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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Ceritinib

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Ceritinib CAS:1032900-25-6

Cas:1032900-25-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Ceritinib (LDK378)

Cas:1032900-25-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Ceritinib LDK378 CAS No.1032900-25-6 API

Cas:1032900-25-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Ceritinib CAS No.: 1032900-25-6 Name: Ceritinib Synonyms: 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine

High purity Ceritinib CAS No.: 1032900-25-6

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Ceritinib;LDK 378

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Ceritinib (LDK378) 1032900-25-6 GMP Manufacturer

Cas:1032900-25-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

Ceritinib

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

LDK 378

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ceritinib dihydrochloride

Cas:1032900-25-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

ceritinib

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hubei DiBo chemical co., LTD

Ceritinib (LDK378) CAS:1032900-25-6 Chinese alias: Seretini English Name: ceritinib English alias: CS-1406; LDK378 Ceritinib; 5-chloro-N2-(2-isopropoxy-5-methyl-4-piperidin-4-piperiperidin-4-piperiperidin-4-piperiperidin-4-yl phenyl) -N

Ceritinib Manufacturer/Cas:1032900-25-6 /99.8% High purity

Cas:1032900-25-6

Min.Order:25 Metric Ton

FOB Price: $4.0 / 5.0

Type:Other

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GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

Buy 1032900-25-6 Ceritinib (LDK378)

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Appearance:White to Off-White solid Storage:-20°C Freezer Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:shanghai

ceritinib Cas no.1032900-25-6 98%

Cas:1032900-25-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

1032900-25-6 Ceritinib (LDK378)

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Ceritinib Powder CAS 1032900-25-6

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1032900-25-6 with competitive price

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name Ceritinib CAS NO. 1032900-25-6 Synonyms Ceritinib Category Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.

Ceritinib CAS: 1032900-25-6

Cas:1032900-25-6

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:ln stock Package:25kg/Barrel Application:Anti-Cancer Transportation:Express/Sea/Air Port:Any port of China

Ceritinib (LDK378)

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 1032900-25-6 Ceritinib (LDK378) with best price

Cas:1032900-25-6

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Good Quality Price Powder Ceritinib dihydrochloride 1380575-43-8

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

LDK-378 1032900-25-6

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Ceritinib (LDK378) CAS:1032900-25-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

Ceritinib (LDK378) CAS:1032900-25-6

Cas:1032900-25-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

LDK-378

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Ceritinib (LDK378)

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

LDK-378

Cas:1032900-25-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Nanjing Fred Technology Co.,Ltd.

Ceritinib(CAS:1032900-25-6) is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer and it's also one of the most competitive products in our company.Pleas

Ceritinib

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Ceritinib CAS 1032900-25-6 with Fast Shipment

Cas:1032900-25-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Afine Chemicals Limited

1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of

Supply LDK378 high quality Hot sale 99.0% cas no.1032900-25-6 price market

Cas:1032900-25-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

Ceritinib (LDK378) Manufacturer CAS:1032900-25-6

Cas:1032900-25-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Synthetic route

C35H40ClN5O3S

C35H40ClN5O3S

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen at 35℃; under 7500.75 Torr;97.9%
4-(4-{5-chloro-4-[2-(propane-2-sulfonyl)phenylamino]pyrimidin-2-ylamino}-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester
1032903-64-2

4-(4-{5-chloro-4-[2-(propane-2-sulfonyl)phenylamino]pyrimidin-2-ylamino}-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 20℃; for 2h;97%
With trifluoroacetic acid In tetrahydrofuran at 0 - 22℃; for 5h; Temperature;90.1%
With trifluoroacetic acid at 20℃; for 1h;39%
With trifluoroacetic acid In dichloromethane
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
2: sodium hydrogencarbonate / water; ethyl acetate
View Scheme
5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(propane-2-sulfonyl)phenyl)pyrimidine-2,4-diamine dihydrochloride

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(propane-2-sulfonyl)phenyl)pyrimidine-2,4-diamine dihydrochloride

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 5℃; pH=8;96%
With sodium hydroxide In ethanol; water; isopropyl alcohol at 55℃; Large scale;93%
With sodium hydroxide In ethanol; water at 20 - 50℃; for 2h; Temperature; Inert atmosphere;90%
2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
761440-16-8

2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

5-chloro-N2-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]pyrimidine-2,4-diamine dihydrochloride

5-chloro-N2-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]pyrimidine-2,4-diamine dihydrochloride

