol for 4.5h; Ambient temperature;	94%
Stage #1: testosterone propionate With ozone In ethyl acetate at -78℃; ozonolysis; Stage #2: With dihydrogen peroxide In water at 20℃; Reduction;	87%

: 57-85-2
testosterone propionate

: 78948-09-1
acetyl hypofluorite

: androstane-5α-acetoxy-4α-fluoro-17β-ol-3-one propionate

Conditions

Conditions	Yield
In chloroform for 0.0833333h;	89%

: 57-85-2
testosterone propionate

: 75-36-5
acetyl chloride

: 63088-08-4
3-acetoxy-17β-(1-oxopropoxy)-androsta-3,5-diene

Conditions

Conditions	Yield
With pyridine; acetic anhydride for 3h; Heating;	88.5%

: 57-85-2
testosterone propionate

A: 35471-70-6, 71788-18-6
Propionic acid (5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl ester

B: 35471-70-6, 71788-18-6
Propionic acid (5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl ester

Conditions

Conditions	Yield
With hydrogen; Cu/Al2O3 In toluene at 60℃; under 760 Torr;	A 85% B 15%

: 57-85-2
testosterone propionate

: 156-57-0
2-mercaptoethylamine hydrochloride

: 81275-72-1
5-androstene-17β-propionyloxy-3-spiro-2'-(1',3'-thiazolidine)

Conditions

Conditions	Yield
In pyridine Ambient temperature;	71%

: 57-85-2
testosterone propionate

A: 855-22-1
3-oxo-5α-androstan-17β-ol propionate

B: 35471-70-6, 71788-18-6
Propionic acid (5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl ester

C: 18179-14-1
3-oxo-5β-androstan-17β-ol propionate

Conditions

Conditions	Yield
With hydrogen; Cu/Al2O3 In toluene at 60℃; under 760 Torr;	A 11% B 12% C 65%

...Expand

: 57-85-2
testosterone propionate

: androstan-3-one-4,5-difluoro-17β-hydroxy propionate

Conditions

Conditions	Yield
With fluorine In ethanol; chloroform; trichlorofluoromethane at -78℃; Inert atmosphere;	65%

: 57-85-2
testosterone propionate

A: 566-08-5
15α-hydroxyandrost-4-ene-3,17-dione

B: 4416-57-3
testololactone

C: 7801-32-3
17a-oxa-D-homo-5α-androstane-3,17-dione

Conditions

Conditions	Yield
With Penicillium notatum KCH 904 In water; acetone at 27℃; for 96h; Enzymatic reaction;	A 29% B 61% C 9%

...Expand

: 57-85-2
testosterone propionate

: 107-21-1
ethylene glycol

A: 81275-73-2
5-androstene-17β-propionyloxy-3-spiro-2'-(1',3'-dioxolane)

B: 81240-03-1
4-androstene-17β-propionyloxy-3-spiro-2'-(1',3'-dioxolane)

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 5h; Heating;	A 28% B 15%

...Expand

: 57-85-2
testosterone propionate

: 868-59-7
L-cysteine ethyl ester hydrochloride

A: 82890-36-6
5-androstene-17β-propionyloxy-3-spiro-2'-(4'-ethoxycarbonyl-1',3'-thiazolidine)

B: 82890-37-7
4-androstene-17β-propionyloxy-3-spiro-2'-(4'-ethoxycarbonyl-1',3'-thiazolidine)

Conditions

Conditions	Yield
In pyridine Ambient temperature; Yields of byproduct given;	A 26% B n/a
In pyridine Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 57-85-2
testosterone propionate

: 60-24-2
2-hydroxyethanethiol

A: 81240-02-0
4-androstene-17β-propionyloxy-3-spiro-2'-(1',3'-oxathiolane)

B: 81240-01-9
5-androstene-17β-propionyloxy-3-spiro-2'-(1',3'-oxathiolane)

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 7h; Heating;	A 12% B 16%

...Expand

: 57-85-2
testosterone propionate

: 58-22-0
testosterone

Conditions

Conditions	Yield
With lipase from Candida cylindracea; octanol In various solvent(s) at 37℃; for 144h;	12%
With water In methanol at 40℃; Rate constant; pH 9, also reaction in the presence of 2-hydroxypropyl-β-cyclodextrin;
With Novozyme 51032 In aq. phosphate buffer at 52.5℃; for 24h; pH=8.5; Reagent/catalyst; Temperature; pH-value; Enzymatic reaction;

: 57-85-2
testosterone propionate

: 120022-91-5
6ζ-(3-Oxo-17β-propionyloxy-5ζ-androstan-4-ζ-yl)-17β-propionyloxyandrost-4-en-3-on

Conditions

Conditions	Yield
With aerosile for 48h; Irradiation;	10.4%

: 126-39-6
2-ethyl-2-methyl-1,3-dioxolane

: 57-85-2
testosterone propionate

: 81275-73-2
5-androstene-17β-propionyloxy-3-spiro-2'-(1',3'-dioxolane)

