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Antimex Chemical Limied

Quick Details ProName: Estradiol hot sales CasNo: 50-28-2 Molecular Formula: C18H24O2 Appearance: White powder Application: Pharmaceuticals DeliveryTime: Within 15 workdays after payment PackAge: accordi

Estradiol

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Hangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the busine

eplerenone supplier in China

Cas:107724-20-9

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Eplerenone

Cas:107724-20-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Kono Chem Co.,Ltd

Items Standards Results Appearance Almost white crystal or crystalline powder Conforms

CAS:107724-20-9 Eplerenone

Cas:107724-20-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa

99% high purity steroid Eplerenone CAS No: 107724-20-9 CAS NO.107724-20-9

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:-20°C Package:1kg/foil bag; 1kg/tin ; 25

Good quality Eplerenone CAS 107724-20-9 supplied by manufacturer

Cas:107724-20-9

Min.Order:100 Gram

FOB Price: $5.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Eplerenone CAS No.:107724-20-9 Name: Eplerenone Synonyms Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester Molecular Structure Molecular Formula: C24H30O6 Molecular Weig

High purity Eplerenone CAS No.:107724-20-9

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Eplerenone

Cas:107724-20-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Eplerenone 107724-20-9 GMP Manufacturer

Cas:107724-20-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Eplerenone

Cas:107724-20-9

Min.Order:10 Milligram

Negotiable

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Eplerenone

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Eplerenone supplier in china

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Eplerenone

Cas:107724-20-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Eplerenone The alias:Eplerenone for system suitability CAS NO:107724-20-9 EINECS NO:600-850-8 Molecular formula:C24H30O6 Molecular weight:414.49 Product Quality 12 years of chemical raw materials Mature operation of the industry Sys

Eplerenone/CAS:107724-20-9/High quality

Cas:107724-20-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Eplerenone Synonyms: pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;EPLERENONE 98%;EPLERENONE USP STANDARD;Elperenone;EplerenoneC24H3006;pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hyd

107724-20-9 Eplerenone

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Eplerenone

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Eplerenone supplier in china CAS NO.107724-20-9

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $260.0 / 300.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 107724-20-9 with best quality

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Eplerenone CAS107724-20-9

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name Eplerenone Synonyms Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester Molecular Formula

Eplerenone

Cas:107724-20-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Eplerenone 107724-20-9

Cas:107724-20-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Eplerenone CAS 107724-20-9

Cas:107724-20-9

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Eplerenone Synonyms: plerenone;(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2&#3

Eplerenone

Cas:107724-20-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

anticancer agent, Eplerenone CAS:107724-20-9

Cas:107724-20-9

Min.Order:1 Gram

FOB Price: $10.5 / 12.3

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Eplerenone CAS: 107724-20-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Eplerenone CAS: 107724-20-9

Cas:107724-20-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Eplerenone

Cas:107724-20-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Eplerenone supplier in china CAS NO.107724-20-9

Cas:107724-20-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Top quality Eplerenone with best price

Cas:107724-20-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

Eplerenone CAS 107724-20-9

Cas:107724-20-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Synthetic route

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 0 - 15℃; for 24h; pH=9;98%
With trichloroacetamide; dihydrogen peroxide; potassium acetate In dichloromethane at 10 - 15℃; for 0.75h; Temperature;91.3%
With potassium phosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 20℃;85.3%
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
192704-58-8

methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; dihydrogen peroxide82%
Multi-step reaction with 2 steps
1: potassium formate; formic acid / acetic anhydride / 100 °C
2: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
methanol
67-56-1