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Stage #1: 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine; 5-chloro-N2-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]pyrimidine-2,4-diamine dihydrochloride In isopropyl alcohol for 16h; Reflux; Large scale;
Stage #2: With sodium hydroxide In ethanol; water; isopropyl alcohol at 55℃; Large scale;
93%
In ethanol; water; isopropyl alcohol for 16h; Reflux; Large scale;93%
In 1,2-dimethoxyethane for 5h; Inert atmosphere; Reflux;74%
2-isopropylsulfonylchlorobenzene
70398-95-7

2-isopropylsulfonylchlorobenzene

C24H34ClN5O3

C24H34ClN5O3

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Stage #1: 2-isopropylsulfonylchlorobenzene; C24H34ClN5O3 With tris-(dibenzylideneacetone)dipalladium(0); potassium tert-butylate In toluene at 85 - 90℃; for 2h;
Stage #2: With hydrogenchloride In ethanol; water at 45℃; for 1h;
92.6%
C36H42ClN5O5S

C36H42ClN5O5S

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
With trifluoroacetic acid In tetrahydrofuran at 8 - 30℃; for 5h; Temperature;91.3%
1-bromo-2-(isopropylsulfonyl)benzene
900174-43-8

1-bromo-2-(isopropylsulfonyl)benzene

C24H34ClN5O3

C24H34ClN5O3

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Stage #1: 1-bromo-2-(isopropylsulfonyl)benzene; C24H34ClN5O3 With palladium diacetate; caesium carbonate; triphenylphosphine In tetrahydrofuran at 65 - 70℃; for 8h;
Stage #2: With trifluoroacetic acid In dichloromethane at 25 - 30℃; for 3h;
90.2%
2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
761440-16-8

2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
1035230-24-0

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Stage #1: 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine With hydrogenchloride In water; isopropyl alcohol at 25 - 30℃; for 1.5h; Buchwald-Hartwig Coupling;
Stage #2: 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine In water; isopropyl alcohol for 44h; Reflux;
75.4%
With N-ethyl-N,N-diisopropylamine at 80℃; Inert atmosphere;2.5 g
With toluene-4-sulfonic acid In isopropyl alcohol at 85℃;
2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
761440-16-8

2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate; XPhos; caesium carbonate / tetrahydrofuran
2: trifluoroacetic acid / dichloromethane
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; isopropyl alcohol / 75 - 77 °C / Large scale
2: sodium hydroxide / acetone; water / 20 - 55 °C / pH 12.0
View Scheme
Multi-step reaction with 3 steps
1: bis(tri-t-butylphosphine)palladium(0); sodium t-butanolate / toluene / 0.33 h / 150 °C / Microwave irradiation
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: sodium hydrogencarbonate / water; ethyl acetate
View Scheme
4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester
1032903-63-1

4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate; XPhos; caesium carbonate / tetrahydrofuran
2: trifluoroacetic acid / dichloromethane
View Scheme
Multi-step reaction with 3 steps
1: bis(tri-t-butylphosphine)palladium(0); sodium t-butanolate / toluene / 0.33 h / 150 °C / Microwave irradiation
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: sodium hydrogencarbonate / water; ethyl acetate
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C
2.1: isopropyl alcohol / 16 h / Reflux; Large scale
2.2: 55 °C / Large scale
View Scheme
1-amino-2-(isopropylsulphonyl)benzene
76697-50-2

1-amino-2-(isopropylsulphonyl)benzene

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chloroform / 6 h / 60 °C
2.1: acetonitrile / 8 h / 80 °C
3.1: hydrogen; 0.5% Pd/C / methanol / 8 h / 20 °C / 760.05 Torr
4.1: nitrous acid isobutyl ester / acetone / 2 h / 10 °C
4.2: 1 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl acetamide / 1 h / 0 °C
1.2: 2 h / 20 - 25 °C
2.1: toluene-4-sulfonic acid / isopropyl alcohol; water / 24 h / 140 °C / Autoclave
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; dimethyl sulfoxide / 0.5 h / 0 °C
1.2: 15 h / 0 - 20 °C
2.1: bis(tri-t-butylphosphine)palladium(0); sodium t-butanolate / toluene / 0.33 h / 150 °C / Microwave irradiation
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4.1: sodium hydrogencarbonate / water; ethyl acetate
View Scheme
2-chloro-4-[2-(propane-2-sulfonyl)phenylamino]-5-nitropyrimidine

