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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Hangzhou Think Chemical Co. Ltd

(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester CAS No.:95716-70-4 Name: (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester Molecular S

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(7α,17α)-17-Hydroxy-3-oxopregna-4,9(11)-diene-7,21-dicarboxylic acid τ-lactone methyl ester

Cas:95716-70-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name: PRL-8-53 The alias:PRL-8053;PRL-8-53;Methyl3-(2-(benzyl(Methyl)aMino)ethyl)benzoatehydrochloride;PRL-8-53HCL;3-(2-Benzyl(methyl)aminoethyl)benzoicacidmethylesterhydrochloride CAS NO:51352-87-5 Molecular formula:C18H22ClNO2 Molecular weight

PRL-8-53/CAS:95716-70-4/ China High quality

Cas:95716-70-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

PROPOLIS(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

CAS No.95716-70-4 (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester Our company was built in 2009 with an ISO certificate.In

CAS No.95716-70-4 (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 95716-70-4 with best quality

Cas:95716-70-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pregna-4,9(11)-diene-7,21-dicarboxylicacid, 17-hydroxy-3-oxo-, g-lactone, 7-methyl ester, (7a,17a)-

Cas:95716-70-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

High Purity Eplerenone Intermediate Eplerenone EP Impurity C

Cas:95716-70-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Eplerenone N-1

Cas:95716-70-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(7A,17A)-17-HYDROXY-3-OXO-PREGNA-4,9(11)-DIENE-7,21-DICARBOXYLICACID G-LACTONE METHYL ESTER

Cas:95716-70-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transp

(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester Synonyms: PREGN-4(5)9(11)-DIENE-7,21-DICARBOXYLICACID,17-HYDROXY-3-OXO-,GAMMA-LACTONE;Pregna-4,9(11)-diene-7,21-dicarboxylic acid, 17-hydr

(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester

Cas:95716-70-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

95716-70-4 CAS NO.95716-70-4

Cas:95716-70-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Pregna-4,9 (11)-Diene-7,21-Carboxylicacid,17-Hydroxy-3-Oxo-g-Lactone,Methyl ester(7a,17a)

Cas:95716-70-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Pregna-4,9(11)-diene-7,21-dicarboxylic acid,17-hydroxy-3-oxo...

Cas:95716-70-4

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:as intermediates Transportation:by courier, air or sea Port:At any port from China

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Eplerenone Intermediates

Cas:95716-70-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

17α-pregna-4-ene-7α,21-dicarboxylic acid-11α,17β-dihydroxy-3-oxo-γ-lactone-7-methyl ester

17α-pregna-4-ene-7α,21-dicarboxylic acid-11α,17β-dihydroxy-3-oxo-γ-lactone-7-methyl ester

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
With phosphorus pentachloride; boron trifluoride diethyl etherate In tetrahydrofuran at 0℃; for 0.166667h; Reagent/catalyst; Temperature;90.9%
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
192704-56-6

11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
With hexafluoropropene-diethylamine adduct; diethyl-(pentafluoro-propenyl)-amine In chloroform at 30℃; for 30h; Solvent; Temperature; Reagent/catalyst;90%
Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With methanesulfonyl chloride; triethylamine In dichloromethane at 5℃; for 1h;
Stage #2: With formic acid; potassium formate; acetic anhydride at 70 - 95℃; for 5 - 9h;
77%
With 1H-imidazole; sulfuryl dichloride In tetrahydrofuran at -10 - 20℃; for 1.5h;71%
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
192704-58-8

methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
With formic acid; potassium formate; acetic anhydride at 70 - 100℃; for 19h; Inert atmosphere;80%
With formic acid; potassium formate; acetic anhydride at 70 - 105℃; for 6.5h;1.9 g
Stage #1: methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone With Isopropenyl acetate; toluene-4-sulfonic acid at 90℃; for 5h;
Stage #2: With sodium acetate; acetic acid at 100℃; for 1h;
0.4 g
11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
192704-56-6

