CAS No.22128-62-7,Chloromethyl chloroformate Suppliers,MSDS download

Hunan Russell Chemicals Technology Co.,Ltd

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Chloromethyl chloroformate, 97% 22128-62-7

Cas:22128-62-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

: 79-22-1
methyl chloroformate

A: 22128-63-8
dichloromethoxycarbonyl chloride

B: 22128-62-7
carbonochloridic acid, chloromethyl ester

Conditions

Conditions	Yield
With chlorine at 65 - 88℃; for 4h; Yields of byproduct given;	A n/a B 22%
With chlorine at 65 - 88℃; for 4h; Yield given. Yields of byproduct given;
With 2,2'-azobis(isobutyronitrile); chlorine at 70℃; for 9.5h;	A 1.94 %Chromat. B 68.5 %Chromat.

: 107-31-3
Methyl formate

: 22128-62-7
carbonochloridic acid, chloromethyl ester

Conditions

Conditions	Yield
bei gemaessigter Chlorierung am Licht;

: 107-31-3
Methyl formate

A: 22128-63-8
dichloromethoxycarbonyl chloride

B: 22128-62-7
carbonochloridic acid, chloromethyl ester

C: 503-38-8
trichloromethyl chloroformate

Conditions

Conditions	Yield
Bei der Chlorierung im Licht;
With oxygen; chlorine at 22.85℃; Kinetics; Further Variations:; Reagents;

...Expand

: 56-23-5
tetrachloromethane

: 79-22-1
methyl chloroformate

: 22128-62-7
carbonochloridic acid, chloromethyl ester

Conditions

Conditions	Yield
at 25℃; Kinetics; Photochlorierung;

: 79-22-1
methyl chloroformate

: 22128-62-7
carbonochloridic acid, chloromethyl ester

Conditions

Conditions	Yield
bei gemaessigter Chlorierung am Licht;
With chlorine Ambient temperature; Irradiation;
With sulfuryl dichloride; Perbenzoic acid Heating;

: 75-44-5
phosgene

: 50-00-0
formaldehyd

: 22128-62-7
carbonochloridic acid, chloromethyl ester

Conditions

Conditions	Yield
benzyltri(n-butyl)ammonium chloride at 0 - 20℃; for 0.5h;

: 7782-50-5
chlorine

: 79-22-1
methyl chloroformate

: 22128-62-7
carbonochloridic acid, chloromethyl ester

Conditions

Conditions	Yield
at 23.5 - 27℃; durch UV-Licht (λ:435.8 nm) initiierten Reaktion in der Dampfphase;

: 107-31-3
Methyl formate

: 7782-50-5
chlorine

A: 22128-63-8
dichloromethoxycarbonyl chloride

B: 22128-62-7
carbonochloridic acid, chloromethyl ester

Conditions

Conditions	Yield
im diffusen Licht;

...Expand

: 123-75-1
pyrrolidine

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 93765-67-4
N-(chloromethyloxycarbonyl)pyrrolidine

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 2h; Substitution;	100%
With pyridine Yield given;

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 100-61-8
N-methylaniline

: 186353-05-9
[N-methyl-N-phenyl]carbamic acid chloromethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	100%
With triethylamine In dichloromethane at 0 - 5℃; for 4h;	73%

: 44897-15-6
sarcosine diethylamide

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 934548-22-8
N-(chloromethyloxycarbonyl)sarcosine diethylamide

Conditions

Conditions	Yield
In dichloromethane at -10 - 20℃;	100%

: 3-R-(N-Boc-prop-2-ynylamino)-indan-5-ol

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: carbonic acid chloromethyl ester 3-R-(N-Boc-prop-2-ynylamino)-indan-5-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h;	100%

: tert-butyl 3-hydroxypropyl (2E)-but-2-enedioate

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: tert-butyl 3-{[(chloromethoxy)carbonyl]oxy}propyl (2E)-but-2-enedioate

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.75h;	100%

: 6-fluoro-1-methyl-4-oxo-7-(((1r,4r)-4-((((3-oxo-4-((2-(trimethylsilyl)ethoxy)methyl)-3,4-dihydro-2H-pyrazino[2,3-b][1,4]oxazin-6-yl)methyl)amino)methyl)cyclohexyl)amino)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 7-(((1r,4r)-4-((((chloromethoxy)carbonyl)((3-oxo-4-((2-(trimethylsilyl)ethoxy)methyl)-3,4-dihydro-2H-pyrazino[2,3-b][1,4]oxazin-6-yl)methyl)amino)methyl)cyclohexyl)amino)-6-fluoro-1-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water at 20℃; for 2h;	100%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 108-98-5
thiophenol

: 133217-39-7
Thiocarbonic acid O-chloromethyl ester S-phenyl ester

Conditions

Conditions	Yield
With triethylamine In diethyl ether 1) 0 to 5 deg C, 30 min, 2) RT, 16h;	99%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 158991-23-2
PD 154075

: 247017-85-2
3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester

Conditions

Conditions	Yield
Stage #1: PD 154075 With potassium hexamethylsilazane In tetrahydrofuran at -78℃; Metallation; Stage #2: carbonochloridic acid, chloromethyl ester In tetrahydrofuran at -78℃; Acylation;	99%

: 112-35-6
triethylene glucol monomethyl ether

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 209551-63-3
chloromethyl (2-(2-(2-methoxyethoxy)ethoxy)ethyl) carbonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 22h; Inert atmosphere;	99%
With pyridine In dichloromethane at 0 - 20℃;	99%
With pyridine In dichloromethane
With pyridine In dichloromethane at 20℃;
With pyridine In dichloromethane at -78℃; for 3h;

: 110-91-8
morpholine

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 93765-68-5
chloromethyl morpholine-4-carboxylate

