-
Name
VERATRIDINE
- EINECS 200-758-4
- CAS No. 71-62-5
- Density 1.45 g/cm3
- Solubility ethanol: 50 mg/mL
- Melting Point 180oC
- Formula C36H51 N O11
- Boiling Point 814.5 °C at 760 mmHg
- Molecular Weight 673.801
- Flash Point 446.4 °C
- Transport Information UN 1544 6
- Appearance powder
- Safety Poison by intraperitoneal, subcutaneous, and intravenous routes. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also VERATRINE.
- Risk Codes 26/27/28-36/37/38
-
Molecular Structure
-
Hazard Symbols
T+
- Synonyms Veratridine(6CI,7CI,8CI); 2H-4,16a-Epoxybenzo[7,8]fluoreno[2,1-b]quinolizine,cevane-3,4,12,14,16,17,20-heptol deriv.; 3-Veratroylveracevine; NSC 7524;Veracevine, veratrate; Veratrine; Veratrine (amorphous)
- PSA 178.61000
- LogP 1.29390
Synthetic route
| Conditions | Yield |
|---|---|
| With pyridine; benzene |
| Conditions | Yield |
|---|---|
| With cation-exchange resin Dowex 50Wx4 at 55 - 70℃; for 27h; | 14% |
Veratridine Chemical Properties
Chemistry informtion about Veratridine (71-62-5) is:
Synonyms: 3-Veratroylveracevine ; Veratridine ; ,4alpha,16beta)- ; 4,9-Epoxycevane-3,4,12,14,16,17,20-Heptol3-(3,4-Dimethoxybenzoate) ; Cevane-3,4,12,14,16,17,20-Heptol,4,9-Epoxy-,3-(3,4-Dimethoxybenzoate),(3beta ; Cevane-3-Beta,4-Alpha,12,14,16-Beta,17,20-Heptol,4,9-Epoxy-,3-(3,4-Dimethox;Veratrine(Amorphous) ; Ybenzoate)
MF: C36H51NO11
MW: 673.79
EINECS: 200-758-4
Density: 1.45 g/cm3
Flash Point: 446.4 °C
Boiling Point: 814.5 °C at 760 mmHg
Vapour Pressure: 4.74E-28 mmHg at 25°C
Enthalpy of Vaporization: 124.14 kJ/mol
Storage temp.: −20°C
Solubility ethanol: 50 mg/mL
Form: powder
Merck: 13,10016
Following is the molecular structure of Veratridine (71-62-5) is:
Veratridine Uses
Veratridine (71-62-5) is used in ointments for the treatment of neuralgia and rheumatoid pain.
Veratridine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 19mg/kg (19mg/kg) | cardiac: arrhythmias (including changes in conduction) | Journal of Pharmacology and Experimental Therapeutics. Vol. 120, Pg. 412, 1957. |
| mouse | LD50 | intraperitoneal | 1350ug/kg (1.35mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951. | |
| mouse | LD50 | subcutaneous | 6300ug/kg (6.3mg/kg) | behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: cyanosis behavioral: ataxia | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955. |
| rat | LD50 | intraperitoneal | 3500ug/kg (3.5mg/kg) | lungs, thorax, or respiration: cyanosis lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands | Journal of Pharmacology and Experimental Therapeutics. Vol. 78, Pg. 238, 1943. |
Veratridine Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also VERATRINE.
Hazard Codes:
T+: Very toxic
Risk Statements:
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1544 6.1/PG 1
WGK Germany: 2
RTECS: YX5600000
F:
F 10: Keep under argon.
HazardClass: 6.1(a)
PackingGroup: II
Veratridine Specification
Veratridine (71-62-5) is a steroid-derived alkaloid from the family of Liliaceae that functions as a neurotoxin by activating sodium ion channels. It is a derivative of veracevine. It is primarily obtained from the herb Veratrum and sabadilla seeds. Its color is white to off-white.
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