11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

A

3-oxo-17α-pregn-4-ene-7α,9:21,17-dicarbolactone

3-oxo-17α-pregn-4-ene-7α,9:21,17-dicarbolactone

B

7-methyl hydrogen 17α-hydroxy-3-oxopregna-4,11-diene-7α,21-dicarboxylate, γ-lactone
192704-70-4

7-methyl hydrogen 17α-hydroxy-3-oxopregna-4,11-diene-7α,21-dicarboxylate, γ-lactone

C

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 1.41667h;
Stage #2: With formic acid; potassium formate; acetic anhydride at 40 - 95℃; for 2h;
A 2.27 g
B 3.72 g
C 68.8%
Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With sulfuryl dichloride In tetrahydrofuran at -70℃; for 0.5h;
Stage #2: With 1H-imidazole In tetrahydrofuran at -70 - 20℃; for 2h;
Stage #1: 11β,17β-dihydroxy-7α-methoxycarbonyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone With methanesulfonyl chloride; triethylamine In dichloromethane at -5 - 0℃; for 1.33333h;
Stage #2: With sodium acetate; acetic anhydride; acetic acid In dichloromethane at 55 - 135℃; for 1.5 - 2h;
methanol
67-56-1

methanol

7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
With ozone at -50℃;49.31%
17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone
95716-74-8

17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
In diethyl ether; dichloromethane for 0.166667h;2.7 g
dimethyl sulfate
77-78-1

dimethyl sulfate

17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone
95716-74-8

17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
In water; acetone at 45℃; for 3h;50.94 g
With tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate In dichloromethane; water at 20 - 25℃; for 11.5h;
Stage #1: dimethyl sulfate; 17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone In water; acetone at 45℃; for 3h;
Stage #2: With potassium hydrogencarbonate; triethylamine In water; acetone at 45℃; for 1h;
17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
610785-40-5

17β-hydroxy-7α-(5'-methyl-2'-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium acetate; dibromantin / acetone; H2O / -10 °C
2.1: aq. HCl / CH2Cl2 / 2.5 h / 20 °C
3.1: O3/O2 / CH2Cl2; propan-2-ol / 0.17 h / -55 °C
3.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.83 h / 20 °C
4.1: 0.865 mg / H2O2; KHCO3 / H2O; methanol / 16 h / 20 °C
5.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium acetate; dibromantin / acetone; H2O / -10 °C
2.1: O3/O2; H2O / CH2Cl2; propan-2-ol / 0.04 h / -55 °C
2.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.75 h / 20 °C
2.3: 86.1 percent / H2O2; KHCO3 / H2O; methanol / 15 h / 20 °C
3.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Multi-step reaction with 5 steps
1.1: O3/O2 / CH2Cl2; methanol / -78 °C
1.2: O2; trimethylphosphite / 1 h / 20 °C
2.1: 1.40 g / aq. HCl / 0.33 h / 20 °C
3.1: O3/O2 / CH2Cl2 / -78 - 20 °C
4.1: H2O2; KHCO3 / H2O / 1.5 h / 20 °C
5.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
C25H32O6

C25H32O6

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.865 mg / H2O2; KHCO3 / H2O; methanol / 16 h / 20 °C
2: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
17β-hydroxy-7α-(2'-hydroperoxy-2'-methoxyacetyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
610785-44-9

17β-hydroxy-7α-(2'-hydroperoxy-2'-methoxyacetyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O2; KHCO3 / H2O / 1.5 h / 20 °C
2: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
17β-hydroxy-7α-(cis-4'-oxo-pent-2'-enoyl)-3-oxo-pregna-4,9(11)-diene-21-carboxylic acid γ-lactone
610785-50-7

17β-hydroxy-7α-(cis-4'-oxo-pent-2'-enoyl)-3-oxo-pregna-4,9(11)-diene-21-carboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aq. HCl / CH2Cl2 / 2.5 h / 20 °C
2.1: O3/O2 / CH2Cl2; propan-2-ol / 0.17 h / -55 °C
2.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.83 h / 20 °C
3.1: 0.865 mg / H2O2; KHCO3 / H2O; methanol / 16 h / 20 °C
4.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Multi-step reaction with 2 steps
1.1: O3/O2; H2O / CH2Cl2; propan-2-ol / 0.04 h / -55 °C
1.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.75 h / 20 °C
1.3: 86.1 percent / H2O2; KHCO3 / H2O; methanol / 15 h / 20 °C
2.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
17β-hydroxy-7α-(trans-4'-oxo-pent-2'-enoyl)-3-oxo-pregna-4,9(11)-dien-21-carboxylic acid γ-lactone
610785-41-6

