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Shanghai Surseechem Co.,Ltd.

ProName: 2-Amino-4-(trifluoromethyl)pyridine CasNo: 106447-97-6 Appearance: white powder Application: Used as Pharmaceutical Intermediates DeliveryTime: within 15 days after placing an order PackAge: 25kg/drum, or as per your

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:100 Gram

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min -----------------------------------------------------------------------------------------------

High purity 2-Amino-4-(trifluoromethyl)pyridine CAS:106447-97-6

Cas:106447-97-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

2-Amino-4-(trifluoromethyl)pyridine manufacturer with low price

Cas:106447-97-6

Min.Order:1 Gram

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High purity 2-Amino-4-(trifluoromethyl)pyridine with best price CAS NO.106447-97-6

Cas:106447-97-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 2-Pyridinamine,4-(trifluoromethyl)- 106447-97-6 ISO Producer

Cas:106447-97-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Kilogram

FOB Price: $1.0

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Amino-4-Trifluoromethylpyridine

Cas:106447-97-6

Min.Order:1 Metric Ton

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Gram

FOB Price: $5.0

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Amino-4-(trifluoromethyl)-pyridine

Cas:106447-97-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 106447-97-6 with fast shipping

Cas:106447-97-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Pyridinamine,4-(trifluoromethyl)- 106447-97-6

Cas:106447-97-6

Min.Order:1 Kilogram

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Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Kilogram

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2-Amino-4-(trifluoromethyl)pyridine 99%

Cas:106447-97-6

Min.Order:1 Kilogram

FOB Price: $214.0 / 235.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-Amino-4-(trifluoromethyl)pyridine CAS:106447-97-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual

2-Amino-4-(trifluoromethyl)pyridine CAS:106447-97-6

Cas:106447-97-6

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Pyridinamine,4-(trifluoromethyl)-

Cas:106447-97-6

Min.Order:1 Kilogram

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

2-Amino-4-(trifluoromethyl)pyridine cas:106447-97-6

Cas:106447-97-6

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Pyridinamine,4-(trifluoromethyl)-

Cas:106447-97-6

Min.Order:0

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Amino-4-(Trifluoromethyl)Pyridine

Cas:106447-97-6

Min.Order:0

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Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Pyridinamine,4-(trifluoromethyl)-

Cas:106447-97-6

Min.Order:0

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Gram

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Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-Amino-4-(Trifluoromethyl)Pyridine

Cas:106447-97-6

Min.Order:10 Gram

FOB Price: $100.0

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:0

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Type:Other

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Henan Tianfu Chemical Co., Ltd.

2-Amino-4-(trifluoromethyl)pyridine Basic information Product Name: 2-Amino-4-(trifluoromethyl)pyridine Synonyms: 4-(TRIFLUOROMETHYL)PYRIDIN-2-AM

106447-97-6 C6H5F3N2 2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Metric Ton

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Metric Ton

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

High Purity 2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:0

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Shanghai Minstar Chemical Co., Ltd

2-Amino-4-(trifluoromethyl)pyridine Chemical Properties Melting point 70-74 °C Boiling point 221.3±40.0 °C(Predicted) density 1.368±0.06 g/cm3(Predicted) storage temp. Room temperature. pka 4.55±0.11(Pr

2-Amino-4-trifluoromethylpyridine

Cas:106447-97-6

Min.Order:200 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

High purity 2-Amino-4-(trifluoromethyl)pyridine with best price CAS NO.106447-97-6

Cas:106447-97-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:0

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Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Amino-4-(trifluoromethyl)pyridine

Cas:106447-97-6

Min.Order:1 Kilogram

FOB Price: $2.0

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Synthetic route

2-chloro-4-trifluoromethyl pyridine
81565-18-6

2-chloro-4-trifluoromethyl pyridine

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With ammonia In water at 170℃; for 24h;76%
With ammonium hydroxide at 180℃;
With ammonium hydroxide
With ammonia
2,6-dichloro-4-(trifluoromethyl)pyridine
39890-98-7

2,6-dichloro-4-(trifluoromethyl)pyridine

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: 2,6-dichloro-4-(trifluoromethyl)pyridine With ammonia In tetrahydrofuran; water at 150℃; for 6h; autoclave;
Stage #2: With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran; water at 100℃; under 15001.5 Torr; for 3h; Product distribution / selectivity;
71.9%
5-ethoxy-3-hydroxy-3-(trifluoromethyl)pent-4-enenitrile
917806-22-5

5-ethoxy-3-hydroxy-3-(trifluoromethyl)pent-4-enenitrile

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With ammonia In water at 125℃; under 10501.1 Torr; for 24h; Autoclave;68%
2-fluoro-4-(trifluoromethyl) Pyridine

