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Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company
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2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With bis(diphenylphosphino)propanepalladium(II) dichloride; lithium triethylborohydride In tetrahydrofuran at -78 - 20℃; for 50h; | 88.7% |
Farnesol
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene
C
(E)-3,7,11-trimethyldodeca-1,6,10-triene
Conditions | Yield |
---|---|
With bis(cyclopentadienyl)titanium dichloride; manganese In tetrahydrofuran for 2h; Solvent; Inert atmosphere; Reflux; regioselective reaction; | A 9% B 8% C 78% |
[(6E,10E,14E,18E)-13-(1-ethoxyethoxy)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-12-yl]sulfonylbenzene
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With (1,2-bis(diphenylphosphino)ethane)palladium(II) chloride; lithium triethylborohydride In tetrahydrofuran; 1,4-dioxane at 20 - 70℃; for 10h; Inert atmosphere; | 77% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate at -78℃; | 70% |
With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate In toluene at -78℃; for 12h; | 70% |
Conditions | Yield |
---|---|
Stage #1: Farnesol With tert.-butyl lithium In tetrahydrofuran; n-heptane at -78 - 20℃; for 0.333333h; Inert atmosphere; Stage #2: With bis(cyclopentadienyl)titanium dichloride; manganese In tetrahydrofuran for 10h; Inert atmosphere; Reflux; | 67% |
Multi-step reaction with 2 steps 1: PBr3 / tetrahydrofuran / 0.5 h / 0 °C 2: CuI; pyrrolidine; n-BuLi / diethyl ether / 1 h / -38 °C View Scheme | |
Multi-step reaction with 2 steps 1: PBr3 / tetrahydrofuran / 0.5 h / 0 °C 2: CuI; pyrrolidine; n-BuLi / diethyl ether / 1 h / -38 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / CH2Cl2 / 0.5 h / -40 °C 2: lithium bromide / CH2Cl2; tetrahydrofuran / 1 h / 0 °C 3: 1) lithium biphenylide, barium iodide / 1) THF, -78 deg C, 30 min, 2) THF, a) -78 deg C, 3 h, b) 23 deg C, 16 h View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / CH2Cl2 / 0.5 h / -40 °C 2: lithium chloride / CH2Cl2; tetrahydrofuran / 1 h / 0 °C 3: 1) lithium biphenylide, barium iodide / 1) THF, -78 deg C, 30 min, 2) THF, a) -78 deg C, 3 h, b) 23 deg C, 16 h View Scheme |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; bis(cyclopentadienyl)titanium dichloride; manganese; chloro-trimethyl-silane; triphenylphosphine; palladium dichloride In tetrahydrofuran at 20℃; for 16h; Wurtz type coupling reaction; Inert atmosphere; stereoselective reaction; | 60% |
farnesyl bromide
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(6E,14E)-2,6,10,11,15,19-Hexamethyl-10,11-divinyl-icosa-2,6,14,18-tetraene
C
(6E,10E,16E)-2,6,10,13,17,21-hexamethyl-13-vinyl-docosa-2,6,10,16,20-pentaene
Conditions | Yield |
---|---|
With chlorotris(triphenylphosphine)cobalt(I) In benzene for 0.5h; Ambient temperature; | A 55% B 12% C 22% |
With chlorotris(triphenylphosphine)cobalt(I) In benzene for 3h; Ambient temperature; | A 55% B 12% C 22% |
Farnesol
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(E)-3,7,11-trimethyldodeca-1,6,10-triene
Conditions | Yield |
---|---|
With bis(cyclopentadienyl)titanium dichloride; manganese In tetrahydrofuran for 6h; Inert atmosphere; Reflux; | A 23% B 42% |
With bis(cyclopentadienyl)titanium dichloride; manganese In tetrahydrofuran for 4h; Time; Inert atmosphere; Reflux; | A 36% B 24% |
farnesyl bromide
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With copper(l) iodide; lithium pyrrolidide | A 15% B 33% C 10% |
4-{Phenyl-[(3E,7E)-4,8,12-trimethyl-1-((1E,5E)-2,6,10-trimethyl-undeca-1,5,9-trienyl)-trideca-3,7,11-trienyl]-phosphinoyl}-morpholine
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With lithium; ethylamine; tert-butyl alcohol In tetrahydrofuran at 0℃; for 2.5h; | 31% |
farnesyl bromide
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With diethyl ether; lithium |
(2E,6E)-farnesyl acetate
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(6E,10Z,14Z,18E)-squalene
C
