Manufacturer supply 5-O-Allyl-2,3,4-tri-O-benzyl-D-ribitol CAS 111549-97-4 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & i
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryNewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryTIANFU-CHEM 5-O-Allyl-2,3,4-tri-O-benzyl-D-ribitolAppearance:white to light yellow crystal powder Storage:room temperature Package:as per buyers Application:Industrial Grade Transportation:By sea , by air or express
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inquiryFactory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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Cas:111549-97-4
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inquiry1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment terms accepted (Btc;MoneyGram;WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery (3-10 DAYS fast deli
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inquiryWatson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L
Cas:111549-97-4
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inquiryPrice, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
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inquiry1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi
Specification Name 5-O-Allyl-2,3,4-tri-O-benzyl-D-ribitol Cas No, 111549-97-4 Structure Formula Purity 99% Ap
Cas:111549-97-4
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inquiryinstock with good quality and wholesale price Storage:Keep in a cool & dry place Package:Packing material and QTY as your request Application:Pharma;Industry;other application Transportation:Express or as your request Port:Any port of China
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inquiryThe company have effective management team, professional technical R & D personnel, the service spirit of customer oriented. We have long-term cooperation with famous domestic manufacturer, and excellent customer resources overseas. We are skilled in
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inquiryAdequate stocks available,prompt shipment,Strictly control on quality,Timely after-sales Application:Intermediate
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inquiryintermediateAppearance:powder Storage:Normal temperature Package:1kg/25kg/customized Application:intermediate Transportation:By Ship/Air
intermediateAppearance:powder Storage:Normal temperature Package:1kg/25kg/customized Application:intermediate Transportation:By Ship/Air Port:any port of china
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inquiryHigh Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate
Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen
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inquiry5-O-allyl-2,3,4-tri-O-benzyl-D-ribose
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol; water for 10h; Reduction; | 90% |
With sodium tetrahydroborate In methanol Yield given; |
5-O-allyl-2,3,4-tri-O-benzyl-1-O-trityl-D-ribitol
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
With water; acetic acid at 80℃; for 1.5h; | 90% |
In water; acetic acid at 80℃; for 1.5h; | 90% |
With water; acetic acid at 80℃; for 1.5h; |
benzyl bromide
5-O-allyl-2,3-di-O-benzyl-D-ribitol
A
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
B
5-O-allyl-1,2,3-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane for 16h; Heating; | A 19% B 56% |
D-ribose
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 75 percent / conc. aq. HCl / 0.5 h / 0 °C 2.1: BuSnO23 / toluene / 4 h / Heating 2.2: 68 percent / CsF / dimethylformamide / 1 h / 20 °C 3.1: NaH / dimethylformamide / 0.5 h / 0 °C 3.2: 63 percent / dimethylformamide / 3.5 h / 0 °C 4.1: 86 percent / aq. HgCl2; CaCO3 / acetonitrile / 1 h / 20 °C 5.1: 90 percent / NaBH4 / methanol; H2O / 10 h View Scheme |
D-ribose diethyl dithioacetal
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: BuSnO23 / toluene / 4 h / Heating 1.2: 68 percent / CsF / dimethylformamide / 1 h / 20 °C 2.1: NaH / dimethylformamide / 0.5 h / 0 °C 2.2: 63 percent / dimethylformamide / 3.5 h / 0 °C 3.1: 86 percent / aq. HgCl2; CaCO3 / acetonitrile / 1 h / 20 °C 4.1: 90 percent / NaBH4 / methanol; H2O / 10 h View Scheme |
5-O-allyl D-ribose diethyl dithioacetal
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide / 0.5 h / 0 °C 1.2: 63 percent / dimethylformamide / 3.5 h / 0 °C 2.1: 86 percent / aq. HgCl2; CaCO3 / acetonitrile / 1 h / 20 °C 3.1: 90 percent / NaBH4 / methanol; H2O / 10 h View Scheme | |