methanol

4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile
192704-54-4

4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile

sodium methylate
124-41-4

sodium methylate

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Stage #1: methanol; 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; sodium methylate for 20.25h; Heating / reflux;
Stage #2: With hydrogenchloride In methanol; water Heating / reflux;
Stage #3: With dipotassium hydrogenphosphate; formic acid; dihydrogen peroxide; potassium formate; acetic anhydride; methanesulfonyl chloride; triethylamine; trichloroacetonitrile more than 3 stages;
27.1%
Stage #1: methanol; 4'S(4'α),7'α-hexadecahydro-11'α-hydroxy-10'β,13'β-dimethyl-3',5,20'-trioxospiro[furan-2(3H),17'β-[4,7]metheno(17H)cyclopenta[a]phenanthrene]-5'β(2'H)-carbonitrile; sodium methylate at 67℃; for 16 - 20h;
Stage #2: With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 0.75h;
Stage #3: With dipotassium hydrogenphosphate; formic acid; dihydrogen peroxide; potassium formate; acetic anhydride; trichloroacetonitrile more than 3 stages;
7.2 g
methanol
67-56-1

methanol

C24H27NO5

C24H27NO5

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene for 24h; Heating / reflux;20%
Δ9(11)-canrenone
95716-71-5

Δ9(11)-canrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 82 g / AlEt3 / hexane; tetrahydrofuran / 0.5 h / Heating
2: 6.9 g / DIBAH / 1,2-dimethoxy-ethane; hexane / 2 h / 5 °C
3: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
4: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
5: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / tetrahydrofuran / -10 °C
2.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran; water / 35 °C
3.1: ozone / dichloromethane; isopropyl alcohol / -20 °C
3.2: 20 °C
4.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C
5.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C
View Scheme
C23H30O4
188988-15-0

C23H30O4

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
2: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
3: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
17β-hydroxy-7α-cyano-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
95716-72-6

17β-hydroxy-7α-cyano-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 6.9 g / DIBAH / 1,2-dimethoxy-ethane; hexane / 2 h / 5 °C
2: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
3: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
4: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone
95716-74-8

17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
2: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
View Scheme
methanol
67-56-1

methanol

C24H27NO5

C24H27NO5

sodium methylate
124-41-4

sodium methylate

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
for 23.5h; Heating / reflux;
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

A

7-methyl hydrogen 17-hydroxy-3,12-dioxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 17-hydroxy-3,12-dioxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

B

7-methyl hydrogen 12α,17-dihydroxy-3-oxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 12α,17-dihydroxy-3-oxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

C

7-methyl hydrogen 4α,5α:9α,11α-diepoxy,17-hydroxy-3-oxo-17α-pregnane-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 4α,5α:9α,11α-diepoxy,17-hydroxy-3-oxo-17α-pregnane-7α,21-dicarboxylate, γ-lactone

D

7-methyl hydrogen 9α,11β,17-trihydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 9α,11β,17-trihydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

E

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetonitrile In dichloromethane; water at 8 - 10℃; for 23h;A n/a
B 123 mg
C n/a
D 46.7 mg
E 3.16 g
C23H28O6

C23H28O6

eplerenone
107724-20-9

eplerenone

11β,17β-dihydroxy-7α-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
1398078-03-9

11β,17β-dihydroxy-7α-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
1.2: 4 h
2.1: potassium carbonate / 0 - 20 °C
3.1: triethylamine / dichloromethane / 0 °C
4.1: potassium formate; formic acid / acetic anhydride / 100 °C
5.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C
1.2: 4 h
2.1: potassium carbonate / acetone / 0 - 20 °C
3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
4.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
5.1: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
1398078-09-5

11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
192704-56-6

11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0 °C
2: potassium formate; formic acid / acetic anhydride / 100 °C
3: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sulfuryl dichloride; 1H-imidazole / tetrahydrofuran / 1.5 h / -10 - 20 °C
2: trichloroacetamide; disodium hydrogenphosphate; dihydrogen peroxide / dichloromethane / 18 h / 15 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
2: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
3: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone
209253-72-5

9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / 0 - 20 °C
2: triethylamine / dichloromethane / 0 °C
3: potassium formate; formic acid / acetic anhydride / 100 °C
4: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 0 - 20 °C
2: triethylamine / dichloromethane / 3 h / 0 - 20 °C
3: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
4: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
11α-hydroxyl canrenone
192569-17-8