(6E,10Z,16E)-2,6,10,13,17,21-Hexamethyl-13-vinyl-docosa-2,6,10,16,20-pentaene
D
(6E,10E,16E)-2,6,10,13,17,21-hexamethyl-13-vinyl-docosa-2,6,10,16,20-pentaene
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; copper; zinc; molybdenum hexacarbonyl In 1,4-dioxane for 115h; Heating; Yield given. Further byproducts given. Yields of byproduct given; |
(2E,6E)-farnesyl acetate
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(6E,10Z,16E)-2,6,10,13,17,21-Hexamethyl-13-vinyl-docosa-2,6,10,16,20-pentaene
C
(6E,10E,16E)-2,6,10,13,17,21-hexamethyl-13-vinyl-docosa-2,6,10,16,20-pentaene
Conditions | Yield |
---|---|
With zinc; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; methanol for 2.5h; Ambient temperature; Yield given. Further byproducts given. Yields of byproduct given; |
farnesyl bromide
(2E,6E)-farnesyl chloride
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With lithium biphenylide; barium(II) iodide 1) THF, -78 deg C, 30 min, 2) THF, a) -78 deg C, 3 h, b) 23 deg C, 16 h; Yield given. Multistep reaction; |
(E)-3,7,11-trimethyldodeca-1,6,10-trien-3-yl acetate
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
squalene
C
(6E,10Z,14Z,18E)-squalene
D
(6E,10E,16E)-2,6,10,13,17,21-hexamethyl-13-vinyl-docosa-2,6,10,16,20-pentaene
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; zinc; molybdenum hexacarbonyl In 1,4-dioxane for 72h; Heating; Yield given. Further byproducts given. Yields of byproduct given; | |
With [2,2]bipyridinyl; zinc; molybdenum hexacarbonyl In 1,4-dioxane for 72h; Heating; Yield given. Further byproducts given. Yields of byproduct given; |
(2E,6E)-farnesyl chloride
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(6E,10E,16E)-2,6,10,13,17,21-hexamethyl-13-vinyl-docosa-2,6,10,16,20-pentaene
Conditions | Yield |
---|---|
With lithium biphenylide; barium(II) iodide In tetrahydrofuran at -78℃; for 1h; Yield given. Yields of byproduct given; | |
With lithium biphenylide; barium(II) iodide In tetrahydrofuran at -78℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With PP1; Tween-80 Kinetics; Mechanism; buffer (KF, MgCl2, DTT, NADHP); |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With (ammonium analogue); inhib. phosphonophosphate 8 Kinetics; Mechanism; |
Conditions | Yield |
---|---|
With lithium triethylborohydride; bis(diphenylphosphino)propanepalladium(II) dichloride In tetrahydrofuran at 0℃; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With iron sulfide; hydrogen sulfide In water at 100℃; under 1500.1 Torr; for 144h; Yield given; |
3,6-dichloro-octane-2,7-dione
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With diethyl ether at -70℃; Behandeln des Reaktionsprodukts mit methanol.Kalilauge, dann mit Natriumjodid und Natriumacetat in Essigsaeure und Propionsaeure bei -20grad bis +20grad; dann mit Zinn(II)-chlorid in Aether und Pyridin und mit Phosphoroxychlorid; |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With tetrahydrofuran; n-butyllithium; diethyl ether Erwaermen des Reaktionsprodukts mit 6,10-Dimethyl-undeca-5t,9-dien-2-on; |
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(3S,7S,10S,13R,16S,20S)-2,3,7,10,13,16,20,21-octamethyl-6,17-bis-methylene-10-vinyl-docosa-1,11t,21-triene
C
(6E,11E,16E)-2,6,10,13,17,21-hexamethyl-10-vinyldocosa-2,6,11,16,20-pentaene
Conditions | Yield |
---|---|
With sodium <14C>bicarbonate Further byproducts given. Title compound not separated from byproducts; |
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(3S,7S,10S,13R,16S,20S)-2,3,7,10,13,16,20,21-octamethyl-6,17-bis-methylene-10-vinyl-docosa-1,11t,21-triene
C
(6E,11E,16E)-2,6,10,13,17,21-hexamethyl-10-vinyldocosa-2,6,11,16,20-pentaene
Conditions | Yield |
---|---|
With sodium <14C>bicarbonate Further byproducts given. Title compound not separated from byproducts; |
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(6E,11E,16E)-2,6,10,13,17,21-hexamethyl-10-vinyldocosa-2,6,11,16,20-pentaene
Conditions | Yield |
---|---|
With sodium <14C>bicarbonate Further byproducts given. Title compound not separated from byproducts; |