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 0.5h;	99%
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1.58333h;

: 22128-62-7
carbonochloridic acid, chloromethyl ester

Triton X-100: Triton X-100

Triton X-100 chloromethyl carbonate: Triton X-100 chloromethyl carbonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 2h; Inert atmosphere;	99%

: 2-(4-fluoro-2-(methyl-d3)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: N-[1-(chloromethyl)-2-oxo-1,2-dihydropyridin-4-yl]-2-[4-fluoro-2-(methyl-d3)phenoxy]-4-(trifluoromethyl)benzamide

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 60℃; for 1.08333h;	99%

: 107-03-9
1-thiopropane

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: O-(chloromethyl) S-propyl carbonothioate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tert-butyl methyl ether at 5 - 20℃;	99%
With N-ethyl-N,N-diisopropylamine In tert-butyl methyl ether at 5 - 20℃;	29 g

: 32399-12-5
2-(N-methylamino)-3-hydroxymethylpyridine

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: chloromethyl (3-(hydroxymethyl)pyridin-2-yl)(methyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 5℃; for 0.0833333h;	99%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -10℃; for 1h;

: 1557084-43-1
3-(2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-7-yl)aniline

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 1557084-82-8
chloromethyl (3-(2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-7-yl)phenyl)carbamate

Conditions

Conditions	Yield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In chloroform at 20℃; Cooling with ice;	98.4%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 67-63-0
isopropyl alcohol

: 35180-01-9
chloromethyl isopropyl carbonate

Conditions

Conditions	Yield
With triethylamine at 0℃;	98%
With pyridine In diethyl ether; isopropyl alcohol at 10℃; for 18h; Cooling;	95%
With pyridine In diethyl ether at 0 - 20℃;	92%

: 111-87-5
octanol

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 920967-14-2
chloromethyl-1-octyl carbonate

Conditions

Conditions	Yield
With pyridine In dichloromethane	98%
With N-ethyl-N,N-diisopropylamine In dichloromethane
With triethylamine In dichloromethane at 0 - 20℃; for 21h;

: (S)-3,4-difluoro-N-(((1-methoxypropan-2-yl)amino)((6-(trifluoromethyl)-1H-indazol-3-yl)amino)methylene)benzamide

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: (S)-chloromethyl 3-(2-(3,4-difluorobenzoyl)-3-(1-methoxypropan-2-yl)guanidino)-6-(trifluoromethyl)-1H-indazole-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -40 - 20℃; for 0.333333h;	98%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 109-89-7
diethylamine

: 133217-92-2
chloromethyl N,N-diethyl carbamate

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 0.5h;	97%
In hexane at -10 - -5℃; for 2.25h;	92%
With triethylamine In diethyl ether 1) 0 to 5 deg C, 30 min, 2) RT, 16h;	71%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 111-27-3
hexan-1-ol

: 663597-51-1
chloromethyl hexyl carbonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 25℃;	97%
With pyridine In dichloromethane at 0 - 20℃; for 20h;	63%

: 90-15-3
α-naphthol

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 132905-86-3
Carbonic acid chloromethyl ester naphthalen-1-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 5℃; for 1.66667h;	96%

: 4-(3,3-dimethylbutanamido)-3,5-difluoro-N-(thiazol-2-yl)benzamide

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 913841-86-8
N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

Conditions

Conditions	Yield
Stage #1: 4-(3,3-dimethylbutyrylamino)-3,5-difluoro-N-thiazol-2-ylbenzamide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Stage #2: carbonochloridic acid, chloromethyl ester In N,N-dimethyl-formamide; mineral oil at 0 - 20℃;	96%
Stage #1: 4-(3,3-dimethylbutyrylamino)-3,5-difluoro-N-thiazol-2-ylbenzamide With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: carbonochloridic acid, chloromethyl ester In N,N-dimethyl-formamide at 20℃;	86%

: 87184-99-4
4-(tert-butyldimethylsiloxy)-1-butanol

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 4-((tert-butyldimethylsilyl)oxy)butyl (chloromethyl) carbonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 2h;	96%

: 100-02-7
4-nitro-phenol

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 50780-50-2
4-chloromethoxycarbonyloxy-1-nitrobenzene

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1h;	95%
With 4-methyl-morpholine In dichloromethane at 0 - 25℃;	94%
With TEA Ambient temperature;	90%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: N-[4-(aminomethyl)benzoyl]alanine benzyl ester

: 502158-15-8
(S)-2-[4-(Chloromethoxycarbonylamino-methyl)-benzoylamino]-propionic acid benzyl ester

Conditions

Conditions	Yield
With TEA In dichloromethane at 0℃;	95%

: 2462-34-2
L-valine benzyl ester hydrochloride

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: (S)-2-chloromethoxycarbonylamino-3-methyl-butyric acid benzyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;	95%

: 177339-15-0
3-[(1-dimethylamino-2-methyl)prop-2-yl]phenol

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 177339-27-4
3-[(1-dimethylamino-2-methyl)prop-2-yl]phenyl chloromethyl carbonate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; triethylamine In dichloromethane	95%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 160738-57-8, 112811-59-3
gatifloxacin

: 925684-58-8
7-(4-(2-chloromethoxycarbonyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinlone-3-carboxylic acid

Conditions

Conditions	Yield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane for 4h; Inert atmosphere;	95%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0℃; for 4h;	95%

: 66085-59-4
nimodipin

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: C23H27ClN2O9

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 0.5h; Inert atmosphere; Cooling with ice;	95%
Stage #1: nimodipin With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Cooling with ice; Stage #2: carbonochloridic acid, chloromethyl ester In tetrahydrofuran at 20℃;	94.84%

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: C13H20ClNO7

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	95%

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