Trimetazidine supplier | CasNO.5011-34-7

Name
Trimetazidine
EINECS 225-690-2
CAS No. 5011-34-7
Article Data7
CAS DataBase
Density 1.092 g/cm³
Solubility
Melting Point 200 - 205oC
Formula C₁₄H₂₂N₂O₃
Boiling Point 364 °C at 760 mmHg
Molecular Weight 266.34
Flash Point 174 °C
Transport Information
Appearance hite or off-white crystalline powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms 1-(2,3,4-Trimethoxybenzyl)piperazine;1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine;Preductal;Vasorel;
PSA 42.96000
LogP 1.38430

Synthetic route

: 1133-49-9
2,3,4-trimethoxybenzyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

Conditions

Conditions	Yield
Stage #1: 2,3,4-trimethoxybenzyl chloride; 1-t-Butoxycarbonylpiperazine With methanol; sodium hydroxide at 35 - 45℃; for 4h; Stage #2: With hydrogenchloride In water at 35 - 45℃; for 2h;	92.1%

: 53531-01-4
4-(2,3,4-trimethoxy-benzyl)-piperazine-1-carboxylic acid ethyl ester

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 130℃; for 2.5h;

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaBH3CN, AcOH / 16 h / Ambient temperature 2: aq. KOH / ethanol / 2.5 h / 130 °C View Scheme

: 79-04-9
chloroacetyl chloride

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 123580-45-0
1-(1-chloroacetyl)-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine

Conditions

Conditions	Yield
In dichloromethane	100%

: 98-03-3
thiophene-2-carbaldehyde

: 7677-24-9
trimethylsilyl cyanide

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1449498-33-2
2-(thiophen-2-yl)-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetonitrile

Conditions

Conditions	Yield
With indium In water at 20℃; Green chemistry;	93%

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 4265-16-1
2-formylbenzo[b]furan

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1449498-50-3
2-(benzofuran-2-yl)-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetonitrile

Conditions

Conditions	Yield
With indium In water at 20℃; Green chemistry;	92%

...Expand

: 3541-37-5
benzothiophene-2-carboxaldehyde

: 7677-24-9
trimethylsilyl cyanide

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1449498-44-5
2-(benzo[b]thiophen-2-yl)-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetonitrile

Conditions

Conditions	Yield
With indium In water at 20℃; Green chemistry;	91%

...Expand

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 138112-84-2
S 20251

: N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-2-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-acetamide

Conditions

Conditions	Yield
With triethylamine for 1h; Heating;	90%

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 440341-75-3
3-[(4-chlorobenzoyl)amino]propionic acid

: C24H30ClN3O5

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	88%

: 27064-94-4
4,4'-difluorobenzhydryl chloride

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 101477-54-7
KB-2796 dihydrochloride

Conditions

Conditions	Yield
Stage #1: 4,4'-difluorobenzhydryl chloride; 1-(2,3,4-trimethoxybenzyl)piperazine With triethylamine In methanol at 65 - 75℃; for 10h; Stage #2: With hydrogenchloride In ethanol at 45℃; for 2h;	87.4%

: 1373427-98-5
methyl 5-(2-bromoacetyl)-2-heptyloxybenzoate

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-07-9
methyl 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(heptyloxy)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	87.3%

: 1018838-11-3
ethyl 6-(bromomethyl)-4-chloroquinoline-3-carboxylate

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1018838-12-4
C27H32ClN3O5

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile	86.1%

: 1373428-29-5
C17H13BrO5

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-30-8
C31H34N2O8

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	86%

: 1373427-97-4
methyl 5-(2-bromoacetyl)-2-hexyloxybenzoate

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-06-8
methyl 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(hexyloxy)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	83.6%

: 98-01-1
furfural

: 7677-24-9
trimethylsilyl cyanide

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1449498-38-7
2-(furan-2-yl)-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetonitrile

Conditions

Conditions	Yield
With indium In water at 20℃; Green chemistry;	83%

...Expand

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)pyrazine

Conditions

Conditions	Yield
With iodine; sodium acetate In acetonitrile at 70℃;	82%

: 4-(4-chloro-6-phenylamino-[1,3,5]triazin-2-yloxy)-1-methyl-1H-quinolin-2-one

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 4-[(4-anilino-6-(4-(2,3,4-trimethoxybenzyl)piperazino)-[1,3,5]-triazin-2-yl)oxy]-1-methyl-1H-quinolin-2-one

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane for 0.0833333h; Microwave irradiation;	80%

: 1280727-80-1
4-[4-chloro-6-(quinolin-8-yloxy)-1,3,5-triazin-2-ylamino]-benzonitrile

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1280727-89-0
4-{4-[quinolin-8-yloxy]-6-[4-(2,3,4-trimethoxybenzyl)-piperazin-1-yl]-1,3,5-triazin-2-ylamino}-benzonitrile

