Product Name

  • Name

    Thyroxine

  • EINECS
  • CAS No. 7488-70-2
  • Density 2.4440 (estimate)
  • Solubility
  • Melting Point 235-236oC
  • Formula C15H11I4NO4
  • Boiling Point
  • Molecular Weight 0
  • Flash Point
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 7488-70-2 (Thyroxine)
  • Hazard Symbols
  • Synonyms
  • PSA 92.78000
  • LogP 5.25760

Thyroxine Chemical Properties

Molecular Structure:

IUPAC Name: 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Molecular Weight: 776.87002 g/mol
Molecular Formula: C15H11I4NO4 
Index of Refraction: 1.795
Molar Refractivity: 125.44 cm3
Molar Volume: 294.7 cm3
Polarizability: 49.73×10-24cm3
Surface Tension: 79.6 dyne/cm
Density: 2.635 g/cm3
Flash Point: 302.3 °C
Enthalpy of Vaporization: 90.78 kJ/mol
Boiling Point: 576.3 °C at 760 mmHg 
XLogP3-AA: 2.4
H-Bond Donor: 3
H-Bond Acceptor: 5
Rotatable Bond Count: 5
Tautomer Count: 2
Exact Mass: 776.68668
MonoIsotopic Mass: 776.68668
Topological Polar Surface Area: 92.8
Heavy Atom Count: 24
Complexity: 420
InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)
InChIKey: XUIIKFGFIJCVMT-UHFFFAOYSA-N

Thyroxine Uses

The Thyronines (CAS NO.7488-70-2) act on nearly every cell in the body. They act to increase the basal metabolic rate, affect protein synthesis, help regulate long bone growth (synergy with growth hormone), neuronal maturation and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness.

Thyroxine Production

 Thyroxine (CAS NO.7488-70-2) is synthesized via the iodination of tyrosines(monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin.

Thyroxine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 485ug/kg (0.485mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION
European Journal of Pediatrics. Vol. 150, Pg. 217, 1991.
man TDLo oral 30ug/kg/3W-I (0.03mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE British Medical Journal. Vol. 292, Pg. 1185, 1986.
women TDLo oral 42ug/kg/1W-I (0.042mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Neurology. Vol. 35, Pg. 1792, 1985.

Thyroxine Safety Profile

Human toxic effects at low oral doses. Human systemic effects by ingestion: EKG changes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of I and NOx.

Thyroxine Specification

 Thyroxine (CAS NO.7488-70-2) is also known as 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid , 2-Amino-3-[4-(4-hydroxy-3,5-diiodphenoxy)-3,5-diiodphenyl]propansäure , 2-ammonio-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate , 3-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine , 3,5,3',5'-Tetraiodothyronine .

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