Product Name

  • Name

    tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

  • EINECS
  • CAS No. 214834-18-1
  • Article Data24
  • CAS DataBase
  • Density 1.158 g/cm3
  • Solubility
  • Melting Point 130 °C
  • Formula C11H20N2O2S
  • Boiling Point 355.992 °C at 760 mmHg
  • Molecular Weight 244.358
  • Flash Point 169.098 °C
  • Transport Information
  • Appearance
  • Safety 26-36/37/39-22
  • Risk Codes 20/21/22-36/37/38-22
  • Molecular Structure Molecular Structure of 214834-18-1 (tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate)
  • Hazard Symbols HarmfulXn, IrritantXi
  • Synonyms 1-tert-Butoxycarbonylpiperidine-4-carbothioamide;1-tert-Butoxycarbonylpiperidyl-4-carbothioamide;4-Thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester;tert-Butyl4-(aminocarbothioyl)tetrahydropyridine-1-carboxylate;tert-Butyl4-thiocarbamoylpiperidine-1-carboxylate;
  • PSA 87.65000
  • LogP 2.55780

Synthetic route

4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester
91419-48-6

4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
With Lawessons reagent In 1,2-dimethoxyethane; dichloromethane at 20℃;92%
With Lawessons reagent In 1,2-dimethoxyethane; dichloromethane at 20℃;92%
With Lawessons reagent In 1,2-dimethoxyethane; dichloromethane at 20℃; for 1.33333h;82%
1-tert-butoxycarbonyl-4-cyanopiperidine
91419-52-2

1-tert-butoxycarbonyl-4-cyanopiperidine

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydrogen sulfide; ammonium chloride In N,N-dimethyl-formamide; mineral oil at 20℃; for 72h;95%
With sodium hydrogen sulfide; ammonium chloride In N,N-dimethyl-formamide at 20℃; for 72h;95%
With sodium hydrogen sulfide; ammonium chloride In N,N-dimethyl-formamide at 20℃; for 72h;
4-carboxamidopiperidine
39546-32-2

4-carboxamidopiperidine

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap / dichloromethane / 2 h / 20 °C
2: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 1.33 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap / dichloromethane / 2 h / 20 °C
2: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 1.33 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 5 h / 1 °C
2: Lawessons reagent / tetrahydrofuran / 3 h / Reflux; Inert atmosphere
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap / dichloromethane / 2 h / 20 °C
2: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 1.33 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap / dichloromethane / 2 h / 20 °C
2: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 1.33 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 5 h / 1 °C
2: Lawessons reagent / tetrahydrofuran / 3 h / Reflux; Inert atmosphere
View Scheme
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
84358-13-4

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1,1-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 °C
1.2: 2.50 g / NH3 / methanol; tetrahydrofuran / 0 - 20 °C
2.1: 38 percent / Lawesson's reagent / tetrahydrofuran / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 16 h / 0 - 20 °C
1.2: 20 h / 0 - 20 °C
2.1: Lawessons reagent / tetrahydrofuran / 22 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h
1.2: 12 h / 20 °C
2.1: Lawessons reagent / 1,4-dioxane / 4 h / 70 °C
View Scheme
phosphorous pentasulfide

phosphorous pentasulfide

4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester
91419-48-6

4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
In 1,4-dioxane; hexane
4-carboxamidopiperidine
39546-32-2

4-carboxamidopiperidine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap / acetonitrile / 20 °C
2: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap / acetonitrile / 20 °C
2: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 20 °C
View Scheme
isonipecotic acid
498-94-2

isonipecotic acid

tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water; tert-butyl alcohol / 3 h / 10 - 20 °C
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 16 h / 0 - 20 °C
2.2: 20 h / 0 - 20 °C
3.1: Lawessons reagent / tetrahydrofuran / 22 h / 20 °C / Reflux
View Scheme
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

1,3-Dichloroacetone
534-07-6

1,3-Dichloroacetone

1,1-dimethylethyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate
650579-82-1