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 80℃; for 0.0833333h; Microwave irradiation;	80%

: 1373427-94-1
methyl 5-(2-bromoacetyl)-2-butoxybenzoate

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-03-5
methyl 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(butoxy)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	79.2%

: 1335017-13-4
4-[4-chloro-6-(quinolin-4-yloxy)-1,3,5-triazin-2-ylamino]-2-trifluoromethyl-benzonitrile

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1335018-42-2
4-(4-(quinolin-4-yloxy)-6-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)-1,3,5-triazin-2-ylamino)-2-trifluoromethyl-benzonitrile

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane Reflux;	78%

: 76310-73-1
methyl 5-(2-bromoacetyl)-2-ethoxybenzoate

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-01-3
methyl 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(ethoxy)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	77.8%

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 160657-99-8
7-hydroxy-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid

: 7-HYDROXY-2-[4-(2,3,4-TRIMETHOXYBENZYL)PIPERAZIN-1-YLCARBONYL]-2,3-DIHYDRO-1,4-BENZODIOXIN

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 18h;	75%
	65%

: 1318780-86-7
7-(4-chloro-6-phenylamino-1,3,5-triazin-2-yloxy)-4-methylchromen-2-one

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: C33H34N6O6

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 70 - 80℃; for 0.1h; Sealed tube; Microwave irradiation;	75%

: 351-04-2
2-chloro-N-(4-fluorophenyl)acetamide

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: N-(4-fluorophenyl)-2-(4-(2,3,4-trimethoxybenzyl) piperazin-1-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	75%

: 24085-34-5
5-bromoacetyl-2-methoxy-benzoic acid methyl ester

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-00-2
methyl 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(methoxy)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	74.5%

: 1372894-46-6
2-chloro-N-(6-iodobenzo[d]thiazol-2-yl)acetamide

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: N-(6-iodobenzo[d]thiazol-2-yl)-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	74%

: 1373427-96-3
methyl 5-(2-bromoacetyl)-2-pentyloxybenzoate

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1373428-05-7
methyl 5-(2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetyl)-2-(pentyloxy)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	73.9%

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 380239-20-3
7-hydroxy-1,4-benzodioxin-2-carboxylic acid

: 7-HYDROXY-2-[4-(2,3,4-TRIMETHOXYBENZYL)PIPERAZIN-1-YLCARBONYL]-1,4-BENZODIOXIN

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 18h;	73%
	73%

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 16634-82-5
N-(p-tolyl)-2-chloroacetamide

: N-(p-tolyl)-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	73%

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: C15H19BrNO

: 906465-09-6
4-phenyl-2,2,5,5-tetramethyl-3-[4-(2,3,4-trimethoxybenzyl)piperazin-1-ylmethyl]-2,5-dihydro-1H-pyrrol-1-yloxyl radical

Conditions

Conditions	Yield
With potassium carbonate In chloroform for 3h; Heating;	72%

: 1375077-25-0
4-(4-(6-bromoquinolin-4-yloxy)-6-chloro-1,3,5-triazin-2-ylamino)-benzonitrile

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 1375077-43-2
C33H31BrN8O4

Conditions

Conditions	Yield
In 1,4-dioxane Reflux;	72%

: 587-65-5
N-chloroacetyl-aniline

: 5011-34-7
1-(2,3,4-trimethoxybenzyl)piperazine

: 119963-55-2
N-phenyl-2-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	72%

Trimetazidine Chemical Properties

Molecular Structure of Trimetazidine (CAS NO.5011-34-7):

IUPAC Name: 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine
Empirical Formula: C₁₄H₂₂N₂O₃
Molecular Weight: 266.3361
H bond acceptors: 5
H bond donors: 1
Freely Rotating Bonds: 5
Polar Surface Area: 34.17 Å²
Index of Refraction: 1.523
Molar Refractivity: 74.56 cm³
Molar Volume: 243.8 cm³
Surface Tension: 37.8 dyne/cm
Density: 1.092 g/cm³
Flash Point: 174 °C
Enthalpy of Vaporization: 61.02 kJ/mol
Boiling Point: 364 °C at 760 mmHg
Vapour Pressure: 1.73E-05 mmHg at 25°C
EINECS: 225-690-2
InChI
InChI=1/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3
Smiles
c1(c(c(c(OC)cc1)OC)OC)CN1CCNCC1
Classification Code: Cardiovascular Agents; Vasodilator agents

Trimetazidine Safety Profile

Hazard Codes: Xi
HazardClass: Irritant

Trimetazidine Specification

Trimetazidine , with CAS number of 5011-34-7, can be called 1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine ; 1-(2,3,4-Trimethoxybenzyl)piperazine ; Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)- ; Vastarel ; Kyurinett .

Product Name

Trimetazidine

Synthetic route

Trimetazidine Chemical Properties

Trimetazidine Safety Profile

Trimetazidine Specification

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