17β-hydroxy-7α-(trans-4'-oxo-pent-2'-enoyl)-3-oxo-pregna-4,9(11)-dien-21-carboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: O3/O2 / CH2Cl2; propan-2-ol / 0.17 h / -55 °C
1.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.83 h / 20 °C
2.1: 0.865 mg / H2O2; KHCO3 / H2O; methanol / 16 h / 20 °C
3.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
17β-hydroxy-7α-(cis-3'-acetoxyacryloyl)-3-oxo-pregna-4,9(11)-diene-21-carboxylic acid γ-lactone
610785-42-7

17β-hydroxy-7α-(cis-3'-acetoxyacryloyl)-3-oxo-pregna-4,9(11)-diene-21-carboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.40 g / aq. HCl / 0.33 h / 20 °C
2: O3/O2 / CH2Cl2 / -78 - 20 °C
3: H2O2; KHCO3 / H2O / 1.5 h / 20 °C
4: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Multi-step reaction with 4 steps
1: 1.40 g / aq. HCl / 0.33 h / 20 °C
2: O3/O2 / CH2Cl2 / 0.02 h / -55 °C
3: H2O2; potassium bicarbonate / H2O / 18 h / 20 °C
4: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
17β-hydroxy-7α-(trans-3'-acetoxyacryloyl)-3-oxo-pregna-4,9(11)-diene-21-carboxylic acid γ-lactone
610785-43-8

17β-hydroxy-7α-(trans-3'-acetoxyacryloyl)-3-oxo-pregna-4,9(11)-diene-21-carboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: O3/O2 / CH2Cl2 / -78 - 20 °C
2: H2O2; KHCO3 / H2O / 1.5 h / 20 °C
3: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Multi-step reaction with 3 steps
1: O3/O2 / CH2Cl2 / 0.02 h / -55 °C
2: H2O2; potassium bicarbonate / H2O / 18 h / 20 °C
3: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
C26H32O8

C26H32O8

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O2; potassium bicarbonate / H2O / 18 h / 20 °C
2: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Δ9(11)-canrenone
95716-71-5

Δ9(11)-canrenone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 77.7 percent / boron trifluoride diethyl etherate; EtOH; isopropanol / acetonitrile / 24 h / -18.4 °C
2.1: potassium acetate; dibromantin / acetone; H2O / -10 °C
3.1: aq. HCl / CH2Cl2 / 2.5 h / 20 °C
4.1: O3/O2 / CH2Cl2; propan-2-ol / 0.17 h / -55 °C
4.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.83 h / 20 °C
5.1: 0.865 mg / H2O2; KHCO3 / H2O; methanol / 16 h / 20 °C
6.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 77.7 percent / boron trifluoride diethyl etherate; EtOH; isopropanol / acetonitrile / 24 h / -18.4 °C
2.1: potassium acetate; dibromantin / acetone; H2O / -10 °C
3.1: O3/O2; H2O / CH2Cl2; propan-2-ol / 0.04 h / -55 °C
3.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.75 h / 20 °C
3.3: 86.1 percent / H2O2; KHCO3 / H2O; methanol / 15 h / 20 °C
4.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 77.7 percent / boron trifluoride diethyl etherate; EtOH; isopropanol / acetonitrile / 24 h / -18.4 °C
2.1: O3/O2 / CH2Cl2; methanol / -78 °C
2.2: O2; trimethylphosphite / 1 h / 20 °C
3.1: 1.40 g / aq. HCl / 0.33 h / 20 °C
4.1: O3/O2 / CH2Cl2 / -78 - 20 °C
5.1: H2O2; KHCO3 / H2O / 1.5 h / 20 °C
6.1: 50.94 g / acetone; H2O / 3 h / 45 °C
View Scheme
C23H30O4
188988-15-0