2-fluoro-4-(trifluoromethyl) Pyridine

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;61%
2-amino-5-bromo-4-(trifluoromethyl)pyridine
944401-56-3

2-amino-5-bromo-4-(trifluoromethyl)pyridine

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

A

4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine
944401-57-4

4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine

B

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 115℃; for 8h; Inert atmosphere;A 48%
B n/a
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane at 115℃; for 8h;
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 115℃; for 8.25h; Heating / reflux;
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 115℃; for 8h; Inert atmosphere;
2,2-dimethyl-3-(4-trifluoromethyl-pyridin-2-yl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one

2,2-dimethyl-3-(4-trifluoromethyl-pyridin-2-yl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With hydrogenchloride Hydrolysis;
1-oxido-4-(trifluoromethyl)pyridin-1-ium
22253-59-4

1-oxido-4-(trifluoromethyl)pyridin-1-ium

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CH2Cl2 / Heating
2: conc. HCl
View Scheme
2,6-dichloro-4-(trifluoromethyl)pyridine
39890-98-7

2,6-dichloro-4-(trifluoromethyl)pyridine

A

4-(trifluoromethyl)pyridine-2,6-diamine
130171-52-7

4-(trifluoromethyl)pyridine-2,6-diamine

B

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: 2,6-dichloro-4-(trifluoromethyl)pyridine With ammonia In water at 150℃; for 15h; autoclave;
Stage #2: With hydrogen; 5%-palladium/activated carbon In water at 100℃; under 13501.4 Torr; for 3h;
2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

2-amino-4-trifluoromethylpyridine hydrochloride
1281872-45-4

2-amino-4-trifluoromethylpyridine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In toluene at 10 - 20℃;96.6%
2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

2-amino-5-bromo-4-(trifluoromethyl)pyridine
944401-56-3

2-amino-5-bromo-4-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With N-Bromosuccinimide In dichloromethane at 25℃; for 2h; Darkness;94%
With N-Bromosuccinimide In tetrahydrofuran at 0 - 20℃; for 1h; Concentration;91%
With N-Bromosuccinimide In dichloromethane at 20℃; Darkness;87.96%
ethyl 2-chloro-3-hydroxyacrylate
10229-12-6

ethyl 2-chloro-3-hydroxyacrylate

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

7-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid
1426135-67-2

7-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-chloro-3-hydroxyacrylate; 2-amino-4-(trifluoromethyl)pyridine In ethanol at 80℃; Sealed tube; Inert atmosphere;
Stage #2: With water; lithium hydroxide In ethanol at 60℃; for 3h;
93%
phenyl chloroformate
1885-14-9

phenyl chloroformate

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

phenyl N-[4-(trifluoromethyl)pyridin-2-yl]carbamate
857265-11-3

phenyl N-[4-(trifluoromethyl)pyridin-2-yl]carbamate

Conditions
ConditionsYield
With pyridine In dichloromethane for 0.5h;92%
With pyridine In dichloromethane for 0.5h;92%
With pyridine In tetrahydrofuran at 0 - 20℃; for 2h;81%
2,6-Dibromo-4-methylpyridine
73112-16-0

2,6-Dibromo-4-methylpyridine

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

6-bromo-4-methyl-N-[4-(trifluoromethyl)pyridine-2-yl]pyridine-2-amine
1407500-61-1

6-bromo-4-methyl-N-[4-(trifluoromethyl)pyridine-2-yl]pyridine-2-amine

Conditions
ConditionsYield
With sodium t-butanolate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In 1,4-dioxane at 75℃; Inert atmosphere;92%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate In 1,4-dioxane at 75℃; Inert atmosphere;92%
With sodium t-butanolate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In 1,4-dioxane at 25 - 75℃; for 12.25h; Inert atmosphere;
3-methylpyridin-2-ylamine
1603-40-3

3-methylpyridin-2-ylamine

Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

N-((8-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

N-((8-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With Trimethylacetic acid In dichloromethane at 60℃; for 8h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Sealed tube; Inert atmosphere; regioselective reaction;92%
Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

4-(trifluoromethyl)-N-((7-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)pyridin-2-amine
1508297-73-1

4-(trifluoromethyl)-N-((7-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)pyridin-2-amine

Conditions
ConditionsYield
With Trimethylacetic acid In dichloromethane at 60℃; for 8h; Sealed tube; Inert atmosphere; regioselective reaction;90%
With acetic acid In acetonitrile at 80℃; for 8h; Green chemistry; regiospecific reaction;88%
Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