2-chloro-4-[2-(propane-2-sulfonyl)phenylamino]-5-nitropyrimidine

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetonitrile / 8 h / 80 °C
2.1: hydrogen; 0.5% Pd/C / methanol / 8 h / 20 °C / 760.05 Torr
3.1: nitrous acid isobutyl ester / acetone / 2 h / 10 °C
3.2: 1 h / 80 °C
View Scheme
C33H46N6O5S

C33H46N6O5S

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Stage #1: C33H46N6O5S With nitrous acid isobutyl ester In acetone at 10℃; for 2h; Sandmeyer Reaction;
Stage #2: With hydrogenchloride In water at 80℃; for 1h; Sandmeyer Reaction;
2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
761440-16-8

2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester
1032903-63-1

4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: boron trifluoride / isopropyl alcohol / 10 h / 65 °C
2: trifluoroacetic acid / tetrahydrofuran / 5 h / 0 - 22 °C
View Scheme
5-chloro-N2-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]pyrimidine-2,4-diamine dihydrochloride

5-chloro-N2-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]pyrimidine-2,4-diamine dihydrochloride

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; isopropyl alcohol / 75 - 77 °C / Large scale
2: sodium hydroxide / acetone; water / 20 - 55 °C / pH 12.0
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol / Reflux
2: sodium hydroxide / water; acetone / 55 °C
View Scheme
2-aminophenyl isopropyl sulphide
6397-33-7

2-aminophenyl isopropyl sulphide

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / Reflux; Large scale
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 15 °C / Large scale
3: isopropyl alcohol / 24 h / Reflux; Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 8 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 2 - 25 °C / Inert atmosphere
3.1: hydrogenchloride / isopropyl alcohol; water / 1.5 h / 25 - 30 °C
3.2: 44 h / Reflux
View Scheme
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 - 90 °C / Large scale
2.1: pyrographite / ethyl acetate / 30 - 40 °C / Large scale
2.2: 1216.08 Torr / Large scale
3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / Reflux; Large scale
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 15 °C / Large scale
5.1: isopropyl alcohol / 24 h / Reflux; Large scale
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 0 - 25 °C
3.1: hydrogen; palladium on activated charcoal / methanol / 6 h / 3102.97 Torr
4.1: sodium hydride / N,N-dimethyl acetamide / 1 h / 0 °C
4.2: 2 h / 20 - 25 °C
5.1: toluene-4-sulfonic acid / isopropyl alcohol; water / 24 h / 140 °C / Autoclave
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 760.05 Torr
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Cooling with ice
4.2: 16 h / 20 °C
5.1: palladium diacetate; caesium carbonate / tetrahydrofuran / 2 h / Reflux
6.1: trifluoroacetic acid / 1 h / 20 °C
View Scheme
2-(isopropyl sulfanyl)nitrobenzene
70415-85-9

2-(isopropyl sulfanyl)nitrobenzene

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyrographite / ethyl acetate / 30 - 40 °C / Large scale
1.2: 1216.08 Torr / Large scale
2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / Reflux; Large scale
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 15 °C / Large scale
4.1: isopropyl alcohol / 24 h / Reflux; Large scale
View Scheme
Multi-step reaction with 4 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 0 - 25 °C
2.1: hydrogen; palladium on activated charcoal / methanol / 6 h / 3102.97 Torr
3.1: sodium hydride / N,N-dimethyl acetamide / 1 h / 0 °C
3.2: 2 h / 20 - 25 °C
4.1: toluene-4-sulfonic acid / isopropyl alcohol; water / 24 h / 140 °C / Autoclave
View Scheme
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 760.05 Torr
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Cooling with ice
3.2: 16 h / 20 °C
4.1: palladium diacetate; caesium carbonate / tetrahydrofuran / 2 h / Reflux
5.1: trifluoroacetic acid / 1 h / 20 °C
View Scheme
2-isopropoxy-5-methyl-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-phenylamine

2-isopropoxy-5-methyl-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-phenylamine

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 100 °C
2: palladium on activated charcoal; hydrogen / 35 °C / 7500.75 Torr
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / water; isopropyl alcohol / pH 1
2: hydrogen / methanol / 8 h / 90 °C / 7500.75 Torr
3: isopropyl alcohol / Reflux
4: sodium hydroxide / water; acetone / 55 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / isopropyl alcohol / pH 1
2.1: palladium on activated charcoal; hydrogen / methanol / 8 h / 90 °C / 7500.75 Torr
2.2: Cooling with ice
3.1: isopropyl alcohol / Reflux
4.1: sodium hydroxide / water; acetone / 55 °C
View Scheme
4-(5-isopropyloxy-2-methyl-4-nitrophenyl)pyridine
1032903-62-0