1,1-dimethylethyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

Conditions
ConditionsYield
With magnesium sulfate; magnesium carbonate In acetone for 12h; Reflux; Inert atmosphere;92%
With magnesium sulfate; magnesium carbonate In acetone at 65℃; for 4h;92.7%
With magnesium sulfate; magnesium carbonate In acetone Heating / reflux;
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

ethyl 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thiazole-4-carboxylate
365413-31-6

ethyl 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thiazole-4-carboxylate

Conditions
ConditionsYield
In methanol for 4h; Reflux;96.5%
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; ethyl Bromopyruvate In DMF (N,N-dimethyl-formamide) at 0 - 20℃;
Stage #2: With triethylamine In DMF (N,N-dimethyl-formamide)		82%
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; ethyl Bromopyruvate In ethanol at 0 - 20℃;
Stage #2: With triethylamine In ethanol		74.2%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-bromo-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
875639-57-9

2-bromo-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

4-[4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
1046793-76-3

4-[4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; 2-bromo-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone In tetrahydrofuran at 20℃; for 3h;
Stage #2: With water; sodium hydrogencarbonate In tetrahydrofuran		100%
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; 2-bromo-1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone In tetrahydrofuran at 20℃; for 3h;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water		100%
In tetrahydrofuran at 20℃; for 3h;100%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

α-bromoacetophenone
70-11-1

α-bromoacetophenone

4-(4-phenylthiazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester
887624-95-5

4-(4-phenylthiazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol for 3h; Reflux;93.2%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 1.5h;55.2%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 1.5h;55%
In tetrahydrofuran at 70℃;1.65 g
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone
4629-54-3

2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone

C21H26N2O4S
948041-00-7

C21H26N2O4S

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 0 - 20℃;68%
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; 2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone In N,N-dimethyl-formamide at 0 - 20℃;
Stage #2: With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;		68%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-Bromo-1-(3,4-dimethoxyphenyl)ethanone
1835-02-5

2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

tert-butyl 4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)piperidine-1-carboxylate

tert-butyl 4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 16h;91%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

4-(2-ethoxycarbonyl-2-oxo-ethylsulanylcarbonimidoyl)-piperidine-1-carboxylic acid tert-butyl ester
1192878-45-7

4-(2-ethoxycarbonyl-2-oxo-ethylsulanylcarbonimidoyl)-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With sodium acetate In ethyl acetate at 5℃; for 16h;75%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2-piperidine-4-yl-thiazole-4-carboxylic acid ethyl ester
721963-02-6

2-piperidine-4-yl-thiazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; ethyl Bromopyruvate In ethanol at 70℃; for 1.5h;
Stage #2: With sodium carbonate In water		74%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-[3-(chloroacetyl)-4,5-dihydro-1,2-oxazol-5-yl]-5-(trifluoromethyl)phenyl methanesulphonate

2-[3-(chloroacetyl)-4,5-dihydro-1,2-oxazol-5-yl]-5-(trifluoromethyl)phenyl methanesulphonate

tert-butyl 4-[4-(5-{2-[(methylsulphonyl)oxy]-4-(trifluoromethyl)phenyl}-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

tert-butyl 4-[4-(5-{2-[(methylsulphonyl)oxy]-4-(trifluoromethyl)phenyl}-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide In tetrahydrofuran at 20℃; for 12h;56%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

N-(2-chloro-3-(2-(2-chloropyrimidin-4-yl)acetyl)phenyl)propane-1-sulfonamide
1307272-36-1

N-(2-chloro-3-(2-(2-chloropyrimidin-4-yl)acetyl)phenyl)propane-1-sulfonamide

1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate
1307272-73-6

1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-chloro-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

Conditions
ConditionsYield
Stage #1: N-(2-chloro-3-(2-(2-chloropyrimidin-4-yl)acetyl)phenyl)propane-1-sulfonamide With N-Bromosuccinimide In ISOPROPYLAMIDE at 20℃; for 1.33333h; Inert atmosphere;
Stage #2: tert-butyl 4-carbamothioylpiperidine-1-carboxylate In ISOPROPYLAMIDE at 20℃; for 72h; Inert atmosphere;		54%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

