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Wuhan Fortuna Chemical Co.,Ltd

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid CAS 113100-53-1 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid CAS 113100-53-1 with factory price

Cas:113100-53-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma

TIANFU 113100-53-1 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid CAS No.

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 113100-53-1 with best quality

Cas:113100-53-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:10 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 1-Methyl-3-trifluoromethyl-4-pyrazolecarboxylic Acid Molecular Formula:C6H5N2O2 F3 Molecular Weight:194.1113 CAS No.:113100-53-1 Appearance:Similar White Solid Appearance:Similar White Solid Storage:Store in cool and dry place, away from su

1-Methyl-3-trifluoromethyl-4-pyrazolecarboxylic Acid

Cas:113100-53-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 113100-53-1

Cas:113100-53-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID CAS: 113100-53-1 MF: C6H5F3N2O2 MW: 194.11 EINECS: 601-232-0 Mol File: 113100-53-1.mol 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Structure 1

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylic Acid

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

1-Methyl-3-trifluoromethylpyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Manufacturers

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid /Manufacturer in China

Cas:113100-53-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid cas no. 113100-53-1 98%

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Cas:113100-53-1

Min.Order:0

Negotiable

Type:Other

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Synthetic route

4-(furan-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole

4-(furan-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium periodate; rhodium(III) chloride hydrate In tetrachloromethane; water; acetonitrile at 20℃; for 0.25h;100%
ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
111493-74-4

ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 60℃;95%
With sodium hydroxide In ethanol at 85℃; for 0.5h;90%
With lithium hydroxide In tetrahydrofuran at 70℃; for 2h; pH=5;89.2%
1-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)ethanone

1-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)ethanone

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With bromine; sodium hydroxide In water at 10 - 15℃; for 3h; Cooling with ice;95%
With bromine; sodium hydroxide In water at 10 - 15℃; for 3h;95%
With dihydrogen peroxide; trifluoroacetic acid In chloroform at 0 - 70℃; for 5h;
1-Methyl-3-(trifluoromethyl)-4-trifluoroacetylpyrazole
142809-80-1

1-Methyl-3-(trifluoromethyl)-4-trifluoroacetylpyrazole

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 4h; Ambient temperature;93%
carbon dioxide
124-38-9

carbon dioxide

4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole
497832-99-2

4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole With tert.-butyl lithium In diethyl ether; pentane at -75℃; for 0.0833333h;
Stage #2: carbon dioxide Further stages.;
85%
3-piperidin-1-yl-acrylic acid methyl ester
90608-65-4

3-piperidin-1-yl-acrylic acid methyl ester

trifluoroacetyl fluoride
354-34-7

trifluoroacetyl fluoride

methylhydrazine
60-34-4

methylhydrazine

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-piperidin-1-yl-acrylic acid methyl ester; trifluoroacetyl fluoride With potassium fluoride In toluene at -30 - 20℃; for 4h;
Stage #2: methylhydrazine In toluene at -50 - 20℃; for 3h;
81%
1-methyl-3-trifluoromethylpyrazol
154471-65-5

1-methyl-3-trifluoromethylpyrazol

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / bromine; iron powder / 4 h / 100 °C
2: 85 percent / tert-butyllithium / pentane; diethyl ether / 0.08 h / -75 °C
View Scheme
β,β-bis(trifluoroacetyl)vinyl i-butyl ether

β,β-bis(trifluoroacetyl)vinyl i-butyl ether

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / acetonitrile / 0.5 h / Ambient temperature
2: 76 percent / CF3COOH, H2O / CHCl3 / 3 h / Ambient temperature
3: 93 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 73 percent / acetonitrile / 1 h / Ambient temperature
2: 93 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature
View Scheme
benzaldehyde N-<β,β-bis(trifluoroacetyl)vinyl>methylhydrazone
142818-04-0

benzaldehyde N-<β,β-bis(trifluoroacetyl)vinyl>methylhydrazone

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76 percent / CF3COOH, H2O / CHCl3 / 3 h / Ambient temperature
2: 93 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature
View Scheme
3-dimethylaminomethylene-1,1,1,5,5,5-hexafluoropentane-2,4-dione
142503-29-5

3-dimethylaminomethylene-1,1,1,5,5,5-hexafluoropentane-2,4-dione

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / acetonitrile / 1 h / Ambient temperature
2: 93 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature
View Scheme
4-Ethylthio-1,1,1-trifluoro-3-(trifluoroacetyl)-3-buten-2-one
142503-30-8

4-Ethylthio-1,1,1-trifluoro-3-(trifluoroacetyl)-3-buten-2-one

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / acetonitrile / 1 h / Ambient temperature
2: 93 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature
View Scheme
1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile
1049772-79-3

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide In methanol at 75℃; for 4h; Product distribution / selectivity;> 99 %Chromat.
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate
155377-19-8

ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide / 20.33 h / 0 - 20 °C
2: lithium hydroxide / tetrahydrofuran / 2 h / 70 °C / pH 5
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / toluene / 20 - 50 °C
2: sodium hydroxide / ethanol; water / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide / 20 h / 0 - 20 °C
2: sodium hydroxide / ethanol / 0.5 h / 85 °C
View Scheme
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate
571-55-1

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrazine hydrate / methanol / 3 h / 80 °C
2: sodium hydride / N,N-dimethyl-formamide / 20.33 h / 0 - 20 °C
3: lithium hydroxide / tetrahydrofuran / 2 h / 70 °C / pH 5
View Scheme
Multi-step reaction with 3 steps
1: hydrazine hydrate / ethanol / 20 °C / Cooling with ice
2: sodium hydrogencarbonate / toluene / 20 - 50 °C
3: sodium hydroxide / ethanol; water / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: ethyl acetate / 4 h / 5 °C / Reflux
2: potassium hydroxide; hydrogenchloride / water / pH 1
View Scheme
ethyl 5-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
231285-86-2

ethyl 5-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
111493-74-4

ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

A

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

B

1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
119083-00-0

1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl 5-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate; ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate With sodium hydroxide In water for 3h; Reflux;
Stage #2: With hydrogenchloride In water; toluene for 1h; Cooling with ice; Overall yield = 0.28 g;
4-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazole

4-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazole

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / tetrahydrofuran / 12 h / 40 °C
2: sodium periodate; rhodium(III) chloride hydrate / water; tetrachloromethane; acetonitrile / 0.25 h / 20 °C
View Scheme
methyl 3-methoxy-2-trichloroacetylacrylate

methyl 3-methoxy-2-trichloroacetylacrylate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 0 - 25 °C
2: pyridine; hydrogen fluoride / 125 - 155 °C
View Scheme
methyl 3-trichloromethyl-1-methyl-1H-pyrazole-4-carboxylate

methyl 3-trichloromethyl-1-methyl-1H-pyrazole-4-carboxylate

A

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

B

1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
119083-00-0

1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With pyridine; hydrogen fluoride at 125 - 155℃;A 119.75 mg
B n/a
ethyl (2E)-2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

ethyl (2E)-2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethyl acetate / 4 h / 5 °C / Reflux
2: potassium permanganate; water / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: ethyl acetate / 4 h / 5 °C / Reflux
2: potassium permanganate / water / 20 °C / pH 1
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 8 h / 60 °C / Cooling with ice
2: potassium hydroxide / ethanol / 24 h / 20 °C
View Scheme
3-dimethylaminomethylene-1,1,1-trifluoro-2,4-pentanedione

3-dimethylaminomethylene-1,1,1-trifluoro-2,4-pentanedione

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane; water / 1 h / -25 - -20 °C
2: sodium hydroxide; bromine / water / 3 h / 10 - 15 °C
View Scheme
1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl chloride
126674-98-4

1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride In diethyl ether at 20℃;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃;99%
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane for 5h; Reflux;90%
diethyl aminomalonate hydrochloride
13433-00-6

diethyl aminomalonate hydrochloride

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

2-[(1-methyl-3-trifluoromethyl-1H-pyrazol-4-carbonyl)-amino]-malonic acid diethyl ester
880478-72-8

2-[(1-methyl-3-trifluoromethyl-1H-pyrazol-4-carbonyl)-amino]-malonic acid diethyl ester

Conditions
ConditionsYield
With bis(2-oxo-3-oxazolidinyl)phosphoric acid chloride; triethylamine In tetrahydrofuran; dichloromethane at 0 - 20℃; for 16h;88.1%
methyl 2'-amino-3,5'-difluorobiphenyl-4-carboxylate
942203-32-9

methyl 2'-amino-3,5'-difluorobiphenyl-4-carboxylate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

methyl 3,5'-difluoro-2'-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)-biphenyl-4-carboxylate
942203-31-8

methyl 3,5'-difluoro-2'-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)-biphenyl-4-carboxylate

Conditions
ConditionsYield
Stage #1: 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid With oxalyl dichloride In dichloromethane; water; N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: methyl 2'-amino-3,5'-difluorobiphenyl-4-carboxylate With triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;
87%
C15H11N3OS

C15H11N3OS

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C21H14F3N5O2S

C21H14F3N5O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;79%
1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

methyl (E)-2-(2-bromomethylphenyl)-3-methoxyacrylate
117428-49-6

methyl (E)-2-(2-bromomethylphenyl)-3-methoxyacrylate

(E)-2-(1,3-dimethoxy-3-oxoprop-1-en-2-yl)benzyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

(E)-2-(1,3-dimethoxy-3-oxoprop-1-en-2-yl)benzyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
Stage #1: 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: methyl (E)-2-(2-bromomethylphenyl)-3-methoxyacrylate In N,N-dimethyl-formamide at 20℃; for 10h;
78.7%
C15H14N2OS