Multi-step reaction with 3 steps 1: 91 percent / sodium hydride, tetra-n-butylammonium iodide / tetrahydrofuran / Ambient temperature 2: mercury(II)chloride, mercury(II)oxide / acetone; H2O / 2 h / Ambient temperature 3: sodium borohydride / methanol View Scheme |
5-O-allyl 2,3,4-tri-O-benzyl-D-ribose diethyl dithioacetal
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / aq. HgCl2; CaCO3 / acetonitrile / 1 h / 20 °C 2: 90 percent / NaBH4 / methanol; H2O / 10 h View Scheme | |
Multi-step reaction with 2 steps 1: mercury(II)chloride, mercury(II)oxide / acetone; H2O / 2 h / Ambient temperature 2: sodium borohydride / methanol View Scheme |
2,3-O-isopropylidene-D-ribonic-γ-lactone
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 40 percent / silver oxide / dimethylformamide / 48 h / in dark 2: 80 percent / sodium borohydride / tetrahydrofuran / 55 °C / 2.) methanol 45 min and 1h 3: acetic acid; H2O / 4 h / 50 °C 4: pyridine / Ambient temperature 5: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 6: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme | |
Multi-step reaction with 7 steps 1: 85 percent / pyridine / acetonitrile / 0 °C / 1.) 40 min; 2.) 1 h 2: LiAlH4, tetrakis(triphenylphosphine)palladium / dioxane / 0.25 h 3: 80 percent / sodium borohydride / tetrahydrofuran / 55 °C / 2.) methanol 45 min and 1h 4: acetic acid; H2O / 4 h / 50 °C 5: pyridine / Ambient temperature 6: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 7: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme | |
Multi-step reaction with 6 steps 1: 85 percent / tetrahydrofuran; pyridine / 2 h / 0 °C 2: 100 percent / palladium tetrakis / dioxane / 0.25 h / Heating 3: 80 percent / NaBH4 / tetrahydrofuran; methanol / 2 h / 55 °C 4: 1.) HOAc, H2O / 1.) 50 degC, 4h 2.) pyridine, roomtemp., overnight 5: 86 percent / NaH / dimethylformamide / 1 h / 0 °C 6: 90 percent / HOAc, H2O / 1.5 h / 80 °C View Scheme |
5-O-allyl-2,3-O-isopropylidene-D-ribitol
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetic acid; H2O / 4 h / 50 °C 2: pyridine / Ambient temperature 3: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 4: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1.) HOAc, H2O / 1.) 50 degC, 4h 2.) pyridine, roomtemp., overnight 2: 86 percent / NaH / dimethylformamide / 1 h / 0 °C 3: 90 percent / HOAc, H2O / 1.5 h / 80 °C View Scheme |
5'-O-allyl-2',3'-O-isopropylidene-D-ribonic-γ-lactone
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 80 percent / sodium borohydride / tetrahydrofuran / 55 °C / 2.) methanol 45 min and 1h 2: acetic acid; H2O / 4 h / 50 °C 3: pyridine / Ambient temperature 4: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 5: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: 80 percent / NaBH4 / tetrahydrofuran; methanol / 2 h / 55 °C 2: 1.) HOAc, H2O / 1.) 50 degC, 4h 2.) pyridine, roomtemp., overnight 3: 86 percent / NaH / dimethylformamide / 1 h / 0 °C 4: 90 percent / HOAc, H2O / 1.5 h / 80 °C View Scheme |
5-O-(allyloxycarbonyl)-2,3-O-isopropylidene-D-ribonolactone
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: LiAlH4, tetrakis(triphenylphosphine)palladium / dioxane / 0.25 h 2: 80 percent / sodium borohydride / tetrahydrofuran / 55 °C / 2.) methanol 45 min and 1h 3: acetic acid; H2O / 4 h / 50 °C 4: pyridine / Ambient temperature 5: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 6: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1: 100 percent / palladium tetrakis / dioxane / 0.25 h / Heating 2: 80 percent / NaBH4 / tetrahydrofuran; methanol / 2 h / 55 °C 3: 1.) HOAc, H2O / 1.) 50 degC, 4h 2.) pyridine, roomtemp., overnight 4: 86 percent / NaH / dimethylformamide / 1 h / 0 °C 5: 90 percent / HOAc, H2O / 1.5 h / 80 °C View Scheme |
5-O-allyl-1-O-trityl-D-ribitol
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 2: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: 86 percent / NaH / dimethylformamide / 1 h / 0 °C 2: 90 percent / HOAc, H2O / 1.5 h / 80 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / Ambient temperature 2: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 3: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme |
D-Ribono-1,4-lactone