α-bromoacetophenone
70-11-1

α-bromoacetophenone

4-(phenylthiazol-2-yl)-piperidine hydrobromide
926891-48-7

4-(phenylthiazol-2-yl)-piperidine hydrobromide

Conditions
ConditionsYield
In methanol at 70℃; for 22h;96%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

1-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yI)-2-chIoroethanone
937047-12-6

1-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yI)-2-chIoroethanone

tert-butyl 4-[4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-1,3-thiazoI-2-yl]piperidine-1-carboxylate
937047-66-0

tert-butyl 4-[4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-1,3-thiazoI-2-yl]piperidine-1-carboxylate

Conditions
ConditionsYield
In ethanol at 20 - 78℃;96%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

α-bromoacetophenone
70-11-1

α-bromoacetophenone

4-(4-phenyl-1,3-thiazol-2-yl)piperidine
887624-98-8

4-(4-phenyl-1,3-thiazol-2-yl)piperidine

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; α-bromoacetophenone In ethanol for 17h; Reflux; Inert atmosphere;
Stage #2: With ammonia In methanol		90%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

1-chloro 1-(3-methylphenyl)acetone
23022-82-4

1-chloro 1-(3-methylphenyl)acetone

4-[4-methyl-5-(3-methylphenyl)thiazole-2-yl]-N-boc-piperidine

4-[4-methyl-5-(3-methylphenyl)thiazole-2-yl]-N-boc-piperidine

Conditions
ConditionsYield
With sodium acetate; acetic acid at 80℃;74.6%
With sodium acetate; acetic acid at 100℃;
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

ethyl 2-chloro-3-oxopropanoate
33142-21-1

ethyl 2-chloro-3-oxopropanoate

tert-butyl 4-(5-(ethoxycarbonyl)-1,3-thiazol-2-yl)piperidine-1-carboxylate

tert-butyl 4-(5-(ethoxycarbonyl)-1,3-thiazol-2-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
In toluene at 90℃; for 2h;72%
In toluene at 90℃; for 2h;2.0 g
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate

8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate

4-oxo-8-(2-piperidin-4-yl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate

4-oxo-8-(2-piperidin-4-yl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate In ethanol at 90℃; for 3h;
Stage #2: With triethylamine In ethanol at 20℃;		17%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-chloro-1-(4,5-dihydro-5-phenyl-3-isoxazolyl)ethanone
1003320-09-9

2-chloro-1-(4,5-dihydro-5-phenyl-3-isoxazolyl)ethanone

1,1-dimethylethyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate
1003319-99-0

1,1-dimethylethyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate

Conditions
ConditionsYield
With pyridine; tetrabutylammomium bromide In ethanol for 2.5h; Reflux;69%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

3-bromocyclohexane-1,2-dione
24829-91-2

3-bromocyclohexane-1,2-dione

tert-butyl 4-(4-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)piperidine-1-carboxylate

tert-butyl 4-(4-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
In tert-butyl alcohol at 85℃; for 5h;46.5%
In pyridine; methanol Solvent;46.5%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

formaldehyd
50-00-0

formaldehyd

1-methylpiperidine-4-carbothioamide
88654-17-5

1-methylpiperidine-4-carbothioamide

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate With hydrogenchloride In 1,4-dioxane for 3h;
Stage #2: formaldehyd With sodium cyanoborohydride; acetic acid In methanol; water at 20℃; for 2h;
Stage #3: With sodium hydrogencarbonate In water; ethyl acetate
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate With hydrogenchloride In 1,4-dioxane at 20℃; for 3h;
Stage #2: formaldehyd With sodium cyanoborohydride; acetic acid In methanol; water at 20℃; for 2h;		2.2 g
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-bromocyclohexane-1,3-dienone
60060-44-8