C23H30O4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
2: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
View Scheme
17β-hydroxy-7α-cyano-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone
95716-72-6

17β-hydroxy-7α-cyano-pregna-4,9(11)-dien-3-one-21-carboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 6.9 g / DIBAH / 1,2-dimethoxy-ethane; hexane / 2 h / 5 °C
2: 6.6 g / aq. CrO3, H2SO4 / acetone / 0.5 h / 5 °C
3: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
View Scheme
methanol
67-56-1

methanol

C24H27NO4

C24H27NO4

sodium methylate
124-41-4

sodium methylate

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Heating / reflux;
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
192704-58-8

methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone

A

3-oxo-17α-pregn-4-ene-7α,9:21,17-dicarbolactone

3-oxo-17α-pregn-4-ene-7α,9:21,17-dicarbolactone

B

7-methyl hydrogen 17α-hydroxy-3-oxopregna-4,11-diene-7α,21-dicarboxylate, γ-lactone
192704-70-4

7-methyl hydrogen 17α-hydroxy-3-oxopregna-4,11-diene-7α,21-dicarboxylate, γ-lactone

C

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
With sodium acetate; acetic acid at 40 - 100℃; for 1.21667h;
With potassium acetate; trifluoroacetic acid; trifluoroacetic anhydride at 30 - 40℃; for 5h;
methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone
192704-58-8

methyl hydrogen 17α-hydroxy-11α-(methylsulfonyl)oxy-3-oxopregn-4-ene-7α,21-dicarboxylate, γ-lactone

A

3-oxo-17α-pregn-4-ene-7α,9:21,17-dicarbolactone

3-oxo-17α-pregn-4-ene-7α,9:21,17-dicarbolactone

B

7-methyl hydrogen 5β-cyano-17-hydroxy-3-oxo-17α-pregn-9(11)-ene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 5β-cyano-17-hydroxy-3-oxo-17α-pregn-9(11)-ene-7α,21-dicarboxylate, γ-lactone

C

7-methyl hydrogen 17α-hydroxy-3-oxopregna-4,11-diene-7α,21-dicarboxylate, γ-lactone
192704-70-4

7-methyl hydrogen 17α-hydroxy-3-oxopregna-4,11-diene-7α,21-dicarboxylate, γ-lactone

D

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
With formic acid; potassium formate; acetic anhydride at 40 - 100℃; for 18h;
11β-hydroxymexrenone

11β-hydroxymexrenone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

9α-hydroxymexrenone

9α-hydroxymexrenone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone
95716-74-8

17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Stage #1: 17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone With dimethyl sulfate In water; acetone at 45℃; for 3h;
Stage #2: With potassium hydrogencarbonate; triethylamine In water; acetone at 45℃; for 1h;
11β,17β-dihydroxy-7α-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
1398078-03-9

11β,17β-dihydroxy-7α-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
1.2: 4 h
2.1: potassium carbonate / 0 - 20 °C
3.1: triethylamine / dichloromethane / 0 °C
4.1: potassium formate; formic acid / acetic anhydride / 100 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C
1.2: 4 h
2.1: potassium carbonate / acetone / 0 - 20 °C
3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
4.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
View Scheme
11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone
1398078-09-5

11β,17β-dihydroxy-7β-nitromethyl-pregna-4-en-3-one-21-carboxylic acid, γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
View Scheme
9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone
209253-72-5

9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarboxylic acid γ-lactone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / 0 - 20 °C
2: triethylamine / dichloromethane / 0 °C
3: potassium formate; formic acid / acetic anhydride / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 0 - 20 °C
2: triethylamine / dichloromethane / 3 h / 0 - 20 °C
3: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
View Scheme
11α-hydroxyl canrenone
192569-17-8

