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Cas:10136-57-9
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiry5-(Chloromethyl)quinolin-8-olAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:10136-57-9
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inquiryHENAN SUNLAKE ENTERPRISE CORPORATION Our company advantages: 1. The highest quality with the competitive price. 2. Professional human services. 3. The fastest and safest delivery service. 4. The faster and safest delivery service. 5. Th
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inquiryPrice, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
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inquiryFor quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,
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inquiry1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi
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inquiryShanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated por
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inquiryWith certain technical reserves, high quality, preferential price and excellent service Application:Synthesis of pharmaceutical raw materials and research and development of new drugs
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inquiryCOA,H-NMR,HPLC availableWe have offices in Boston,MA,USAWe ship it in real nameMerck and Sigma are our customersPayment:Credit card/Net 30 daysWeb:www.alliconpharma.com Storage:Store in a cool, dry, well-ventilated area away from incompatible substan
Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen
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inquiryConditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; for 12h; | 91.4% |
With hydrogenchloride In water at 0 - 60℃; for 10h; | 90% |
With hydrogenchloride In water at 80℃; for 6h; | 87% |
5-(hydroxymethyl)-8-hydroxyquinoline
5-(chloromethyl)quinolin-8-ol
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; for 6h; |
5-(chloromethyl)quinolin-8-ol
debenzyldonepezil
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 8h; Reflux; | 88% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 48h; | 81% |
5-(chloromethyl)quinolin-8-ol
(1-1-benzylpiperidin-4-yl)(prop-2-yn-1-yl-amino)acetonitrile
2-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)acetonitrile
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 80.6% |
With triethylamine In dichloromethane at 20℃; for 0.5h; | 80.6% |
5-(chloromethyl)quinolin-8-ol
5-(aminomethyl)-8-hydroxyquinoline
5,5',5''-nitrilotris(methylene)triquinolin-8-ol
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 50℃; for 24h; | 73% |
5-(chloromethyl)quinolin-8-ol
5-(aminomethyl)-8-hydroxyquinoline
Conditions | Yield |
---|---|
Stage #1: 5-(chloromethyl)quinolin-8-ol With hexamethylenetetramine In dimethyl sulfoxide at 20℃; Stage #2: With hydrogenchloride In water at 20℃; for 48h; | 70% |
Stage #1: 5-(chloromethyl)quinolin-8-ol With potassium phtalimide In N,N-dimethyl-formamide at 150℃; for 5h; Stage #2: With hydrogenchloride In water at 150℃; for 9h; | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 5 h / 150 °C 2: hydrogenchloride / water / 20 °C / Reflux View Scheme |
5-(chloromethyl)quinolin-8-ol
3-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)propanenitrile
3-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)propanenitrile
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 69.5% |
5-(chloromethyl)quinolin-8-ol
4-(1-benzylpiperidin-4-yl)-2-(prop-2-yn-1-ylamino)butanenitrile
4-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)butanenitrile
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 65.4% |
With triethylamine In dichloromethane at 0 - 20℃; | 65.4% |
piperazine
5-(chloromethyl)quinolin-8-ol
5,5'-(piperazine-1,4-diylbis(methylene))diquinolin-8-ol
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; for 72h; | 60% |
5-(chloromethyl)quinolin-8-ol
Trimethylenediamine
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; | 55% |
5-(chloromethyl)quinolin-8-ol
1,8,12-tri-tertbutoxycarbonyl-1,4,8,12-tetraazacyclopentadecane
tri(tert-butyl) 12-((8-hydroxyquinolin-5-yl)methyl)-1,4,8,12-tetraazacyclopentadecane-1,4,8-tricarboxylate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; | 55% |
5-(chloromethyl)quinolin-8-ol
N-[(1-benzylpiperidin-4-yl)methyl]prop-2-yn-1-amine
5-((((1-benzylpiperidin-4-yl)methyl)(prop-2-ynyl)amino)methyl)quinolin-8-ol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; | 55% |
With triethylamine In dichloromethane at 20℃; | 55% |
5-(chloromethyl)quinolin-8-ol
N-[3-(1-benzylpiperidin-4-yl)propyl]prop-2-yn-1-amine
5-(((3-(1-benzylpiperidin-4-yl)propyl)(prop-2-ynyl)amino)methyl)quinolin-8-ol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 54.3% |
With triethylamine In dichloromethane at 0 - 20℃; | 54.3% |
5-(chloromethyl)quinolin-8-ol
p-xylylidenediamine
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 72h; | 50% |
5-(chloromethyl)quinolin-8-ol
1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane
tri-tert-butyl 11-((8-hydroxyquinolin-5-yl)methyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; | 45% |
5-(chloromethyl)quinolin-8-ol
diethyl malonate
5-[(2,2-bisethoxycarbonyl)ethyl]-8-hydroxyquinoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h; | 40% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h; |
1,4,7,10-tetra-azacyclotridecane-11,13-dione
5-(chloromethyl)quinolin-8-ol
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80 - 90℃; for 72h; | 34% |
5-(chloromethyl)quinolin-8-ol
1-benzyl-N-(prop-2-ynyl)aminopiperidine
5-(((1-benzylpiperidin-4-yl)(prop-2-ynyl)amino)methyl)quinolin-8-ol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; | 33.8% |
5-(chloromethyl)quinolin-8-ol
allyl alcohol
5-(allyloxy)methyl-8-hydroxyquinoline
Conditions | Yield |
---|---|
for 12h; Reflux; | 32.1% |
5-(chloromethyl)quinolin-8-ol
triethyl phosphite
8-hydroxy-5-quinolylmethylphosphonic acid diethyl ester
Conditions | Yield |
---|---|
at 160℃; for 32h; | 24% |
for 5h; Reflux; |
5-(chloromethyl)quinolin-8-ol
sodium cyanide
2-(8-hydroxyquinolin-5-yl)acetonitrile
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 90℃; |
11-[3-(4,8-bis-tert-butoxycarbonyl-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl)-benzyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester
5-(chloromethyl)quinolin-8-ol
11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; |
5-(chloromethyl)quinolin-8-ol
4,8-bis-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane
di(tert-butyl) 4,8-bis((8-hydroxyquinolin-5-yl)methyl)-1,4,8,11-tetraazacyclotetradecane-1,11-dicarboxylate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; |
5-(chloromethyl)quinolin-8-ol
N,N'-bis(2-aminoethyl)-2-(5-methyl-8-hydroxyquinoline) malondiamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 40 percent / K2CO3 / dimethylformamide / 72 h / 20 °C 2: 38 percent / 120 h / 20 °C View Scheme |
5-(chloromethyl)quinolin-8-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: K2CO3 / dimethylformamide / 72 h / 20 °C 2: 22.1 percent / ethanol / 240 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 40 percent / K2CO3 / dimethylformamide / 72 h / 20 °C 2: 14 percent / ethanol / 336000 h / Heating View Scheme |
5-(chloromethyl)quinolin-8-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 45 percent / DIEA / CH2Cl2 / 20 °C 2: 100 percent / HCl / diethyl ether / 20 °C View Scheme |
5-(chloromethyl)quinolin-8-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 55 percent / DIEA / CH2Cl2 / 20 °C 2: 100 percent / HCl / diethyl ether / 20 °C View Scheme |
5-(chloromethyl)quinolin-8-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: DIEA / CH2Cl2 / 20 °C 2: HCl / diethyl ether / 20 °C View Scheme |
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