2-bromocyclohexane-1,3-dienone

tert-butyl 4-(7-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)piperidine-1-carboxylate

tert-butyl 4-(7-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
In ethanol at 20 - 85℃; for 4.75h;25.4%
With triethylamine In tert-butyl alcohol
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-bromo-1-[3-(3-bromo-phenyl)-5-methyl-isoxazol-4-yl]-ethanone
864958-50-9

2-bromo-1-[3-(3-bromo-phenyl)-5-methyl-isoxazol-4-yl]-ethanone

2-(4-piperidine)-4-[3-(3-bromophenyl)-5-methylisoxazolyl]thiazole hydrobromide
864958-53-2

2-(4-piperidine)-4-[3-(3-bromophenyl)-5-methylisoxazolyl]thiazole hydrobromide

Conditions
ConditionsYield
In ethanol for 2h; Heating / reflux;89%
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-bromo-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethanone
14386-64-2

2-bromo-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethanone

C27H40N2O3S

C27H40N2O3S

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; 2-bromo-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethanone In tetrahydrofuran; ethanol at 20℃;
Stage #2: With di-tert-butyl dicarbonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

C10H4Br2F6O2

C10H4Br2F6O2

C21H21BrF6N2O3S

C21H21BrF6N2O3S

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; C10H4Br2F6O2 In tetrahydrofuran; ethanol at 45℃; for 3h;
Stage #2: With di-tert-butyl dicarbonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

C13H14BrF3O2
1124143-07-2

C13H14BrF3O2

C24H31F3N2O3S
1124143-24-3

C24H31F3N2O3S

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; C13H14BrF3O2 In tetrahydrofuran; ethanol at 20℃;
Stage #2: With di-tert-butyl dicarbonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
tert-butyl 4-carbamothioylpiperidine-1-carboxylate
214834-18-1

tert-butyl 4-carbamothioylpiperidine-1-carboxylate

2-Bromo-1-(3-bromo-4-methoxy-5-trifluoromethylphenyl)ethanone
1005515-07-0

2-Bromo-1-(3-bromo-4-methoxy-5-trifluoromethylphenyl)ethanone

C21H24BrF3N2O3S
1124145-06-7

C21H24BrF3N2O3S

Conditions
ConditionsYield
Stage #1: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; 2-Bromo-1-(3-bromo-4-methoxy-5-trifluoromethylphenyl)ethanone In tetrahydrofuran; ethanol
Stage #2: With di-tert-butyl dicarbonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate Specification

The tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate with its cas register number is 214834-18-1. It also can be called as 1-tert-Butoxycarbonylpiperidine-4-carbothioamide and the IUPAC Name about this chemical is tert-butyl 4-carbamothioylpiperidine-1-carboxylate. It belongs to the following product categories, such as Pyrans, Piperidines &Piperazines and Pyrans, Piperidines & Piperazines.

Physical properties about tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate are: (1)ACD/LogP: 1.63; (2)ACD/LogD (pH 5.5): 1.629; (3)ACD/LogD (pH 7.4): 1.629; (4)ACD/BCF (pH 5.5): 10.18; (5)ACD/BCF (pH 7.4): 10.181; (6)ACD/KOC (pH 5.5): 183.215; (7)ACD/KOC (pH 7.4): 183.234; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 87.65Å2; (12)Index of Refraction: 1.546; (13)Molar Refractivity: 66.807 cm3; (14)Molar Volume: 210.987 cm3; (15)Polarizability: 26.484x10-24cm3; (16)Surface Tension: 50.887 dyne/cm; (17)Enthalpy of Vaporization: 60.12 kJ/mol

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed, also it is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing, gloves and eye/face protection, and also not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)C(=S)N
(2)InChI: InChI=1S/C11H20N2O2S/c1-11(2,3)15-10(14)13-6-4-8(5-7-13)9(12)16/h8H,4-7H2,1-3H3,(H2,12,16) 
(3)InChIKey: SCGQNJHAAYUQOO-UHFFFAOYSA-N 

 

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View