farnesyl bromide
B
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With manganese; bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran at 20℃; |
trans-geranyl bromide
farnesyl bromide
A
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
digeranyl
C
2,6,10,15,19-pentamethyleicosa-(6E,10E,14E)-2,6,10,14,18-pentaene
Conditions | Yield |
---|---|
With pyrrolidine; copper(l) iodide; n-butyllithium In diethyl ether at -38℃; for 1h; | A n/a B 20 mg C 28 mg |
farnesyl bromide
prenyl bromide
B
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With pyrrolidine; copper(l) iodide; n-butyllithium In diethyl ether at -38℃; for 1h; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: PBr3 / tetrahydrofuran / 0.5 h / 0 °C 2: CuI; pyrrolidine; n-BuLi / diethyl ether / 1 h / -38 °C View Scheme |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
2,6,10,15,19,23-hexamethyltetracosane
Conditions | Yield |
---|---|
With hydrogen In ethanol at 50℃; under 760.051 Torr; for 6h; Reagent/catalyst; Temperature; Solvent; chemoselective reaction; | 99.6% |
With hydrogen; nickel | |
With palladium 10% on activated carbon; hydrogen In ethanol at 100℃; under 3750.38 Torr; for 1h; Autoclave; |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
2,3,22,23-Dioxidosqualene
Conditions | Yield |
---|---|
Stage #1: 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene With N-Bromosuccinimide; water In tetrahydrofuran for 3h; Stage #2: With potassium carbonate In methanol for 2h; Further stages.; | 90% |
With potassium carbonate; 3-chloro-benzenecarboperoxoic acid or NBS; Multistep reaction; | |
Multi-step reaction with 2 steps 1: 22 percent / dimethyldioxirane 2: 60 percent / methyl(trifluoromethyl)dioxirane View Scheme |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
(rac)-hexaepoxysqualene
Conditions | Yield |
---|---|
With polyoxotungstate PW4O24[methyltri((C8-C10)alkyl)ammonium]3 In water at 20℃; for 12h; pH=7.0; Green chemistry; | 89% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
2,2-dimethoxy-propane
(3R)-2,3-isopropylidenedioxy-2,3-dihydrosqualene
Conditions | Yield |
---|---|
Stage #1: 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene With potassium osmate(VI); methanesulfonamide; potassium hexacyanoferrate(III); chiral monocinchona derivative C70H63N5O3; potassium carbonate In water; tert-butyl alcohol at 0℃; for 20h; Stage #2: 2,2-dimethoxy-propane With toluene-4-sulfonic acid at 23℃; for 1h; Further stages.; | 88% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
(4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al
Conditions | Yield |
---|---|
With periodic acid In tetrahydrofuran; water at 0 - 20℃; for 10h; | 86% |
Stage #1: 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene With 3-chloro-benzenecarboperoxoic acid In dichloromethane Epoxidation; Stage #2: With periodic acid Oxidation; | |
Stage #1: 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; for 2h; Stage #2: With periodic acid In diethyl ether | 3.1 g |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
2,6,10,15,19,23-hexamethyltetracosane-3,7,11,14,18,22-hexaol
Conditions | Yield |
---|---|
Stage #1: 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran for 1.33333h; Stage #2: With dihydrogen peroxide In tetrahydrofuran for 0.5h; Further stages.; | 67% |
Stage #1: 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene With borane-THF; 2-methyl-but-2-ene In tetrahydrofuran at 0 - 4℃; for 77h; Stage #2: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; water at 20℃; for 12h; | 51% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
Stage #1: 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene With N-Bromosuccinimide; water In tetrahydrofuran for 0.75h; Stage #2: With methanol; potassium carbonate for 0.333333h; | 62% |
With 3,3-dimethyldioxirane | 22% |
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; for 1h; | 14% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
(3R)-(6E,10E,14E,18E)-2,3-dihydroxy-2,3-dihydrosqualene