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 1.) hydrochloric acid; 2.) pyridine / 1.) 24 h, room temperature; 2.) acetonitrile, 0 deg C 45 min and 0 deg C 1 h 2: LiAlH4, tetrakis(triphenylphosphine)palladium / dioxane / 0.25 h 3: 80 percent / sodium borohydride / tetrahydrofuran / 55 °C / 2.) methanol 45 min and 1h 4: acetic acid; H2O / 4 h / 50 °C 5: pyridine / Ambient temperature 6: 86 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C 30 min; 2.) 0 deg C 30 min; 3.) room temperature overnight 7: 90 percent / acetic acid; H2O / 1.5 h / 80 °C View Scheme | |
Multi-step reaction with 7 steps 1: 95 percent / H(+) / 24 h / Ambient temperature 2: 85 percent / tetrahydrofuran; pyridine / 2 h / 0 °C 3: 100 percent / palladium tetrakis / dioxane / 0.25 h / Heating 4: 80 percent / NaBH4 / tetrahydrofuran; methanol / 2 h / 55 °C 5: 1.) HOAc, H2O / 1.) 50 degC, 4h 2.) pyridine, roomtemp., overnight 6: 86 percent / NaH / dimethylformamide / 1 h / 0 °C 7: 90 percent / HOAc, H2O / 1.5 h / 80 °C View Scheme |
β-5-O-allyl-1-O-methyl-2,3-O,O-isopropylidene-D-ribofuranoside
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 100 percent / aqueous 50percent trifluoroacetic acide / H2O; methanol / 8 h / Heating 2: 58 percent / pulverized potassium hydroxide / dimethylsulfoxide / Ambient temperature 3: 86 percent / 2M hydrochloric acid / dioxane / 8 h / Heating 4: 95 percent / sodium borohydride / ethanol / 2 h / Ambient temperature 5: 19 percent / aqueous 5percent sodium hydroxide, tetrabutylammonium bromide / CH2Cl2 / 16 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: water, sulfuric acid / methanol / 2 h / Heating 2: 94 percent / zinc chloride / 0.25 h / Ambient temperature 3: 91 percent / sodium hydride, tetra-n-butylammonium iodide / tetrahydrofuran / Ambient temperature 4: mercury(II)chloride, mercury(II)oxide / acetone; H2O / 2 h / Ambient temperature 5: sodium borohydride / methanol View Scheme |
((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 87 percent / aqueous 50percent sodium hydroxide, tetrabutylammonium bromide / H2O / 6 h 2: 100 percent / aqueous 50percent trifluoroacetic acide / H2O; methanol / 8 h / Heating 3: 58 percent / pulverized potassium hydroxide / dimethylsulfoxide / Ambient temperature 4: 86 percent / 2M hydrochloric acid / dioxane / 8 h / Heating 5: 95 percent / sodium borohydride / ethanol / 2 h / Ambient temperature 6: 19 percent / aqueous 5percent sodium hydroxide, tetrabutylammonium bromide / CH2Cl2 / 16 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1: 97 percent / sodium hydride, tetra-n-butylammonium iodide / tetrahydrofuran / Ambient temperature 2: water, sulfuric acid / methanol / 2 h / Heating 3: 94 percent / zinc chloride / 0.25 h / Ambient temperature 4: 91 percent / sodium hydride, tetra-n-butylammonium iodide / tetrahydrofuran / Ambient temperature 5: mercury(II)chloride, mercury(II)oxide / acetone; H2O / 2 h / Ambient temperature 6: sodium borohydride / methanol View Scheme |
methyl 5-O-allyl-D-ribofuranoside
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 58 percent / pulverized potassium hydroxide / dimethylsulfoxide / Ambient temperature 2: 86 percent / 2M hydrochloric acid / dioxane / 8 h / Heating 3: 95 percent / sodium borohydride / ethanol / 2 h / Ambient temperature 4: 19 percent / aqueous 5percent sodium hydroxide, tetrabutylammonium bromide / CH2Cl2 / 16 h / Heating View Scheme |
5-O-allyl-2,3-di-O-benzyl-β-D-ribofuranose
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / sodium borohydride / ethanol / 2 h / Ambient temperature 2: 19 percent / aqueous 5percent sodium hydroxide, tetrabutylammonium bromide / CH2Cl2 / 16 h / Heating View Scheme |
(2R,3R,4R,5R)-2-(allyloxymethyl)-3,4-bis(benzyloxy)-5-methoxytetrahydrofuran
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / 2M hydrochloric acid / dioxane / 8 h / Heating 2: 95 percent / sodium borohydride / ethanol / 2 h / Ambient temperature 3: 19 percent / aqueous 5percent sodium hydroxide, tetrabutylammonium bromide / CH2Cl2 / 16 h / Heating View Scheme |
benzyl bromide
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / NaH / dimethylformamide / 1 h / 0 °C 2: 90 percent / HOAc, H2O / 1.5 h / 80 °C View Scheme |
Methyl 5-O-allyl-D-ribofuranoside
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 94 percent / zinc chloride / 0.25 h / Ambient temperature 2: 91 percent / sodium hydride, tetra-n-butylammonium iodide / tetrahydrofuran / Ambient temperature 3: mercury(II)chloride, mercury(II)oxide / acetone; H2O / 2 h / Ambient temperature 4: sodium borohydride / methanol View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