1-dodecylthiol
112-55-0

1-dodecylthiol

3-((dodecylthio)(phenyl)methyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridine
1508297-75-3

3-((dodecylthio)(phenyl)methyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With trifluoroacetic acid In N,N-dimethyl-formamide at 130℃; for 0.5h; Microwave irradiation;90%
With acetic acid In acetonitrile at 80℃; for 8h; Green chemistry; regiospecific reaction;80%
ethylbenzene
100-41-4

ethylbenzene

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

2-phenyl-7-trifluoromethylimidazo[1,2-α]pyridine
1629889-70-8

2-phenyl-7-trifluoromethylimidazo[1,2-α]pyridine

Conditions
ConditionsYield
Stage #1: ethylbenzene With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In water at 60℃; for 4h;
Stage #2: 2-amino-4-(trifluoromethyl)pyridine With sodium hydrogencarbonate In water at 80℃; for 2h;
89%
Stage #1: ethylbenzene With tert.-butylhydroperoxide; 5,5-dibromohydantoin In water at 60℃; for 4h;
Stage #2: 2-amino-4-(trifluoromethyl)pyridine With sodium hydrogencarbonate In water at 80℃; for 2h;
87%
succinic acid anhydride
108-30-5

succinic acid anhydride

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

1-[4-(trifluoromethyl)-2-pyridyl]pyrrolidine-2,5-dione
1621153-60-3

1-[4-(trifluoromethyl)-2-pyridyl]pyrrolidine-2,5-dione

Conditions
ConditionsYield
In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 16h; Sealed tube;87%
In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 16h;87%
2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

6-bromo-1,2,3,4-tetrahydro-β-carboline
23046-69-7

6-bromo-1,2,3,4-tetrahydro-β-carboline

C17H15F3N4

C17H15F3N4

Conditions
ConditionsYield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; palladium diacetate; sodium t-butanolate In 1,4-dioxane at 100℃; for 14h; Suzuki Coupling;87%
Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

ethanol
64-17-5

ethanol

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

3-(ethoxy(phenyl)methyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridine
1508296-88-5

3-(ethoxy(phenyl)methyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
With acetic acid at 20 - 80℃; for 9h; Green chemistry; regiospecific reaction;86%
2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

2,6-dichloro-4-nitro-pyridine
25194-01-8

2,6-dichloro-4-nitro-pyridine

6-chloro-4-nitro-N-[4-(trifluoromethyl)pyridin-2-yl]pyridin-2-amine
1370453-15-8

6-chloro-4-nitro-N-[4-(trifluoromethyl)pyridin-2-yl]pyridin-2-amine

Conditions
ConditionsYield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 1h; Inert atmosphere; Sealed tube;84%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane Inert atmosphere; Schlenk technique;84%
2-(2-bromoacetyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

2-(2-bromoacetyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

6-methyl-2-(7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione

6-methyl-2-(7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione

Conditions
ConditionsYield
Stage #1: 2-(2-bromoacetyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione; 2-amino-4-(trifluoromethyl)pyridine In acetonitrile at 70℃; for 60h;
Stage #2: With triethylamine In acetonitrile at 70℃;
84%
Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

1-thiopropane
107-03-9

1-thiopropane

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

C18H17F3N2S

C18H17F3N2S

Conditions
ConditionsYield
With trifluoroacetic acid In N,N-dimethyl-formamide at 130℃; for 0.5h; Microwave irradiation;83%
2-Amino-4-methylpyridine
695-34-1

2-Amino-4-methylpyridine

Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

N-((7-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

N-((7-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With Trimethylacetic acid In dichloromethane at 60℃; for 8h; Sealed tube; Inert atmosphere; regioselective reaction;83%
2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

4-bromo-3-fluorobenzoic acid
153556-42-4

4-bromo-3-fluorobenzoic acid

4-bromo-3-fluoro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
1419221-61-6

4-bromo-3-fluoro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Conditions
ConditionsYield
With triethylamine; HATU In tetrahydrofuran at 20 - 60℃; for 60h;82%
With triethylamine; HATU In tetrahydrofuran at 20 - 60℃; for 60h;82%
With triethylamine; HATU In tetrahydrofuran at 20 - 60℃; for 60h;82%
With triethylamine; HATU In tetrahydrofuran at 20 - 60℃; for 60h;
Ethyl 2-butynoate
4341-76-8

