1. We integrate research and development, production, and sales. A 1800 square meter research and development center,The company has conducted over 50 research and development and technical service projects annually, applied for more than 10 patents,
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:105816-04-4
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:105816-04-4
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryUnique advantages of Nateglinide Cas 105816-04-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Cool dry place Package:1kg/foill bag
Cas:105816-04-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable
APIs Appearance:White Crystalline Powder Storage:Room temp Package:25kg/drum or acc to customers' request Application:antidiabetic KATP channel blocker; An Amino-acid derivative that stimulates insulin secretion. Used as an antidiabetic; Transporta
Cas:105816-04-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:105816-04-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:105816-04-4
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:105816-04-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:105816-04-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryProduct Name Nateglinide Molecular Formula C19H27NO3 Molecular Weight 317.42 CAS NO. 105816-04-4 Assay HPLC Melting Point
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:105816-04-4
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Nateglinide Molecular Structure: Formula: C19H27NO3 Molecular Weight : 317.42 Synonyms: (-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine;ay4166
1,In No Less five years exporting experience. 2,Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White crystalline powder Sto
Cas:105816-04-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:105816-04-4
Min.Order:10 Gram
FOB Price: $0.6
Type:Trading Company
inquiryNateglinide CAS: 105816-04-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:105816-04-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Product Name: Nateglinide Synonyms: N-(Trans-4-Isopropylcyclohexyl-1-Carbonyl)-D-Phenylalamine;trans-d-phenylalanine;NATAGLINIDE;Fastic, N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine, Starlix, Starsis;N-(4α-Isopropylcyclohexane
Cas:105816-04-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:105816-04-4
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
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Nateglinide 105816-04-4 1:Nateglinide 2;105816-04-4 3:main manfacture 4:prompt delivery Appearance:white Storage:cool and dry Package:durm Application:api Transportation:by sea or by air Port:shanghai
Cas:105816-04-4
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryOur products mainly developing direction is "the best quality, the best service". In recent years, with the frequently international trading, which are sold well in Europe, America, Japan, Southeast Asia, more than 40 countries and regions,
Cas:105816-04-4
Min.Order:1 Gram
FOB Price: $10.0
Type:Trading Company
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Cas:105816-04-4
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirymoderate price & quick delivery. Appearance:white crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package: 1g/bag, 5g/bag, 10g/bag, 100g/bag, 1kg/bag or as per your request Application:An Amino
N-<(trans-4-Isopropylcyclohexyl)carbonyl>-D-phenylalanine methyl ester
nateglinide
Conditions | Yield |
---|---|
Stage #1: N-<(trans-4-Isopropylcyclohexyl)carbonyl>-D-phenylalanine methyl ester With water; sodium hydroxide In methanol at 25 - 30℃; for 5h; Stage #2: With hydrogenchloride In water pH=2.0 - 2.5; | 80.8% |
With sodium hydroxide In methanol Yield given; | |
Stage #1: N-<(trans-4-Isopropylcyclohexyl)carbonyl>-D-phenylalanine methyl ester With sodium hydroxide In acetone at 20 - 25℃; for 2h; Stage #2: With hydrogenchloride In water at 10℃; for 1h; pH=2 - 3; Product distribution / selectivity; |
trans-4-isopropylcyclohexane-1-carboxylic acid
D-(R)-phenylalanine
chloroformic acid ethyl ester
A
N-(ethoxycarbonyl)-(D)-phenylalanine
B
nateglinide
Conditions | Yield |
---|---|
Stage #1: trans-4-isopropylcyclohexane-1-carboxylic acid; chloroformic acid ethyl ester With triethylamine In acetone at -10 - -5℃; for 1.25h; Stage #2: D-(R)-phenylalanine With 4-methyl-morpholine; triethylamine In water; acetone at -10 - -5℃; | A n/a B 80% C n/a |
Conditions | Yield |
---|---|
In dichloromethane at 25 - 30℃; for 18.5h; | 75% |
D-(R)-phenylalanine
4-iso-propylcyclohexanecarbonyl chloride
nateglinide
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid | 65% |
With sodium hydroxide; sulfuric acid In n-heptane; ethyl acetate | 65% |
With potassium hydroxide In water; acetone |
trans-4-iso-propylcyclohexylcarbonyl chloride
nateglinide
Conditions | Yield |