p-methoxybenzyl chloride
5-O-allyl-2,3,4-tri-O-benzyl-1-O-p-methoxybenzyl-D-ribitol
Conditions | Yield |
---|---|
Stage #1: 2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.333333h; Metallation; Stage #2: p-methoxybenzyl chloride In N,N-dimethyl-formamide at 20℃; for 4h; Alkylation; | 89% |
O-(3-O-acetyl-2-azido-4-O-benzyl-6-O-tert-butyl-diphenylsilyl-2-deoxy-D-galactopyranosyl) trichloroacetimidate
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
5-O-allyl-2,3,4-tri-O-benzyl-1-O-(3-O-acetyl-2-azido-4-O-benzyl-6-O-tert-butyl-diphenylsilyl-2-deoxy-β-D-galactopyranosyl)-D-ribitol
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -40℃; | 88% |
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -40℃; for 2h; | 81% |
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
5-O-allyl-1-O-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-2,3,4-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane for 3h; Ambient temperature; | 85% |
With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve 1.) 1,2-dichloroethane, 90 min, room temperature; 2.) 1,2-dichloroethane, room temperature 2 h and 3 h; Yield given. Multistep reaction; |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
1-O-(2-O-Acetyl-3-O-allyl-5-O-benzyl-β-D-ribofuranosyl)-5-O-allyl-2,3,4-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve In dichloromethane for 0.0833333h; | 81% |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
5-O-allyl-1-O-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-2,3,4-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve In dichloromethane for 0.0833333h; | 81% |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
1-O-(3-O-Allyl-2,5-di-O-benzoyl-β-D-ribofuranosyl)-5-O-allyl-2,3,4-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With 4 A molecular sieve; trimethylsilyl trifluoromethanesulfonate In dichloromethane 1.) r.t., 30 min, 2.) 0 deg C; | 80% |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -30 - 10℃; for 3h; Molecular sieve; | 74% |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
1,2,3,5-tetraacetylribose
1-O-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-5-O-allyl-2,3,4-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In 1,2-dichloro-ethane for 0.25h; | 72% |
Stage #1: 2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol With 4 A molecular sieve; boron trifluoride diethyl etherate In 1,2-dichloro-ethane at 0 - 25℃; Stage #2: 1,2,3,5-tetraacetylribose In 1,2-dichloro-ethane for 3.33333h; |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
1-O-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-5-O-allyl-2,3,4-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve In dichloromethane for 0.0833333h; | 54% |
Acetic acid (3R,4R,5R)-4-allyloxy-5-benzyloxymethyl-2-chloro-tetrahydro-furan-3-yl ester
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
1-O-(2-O-Acetyl-3-O-allyl-5-O-benzyl-β-D-ribofuranosyl)-5-O-allyl-2,3,4-tri-O-benzyl-D-ribitol
Conditions | Yield |
---|---|
With molecular sieve; silver perchlorate In acetonitrile at -40℃; for 4h; Yield given; |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
p-toluenesulfonyl chloride
Conditions | Yield |
---|---|
In pyridine Ambient temperature; |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
pivaloyl chloride
5-O-allyl-2,3,4-tri-O-benzyl-1-O-pivaloyl-D-ribitol
Conditions | Yield |
---|---|
With pyridine at 0 - 23℃; for 2h; |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: pyridine / 2 h / 0 - 23 °C 2.1: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3.1: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C 4.1: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C 5.1: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C 6.1: 61 percent / EtN(i-Pr)2 / 1,2-dichloro-ethane / 2 h / 0 - 23 °C 7.1: tetrazole / acetonitrile / 1 h / 23 °C 7.2: 77 percent / pyridine; iodine / acetonitrile; tetrahydrofuran; H2O 8.1: 88 percent / HOAc; water / CH2Cl2 / 4 h / 23 °C 9.1: NH4OH / methanol / 8 h / Heating 9.2: Dowex 50 x 8-100 (Na(+)) / methanol 9.3: 88 percent / H2 / Pd/C / 2-methyl-propan-2-ol; H2O / 48 h / 23 °C / 10343 Torr View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: pyridine / 2 h / 0 - 23 °C 2.1: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3.1: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C 4.1: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C 5.1: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C 6.1: 61 percent / EtN(i-Pr)2 / 1,2-dichloro-ethane / 2 h / 0 - 23 °C 7.1: tetrazole / acetonitrile / 1 h / 23 °C 7.2: 77 percent / pyridine; iodine / acetonitrile; tetrahydrofuran; H2O 8.1: 88 percent / HOAc; water / CH2Cl2 / 4 h / 23 °C 9.1: NH4OH / methanol / 8 h / Heating 9.2: Dowex 50 x 8-100 (Na(+)) / methanol 9.3: 88 percent / H2 / Pd/C / 2-methyl-propan-2-ol; H2O / 48 h / 23 °C / 10343 Torr 10.1: MeOH; Et3N / H2O / 23 °C 10.2: Dowex 50 x 8-100 (Na(+)) / H2O View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