4-(5-isopropyloxy-2-methyl-4-nitrophenyl)pyridine

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetone / Reflux
2: sodium tetrahydroborate / tetrahydrofuran / 5 °C / Inert atmosphere
3: iron(III) chloride; pyrographite; hydrazine hydrate / ethanol / Reflux
4: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 100 °C
5: palladium on activated charcoal; hydrogen / 35 °C / 7500.75 Torr
View Scheme
Multi-step reaction with 5 steps
1: ethyl acetate
2: sodium tetrahydroborate / tetrahydrofuran / 5 °C / Inert atmosphere
3: palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
4: hydrogenchloride / ethyl acetate
5: 1,2-dimethoxyethane / 130 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride / ethyl acetate
2: sodium tetrahydroborate / tetrahydrofuran / 5 °C / Inert atmosphere
3: palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
4: hydrogenchloride / ethyl acetate
5: 1,2-dimethoxyethane / 130 °C / Inert atmosphere
View Scheme
4-(5-(propan-2-yloxy)-2-methyl-4-nitro-phenyl)-1-benzyl-pyridinium bromide

4-(5-(propan-2-yloxy)-2-methyl-4-nitro-phenyl)-1-benzyl-pyridinium bromide

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / tetrahydrofuran / 5 °C / Inert atmosphere
2: iron(III) chloride; pyrographite; hydrazine hydrate / ethanol / Reflux
3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 100 °C
4: palladium on activated charcoal; hydrogen / 35 °C / 7500.75 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / ethanol / 16 h / 20 - 25 °C
2.1: palladium; hydrogen / methanol / 6 h / 50 °C / 2660.18 Torr
3.1: hydrogenchloride / isopropyl alcohol; water / 1.5 h / 25 - 30 °C
3.2: 44 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: sodium tetrahydroborate; hydrogenchloride / methanol; water
2: hydrogenchloride / water; isopropyl alcohol / pH 1
3: hydrogen / methanol / 8 h / 90 °C / 7500.75 Torr
4: isopropyl alcohol / Reflux
5: sodium hydroxide / water; acetone / 55 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate; hydrogenchloride; methanol / water / Cooling
2.1: hydrogenchloride / isopropyl alcohol / pH 1
3.1: palladium on activated charcoal; hydrogen / methanol / 8 h / 90 °C / 7500.75 Torr
3.2: Cooling with ice
4.1: isopropyl alcohol / Reflux
5.1: sodium hydroxide / water; acetone / 55 °C
View Scheme
1-benzyl-4-(5-isopropyloxy-2-methyl-4-nitrophenyl)-1,2,3,6-tetrahydropyridine

1-benzyl-4-(5-isopropyloxy-2-methyl-4-nitrophenyl)-1,2,3,6-tetrahydropyridine

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron(III) chloride; pyrographite; hydrazine hydrate / ethanol / Reflux
2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / tetrahydrofuran / 100 °C
3: palladium on activated charcoal; hydrogen / 35 °C / 7500.75 Torr
View Scheme
Multi-step reaction with 3 steps
1: hydrogen; 50% palladium on charcoal / methanol / 72 h / 4137.29 Torr
2: hydrogenchloride / methanol / 0.17 h / 0 °C
3: toluene-4-sulfonic acid / isopropyl alcohol; water / 24 h / 140 °C / Autoclave
View Scheme
Multi-step reaction with 2 steps
1.1: palladium; hydrogen / methanol / 6 h / 50 °C / 2660.18 Torr
2.1: hydrogenchloride / isopropyl alcohol; water / 1.5 h / 25 - 30 °C
2.2: 44 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen; palladium on activated charcoal / methanol / 25 - 30 °C / 3102.97 Torr
1.2: 0 - 50 °C
2.1: isopropyl alcohol / 20 h / Inert atmosphere; Reflux
2.2: 55 - 60 °C / pH 9.7
View Scheme
Multi-step reaction with 3 steps
1.1: platinum(IV) oxide; hydrogen / methanol / 25 - 30 °C / 3102.97 Torr
2.1: hydrogen; 5%-palladium/activated carbon / methanol / 25 - 30 °C / 3361.55 Torr
2.2: 25 - 30 °C / pH 1.6
3.1: isopropyl alcohol / 20 h / Inert atmosphere; Reflux
3.2: 55 - 60 °C / pH 9.7
View Scheme
C15H20N2O3