Conditions

Conditions	Yield
With toluene-4-sulfonic acid

: 110-86-1
pyridine

: 57-85-2
testosterone propionate

: 1-(17β-propionyloxy-androsta-3,5-dien-3-yl)-pyridinium; chloride

Conditions

Conditions	Yield
With trichlorophosphate

: 74-96-4
ethyl bromide

: 57-85-2
testosterone propionate

: 4,4-diethyl-17β-hydroxy-androst-5-en-3-one

Conditions

Conditions	Yield
With isopropyl alcohol; sodium t-butanolate; tert-butyl alcohol

: 917-64-6
methyl magnesium iodide

: 57-85-2
testosterone propionate

: 3-methyl-androst-4-ene-3ξ,17β-diol

Conditions

Conditions	Yield
With diethyl ether

: 57-85-2
testosterone propionate

: 75-16-1
methylmagnesium bromide

: 3-methyl-androst-4-ene-3ξ,17β-diol

Conditions

Conditions	Yield
With diethyl ether
In diethyl ether Heating;

: 57-85-2
testosterone propionate

: 2162-45-0
4-bromo-17β-propionyloxy-androst-4-en-3-one

Conditions

Conditions	Yield
With oxirane; bromine
With 2,4,6-trimethyl-pyridine; bromine
With bromine azide
Multi-step reaction with 2 steps 1: NBS, HN3 / CHCl3; 2-methyl-propan-2-ol 2: SiO2 / benzene View Scheme
Multi-step reaction with 2 steps 1: NBS, HN3 / CHCl3; 2-methyl-propan-2-ol 2: SiO2 / benzene View Scheme

: 57-85-2
testosterone propionate

: 114794-73-9
4β,5-dichloro-17β-propionyloxy-5α-androstan-3-one

Conditions

Conditions	Yield
With 1,4-dioxane; diethyl ether; chlorine; propionic acid

: 57-85-2
testosterone propionate

: 5996-42-9
17β-propionyloxy-androst-4-en-3-one oxime

Conditions

Conditions	Yield
With hydroxylamine

: 57-85-2
testosterone propionate

: 117272-05-6
17β,17'β-bis-propionyloxy-3βH,3'βH-[3,3']biandrost-4-enyl-3,3'-diol

Conditions

Conditions	Yield
With lithium chloride Reduktion an Quecksilber-Kathoden;

Testosterone Propionate Specification

The Testosterone Propionate, with the cas registry number 57-85-2, has its systematic name of (17beta)-3-oxoandrost-4-en-17-yl propanoate. This is a kind of white solid and is insoluble in water, and it belongs to the product categories of steroids. As to its usage, it is usually applied for curing breast cancer, oophoroma, myoma of uterus, Huppert's [Kahler's] disease, kidney cancer and so on.

The characteristics of this chemical are as following: (1)ACD/LogP: 4.90 ; (2)ACD/LogD (pH 5.5): 4.9; (3)ACD/LogD (pH 7.4): 4.9; (4)ACD/BCF (pH 5.5): 3132.11; (5)ACD/BCF (pH 7.4): 3132.11; (6)ACD/KOC (pH 5.5): 11064.07; (7)ACD/KOC (pH 7.4): 11064.07; (8)#H bond acceptors: 3 ; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 43.37; (11)Index of Refraction: 1.537; (12)Molar Refractivity: 97.32 cm³; (13)Molar Volume: 311.2 cm³; (14)Polarizability: 38.58 ×10^-24cm³; (15)Surface Tension: 42 dyne/cm; (16)Density: 1.1 g/cm³; (17)Flash Point: 196.3 °C; (18)Enthalpy of Vaporization: 71.42 kJ/mol; (19)Boiling Point: 454.6 °C at 760 mmHg; (20)Vapour Pressure: 1.89E-08 mmHg at 25°C; (21)Tautomer Count: 5 ; (22)Exact Mass: 344.235145 ; (23)MonoIsotopic Mass: 344.235145 ; (24)Topological Polar Surface Area: 43.4 ; (25)Heavy Atom Count: 25.

When you deal with this chemical, you should be very cautious. For as a kind of toxic chemical, it may at low levels cause damage to health, and even could cause cancer. If swallowed, it is very harmful; Besides, it has possible risk of harm to the unborn child. Therefore, you should take the following instructions. Wear suitable protective clothing and gloves, and avoid exposure - obtain special instructions before use. If in case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

In addition, you could convert the following datas into the molecular structure：
(1)SMILES:O=C4\C=C2/[C@]([C@H]1CC[C@@]3([C@@H](OC(=O)CC)CC[C@H]3[C@@H]1CC2)C)(C)CC4
(2)InChI:InChI=1/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	970mg/kg (970mg/kg)	Drugs in Japan Vol. 6, Pg. 487, 1982.
mouse	LD50	oral	1350mg/kg (1350mg/kg)	Drugs in Japan Vol. 6, Pg. 487, 1982.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	Drugs in Japan Vol. 6, Pg. 487, 1982.
rat	LD50	intraperitoneal	585mg/kg (585mg/kg)	Drugs in Japan Vol. 6, Pg. 487, 1982.
rat	LD50	oral	1gm/kg (1000mg/kg)	Drugs in Japan Vol. 6, Pg. 487, 1982.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	Drugs in Japan Vol. 6, Pg. 487, 1982.

Product Name

Testosterone propionate

Synthetic route

Testosterone Propionate Specification

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