Conditions | Yield |
---|---|
With potassium osmate(VI); methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III) In water; butan-1-ol at 0℃; for 19h; ligand: 1,4-bisnaphthopyridazine Monomethiodide Salt; | 62% |
With osmium(VIII) oxide; methanesulfonamide; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) In tert-butyl alcohol at 0℃; for 48h; optical yield given as %ee; enantioselective reaction; | 12% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With N-chloro-succinimide; selenenyl bromide In dichloromethane at 20℃; for 8h; | A 18% B 55% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
squalene monobromohydrin: 3-bromo-2,6,10,15,19,23-hexamethyl-6,10,14,18,22-tetracosapentaen-2-ol (all E)
Conditions | Yield |
---|---|
With N-Bromosuccinimide; water In tetrahydrofuran at 20℃; for 1h; | 51% |
With N-Bromosuccinimide; water In tetrahydrofuran for 1h; Ambient temperature; | 35% |
With N-Bromosuccinimide In tetrahydrofuran; water 1.) 0 deg C, 30 min; 2.) RT, 1 h; | 35% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With sodium periodate; ruthenium(IV) oxide In water; ethyl acetate; acetonitrile for 0.5h; | 50% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With sodium periodate; ruthenium(IV) oxide In ethanol; water; acetonitrile at 0℃; for 0.5h; | 50% |
With sodium periodate; ruthenium tetroxide | |
With sodium periodate; ruthenium tetroxide |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With Hoveyda-Grubbs catalyst second generation In dichloromethane at 40℃; for 1h; Cross Metathesis; regioselective reaction; | A 45% B 6.3% C 20.3% D 8.5% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
Conditions | Yield |
---|---|
With potassium osmate(VI); methanesulfonamide; potassium hexacyanoferrate(III); chiral monocinchona derivative C70H63N5O3; potassium carbonate In methanol; water; tert-butyl alcohol at 0℃; for 3h; | 40% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
A
squalene monobromohydrin: 3-bromo-2,6,10,15,19,23-hexamethyl-6,10,14,18,22-tetracosapentaen-2-ol (all E)
B
squalene dibromohydrin: 3,22-dibromo-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraen-2,23-diol (all E)
Conditions | Yield |
---|---|
With N-Bromosuccinimide In tetrahydrofuran; water 1.) 30 min, 0 deg C; 2.) 1 h, RT; | A n/a B 30% |
With N-Bromosuccinimide; water In tetrahydrofuran for 1h; Ambient temperature; | A n/a B 30% |
With N-Bromosuccinimide; water In tetrahydrofuran at 0℃; for 1.5h; |
Conditions | Yield |
---|---|
With sodium periodate; ruthenium(IV) oxide In ethanol; water; acetonitrile at 0℃; for 0.0666667h; | A 5% B 4.5% C 4.3% D 28% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
squalene dibromohydrin: 3,22-dibromo-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraen-2,23-diol (all E)
Conditions | Yield |
---|---|
With N-Bromosuccinimide In tetrahydrofuran at 0℃; | 27% |
With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one In 1,2-dimethoxyethane; dichloromethane; water Ambient temperature; | |
With N-Bromosuccinimide; water In tetrahydrofuran |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
(4E, 8E)-5,9,13-trimethyl-4,8,12-tetradecatrienal
Conditions | Yield |
---|---|
With MMPP In tetrahydrofuran; water at 25℃; for 48h; | 26% |
Multi-step reaction with 2 steps 1: MCPBA / CH2Cl2 / 0 °C 2: HIO4 / diethyl ether / 25 °C View Scheme |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
(2E,6E,10E,14E,18E,22E)-2,6,10,15,19,23-Hexamethyl-tetracosa-2,6,10,14,18,22-hexaenedioic acid
Conditions | Yield |
---|---|
soil bacterium; | 26% |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
B
(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosadeca-1,6,10,14,18,22-hexaen-3-ol
C
(2E,6E,10E,14E,18E,22E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene-1-ol
D
(2E,6E,10E,14E,18E,22E)-2,6,10,15,19,23-hexamethyltetracosadeca-2,6,10,14,18,22-hexaene-1,24-diol
Conditions | Yield |
---|---|
Multistep reaction; | A 9% B 26% C 20% D 6% |
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