C15H20N2O3

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
2: hydrogenchloride / ethyl acetate
3: 1,2-dimethoxyethane / 130 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 20 °C / 7500.75 Torr
2: hydrogenchloride / ethyl acetate
3: 1,2-dimethoxyethane / 5 h / Inert atmosphere; Reflux
View Scheme
C15H16N2O3*ClH

C15H16N2O3*ClH

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / tetrahydrofuran / 5 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
3: hydrogenchloride / ethyl acetate
4: 1,2-dimethoxyethane / 130 °C / Inert atmosphere
View Scheme
C15H16N2O3*CH4O3S

C15H16N2O3*CH4O3S

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / tetrahydrofuran / 5 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
3: hydrogenchloride / ethyl acetate
4: 1,2-dimethoxyethane / 130 °C / Inert atmosphere
View Scheme
1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene
1032903-50-6

1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 5 h / 120 °C / Inert atmosphere
2: 5%-palladium/activated carbon; hydrogen / methanol; water / 20 °C
3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 10 h / 120 °C / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 2 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,4-dioxane / 48 h / 100 °C
2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 48 h / 20 °C
3: bis(tri-t-butylphosphine)palladium(0); sodium t-butanolate / toluene / 0.33 h / 150 °C / Microwave irradiation
4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
5: sodium hydrogencarbonate / water; ethyl acetate
View Scheme
Multi-step reaction with 7 steps
1: potassium carbonate; palladium diacetate; triphenylphosphine / 1,4-dioxane / 24 h / Reflux; Inert atmosphere
2: tetrahydrofuran / Reflux
3: sodium tetrahydroborate; hydrogenchloride / methanol; water
4: hydrogenchloride / water; isopropyl alcohol / pH 1
5: hydrogen / methanol / 8 h / 90 °C / 7500.75 Torr
6: isopropyl alcohol / Reflux
7: sodium hydroxide / water; acetone / 55 °C
View Scheme
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate
375853-82-0, 286961-14-6

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 5 h / 120 °C / Inert atmosphere
2: 5%-palladium/activated carbon; hydrogen / methanol; water / 20 °C
3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 10 h / 120 °C / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 2 h / 20 °C
View Scheme
4-(2-methyl-4-nitro-5-isopropoxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester
1032903-52-8

4-(2-methyl-4-nitro-5-isopropoxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5%-palladium/activated carbon; hydrogen / methanol; water / 20 °C
2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 10 h / 120 °C / Inert atmosphere
3: hydrogenchloride / ethyl acetate / 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 48 h / 20 °C
2: bis(tri-t-butylphosphine)palladium(0); sodium t-butanolate / toluene / 0.33 h / 150 °C / Microwave irradiation
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: sodium hydrogencarbonate / water; ethyl acetate
View Scheme
N,N-dibenzyl-4-bromo-2-isopropoxy-5-methylaniline

N,N-dibenzyl-4-bromo-2-isopropoxy-5-methylaniline

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tris-(dibenzylideneacetone)dipalladium(0); XPhos; toluene-4-sulfonic acid hydrazide; lithium tert-butoxide / 1,4-dioxane / 0.08 h / Inert atmosphere
1.2: 16 h / 110 °C / Inert atmosphere
2.1: hydrogen; palladium on activated charcoal / methanol / 72 h / 4137.29 Torr
3.1: hydrogenchloride / methanol / 0.17 h / 0 °C
4.1: toluene-4-sulfonic acid / isopropyl alcohol; water / 24 h / 140 °C / Autoclave
View Scheme
Multi-step reaction with 5 steps
1: TurboGrignard / tetrahydrofuran / 6.1 h / Inert atmosphere; Reflux
2: toluene-4-sulfonic acid / toluene / Reflux
3: hydrogen; palladium on activated charcoal / methanol / 72 h / 4137.29 Torr
4: hydrogenchloride / methanol / 0.17 h / 0 °C
5: toluene-4-sulfonic acid / isopropyl alcohol; water / 24 h / 140 °C / Autoclave
View Scheme
N,N-dibenzyl-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylaniline

N,N-dibenzyl-4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylaniline

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen; palladium on activated charcoal / methanol / 72 h / 4137.29 Torr
2: hydrogenchloride / methanol / 0.17 h / 0 °C
3: toluene-4-sulfonic acid / isopropyl alcohol; water / 24 h / 140 °C / Autoclave
View Scheme
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

dibenzyl phosphochloridate
538-37-4

dibenzyl phosphochloridate

dibenzyl (4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)phosphonate

dibenzyl (4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)phosphonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 24h;96%
pentyl chloroformate
638-41-5

pentyl chloroformate

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

pentyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

pentyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃;96%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

diphenyl (4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)phosphonate

diphenyl (4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)phosphonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 24h;95%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

methyl chloroformate
79-22-1

methyl chloroformate

methyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

methyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃;95%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

isobutyl chloroformate
17462-58-7

isobutyl chloroformate

sec-butyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

sec-butyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃;95%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

3-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)-amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)-piperidin-1-yl)propanoic acid

3-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)-amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)-piperidin-1-yl)propanoic acid

Conditions
ConditionsYield
Stage #1: 5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine; acrylic acid methyl ester With triethylamine at 20℃; for 8h; Michael Addition;
Stage #2: With sodium hydroxide In methanol; water at 20℃; for 8h;
Stage #3: With hydrogenchloride In water pH=2;
95%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

ethyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

ethyl 4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃;94%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

diethyl (4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)phosphonate

diethyl (4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)phosphonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 24h;90%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

C32H42ClN5O5S

C32H42ClN5O5S

Conditions
ConditionsYield
With triethylamine In methanol at 20℃; for 8h;90%
With triethylamine In methanol at 20℃; for 8h;90%
With triethylamine In methanol at 20℃; for 8h;90%
With triethylamine In methanol at 20℃; for 8h;90%
2-hydroxyethyl 4-methylbenzenesulfonate
42772-85-0

2-hydroxyethyl 4-methylbenzenesulfonate

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

2-[4-(4-{5-chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-5-isopropoxy-2-methyl-phenyl)-piperidin-1-yl]-ethanol
1032900-27-8

2-[4-(4-{5-chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-5-isopropoxy-2-methyl-phenyl)-piperidin-1-yl]-ethanol

Conditions
ConditionsYield
With triethylamine In acetonitrile at 85℃;88%
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

tert-butyl 2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)acetate

tert-butyl 2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 5h; Reflux;76%
With potassium carbonate In acetonitrile for 5h; Reflux;76%
With potassium carbonate In acetonitrile for 5h; Reflux;76%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;75%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

[(18)F]-2-fluoroethyltosylate
113426-12-3

[(18)F]-2-fluoroethyltosylate

C30H39Cl(18)FN5O3S

C30H39Cl(18)FN5O3S

Conditions
ConditionsYield
In acetonitrile for 0.333333h; Heating;74%
fluorescein isothiocyanate
3326-32-7, 27072-45-3

fluorescein isothiocyanate

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)-N-(3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthen]-5-yl)piperidine-1-carbothioamide

4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)-N-(3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthen]-5-yl)piperidine-1-carbothioamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 40℃; for 1h; Darkness;72%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

6-bromo-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide

6-bromo-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide

C47H55ClN8O8S

C47H55ClN8O8S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃; for 6h;68%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

1-azido-4-iodobutane
148759-55-1

1-azido-4-iodobutane

N2-(4-(1-(4-azidobutyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

N2-(4-(1-(4-azidobutyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)-5-chloro-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 16h;66%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

C17H15N3O7

C17H15N3O7

C45H49ClN8O9S

C45H49ClN8O9S

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h;65%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

2-fluoroethyl tosylate
383-50-6

2-fluoroethyl tosylate

fluoroethyl ceritinib

fluoroethyl ceritinib

Conditions
ConditionsYield
With triethylamine In acetonitrile at 85℃; for 4h;64%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

C30H37Cl2N5O5S

C30H37Cl2N5O5S

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃;63%
5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

C39H50N2O14S5

C39H50N2O14S5

2-((E)-2-((E)-2-((3-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)thio)-3-(2-((E)-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(3-sulfopropyl)-3H-indole-5-sulfonic acid

2-((E)-2-((E)-2-((3-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)thio)-3-(2-((E)-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(3-sulfopropyl)-3H-indole-5-sulfonic acid

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 40℃; for 2h; Darkness;62%
1,10-decanedioic acid
111-20-6

1,10-decanedioic acid

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

C38H52ClN5O6S

C38H52ClN5O6S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 10h;53%
[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid
927670-97-1

[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
1032900-25-6

5-chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine

4-((2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 20℃;52%

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