11α-hydroxyl canrenone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / 0 - 20 °C
4.1: triethylamine / dichloromethane / 0 °C
5.1: potassium formate; formic acid / acetic anhydride / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C
2.1: potassium carbonate; benzalkonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C
3.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C
3.2: 4 h
4.1: potassium carbonate / 0 - 20 °C
5.1: triethylamine / dichloromethane / 0 °C
6.1: potassium formate; formic acid / acetic anhydride / 100 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate; benzalkonium chloride / N,N-dimethyl-formamide / 48 h / 90 - 100 °C
2.1: sodium nitrite / N,N-dimethyl-formamide / 1.5 h / 45 °C
2.2: 4 h
3.1: potassium carbonate / acetone / 0 - 20 °C
4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
5.1: acetic anhydride; potassium formate; formic acid / 19 h / 70 - 100 °C / Inert atmosphere
View Scheme
9(11)-encanrenone
41850-21-9

9(11)-encanrenone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -25 - -20 °C / Inert atmosphere
2: potassium carbonate; 5,5-dibromohydantoin / tetrahydrofuran; water / 20 °C / Inert atmosphere
3: ozone / -50 °C
View Scheme
7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

7a-(1,4-dicarbonylpentenyl)-9(11)-encanrenone

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: ozone / dichloromethane; isopropyl alcohol / -20 °C
1.2: 20 °C
2.1: potassium hydrogencarbonate / tetrahydrofuran / 10 °C
View Scheme
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 0 - 15℃; for 24h; pH=9;98%
With trichloroacetamide; dihydrogen peroxide; potassium acetate In dichloromethane at 10 - 15℃; for 0.75h; Temperature;91.3%
With potassium phosphate; trichloroacetamide; dihydrogen peroxide In dichloromethane at 20℃;85.3%
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

eplerenone

eplerenone

Conditions
ConditionsYield
Stage #1: 17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester With dipotassium hydrogenphosphate; trichloroacetamide In dichloromethane at 25℃; for 0.5 - 1.5h;
Stage #2: With dihydrogen peroxide In dichloromethane at 20 - 31℃; for 6.16667 - 8.25h; Product distribution / selectivity;
86.4%
Stage #1: 17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester With trichloroacetonitrile In dichloromethane for 1h; Heating / reflux;
Stage #2: With dihydrogen peroxide In dichloromethane; water for 27 - 29h; Heating / reflux;
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

9,11β-dichloro-7α-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

9,11β-dichloro-7α-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone

Conditions
ConditionsYield
With pyridine; sulfuryl dichloride In chlorobenzene at 0 - 20℃; for 1.5h;41%
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

A

7-(methoxycarbonyl)-3-oxo-17α-pregna-4,9(11)-diene-21,17-carbolactone

7-(methoxycarbonyl)-3-oxo-17α-pregna-4,9(11)-diene-21,17-carbolactone

B

7β-(methoxycarbonyl)-3-oxo-17α-pregna-4,9(11)-diene-21,17-carbolactone

7β-(methoxycarbonyl)-3-oxo-17α-pregna-4,9(11)-diene-21,17-carbolactone

Conditions
ConditionsYield
With sodium methylate In methanol for 24h; Reflux;A 0.78 g
B 37%
17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester
95716-70-4

17α-pregna-4,9(11)-diene-7α,21-dicarboxylic acid-17β-hydroxy-3-oxo-γ-lactone-7-methyl ester

A

7-methyl hydrogen 17-hydroxy-3,12-dioxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 17-hydroxy-3,12-dioxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

B

7-methyl hydrogen 12α,17-dihydroxy-3-oxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 12α,17-dihydroxy-3-oxo-17α-pregna-4,9(11)-diene-7α,21-dicarboxylate, γ-lactone

C

7-methyl hydrogen 4α,5α:9α,11α-diepoxy,17-hydroxy-3-oxo-17α-pregnane-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 4α,5α:9α,11α-diepoxy,17-hydroxy-3-oxo-17α-pregnane-7α,21-dicarboxylate, γ-lactone

D

7-methyl hydrogen 9α,11β,17-trihydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

7-methyl hydrogen 9α,11β,17-trihydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylate, γ-lactone

E

eplerenone
107724-20-9

eplerenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; dihydrogen peroxide; trichloroacetonitrile In dichloromethane; water at 8 - 10℃; for 23h;A n/a
B 123 mg
C n/a
D 46.7 mg
E 3.16 g

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