Ethyl 2-butynoate

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

N-(4-(trifluoromethyl)pyridin-2-yl)but-2-ynamide

N-(4-(trifluoromethyl)pyridin-2-yl)but-2-ynamide

Conditions
ConditionsYield
Stage #1: 2-amino-4-(trifluoromethyl)pyridine With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: Ethyl 2-butynoate In tetrahydrofuran at -78 - 20℃; Inert atmosphere; regioselective reaction;
82%
(5-methyl-pyridin-2-yl)amine
1603-41-4

(5-methyl-pyridin-2-yl)amine

Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

N-((6-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

N-((6-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With Trimethylacetic acid In dichloromethane at 60℃; for 8h; Sealed tube; Inert atmosphere; regioselective reaction;82%
Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

phenyl(7-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)methanone

phenyl(7-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)methanone

Conditions
ConditionsYield
With [2,2]bipyridinyl; copper(l) iodide; acetic acid In dichloromethane at 20℃; for 12h; regioselective reaction;81%
Multi-step reaction with 2 steps
1: acetic acid / dichloromethane / 0.5 h / 25 °C
2: silver hexafluoroantimonate / dichloromethane / 12 h / 25 °C / Green chemistry
View Scheme
ethyl 3,3-diethoxypropanoate
10601-80-6

ethyl 3,3-diethoxypropanoate

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

ethyl (E)-3-(8-(trifluoromethyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

ethyl (E)-3-(8-(trifluoromethyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 80℃; for 6h;80%
4-Bromobenzoic acid
586-76-5

4-Bromobenzoic acid

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

4-bromo-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

4-bromo-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Conditions
ConditionsYield
Stage #1: 4-Bromobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: 2-amino-4-(trifluoromethyl)pyridine With pyridine In dichloromethane at 0℃;
79%
With pyridine; trichlorophosphate for 0.0833333h; Cooling with ice;60%
Stage #1: 4-Bromobenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: 2-amino-4-(trifluoromethyl)pyridine In N,N-dimethyl-formamide at 0 - 20℃; for 12h;
2-phenoxy-1-phenylethanone
721-04-0

2-phenoxy-1-phenylethanone

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

3-phenoxy-2-phenyl-7-trifluoromethylimidazo[1,2-a]pyridine

3-phenoxy-2-phenyl-7-trifluoromethylimidazo[1,2-a]pyridine

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine In water; 1,2-dichloro-ethane at 110℃; under 760.051 Torr; for 16h;79%
2-amino-5-iodopyridine
20511-12-0

2-amino-5-iodopyridine

Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

N-((6-iodoimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

N-((6-iodoimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With Trimethylacetic acid In dichloromethane at 60℃; for 8h; Sealed tube; Inert atmosphere; regioselective reaction;79%
2,6-dichloro-N-(propyl-2-yl)pyridin-4-amine

2,6-dichloro-N-(propyl-2-yl)pyridin-4-amine

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

C14H14ClF3N4

C14H14ClF3N4

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 80℃; for 24h; Buchwald-Hartwig Coupling;77%
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl at 80℃; for 24h; Sealed tube; Inert atmosphere;
2-Amino-6-methylpyridine
1824-81-3

2-Amino-6-methylpyridine

Phenylpropargyl aldehyde
2579-22-8

Phenylpropargyl aldehyde

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

N-((5-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

N-((5-methylimidazo[1,2-a]pyridin-3-yl)(phenyl)methyl)-4-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With Trimethylacetic acid In dichloromethane at 60℃; for 8h; Sealed tube; Inert atmosphere; regioselective reaction;77%
acetophenone
98-86-2

acetophenone

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

2-phenyl-7-trifluoromethylimidazo[1,2-α]pyridine
1629889-70-8

2-phenyl-7-trifluoromethylimidazo[1,2-α]pyridine

Conditions
ConditionsYield
In ethanol at 70℃; for 24h;75%
4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

(4-nitrophenyl) N-[4-(trifluoromethyl)-2-pyridyl]carbamate

(4-nitrophenyl) N-[4-(trifluoromethyl)-2-pyridyl]carbamate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 3.75h;75%
3-methyl-2-oxo-1,3-oxazolidine
19836-78-3

3-methyl-2-oxo-1,3-oxazolidine

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

1-(2-hydroxyethyl)-1-methyl-3-[4-(trifluoromethyl)-2-pyridyl]urea

1-(2-hydroxyethyl)-1-methyl-3-[4-(trifluoromethyl)-2-pyridyl]urea

Conditions
ConditionsYield
Stage #1: 2-amino-4-(trifluoromethyl)pyridine With sodium t-butanolate In toluene for 0.0833333h;
Stage #2: 3-methyl-2-oxo-1,3-oxazolidine In toluene at 20℃; for 3.5h; Reagent/catalyst; Solvent; Temperature;
75%

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