C15H14N2OS

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C21H17F3N4O2S

C21H17F3N4O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;76%
C14H11BrN2OS

C14H11BrN2OS

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C20H14BrF3N4O2S

C20H14BrF3N4O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;74%
2-(4-chlorobenzylthio)benzo[d]oxazol-5-amine

2-(4-chlorobenzylthio)benzo[d]oxazol-5-amine

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C20H14ClF3N4O2S

C20H14ClF3N4O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;70%
6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one

6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

1-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

1-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Conditions
ConditionsYield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 100℃; Sealed tube;70%
benzyl (3-(2-amino-5-carbamoyl-7-methoxy-1H-benzo(d)imidazol-1-yl)propyl)carbamate

benzyl (3-(2-amino-5-carbamoyl-7-methoxy-1H-benzo(d)imidazol-1-yl)propyl)carbamate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

benzyl 3-(5-carbamoyl-7-methoxy-2-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)-1H-benzo[d]imidazol-1-yl)propylcarbamate

benzyl 3-(5-carbamoyl-7-methoxy-2-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)-1H-benzo[d]imidazol-1-yl)propylcarbamate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 85℃;69.3%
9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalene-5-amine

9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalene-5-amine

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylidene-benzonorbornene-5-yl)amide

1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylidene-benzonorbornene-5-yl)amide

Conditions
ConditionsYield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 23h;69%
C15H11F3N2O2S

C15H11F3N2O2S

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C21H14F6N4O3S

C21H14F6N4O3S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;65%
C15H14N2O2S

C15H14N2O2S

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C21H17F3N4O3S

C21H17F3N4O3S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;62%
C14H11ClN2OS

C14H11ClN2OS

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C20H14ClF3N4O2S

C20H14ClF3N4O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;62%
2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2-methyl-1-propanamine hydrochloride
856245-39-1

2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2-methyl-1-propanamine hydrochloride

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2-methylpropyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2-methylpropyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Conditions
ConditionsYield
With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol at 20℃;59%
C14H10F2N2OS

C14H10F2N2OS

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C20H13F5N4O2S

C20H13F5N4O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;59%
ruthenocenylmethylamine

ruthenocenylmethylamine

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

N-methylruthenocenyl,3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylamide

N-methylruthenocenyl,3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Darkness;58%
2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine
856245-38-0

2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Conditions
ConditionsYield
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In ethanol at 20℃;57%
C15H11F3N2OS

C15H11F3N2OS

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C21H14F6N4O2S

C21H14F6N4O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;56%
4-(5-(4-(3,4-dimethylpiperazin-1-yl)-2-fluoro-5-aminophenyl)pyrimidin-2-yl)morpholine

4-(5-(4-(3,4-dimethylpiperazin-1-yl)-2-fluoro-5-aminophenyl)pyrimidin-2-yl)morpholine

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

N-[4-fluoro-5-(2-morpholin-4-ylpyrimidin-5-yl)-2-[rac-(3R)-3,4-dimethylpiperazin-1-yl]phenyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxamide

N-[4-fluoro-5-(2-morpholin-4-ylpyrimidin-5-yl)-2-[rac-(3R)-3,4-dimethylpiperazin-1-yl]phenyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 50 - 60℃;55%
1-(2-amino-5-fluoro-4-(2-morpholinopyrimidin-5-yl)phenyl)-N,N-dimethylpyrrolidin-3-amine

1-(2-amino-5-fluoro-4-(2-morpholinopyrimidin-5-yl)phenyl)-N,N-dimethylpyrrolidin-3-amine

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

N-[4-fluoro-5-(2-morpholin-4-ylpyrimidin-5-yl)-2-[rac-(3R)-3-(dimethylamino)pyrrolidin-1-yl]phenyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxamide

N-[4-fluoro-5-(2-morpholin-4-ylpyrimidin-5-yl)-2-[rac-(3R)-3-(dimethylamino)pyrrolidin-1-yl]phenyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 50 - 60℃;55%
glycine ethyl ester hydrochloride
623-33-6

glycine ethyl ester hydrochloride

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

ethyl (1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl) glycinate
916147-04-1

ethyl (1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl) glycinate

Conditions
ConditionsYield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In tetrahydrofuran; dichloromethane at 0 - 20℃; for 19h;54%
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In tetrahydrofuran; dichloromethane at 0 - 20℃;54%
C14H11FN2OS

C14H11FN2OS

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

C20H14F4N4O2S

C20H14F4N4O2S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;51%
1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

1,1-dimethylhydrazine
57-14-7

1,1-dimethylhydrazine

N’,N’,1-trimethyl-3-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide

N’,N’,1-trimethyl-3-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide

Conditions
ConditionsYield
Stage #1: 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid With triethylamine In dichloromethane at 20℃; for 0.0833333h;
Stage #2: N,N-Dimethylhydrazine With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
50%

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