---|---|
In acetonitrile at -5 - 0℃; for 3.58333 - 3.66667h; Heating / reflux; |
trans-4-isopropylcyclohexane-1-carboxylic acid
nateglinide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) N-hydroxysuccinimide, dicyclohexylcarbodiimide / 1) CHCl3, 3 h, 2) CHCl3, 25 deg C, 1 d 2: 2N NaOH / methanol View Scheme |
D-phenylalanine methyl ester
nateglinide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) N-hydroxysuccinimide, dicyclohexylcarbodiimide / 1) CHCl3, 3 h, 2) CHCl3, 25 deg C, 1 d 2: 2N NaOH / methanol View Scheme | |
Multi-step reaction with 2 steps 1.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 25 °C / Inert atmosphere 1.2: 3.25 h / 0 - 15 °C 2.1: sodium hydroxide / acetone / 2 h / 20 - 25 °C 2.2: 1 h / 10 °C / pH 2 - 3 View Scheme |
p-menthan-7-oic acid methyl ester
nateglinide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1) NaH, 2) 2N aq. NaOH / 1) 150 deg C, 2 h, 2) MeOH, 20 deg C, 10 min 2: 1) N-hydroxysuccinimide, dicyclohexylcarbodiimide / 1) CHCl3, 3 h, 2) CHCl3, 25 deg C, 1 d 3: 2N NaOH / methanol View Scheme |
C19H26NO3(1-)*K(1+)
nateglinide
Conditions | Yield |
---|---|
With hydrogenchloride In water at 15 - 20℃; pH=2.0 - 3.0; Product distribution / selectivity; |
C19H26NO3(1-)*Na(1+)
nateglinide
Conditions | Yield |
---|---|
With hydrogenchloride; water at 25℃; for 0.5h; pH=2 - 3; Product distribution / selectivity; |
D-(R)-phenylalanine
4-iso-propylcyclohexanecarbonyl chloride
nateglinide
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid In n-heptane |
trans-4-isopropylcyclohexane-1-carboxylic acid
D-(R)-phenylalanine
nateglinide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: thionyl chloride / 12.5 h / 5 - 25 °C / Inert atmosphere 1.2: 0.25 h / 25 °C / Inert atmosphere 1.3: 3.25 h / 0 - 15 °C 2.1: sodium hydroxide / acetone / 2 h / 20 - 25 °C 2.2: 1 h / 10 °C / pH 2 - 3 View Scheme |
D-(R)-phenylalanine
nateglinide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / 12.5 h / 5 - 25 °C / Inert atmosphere 2.1: ammonia / dichloromethane; water / 0.5 h / 10 °C 3.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 25 °C / Inert atmosphere 3.2: 3.25 h / 0 - 15 °C 4.1: sodium hydroxide / acetone / 2 h / 20 - 25 °C 4.2: 1 h / 10 °C / pH 2 - 3 View Scheme | |
Multi-step reaction with 3 steps 1.1: thionyl chloride / 12.5 h / 5 - 25 °C / Inert atmosphere 2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 25 °C / Inert atmosphere 2.2: 3 h / 0 - 15 °C 3.1: sodium hydroxide / acetone / 2 h / 20 - 25 °C 3.2: 1 h / 10 °C / pH 2 - 3 View Scheme |
D-phenylalanine methyl ester hydrochloride
nateglinide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ammonia / dichloromethane; water / 0.5 h / 10 °C 2.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 25 °C / Inert atmosphere 2.2: 3.25 h / 0 - 15 °C 3.1: sodium hydroxide / acetone / 2 h / 20 - 25 °C 3.2: 1 h / 10 °C / pH 2 - 3 View Scheme |
trans-4-iso-propylcyclohexylcarbonyl chloride
D-(R)-phenylalanine
nateglinide
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone at 20℃; for 20h; Temperature; | 70 g |
4-(1-hydroxyethyl)benzyl alcohol
nateglinide
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 97% |
methanol
nateglinide
N-<(trans-4-Isopropylcyclohexyl)carbonyl>-D-phenylalanine methyl ester
Conditions | Yield |
---|---|
With sulfuric acid Reflux; | 97% |
nateglinide
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate In dimethyl sulfoxide Irradiation; Inert atmosphere; Sealed tube; | 53% |
nateglinide
ethyl acrylate
Conditions | Yield |
---|---|
With Ir(dF(CF3)ppy)2(bpy)PF6; caesium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Sealed tube; Inert atmosphere; Irradiation; | 44% |
3-(nitrooxymethyl)benzyl alcohol
nateglinide
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; | 32% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; | 23% |
diisopropylamine
nateglinide
Conditions | Yield |
---|---|
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide 1) CHCl3, 1 d, 2) CHCl3, 25 deg C, 1 d; Yield given. Multistep reaction; |
nateglinide
Conditions | Yield |
---|---|
With ammonium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide 1) CHCl3, 1 d, 2) CHCl3, 25 deg C, 1 d; Yield given. Multistep reaction; |
nateglinide
Conditions | Yield |
---|---|
Stage #1: nateglinide In methanol; water at 39℃; for 0.5h; pH=4; Stage #2: With ammonia In methanol; water at 0℃; for 1h; pH=5; | |
Stage #1: nateglinide In water; acetone at 35℃; Stage #2: In water; acetone at -10℃; for 3h; |
ethanol
nateglinide
ethyl (trans-4-isopropylcyclohexane-1-carbonyl)-D-phenylalaninate
Conditions | Yield |
---|---|
With thionyl chloride |
Conditions | Yield |
---|---|
at 25℃; |
Conditions | Yield |
---|---|
at 25℃; |
Conditions | Yield |
---|---|
at 25℃; |
Conditions | Yield |
---|---|
at 25℃; |
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