2,3,4-tri-O-benzyl-1-O-pivaloyl-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / 2 h / 0 - 23 °C 2: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 2 h / 0 - 23 °C 2: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
2,3,4-tri-O-benzyl-5-O-(4,4'-dimethoxytrityl)-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: pyridine / 2 h / 0 - 23 °C 2: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C 4: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C 5: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: pyridine / 2 h / 0 - 23 °C 2.1: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3.1: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C 4.1: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C 5.1: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C 6.1: 61 percent / EtN(i-Pr)2 / 1,2-dichloro-ethane / 2 h / 0 - 23 °C 7.1: tetrazole / acetonitrile / 1 h / 23 °C 7.2: 77 percent / pyridine; iodine / acetonitrile; tetrahydrofuran; H2O 8.1: 88 percent / HOAc; water / CH2Cl2 / 4 h / 23 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
2,3,4-tri-O-benzyl-5-O-(4,4'-dimethoxytrityl)-1-O-pivaloyl-D-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine / 2 h / 0 - 23 °C 2: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C 4: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
2-cyanoethyl [2,3,4-tri-O-benzyl-5-O-(4,4'-dimethoxytrityl)-1-D-ribityl] N,N-diisopropylphosphoramidite
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: pyridine / 2 h / 0 - 23 °C 2: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C 4: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C 5: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C 6: 61 percent / EtN(i-Pr)2 / 1,2-dichloro-ethane / 2 h / 0 - 23 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl [2,3,4-tri-O-benzyl-5-O-(4,4'-dimethoxytrityl)-1-D-ribityl] phosphate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: pyridine / 2 h / 0 - 23 °C 2.1: (1,5-cyclooctadiene)-bis(Me-diphenylphosphine)Ir F6phosphate / tetrahydrofuran / 4 h / 23 °C 3.1: 4.65 g / HgO; HgCl2 / acetone; H2O / 0.5 h / 23 °C 4.1: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C 5.1: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C 6.1: 61 percent / EtN(i-Pr)2 / 1,2-dichloro-ethane / 2 h / 0 - 23 °C 7.1: tetrazole / acetonitrile / 1 h / 23 °C 7.2: 77 percent / pyridine; iodine / acetonitrile; tetrahydrofuran; H2O View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
2,3,4-tri-O-benzyl-5-O-p-methoxybenzyl-L-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / 0.33 h / 0 °C 1.2: 89 percent / dimethylformamide / 4 h / 20 °C 2.1: 69 percent / 10 percent Pd/C / methanol; H2O / 10 h / 60 °C View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 2,3,4-tri-O-benzyl-L-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide / 0.33 h / 0 °C 1.2: 89 percent / dimethylformamide / 4 h / 20 °C 2.1: 69 percent / 10 percent Pd/C / methanol; H2O / 10 h / 60 °C 3.1: 16 percent / TMSOTf / acetonitrile / 0.67 h / -50 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: NaH / dimethylformamide / 0.33 h / 0 °C 1.2: 89 percent / dimethylformamide / 4 h / 20 °C 2.1: 69 percent / 10 percent Pd/C / methanol; H2O / 10 h / 60 °C 3.1: 17 percent / TMSOTf / acetonitrile / 0.67 h / -50 °C 4.1: 63 percent / DDQ / CH2Cl2; H2O / 4 h View Scheme |
2,3,4-Tris-O-(phenylmethyl)-5-O-(prop-2-enyl)-D-ribitol
1-O-(2-azido-4,6-O-benzylidene-2-deoxy-3-O-methyl-β-D-galactopyranosyl) 5-O-p-methoxybenzyl-2,3,4-tri-O-benzyl-L-ribitol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide / 0.33 h / 0 °C 1.2: 89 percent / dimethylformamide / 4 h / 20 °C 2.1: 69 percent / 10 percent Pd/C / methanol; H2O / 10 h / 60 °C 3.1: 17 percent / TMSOTf / acetonitrile / 0.67 h / -50 °C View Scheme |
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