11α-hydroxyl canrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
6.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C
2.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C
3.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
3.2: 4 h
4.1: potassium carbonate / 0 - 20 °C
5.1: triethylamine / dichloromethane / 0 °C
6.1: potassium formate; formic acid / acetic anhydride / 100 °C
7.1: trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 - 100 °C
2.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / acetone / 0 - 20 °C
4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
5.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
6.1: dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetamide / dichloromethane / 24 h / 0 - 15 °C / pH 9
View Scheme
9(11)-encanrenone
41850-21-9

9(11)-encanrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -25 - -20 °C / Inert atmosphere
2: potassium carbonate; 5,5-dibromohydantoin / tetrahydrofuran; water / 20 °C / Inert atmosphere
3: ozone / -50 °C
4: trichloroacetamide; potassium phosphate; dihydrogen peroxide / dichloromethane / 20 °C
View Scheme
17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
610785-40-5

17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; 5,5-dibromohydantoin / tetrahydrofuran; water / 20 °C / Inert atmosphere
2: ozone / -50 °C
3: trichloroacetamide; potassium phosphate; dihydrogen peroxide / dichloromethane / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran; water / 35 °C
2.1: ozone / dichloromethane; isopropyl alcohol / -20 °C
2.2: 20 °C
3.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C
4.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C
View Scheme
7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ozone / dichloromethane; isopropyl alcohol / -20 °C
1.2: 20 °C
2.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C
3.1: dipotassium hydrogenphosphate; 2-chloro-2,2-difluoroacetamide; dihydrogen peroxide / toluene / 55 °C
View Scheme
eplerenone
107724-20-9

eplerenone

9,11α-epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, γ-lactone

9,11α-epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, γ-lactone

Conditions
ConditionsYield
Stage #1: eplerenone With sodium hydroxide In water; acetonitrile at 25 - 90℃; for 66.67h; Heating / reflux;
Stage #2: With sulfuric acid In water; acetonitrile
67%
Multi-step reaction with 2 steps
1: lithium hydroxide / water / 48 h
2: hydrogenchloride / water
View Scheme
eplerenone
107724-20-9

eplerenone

A

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

B

9,11α-epoxy-7-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

9,11α-epoxy-7-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

Conditions
ConditionsYield
With sodium methylate In methanol for 24h; Reflux;A 49%
B 0.55 g
eplerenone
107724-20-9

eplerenone

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, dipotassium salt

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, dipotassium salt

Conditions
ConditionsYield
With potassium hydroxide In 1,4-dioxane; water at 25 - 70℃; for 6h;0.55 g
eplerenone
107724-20-9

eplerenone

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, disodium salt

9,11α-epoxy,17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid, disodium salt

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 70℃; for 0.666667h;
eplerenone
107724-20-9

eplerenone

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

9,11α-epoxy-7β-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

Conditions
ConditionsYield
With sodium methylate In methanol at 50 - 65℃; for 16.5h; Heating / reflux;400 mg
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

eplerenone
107724-20-9

eplerenone

7-methyl hydrogen 9,11α-epoxy-3-ethoxy-17-hydroxy-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 9,11α-epoxy-3-ethoxy-17-hydroxy-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

Conditions
ConditionsYield
Stage #1: orthoformic acid triethyl ester; eplerenone; toluene-4-sulfonic acid In ethanol at 20℃; for 0.5h;
Stage #2: With pyridine; sodium acetate In ethanol
33.8 g
eplerenone
107724-20-9

eplerenone

C47H42O10
1621954-04-8

C47H42O10

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium hydroxide / water / 48 h
2: hydrogenchloride / water
3: dmap; dicyclohexyl-carbodiimide
View Scheme
eplerenone
107724-20-9

eplerenone

C23H30O7
1621954-05-9

C23H30O7

Conditions
ConditionsYield
With lithium hydroxide In water for 48h;

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